Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts

Nature

Volumn 428, Issue 6983, 2004, Pages 664-668

  Murry, Charles E ^a   Soonpaa, Mark H ^b   Reinecke, Hans ^a   Nakajima, Hidehiro ^b   Nakajima, Hisako O ^b   Rubart, Michael ^b   Pasumarthi, Kishore B S ^b,c   Virag, Jiika Ismail ^a   Bartelmez, Stephen H ^a   Poppa, Veronica ^a   Bradford, Gillian ^b   Dowell, Joshua D ^b   Williams, David A ^b,d   Field, