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Volumn 492, Issue 7429, 2012, Pages 376-381

Functional screening identifies miRNAs inducing cardiac regeneration

Author keywords

[No Author keywords available]

Indexed keywords

AURORA B KINASE; HISTONE H3; MICRORNA; MICRORNA 199A; MICRORNA 590; UNCLASSIFIED DRUG;

EID: 84871442001     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11739     Document Type: Article
Times cited : (866)

References (50)
  • 1
    • 34248593790 scopus 로고    scopus 로고
    • Cardiac myocyte cell cycle control in development, disease, and regeneration
    • Ahuja, P., Sdek, P. & MacLellan, W. R. Cardiac myocyte cell cycle control in development, disease, and regeneration. Physiol. Rev. 87, 521-544 (2007).
    • (2007) Physiol. Rev , vol.87 , pp. 521-544
    • Ahuja, P.1    Sdek, P.2    MacLellan, W.R.3
  • 2
    • 57149146866 scopus 로고    scopus 로고
    • Features ofCMproliferation and its potential for cardiac regeneration
    • van Amerongen, M. J. & Engel, F. B. Features ofCMproliferation and its potential for cardiac regeneration. J. Cell. Mol. Med. 12, 2233-2244 (2008).
    • (2008) J. Cell. Mol. Med , vol.12 , pp. 2233-2244
    • Van Amerongen, M.J.1    Engel, F.B.2
  • 4
    • 64249107059 scopus 로고    scopus 로고
    • Evidence forCMrenewal inhumans
    • Bergmann, O. et al. Evidence forCMrenewal inhumans. Science324, 98-102(2009).
    • (2009) Science , vol.324 , pp. 98-102
    • Bergmann, O.1
  • 5
    • 77955172516 scopus 로고    scopus 로고
    • Cardiomyogenesis in the adult human heart
    • Kajstura, J. et al. Cardiomyogenesis in the adult human heart. Circ. Res. 107, 305-315 (2010).
    • (2010) Circ. Res , vol.107 , pp. 305-315
    • Kajstura, J.1
  • 6
    • 0035821988 scopus 로고    scopus 로고
    • Evidence that human cardiacmyocytes divide aftermyocardial infarction
    • Beltrami, A. P. et al. Evidence that human cardiacmyocytes divide aftermyocardial infarction. N. Engl. J. Med. 344, 1750-1757 (2001).
    • (2001) N. Engl. J. Med , vol.344 , pp. 1750-1757
    • Beltrami, A.P.1
  • 7
    • 77049264833 scopus 로고
    • Myocardial regenerationinyoungrats
    • Robledo, M. Myocardial regenerationinyoungrats. Am. J. Pathol. 32, 1215-1239(1956).
    • (1956) Am. J. Pathol , vol.32 , pp. 1215-1239
    • Robledo, M.1
  • 8
    • 0020954655 scopus 로고
    • DNA synthesis in rat heart cells after injury and the regeneration of myocardia
    • Nag, A. C., Carey, T. R. & Cheng, M. DNA synthesis in rat heart cells after injury and the regeneration of myocardia. Tissue Cell 15, 597-613 (1983).
    • (1983) Tissue Cell , vol.15 , pp. 597-613
    • Nag, A.C.1    Carey, T.R.2    Cheng, M.3
  • 9
    • 0028006390 scopus 로고
    • Myocyte cellular hyperplasia and myocyte cellular hypertrophy contribute to chronic ventricular remodeling in coronary artery narrowinginduced cardiomyopathy in rats
    • Kajstura, J. et al. Myocyte cellular hyperplasia and myocyte cellular hypertrophy contribute to chronic ventricular remodeling in coronary artery narrowinginduced cardiomyopathy in rats. Circ. Res. 74, 383-400 (1994).
