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Volumn 143, Issue 3, 2016, Pages 387-397

View from the heart: Cardiac fibroblasts in development, scarring and regeneration

Author keywords

Fibroblasts; Heart; Regeneration; Scarring

Indexed keywords

CARDIAC STEM CELL; GENE EXPRESSION; HEART DEVELOPMENT; HEART FIBROBLAST; HEART FUNCTION; HEART MUSCLE CELL; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; SCAR FORMATION; TISSUE REGENERATION; ANIMAL; CYTOLOGY; EMBRYOLOGY; FIBROBLAST; GENE EXPRESSION PROFILING; HEART; PATHOLOGY; REGENERATION; SCAR; STEM CELL;

EID: 84956661487     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.120576     Document Type: Review
Times cited : (113)

References (123)
  • 1
    • 0035877019 scopus 로고    scopus 로고
    • Peripheral blood fibrocytes: Differentiation pathway and migration to wound sites
    • Abe, R., Donnelly, S. C., Peng, T., Bucala, R. and Metz, C. N. (2001). Peripheral blood fibrocytes: differentiation pathway and migration to wound sites. J. Immunol. 166, 7556-7562.
    • (2001) J. Immunol , vol.166 , pp. 7556-7562
    • Abe, R.1    Donnelly, S.C.2    Peng, T.3    Bucala, R.4    Metz, C.N.5
  • 3
    • 34248593790 scopus 로고    scopus 로고
    • Cardiac myocyte cell cycle control in development, disease, and regeneration
    • Ahuja, P., Sdek, P. and MacLellan, W. R. (2007). Cardiac myocyte cell cycle control in development, disease, and regeneration. Physiol. Rev. 87, 521-544.
    • (2007) Physiol. Rev , vol.87 , pp. 521-544
    • Ahuja, P.1    Sdek, P.2    Maclellan, W.R.3
  • 5
    • 84904596460 scopus 로고    scopus 로고
    • Embryonic stem cell-derived cardiac myocytes are not ready for human trials
    • Anderson, M. E., Goldhaber, J., Houser, S. R., Puceat, M. and Sussman, M. A. (2014). Embryonic stem cell-derived cardiac myocytes are not ready for human trials. Circ. Res. 115, 335-338.
    • (2014) Circ. Res , vol.115 , pp. 335-338
    • Anderson, M.E.1    Goldhaber, J.2    Houser, S.R.3    Puceat, M.4    Sussman, M.A.5
  • 7
    • 79961230399 scopus 로고    scopus 로고
    • Pericytes: Developmental, physiological, and pathological perspectives, problems, and promises
    • Armulik, A., Genové, G. and Betsholtz, C. (2011). Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. Dev. Cell 21, 193-215.
    • (2011) Dev. Cell , vol.21 , pp. 193-215
    • Armulik, A.1    Genové, G.2    Betsholtz, C.3
  • 8
    • 0036841474 scopus 로고    scopus 로고
    • Side population cells from diverse adult tissues are capable of in vitro hematopoietic differentiation
    • Asakura, A. and Rudnicki, M. A. (2002). Side population cells from diverse adult tissues are capable of in vitro hematopoietic differentiation. Exp. Hematol. 30, 1339-1345.
    • (2002) Exp. Hematol , vol.30 , pp. 1339-1345
    • Asakura, A.1    Rudnicki, M.A.2
  • 9
    • 84908545287 scopus 로고    scopus 로고
    • Tipping the balance from angiogenesis to fibrosis in CKD
    • Ballermann, B. J. and Obeidat, M. (2014). Tipping the balance from angiogenesis to fibrosis in CKD. Kidney Int. Suppl. 4, 45-52.
    • (2014) Kidney Int. Suppl , vol.4 , pp. 45-52
    • Ballermann, B.J.1    Obeidat, M.2
  • 15
    • 33847347313 scopus 로고    scopus 로고
    • ECM remodeling in hypertensive heart disease
    • Berk, B. C., Fujiwara, K. and Lehoux, S. (2007). ECM remodeling in hypertensive heart disease. J. Clin. Invest. 117, 568-575.
    • (2007) J. Clin. Invest , vol.117 , pp. 568-575
    • Berk, B.C.1    Fujiwara, K.2    Lehoux, S.3
  • 16
    • 77951181560 scopus 로고    scopus 로고
    • A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates
    • Blin, G., Nury, D., Stefanovic, S., Neri, T., Guillevic, O., Brinon, B., Bellamy, V., Rücker-Martin, C., Barbry, P., Bel, A. et al. (2010). A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates. J. Clin. Invest. 120, 1125-1139.
