Acute myocardial infarction activates distinct inflammation and proliferation pathways in circulating monocytes, prior to recruitment, and identified through conserved transcriptional responses in mice and humans

European Heart Journal

Volumn 36, Issue 29, 2015, Pages 1923-1934

  Ruparelia, Neil ^a   Godec, Jernej ^b   Lee, Regent ^a   Chai, Joshua T ^a   Dall'Armellina, Erica ^a   McAndrew, Debra ^a   Digby, Janet E ^a   Forfar, J Colin ^a   Prendergast, Bernard D ^a   Kharbanda, Rajesh K ^a   Banning, Adrian P ^a   Neubauer, Stefan ^a   Lygate, Craig A ^a   Channon, Keith M ^a   Haining, Nicholas W ^b   Choudhury, Robin P ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Acute myocardial infarction; Genomics; Inflammation; Mitosis; Monocytes

Indexed keywords

ACETYLSALICYLIC ACID; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CD11B ANTIGEN; CD14 ANTIGEN; CD16 ANTIGEN; CLOPIDOGREL; DIURETIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PRASUGREL; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTOME;

ACUTE HEART INFARCTION; ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY LIGATION; FEMALE; GENE EXPRESSION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE INJURY; HUMAN; INFLAMMATION; MALE; MONOCYTE; MONOCYTOSIS; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; TRANSTHORACIC ECHOCARDIOGRAPHY; UPREGULATION; ANIMAL; C57BL MOUSE; CASE CONTROL STUDY; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; GENETICS; HEART INFARCTION; IMMUNOLOGY; LIGATION; MAGNETIC RESONANCE ANGIOGRAPHY; MIDDLE AGED; MONONUCLEAR CELL; PATHOLOGY; PHENOTYPE; PHYSIOLOGY; TRANSCRIPTION INITIATION;

AGED; ANIMALS; CASE-CONTROL STUDIES; CELL PROLIFERATION; FEMALE; GENE EXPRESSION PROFILING; HUMANS; INFLAMMATION; LEUKOCYTES, MONONUCLEAR; LIGATION; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; MICE, INBRED C57BL; MIDDLE AGED; MYOCARDIAL INFARCTION; PHENOTYPE; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 84939560620     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehv195     Document Type: Article

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