    • (1994) Circ. Res , vol.74 , pp. 383-400
    • Kajstura, J.1
  • 10
    • 0027292195 scopus 로고
    • Impairment of myocyte contractility following coronary artery narrowing is associated with activation of the myocyte IGF1 autocrine system, enhanced expression of late growth related genes, DNAsyn thesis, andmyocyte nuclear mitotic division in rats
    • Reiss, K., Kajstura, J., Capasso, J. M., Marino, T. A. & Anversa, P. Impairment of myocyte contractility following coronary artery narrowing is associated with activation of the myocyte IGF1 autocrine system, enhanced expression of late growth related genes, DNAsynthesis, andmyocyte nuclear mitotic division in rats. Exp. Cell Res. 207, 348-360 (1993).
    • (1993) Exp. Cell Res , vol.207 , pp. 348-360
    • Reiss, K.1    Kajstura, J.2    Capasso, J.M.3    Marino, T.A.4    Anversa, P.5
  • 11
    • 58249088751 scopus 로고    scopus 로고
    • MiRNAs: Target recognition and regulatory functions
    • Bartel, D. P. MiRNAs: target recognition and regulatory functions. Cell 136, 215-233 (2009).
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 12
    • 84858446579 scopus 로고    scopus 로고
    • MiRNAs and their targets: Recognition, regulation and an emerging reciprocal relationship
    • Pasquinelli, A. E. MiRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Nature Rev. Genet. 13, 271-282 (2012).
    • (2012) Nature Rev. Genet , vol.13 , pp. 271-282
    • Pasquinelli, A.E.1
  • 13
    • 41149147013 scopus 로고    scopus 로고
    • Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure
    • Chen, J. F. et al. Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc. Natl Acad. Sci. USA 105, 2111-2116 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 2111-2116
    • Chen, J.F.1
  • 14
    • 70349254444 scopus 로고    scopus 로고
    • Loss of cardiac miRNA-mediated regulation leads to dilated cardiomyopathy and heart failure
    • Rao, P. K. et al. Loss of cardiac miRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ. Res. 105, 585-594 (2009).
    • (2009) Circ. Res , vol.105 , pp. 585-594
    • Rao, P.K.1
  • 15
    • 36248948593 scopus 로고    scopus 로고
    • Altered miRNA expression in human heart disease
    • Ikeda, S. et al. Altered miRNA expression in human heart disease. Physiol. Genomics 31, 367-373 (2007).
    • (2007) Physiol. Genomics , vol.31 , pp. 367-373
    • Ikeda, S.1
  • 16
    • 63649096271 scopus 로고    scopus 로고
    • Reciprocal regulation of myocardial miRNAs and messenger RNA in human cardiomyopathy and reversal of the miRNA signature by biomechanical support
    • Matkovich, S. J. et al. Reciprocal regulation of myocardial miRNAs and messenger RNA in human cardiomyopathy and reversal of the miRNA signature by biomechanical support. Circulation 119, 1263-1271 (2009).
    • (2009) Circulation , vol.119 , pp. 1263-1271
    • Matkovich, S.J.1
  • 17
    • 34547579291 scopus 로고    scopus 로고
    • MiRNAs in the human heart: A clue to fetal gene reprogramming in heart failure
    • Thum, T. et al. MiRNAs in the human heart: a clue to fetal gene reprogramming in heart failure. Circulation 116, 258-267 (2007).
    • (2007) Circulation , vol.116 , pp. 258-267
    • Thum, T.1
  • 18
    • 33845317603 scopus 로고    scopus 로고
    • A signature pattern of stress-responsive miRNAs that can evoke cardiac hypertrophy and heart failure
    • van Rooij, E. et al. A signature pattern of stress-responsive miRNAs that can evoke cardiac hypertrophy and heart failure. Proc. Natl Acad. Sci. USA 103, 18255-18260 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 18255-18260
    • Van Rooij, E.1
  • 19
    • 22444437609 scopus 로고    scopus 로고
    • Serumresponsefactor regulatesamuscle-specific miRNA that targets Hand2 during cardiogenesis
    • Zhao, Y., Samal, E. & Srivastava, D. Serumresponsefactor regulatesamuscle-specific miRNA that targets Hand2 during cardiogenesis. Nature 436, 214-220 (2005).