    • (2010) J. Clin. Invest , vol.120 , pp. 1125-1139
    • Blin, G.1    Nury, D.2    Stefanovic, S.3    Neri, T.4    Guillevic, O.5    Brinon, B.6    Bellamy, V.7    Rücker-Martin, C.8    Barbry, P.9    Bel, A.10
  • 18
    • 79151482466 scopus 로고    scopus 로고
    • Resident cardiac progenitor cells: At the heart of regeneration
    • Bollini, S., Smart, N. and Riley, P. R. (2011). Resident cardiac progenitor cells: at the heart of regeneration. J. Mol. Cell. Cardiol. 50, 296-303.
    • (2011) J. Mol. Cell. Cardiol , vol.50 , pp. 296-303
    • Bollini, S.1    Smart, N.2    Riley, P.R.3
  • 20
    • 0035873502 scopus 로고    scopus 로고
    • Identification and characterization of Lbh, a novel conserved nuclear protein expressed during early limb and heart development
    • Briegel, K. J. and Joyner, A. L. (2001). Identification and characterization of Lbh, a novel conserved nuclear protein expressed during early limb and heart development. Dev. Biol. 233, 291-304.
    • (2001) Dev. Biol , vol.233 , pp. 291-304
    • Briegel, K.J.1    Joyner, A.L.2
  • 21
    • 13844312743 scopus 로고    scopus 로고
    • The cardiac fibroblast: Therapeutic target in myocardial remodeling and failure
    • Brown, R. D., Ambler, S. K., Mitchell, M. D. and Long, C. S. (2005). The cardiac fibroblast: therapeutic target in myocardial remodeling and failure. Annu. Rev. Pharmacol. Toxicol. 45, 657-687.
    • (2005) Annu. Rev. Pharmacol. Toxicol , vol.45 , pp. 657-687
    • Brown, R.D.1    Ambler, S.K.2    Mitchell, M.D.3    Long, C.S.4
  • 23
    • 11144346203 scopus 로고    scopus 로고
    • Structural and functional characterisation of cardiac fibroblasts
    • Camelliti, P., Borg, T. K. and Kohl, P. (2005). Structural and functional characterisation of cardiac fibroblasts. Cardiovasc. Res. 65, 40-51.
    • (2005) Cardiovasc. Res , vol.65 , pp. 40-51
    • Camelliti, P.1    Borg, T.K.2    Kohl, P.3
  • 24
    • 50849122983 scopus 로고    scopus 로고
    • All MSCs are pericytes?
    • Caplan, A. I. (2008). All MSCs are pericytes? Cell Stem Cell 3, 229-230.
    • (2008) Cell Stem Cell , vol.3 , pp. 229-230
    • Caplan, A.I.1
  • 29
    • 84879383428 scopus 로고    scopus 로고
    • Progenitor cells identified by PDGFR-alpha expression in the developing and diseased human heart
    • Chong, J. J. H., Reinecke, H., Iwata, M., Torok-Storb, B., Stempien-Otero, A. and Murry, C. E. (2013). Progenitor cells identified by PDGFR-alpha expression in the developing and diseased human heart. Stem Cells Dev. 22, 1932-1943.
    • (2013) Stem Cells Dev , vol.22 , pp. 1932-1943
    • Chong, J.J.H.1    Reinecke, H.2    Iwata, M.3    Torok-Storb, B.4    Stempien-Otero, A.5    Murry, C.E.6
  • 31
    • 84898657013 scopus 로고    scopus 로고
    • Cardiac (Myo)fibroblast: Novel strategies for its targeting following myocardial infarction
    • Daskalopoulos, E. P., Hermans, K. C. and Blankesteijn, W. M. (2014). Cardiac (myo)fibroblast: Novel strategies for its targeting following myocardial infarction. Curr. Pharm. Des. 20, 1987-2002.
    • (2014) Curr. Pharm. Des , vol.20 , pp. 1987-2002
    • Daskalopoulos, E.P.1    Hermans, K.C.2    Blankesteijn, W.M.3
  • 32
    • 84899045255 scopus 로고    scopus 로고
    • Cell-cell interaction in the heart via Wnt/beta-catenin pathway after cardiac injury
    • Deb, A. (2014). Cell-cell interaction in the heart via Wnt/beta-catenin pathway after cardiac injury. Cardiovasc. Res. 102, 214-223.
