Anti-remodeling and anti-fibrotic effects of the Neuregulin-1ß glial growth factor 2 in a large animal model of heart failure

Journal of the American Heart Association

Volumn 3, Issue 5, 2014, Pages

  Galindo, Cristi L ^a   Kasasbeh, Ehab ^a   Murphy, Abigail ^a   Ryzhov, Sergey ^a   Lenihan, Sean ^a   Ahmad, Farhaan A ^a   Williams, Philip ^a   Nunnally, Amy ^a   Adcock, Jamie ^a   Song, Yanna ^b   Harrell, Frank E ^b   Tran, Truc Linh ^a   Parry, Tom J ^d   Iaci, Jen ^d   Ganguly, Anindita ^d   Feoktistov, Igor ^a   Stephenson, Matthew K ^c   Caggiano, Anthony O ^d   Sawyer, Douglas B ^a   Cleator, John H ^b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c VANDERBILT INGRAM CANCER CENTER   (United States)

^d ACORDA THERAPEUTICS INC   (United States)

Author keywords

Extracellular matrix; Fibroblasts; Fibrosis; myocardial infarction; Neuregulin

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CIMAGLERMIN ALFA; COLLAGEN; COLLAGEN TYPE 4; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; ACTIN; NEU DIFFERENTIATION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIFIBROTIC ACTIVITY; ANTIREMODELLING ACTIVITY; ARTICLE; CELL ISOLATION; CELL ULTRASTRUCTURE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG MECHANISM; ELECTRON MICROSCOPY; EXTRACELLULAR MATRIX; FIBROBLAST; GENE EXPRESSION REGULATION; HEART CONTRACTION; HEART FAILURE; HEART FUNCTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART MITOCHONDRION; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART VENTRICLE REMODELING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; MICROARRAY ANALYSIS; MOUSE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; RAT; SWINE; TRANSCRIPTION REGULATION; ANIMAL; C57BL MOUSE; CARDIAC MUSCLE; CELL CULTURE; DISEASE MODEL; DRUG EFFECTS; FIBROSIS; GENETIC TRANSCRIPTION; GENETICS; HEART LEFT VENTRICLE FUNCTION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; PIG; SPRAGUE DAWLEY RAT; TIME FACTOR;

ACTINS; ANIMALS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROSIS; GENE EXPRESSION REGULATION; HEART FAILURE; MALE; MICE, INBRED C57BL; MYOCARDIAL CONTRACTION; MYOCARDIUM; MYOFIBROBLASTS; NEUREGULIN-1; PHOSPHORYLATION; RATS, SPRAGUE-DAWLEY; SMAD3 PROTEIN; SWINE; TIME FACTORS; TRANSCRIPTION, GENETIC; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 84930674628     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: None     Document Type: Article

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