    • (2005) Nature , vol.436 , pp. 214-220
    • Zhao, Y.1    Samal, E.2    Srivastava, D.3
  • 20
    • 34147153781 scopus 로고    scopus 로고
    • Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2
    • Zhao, Y. et al. Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell 129, 303-317 (2007).
    • (2007) Cell , vol.129 , pp. 303-317
    • Zhao, Y.1
  • 21
    • 57749121689 scopus 로고    scopus 로고
    • MiRNA-133a regulates CM proliferation and suppresses smooth muscle gene expression in the heart
    • Liu, N. et al. miRNA-133a regulates CM proliferation and suppresses smooth muscle gene expression in the heart. Genes Dev. 22, 3242-3254 (2008).
    • (2008) Genes Dev , vol.22 , pp. 3242-3254
    • Liu, N.1
  • 22
    • 80052557916 scopus 로고    scopus 로고
    • MiR-15 family regulates postnatal mitotic arrest of CMs
    • Porrello, E. R. et al. MiR-15 family regulates postnatal mitotic arrest of CMs. Circ. Res. 109, 670-679 (2011).
    • (2011) Circ. Res , vol.109 , pp. 670-679
    • Porrello, E.R.1
  • 23
    • 40649111377 scopus 로고    scopus 로고
    • A chemical method for fast and sensitive detection of DNA synthesis in vivo
    • Salic, A. & Mitchison, T. J. A chemical method for fast and sensitive detection of DNA synthesis in vivo. Proc. Natl Acad. Sci. USA 105, 2415-2420 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 2415-2420
    • Salic, A.1    Mitchison, T.J.2
  • 25
    • 0030219688 scopus 로고    scopus 로고
    • Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development
    • Li, F., Wang, X., Capasso, J. M. & Gerdes, A. M. Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development. J. Mol. Cell. Cardiol. 28, 1737-1746 (1996).
    • (1996) J. Mol. Cell. Cardiol , vol.28 , pp. 1737-1746
    • Li, F.1    Wang, X.2    Capasso, J.M.3    Gerdes, A.M.4
  • 26
    • 80755156297 scopus 로고    scopus 로고
    • Oncostatin M is a major mediator of CM dedifferentiation and remodeling
    • Kubin, T. et al. Oncostatin M is a major mediator of CM dedifferentiation and remodeling. Cell Stem Cell 9, 420-432 (2011).
    • (2011) Cell Stem Cell , vol.9 , pp. 420-432
    • Kubin, T.1
  • 27
    • 12944268866 scopus 로고    scopus 로고
    • Interactions between cardiac cells enhanceCMhypertrophy and increase fibroblast proliferation
    • Fredj, S., Bescond, J., Louault, C. & Potreau, D. Interactions between cardiac cells enhanceCMhypertrophy and increase fibroblast proliferation. J. Cell. Physiol. 202, 891-899 (2005).
    • (2005) J. Cell. Physiol , vol.202 , pp. 891-899
    • Fredj, S.1    Bescond, J.2    Louault, C.3    Potreau, D.4
  • 28
    • 77958614288 scopus 로고    scopus 로고
    • Dedifferentiation and proliferation ofmammalianCMs
    • Zhang, Y. et al. Dedifferentiation and proliferation ofmammalianCMs. PLoSONE 5, e12559 (2010).
    • (2010) PLoS ONE , vol.5
    • Zhang, Y.1
  • 29
    • 0038707452 scopus 로고    scopus 로고
    • ThehumanadultCMphenotype
    • Bird, S. D. et al. ThehumanadultCMphenotype. Cardiovasc. Res. 58, 423-434(2003).
    • (2003) Cardiovasc. Res , vol.58 , pp. 423-434
    • Bird, S.D.1
  • 30
    • 70450248659 scopus 로고    scopus 로고
    • Homer and the ryanodine receptor
    • Pouliquin, P. & Dulhunty, A. F. Homer and the ryanodine receptor. Eur. Biophys. J. 39, 91-102 (2009).