    • (2014) Cardiovasc. Res , vol.102 , pp. 214-223
    • Deb, A.1
  • 33
    • 84873665320 scopus 로고    scopus 로고
    • Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury
    • Del Re, D. P., Yang, Y., Nakano, N., Cho, J., Zhai, P., Yamamoto, T., Zhang, N., Yabuta, N., Nojima, H., Pan, D. et al. (2013). Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury. J. Biol. Chem. 288, 3977-3988.
    • (2013) J. Biol. Chem , vol.288 , pp. 3977-3988
    • Del Re, D.P.1    Yang, Y.2    Nakano, N.3    Cho, J.4    Zhai, P.5    Yamamoto, T.6    Zhang, N.7    Yabuta, N.8    Nojima, H.9    Pan, D.10
  • 35
    • 84942512037 scopus 로고    scopus 로고
    • Origin of fibrosing cells in systemic sclerosis
    • Ebmeier, S. and Horsley, V. (2015). Origin of fibrosing cells in systemic sclerosis. Curr. Opin. Rheumatol. 27, 555-562.
    • (2015) Curr. Opin. Rheumatol , vol.27 , pp. 555-562
    • Ebmeier, S.1    Horsley, V.2
  • 36
    • 84892450644 scopus 로고    scopus 로고
    • Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation
    • Epelman, S., Lavine, K. J., Beaudin, A. E., Sojka, D. K., Carrero, J. A., Calderon, B., Brija, T., Gautier, E. L., Ivanov, S., Satpathy, A. T. et al. (2014). Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation. Immunity 40, 91-104.
    • (2014) Immunity , vol.40 , pp. 91-104
    • Epelman, S.1    Lavine, K.J.2    Beaudin, A.E.3    Sojka, D.K.4    Carrero, J.A.5    Calderon, B.6    Brija, T.7    Gautier, E.L.8    Ivanov, S.9    Satpathy, A.T.10
  • 37
    • 84951750749 scopus 로고    scopus 로고
    • Maturing human pluripotent stem cell-derived cardiomyocytes in human engineered cardiac tissues
    • Feric, N. T. and Radisic, M. (2016). Maturing human pluripotent stem cell-derived cardiomyocytes in human engineered cardiac tissues. Adv. Drug Deliv. Rev. 96, 110-134.
    • (2016) Adv. Drug Deliv. Rev , vol.96 , pp. 110-134
    • Feric, N.T.1    Radisic, M.2
  • 42
    • 0028785406 scopus 로고
    • Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor
    • Gassmann, M., Casagranda, F., Orioli, D., Simon, H., Lai, C., Klein, R. and Lemke, G. (1995). Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature 378, 390-394.
    • (1995) Nature , vol.378 , pp. 390-394
    • Gassmann, M.1    Casagranda, F.2    Orioli, D.3    Simon, H.4    Lai, C.5    Klein, R.6    Lemke, G.7
  • 44
    • 84884900100 scopus 로고    scopus 로고
    • Cardiac resident progenitor cells: Evidence and functional significance
    • Guan, K. and Hasenfuss, G. (2013). Cardiac resident progenitor cells: evidence and functional significance. Eur. Heart J. 34, 2784-2787.
    • (2013) Eur. Heart J , vol.34 , pp. 2784-2787
    • Guan, K.1    Hasenfuss, G.2
  • 48
    • 78650489190 scopus 로고    scopus 로고
    • Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction
    • He, W., Zhang, L., Ni, A., Zhang, Z., Mirotsou, M., Mao, L., Pratt, R. E. and Dzau, V. J. (2010). Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction. Proc. Natl. Acad. Sci. USA 107, 21110-21115.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 21110-21115
    • He, W.1    Zhang, L.2    Ni, A.3    Zhang, Z.4    Mirotsou, M.5    Mao, L.6    Pratt, R.E.7    Dzau, V.J.8
  • 49
    • 59649110883 scopus 로고    scopus 로고
    • Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling
    • Ieda, M., Tsuchihashi, T., Ivey, K. N., Ross, R. S., Hong, T.-T., Shaw, R. M. and Srivastava, D. (2009). Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. Dev. Cell 16, 233-244.