    • (2009) Eur. Biophys. J , vol.39 , pp. 91-102
    • Pouliquin, P.1    Dulhunty, A.F.2
  • 31
    • 77956604362 scopus 로고    scopus 로고
    • Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation
    • Trivedi, C. M. et al. Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation. Dev. Cell 19, 450-459 (2010).
    • (2010) Dev. Cell , vol.19 , pp. 450-459
    • Trivedi, C.M.1
  • 32
    • 33745143956 scopus 로고    scopus 로고
    • Robust systemic transduction with AAV9 vectors in mice: Efficient global cardiac gene transfer superior to that of AAV8
    • Inagaki, K. et al. Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8. Mol. Ther. 14, 45-53 (2006).
    • (2006) Mol. Ther , vol.14 , pp. 45-53
    • Inagaki, K.1
  • 33
    • 79957497037 scopus 로고    scopus 로고
    • Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling
    • Katare, R. et al. Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling. Circ. Res. 108, 1238-1251 (2011).
    • (2011) Circ. Res , vol.108 , pp. 1238-1251
    • Katare, R.1
  • 34
    • 33749531597 scopus 로고    scopus 로고
    • Systemic tumor necrosis factor-related apoptosis-inducing ligand delivery shows antiatherosclerotic activity in apolipoprotein E-null diabetic mice
    • Secchiero, P. et al. Systemic tumor necrosis factor-related apoptosis-inducing ligand delivery shows antiatherosclerotic activity in apolipoprotein E-null diabetic mice. Circulation 114, 1522-1530 (2006).
    • (2006) Circulation , vol.114 , pp. 1522-1530
    • Secchiero, P.1
  • 35
    • 4344717801 scopus 로고    scopus 로고
    • Sequentialmyofibrillar breakdown accompaniesmitoticdivisionofmammalianCMs
    • Ahuja, P., Perriard, E., Perriard, J. C. & Ehler, E. Sequentialmyofibrillar breakdown accompaniesmitoticdivisionofmammalianCMs. J. Cell Sci. 117, 3295-3306(2004).
    • (2004) J. Cell Sci , vol.117 , pp. 3295-3306
    • Ahuja, P.1    Perriard, E.2    Perriard, J.C.3    Ehler, E.4
  • 36
    • 77952294182 scopus 로고    scopus 로고
    • CM VEGFR-1 activation by VEGF-B induces compensatory hypertrophy and preserves cardiac function after myocardial infarction
    • Zentilin, L. et al. CM VEGFR-1 activation by VEGF-B induces compensatory hypertrophy and preserves cardiac function after myocardial infarction. FASEB J. 24, 1467-1478 (2010).
    • (2010) FASEB J , vol.24 , pp. 1467-1478
    • Zentilin, L.1
  • 37
    • 53849117806 scopus 로고    scopus 로고
    • Notch1 signaling stimulates proliferation of immature CMs
    • Collesi, C., Zentilin, L., Sinagra, G. & Giacca, M. Notch1 signaling stimulates proliferation of immature CMs. J. Cell Biol. 183, 117-128 (2008).
    • (2008) J. Cell Biol , vol.183 , pp. 117-128
    • Collesi, C.1    Zentilin, L.2    Sinagra, G.3    Giacca, M.4
  • 38
    • 77950200829 scopus 로고    scopus 로고
    • Zebrafish heart regeneration occurs by CM dedifferentiation and proliferation
    • Jopling, C. et al. Zebrafish heart regeneration occurs by CM dedifferentiation and proliferation. Nature 464, 606-609 (2010).
    • (2010) Nature , vol.464 , pp. 606-609
    • Jopling, C.1
  • 39
    • 77950201708 scopus 로고    scopus 로고
    • Primary contribution to zebrafish heart regeneration by gata41 CMs
    • Kikuchi, K. et al. Primary contribution to zebrafish heart regeneration by gata41 CMs. Nature 464, 601-605 (2010).
    • (2010) Nature , vol.464 , pp. 601-605
    • Kikuchi, K.1
  • 40
    • 0037073890 scopus 로고    scopus 로고
    • Heart regeneration in zebrafish
    • Poss, K. D., Wilson, L. G. & Keating, M. T. Heart regeneration in zebrafish. Science 298, 2188-2190 (2002).
    • (2002) Science , vol.298 , pp. 2188-2190
    • Poss, K.D.1    Wilson, L.G.2    Keating, M.T.3
  • 41
    • 79952065525 scopus 로고    scopus 로고
    • Transient regenerative potential of the neonatal mouse heart
    • Porrello, E. R. et al. Transient regenerative potential of the neonatal mouse heart. Science 331, 1078-1080 (2011).
    • (2011) Science , vol.331 , pp. 1078-1080
    • Porrello, E.R.1
  • 42
    • 59449098471 scopus 로고    scopus 로고
    • Apoptotic and non-apoptotic programmed CM death in ventricular remodeling
    • Dorn, G. W. II. Apoptotic and non-apoptotic programmed CM death in ventricular remodelling. Cardiovasc. Res. 81, 465-473 (2009).
    • (2009) Cardiovasc. Res , vol.81 , pp. 465-473
    • Dorn, I.I.G.W.1
  • 43
    • 52949136220 scopus 로고    scopus 로고
    • Celldeathinheart failure
    • Nishida, K. & Otsu, K. Celldeathinheart failure. Circ. J. 72(Suppl. A)A17-A21(2008).
    • (2008) Circ. J , vol.72 , Issue.SUPPL. A
    • Nishida, K.1    Otsu, K.2
  • 44
    • 82255175382 scopus 로고    scopus 로고
    • Cardiac stemcells inpatientswithischaemic cardiomyopathy(SCIPIO): Initial results of a randomised phase 1 trial
    • Bolli, R. et al. Cardiac stemcells inpatientswithischaemic cardiomyopathy(SCIPIO): initial results of a randomised phase 1 trial. Lancet 378, 1847-1857 (2011).
    • (2011) Lancet , vol.378 , pp. 1847-1857
    • Bolli, R.1
  • 45
    • 84858019974 scopus 로고    scopus 로고
    • Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): A prospective, randomised phase 1 trial
    • Makkar, R. R. et al. Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial. Lancet 379, 895-904 (2012).
    • (2012) Lancet , vol.379 , pp. 895-904
    • Makkar, R.R.1
  • 46
    • 0034970775 scopus 로고    scopus 로고
    • MEK1/2-ERK1/2 mediates a1-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes
    • Xiao, L. et al. MEK1/2-ERK1/2 mediates a1-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes. J. Mol. Cell. Cardiol. 33, 779-787 (2001).
    • (2001) J. Mol. Cell. Cardiol , vol.33 , pp. 779-787
    • Xiao, L.1
  • 47
    • 0037689525 scopus 로고    scopus 로고
    • Induction of functional neovascularization by combined VEGF and angiopoietin-1 gene transfer using AAV vectors
    • Arsic, N. et al. Induction of functional neovascularization by combined VEGF and angiopoietin-1 gene transfer using AAV vectors. Mol. Ther. 7, 450-459 (2003).
    • (2003) Mol. Ther , vol.7 , pp. 450-459
    • Arsic, N.1
  • 48
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 22DDCT Method
    • Livak, K. J. & Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 22DDCT Method. Methods 25, 402-408 (2001).
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 49
    • 0036169031 scopus 로고    scopus 로고
    • Genesis cluster analysis of microarray data
    • Sturn, A., Quackenbush, J. & Trajanoski, Z. Genesis: cluster analysis of microarray data. Bioinformatics 18, 207-208 (2002).
    • (2002) Bioinformatics , vol.18 , pp. 207-208
    • Sturn, A.1    Quackenbush, J.2    Trajanoski, Z.3


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