    • (2009) Dev. Cell , vol.16 , pp. 233-244
    • Ieda, M.1    Tsuchihashi, T.2    Ivey, K.N.3    Ross, R.S.4    Hong, T.-T.5    Shaw, R.M.6    Srivastava, D.7
  • 52
    • 74049114704 scopus 로고    scopus 로고
    • Intramyocardial fibroblast myocyte communication
    • Kakkar, R. and Lee, R. T. (2010). Intramyocardial fibroblast myocyte communication. Circ. Res. 106, 47-57.
    • (2010) Circ. Res , vol.106 , pp. 47-57
    • Kakkar, R.1    Lee, R.T.2
  • 53
    • 79551597211 scopus 로고    scopus 로고
    • Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines
    • Kattman, S. J., Witty, A. D., Gagliardi, M., Dubois, N. C., Niapour, M., Hotta, A., Ellis, J. and Keller, G. (2011). Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. Cell Stem Cell 8, 228-240.
    • (2011) Cell Stem Cell , vol.8 , pp. 228-240
    • Kattman, S.J.1    Witty, A.D.2    Gagliardi, M.3    Dubois, N.C.4    Niapour, M.5    Hotta, A.6    Ellis, J.7    Keller, G.8
  • 55
    • 84930082728 scopus 로고    scopus 로고
    • The clinical application of mesenchymal stem cells and cardiac stem cells as a therapy for cardiovascular disease
    • Kim, J., Shapiro, L. and Flynn, A. (2015). The clinical application of mesenchymal stem cells and cardiac stem cells as a therapy for cardiovascular disease. Pharmacol. Ther. 151, 8-15.
    • (2015) Pharmacol. Ther , vol.151 , pp. 8-15
    • Kim, J.1    Shapiro, L.2    Flynn, A.3
  • 56
    • 34547738523 scopus 로고    scopus 로고
    • Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy
    • Kirk, E. P., Sunde, M., Costa, M. W., Rankin, S. A., Wolstein, O., Castro, M. L., Butler, T. L., Hyun, C., Guo, G., Otway, R. et al. (2007). Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy. Am. J. Hum. Genet. 81, 280-291.
    • (2007) Am. J. Hum. Genet , vol.81 , pp. 280-291
    • Kirk, E.P.1    Sunde, M.2    Costa, M.W.3    Rankin, S.A.4    Wolstein, O.5    Castro, M.L.6    Butler, T.L.7    Hyun, C.8    Guo, G.9    Otway, R.10
  • 57
    • 58149333154 scopus 로고    scopus 로고
    • Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction
    • Kobayashi, K., Luo, M., Zhang, Y., Wilkes, D. C., Ge, G., Grieskamp, T., Yamada, C., Liu, T.-C., Huang, G., Basson, C. T. et al. (2009). Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction. Nat. Cell Biol. 11, 46-55.
    • (2009) Nat. Cell Biol , vol.11 , pp. 46-55
    • Kobayashi, K.1    Luo, M.2    Zhang, Y.3    Wilkes, D.C.4    Ge, G.5    Grieskamp, T.6    Yamada, C.7    Liu, T.-C.8    Huang, G.9    Basson, C.T.10
  • 58
    • 84899113897 scopus 로고    scopus 로고
    • Fibroblast–myocyte electrotonic coupling: Does it occur in native cardiac tissue
    • Kohl, P. and Gourdie, R. G. (2014). Fibroblast–myocyte electrotonic coupling: does it occur in native cardiac tissue? J. Mol. Cell. Cardiol. 70, 37-46.
    • (2014) J. Mol. Cell. Cardiol , vol.70 , pp. 37-46
    • Kohl, P.1    Gourdie, R.G.2
  • 59
    • 77957729712 scopus 로고    scopus 로고
    • The origin of fibroblasts and mechanism of cardiac fibrosis
    • Krenning, G., Zeisberg, E. M. and Kalluri, R. (2010). The origin of fibroblasts and mechanism of cardiac fibrosis. J. Cell. Physiol. 225, 631-637.
    • (2010) J. Cell. Physiol , vol.225 , pp. 631-637
    • Krenning, G.1    Zeisberg, E.M.2    Kalluri, R.3
  • 60
    • 80054008597 scopus 로고    scopus 로고
    • Blocking of frizzled signaling with a homologous peptide fragment of wnt3a/wnt5a reduces infarct expansion and prevents the development of heart failure after myocardial infarction
    • Laeremans, H., Hackeng, T. M., van Zandvoort, M. A. M. J., Thijssen, V. L. J. L., Janssen, B. J. A., Ottenheijm, H. C. J., Smits, J. F. M. and Blankesteijn, W. M. (2011). Blocking of frizzled signaling with a homologous peptide fragment of wnt3a/wnt5a reduces infarct expansion and prevents the development of heart failure after myocardial infarction. Circulation 124, 1626-1635.
    • (2011) Circulation , vol.124 , pp. 1626-1635
    • Laeremans, H.1    Hackeng, T.M.2    Van Zandvoort, M.A.M.J.3    Thijssen, V.L.J.L.4    Janssen, B.J.A.5    Ottenheijm, H.C.J.6    Smits, J.F.M.7    Blankesteijn, W.M.8
  • 62
    • 84898829296 scopus 로고    scopus 로고
    • Origin, development, and differentiation of cardiac fibroblasts
    • Lajiness, J. D. and Conway, S. J. (2014). Origin, development, and differentiation of cardiac fibroblasts. J. Mol. Cell. Cardiol. 70, 2-8.
    • (2014) J. Mol. Cell. Cardiol , vol.70 , pp. 2-8
    • Lajiness, J.D.1    Conway, S.J.2
  • 64
    • 77953808712 scopus 로고    scopus 로고
    • Potential therapeutic targets for cardiac fibrosis: TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation
    • Leask, A. (2010). Potential therapeutic targets for cardiac fibrosis: TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation. Circ. Res. 106, 1675-1680.
    • (2010) Circ. Res , vol.106 , pp. 1675-1680
    • Leask, A.1
  • 65
    • 0028884413 scopus 로고
    • Requirement for neuregulin receptor erbB2 in neural and cardiac development
    • Lee, K.-F., Simon, H., Chen, H., Bates, B., Hung, M.-C. and Hauser, C. (1995). Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 378, 394-398.
    • (1995) Nature , vol.378 , pp. 394-398
    • Lee, K.-F.1    Simon, H.2    Chen, H.3    Bates, B.4    Hung, M.-C.5    Hauser, C.6
  • 66
    • 0030219688 scopus 로고    scopus 로고
    • Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development
    • Li, F., Wang, X., Capasso, J. M. and Gerdes, A. M. (1996). Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development. J. Mol. Cell. Cardiol. 28, 1737-1746.
    • (1996) J. Mol. Cell. Cardiol , vol.28 , pp. 1737-1746
    • Li, F.1    Wang, X.2    Capasso, J.M.3    Gerdes, A.M.4
  • 67
    • 0035793914 scopus 로고    scopus 로고
    • Cardiac-specific overexpression of cyclindependent kinase 2 increases smaller mononuclear cardiomyocytes
    • Liao, H.-S., Kang, P. M., Nagashima, H., Yamasaki, N., Usheva, A., Ding, B., Lorell, B. H. and Izumo, S. (2001). Cardiac-specific overexpression of cyclindependent kinase 2 increases smaller mononuclear cardiomyocytes. Circ. Res. 88, 443-450.
    • (2001) Circ. Res , vol.88 , pp. 443-450
    • Liao, H.-S.1    Kang, P.M.2    Nagashima, H.3    Yamasaki, N.4    Usheva, A.5    Ding, B.6    Lorell, B.H.7    Izumo, S.8
  • 68
    • 84904746093 scopus 로고    scopus 로고
    • Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model
    • Lin, Z., von Gise, A., Zhou, P., Gu, F., Ma, Q., Jiang, J., Yau, A. L., Buck, J. N., Gouin, K. A., van Gorp, P. R. R. et al. (2014). Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model. Circ. Res. 115, 354-363.
    • (2014) Circ. Res , vol.115 , pp. 354-363
    • Lin, Z.1    Von Gise, A.2    Zhou, P.3    Gu, F.4    Ma, Q.5    Jiang, J.6    Yau, A.L.7    Buck, J.N.8    Gouin, K.A.9    Van Gorp, P.R.R.10
  • 70
    • 84890915793 scopus 로고    scopus 로고
    • Validation of contrast-enhanced magnetic resonance imaging to monitor regenerative efficacy after cell therapy in a porcine model of convalescent myocardial infarction
    • Malliaras, K., Smith, R. R., Kanazawa, H., Yee, K., Seinfeld, J., Tseliou, E., Dawkins, J. F., Kreke, M., Cheng, K., Luthringer, D. et al. (2013). Validation of contrast-enhanced magnetic resonance imaging to monitor regenerative efficacy after cell therapy in a porcine model of convalescent myocardial infarction. Circulation 128, 2764-2775.
    • (2013) Circulation , vol.128 , pp. 2764-2775
    • Malliaras, K.1    Smith, R.R.2    Kanazawa, H.3    Yee, K.4    Seinfeld, J.5    Tseliou, E.6    Dawkins, J.F.7    Kreke, M.8    Cheng, K.9    Luthringer, D.10
  • 71
    • 84892394170 scopus 로고    scopus 로고
    • Intracoronary cardiosphere-derived cells after myocardial infarction: Evidence of therapeutic regeneration in the final 1-year results of the CADUCEUS trial (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction)
    • Malliaras, K., Makkar, R. R., Smith, R. R., Cheng, K., Wu, E., Bonow, R. O., Marbán, L., Mendizabal, A., Cingolani, E., Johnston, P. V. et al. (2014). Intracoronary cardiosphere-derived cells after myocardial infarction: evidence of therapeutic regeneration in the final 1-year results of the CADUCEUS trial (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction). J. Am. Coll. Cardiol. 63, 110-122.
    • (2014) J. Am. Coll. Cardiol , vol.63 , pp. 110-122
    • Malliaras, K.1    Makkar, R.R.2    Smith, R.R.3    Cheng, K.4    Wu, E.5    Bonow, R.O.6    Marbán, L.7    Mendizabal, A.8    Cingolani, E.9    Johnston, P.V.10
  • 77
    • 84878469136 scopus 로고    scopus 로고
    • Heart repair by cardiac reprogramming
    • Nam, Y.-J., Song, K. and Olson, E. N. (2013b). Heart repair by cardiac reprogramming. Nat. Med. 19, 413-415.
    • (2013) Nat. Med , vol.19 , pp. 413-415
    • Nam, Y.-J.1    Song, K.2    Olson, E.N.3
  • 81
    • 67649648025 scopus 로고    scopus 로고
    • Developmental origins of hypertrophic cardiomyopathy phenotypes: A unifying hypothesis
    • Olivotto, I., Cecchi, F., Poggesi, C. and Yacoub, M. H. (2009). Developmental origins of hypertrophic cardiomyopathy phenotypes: a unifying hypothesis. Nat. Rev. Cardiol. 6, 317-321.
    • (2009) Nat. Rev. Cardiol , vol.6 , pp. 317-321
    • Olivotto, I.1    Cecchi, F.2    Poggesi, C.3    Yacoub, M.H.4
  • 82
    • 11844292733 scopus 로고    scopus 로고
    • Targeted expression of cyclin D2 results in cardiomyocyte DNA synthesis and infarct regression in transgenic mice
    • Pasumarthi, K. B. S., Nakajima, H., Nakajima, H. O., Soonpaa, M. H. and Field, L. J. (2005). Targeted expression of cyclin D2 results in cardiomyocyte DNA synthesis and infarct regression in transgenic mice. Circ. Res. 96, 110-118.
    • (2005) Circ. Res , vol.96 , pp. 110-118
    • Pasumarthi, K.B.S.1    Nakajima, H.2    Nakajima, H.O.3    Soonpaa, M.H.4    Field, L.J.5
  • 89
    • 84879333188 scopus 로고    scopus 로고
    • Reprogramming of mouse fibroblasts into cardiomyocyte-like cells in vitro
    • Qian, L., Berry, E. C., Fu, J.-d., Ieda, M. and Srivastava, D. (2013). Reprogramming of mouse fibroblasts into cardiomyocyte-like cells in vitro. Nat. Protoc. 8, 1204-1215.
    • (2013) Nat. Protoc , vol.8 , pp. 1204-1215
    • Qian, L.1    Berry, E.C.2    Fu, J.-D.3    Ieda, M.4    Srivastava, D.5
  • 90
    • 84860338564 scopus 로고    scopus 로고
    • Genetic analysis of the TBX20 gene promoter region in patients with ventricular septal defects
    • Qiao, Y., Wanyan, H., Xing, Q., Xie, W., Pang, S., Shan, J. and Yan, B. (2012). Genetic analysis of the TBX20 gene promoter region in patients with ventricular septal defects. Gene 500, 28-31.
    • (2012) Gene , vol.500 , pp. 28-31
    • Qiao, Y.1    Wanyan, H.2    Xing, Q.3    Xie, W.4    Pang, S.5    Shan, J.6    Yan, B.7
  • 91
    • 0033393087 scopus 로고    scopus 로고
    • The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis
    • Quaggin, S. E., Schwartz, L., Cui, S., Igarashi, P., Deimling, J., Post, M. and Rossant, J. (1999). The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis. Development 126, 5771-5783.
    • (1999) Development , vol.126 , pp. 5771-5783
    • Quaggin, S.E.1    Schwartz, L.2    Cui, S.3    Igarashi, P.4    Deimling, J.5    Post, M.6    Rossant, J.7
  • 94
    • 78649747488 scopus 로고    scopus 로고
    • Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeling
    • Saraswati, S., Alfaro, M. P., Thorne, C. A., Atkinson, J., Lee, E. and Young, P. P. (2010). Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeling. PLoS ONE 5, e15521.
    • (2010) Plos ONE , vol.5
    • Saraswati, S.1    Alfaro, M.P.2    Thorne, C.A.3    Atkinson, J.4    Lee, E.5    Young, P.P.6
  • 96
    • 84942816649 scopus 로고    scopus 로고
    • Liver fibrosis: Common mechanisms and antifibrotic therapies
    • Schuppan, D. (2015). Liver fibrosis: Common mechanisms and antifibrotic therapies. Clin. Res. Hepatol. Gastroenterol. 39, S51-S59.
    • (2015) Clin. Res. Hepatol. Gastroenterol , vol.39 , pp. S51-S59
    • Schuppan, D.1
  • 100
    • 84864022989 scopus 로고    scopus 로고
    • Regulatory variation in a TBX5 enhancer leads to isolated congenital heart disease. Hum. Mol
    • Smemo, S., Campos, L. C., Moskowitz, I. P., Krieger, J. E., Pereira, A. C. and Nobrega, M. A. (2012). Regulatory variation in a TBX5 enhancer leads to isolated congenital heart disease. Hum. Mol. Genet. 21, 3255-3263.
    • (2012) Genet , vol.21 , pp. 3255-3263
    • Smemo, S.1    Campos, L.C.2    Moskowitz, I.P.3    Krieger, J.E.4    Pereira, A.C.5    Nobrega, M.A.6
  • 101
    • 79958799319 scopus 로고    scopus 로고
    • Epicardialderived cell epithelial-to-mesenchymal transition and fate specification require PDGF receptor signaling
    • Smith, C. L., Baek, S. T., Sung, C. Y. and Tallquist, M. D. (2011). Epicardialderived cell epithelial-to-mesenchymal transition and fate specification require PDGF receptor signaling. Circ. Res. 108, e15-e26.
    • (2011) Circ. Res , vol.108 , pp. e15-e26
    • Smith, C.L.1    Baek, S.T.2    Sung, C.Y.3    Tallquist, M.D.4
  • 102
    • 1842370870 scopus 로고    scopus 로고
    • Cyclin D1 overexpression promotes cardiomyocyte DNA synthesis and multinucleation in transgenic mice
    • Soonpaa, M. H., Koh, G. Y., Pajak, L., Jing, S., Wang, H., Franklin, M. T., Kim, K. K. and Field, L. J. (1997). Cyclin D1 overexpression promotes cardiomyocyte DNA synthesis and multinucleation in transgenic mice. J. Clin. Invest. 99, 2644-2654.
    • (1997) J. Clin. Invest , vol.99 , pp. 2644-2654
    • Soonpaa, M.H.1    Koh, G.Y.2    Pajak, L.3    Jing, S.4    Wang, H.5    Franklin, M.T.6    Kim, K.K.7    Field, L.J.8
  • 103
    • 73349122017 scopus 로고    scopus 로고
    • Cardiac fibroblast: The renaissance cell
    • Souders, C. A., Bowers, S. L. and Baudino, T. A. (2009). Cardiac fibroblast: the renaissance cell. Circ. Res. 105, 1164-1176.
    • (2009) Circ. Res , vol.105 , pp. 1164-1176
    • Souders, C.A.1    Bowers, S.L.2    Baudino, T.A.3
  • 104
    • 84942884150 scopus 로고    scopus 로고
    • Personalized medicine in idiopathic pulmonary fibrosis: Facts and promises
    • Spagnolo, P., Tzouvelekis, A. and Maher, T. M. (2015). Personalized medicine in idiopathic pulmonary fibrosis: facts and promises. Curr. Opin. Pulm. Med. 21, 470-478.
    • (2015) Curr. Opin. Pulm. Med , vol.21 , pp. 470-478
    • Spagnolo, P.1    Tzouvelekis, A.2    Maher, T.M.3
  • 105
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi, K. and Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 106
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K. and Yamanaka, S. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 108
    • 84921314269 scopus 로고    scopus 로고
    • Expression of concern: The SCIPIO trial
    • The Lancet Editors (2014). Expression of concern: the SCIPIO trial. Lancet 383, 1279.
    • (2014) Lancet , vol.383 , pp. 1279
  • 113
    • 84934292637 scopus 로고    scopus 로고
    • Immaturity of human stem-cell-derived cardiomyocytes in culture: Fatal flaw or soluble problem?
    • Veerman, C. C., Kosmidis, G., Mummery, C. L., Casini, S., Verkerk, A. O. and Bellin, M. (2015). Immaturity of human stem-cell-derived cardiomyocytes in culture: fatal flaw or soluble problem? Stem Cells Dev. 24, 1035-1052.
    • (2015) Stem Cells Dev , vol.24 , pp. 1035-1052
    • Veerman, C.C.1    Kosmidis, G.2    Mummery, C.L.3    Casini, S.4    Verkerk, A.O.5    Bellin, M.6
  • 115
  • 116
    • 33747180560 scopus 로고    scopus 로고
    • Myocardial Protection and Vascular Biology: Therapeutic delivery of cyclin A2 induces myocardial regeneration and enhances cardiac function in ischemic heart failure
    • Woo, Y. J., Panlilio, C. M., Cheng, R. K., Liao, G. P., Atluri, P., Hsu, V. M., Cohen, J. E. and Chaudhry, H. W. (2006). Myocardial Protection and Vascular Biology: therapeutic delivery of cyclin A2 induces myocardial regeneration and enhances cardiac function in ischemic heart failure. Circulation 114, I206-I213.
    • (2006) Circulation , vol.114 , pp. I206-I213
    • Woo, Y.J.1    Panlilio, C.M.2    Cheng, R.K.3    Liao, G.P.4    Atluri, P.5    Hsu, V.M.6    Cohen, J.E.7    Chaudhry, H.W.8
  • 117
    • 38549159026 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of fibrosis
    • Wynn, T. A. (2008). Cellular and molecular mechanisms of fibrosis. J. Pathol. 214, 199-210.
    • (2008) J. Pathol , vol.214 , pp. 199-210
    • Wynn, T.A.1
  • 120
    • 84929129520 scopus 로고    scopus 로고
    • CADUCEUS, SCIPIO, ALCADIA: Cell therapy trials using cardiac-derived cells for patients with post myocardial infarction LV dysfunction, still evolving
    • Yacoub, M. H. and Terrovitis, J. (2013). CADUCEUS, SCIPIO, ALCADIA: cell therapy trials using cardiac-derived cells for patients with post myocardial infarction LV dysfunction, still evolving. Glob. Cardiol. Sci. Pract. 2013, 3.
    • (2013) Glob. Cardiol. Sci. Pract , pp. 3
    • Yacoub, M.H.1    Terrovitis, J.2
  • 121
    • 78650358123 scopus 로고    scopus 로고
    • Origins of cardiac fibroblasts
    • Zeisberg, E. M. and Kalluri, R. (2010). Origins of cardiac fibroblasts. Circ. Res. 107, 1304-1312.
    • (2010) Circ. Res , vol.107 , pp. 1304-1312
    • Zeisberg, E.M.1    Kalluri, R.2
  • 123
    • 84942939090 scopus 로고    scopus 로고
    • Akt1/protein kinase B enhances transcriptional reprogramming of fibroblasts to functional cardiomyocytes
    • Zhou, H., Dickson, M. E., Kim, M. S., Bassel-Duby, R. and Olson, E. N. (2015). Akt1/protein kinase B enhances transcriptional reprogramming of fibroblasts to functional cardiomyocytes. Proc. Natl. Acad. Sci. USA 112, 11864-11869.
    • (2015) Proc. Natl. Acad. Sci. USA , vol.112 , pp. 11864-11869
    • Zhou, H.1    Dickson, M.E.2    Kim, M.S.3    Bassel-Duby, R.4    Olson, E.N.5


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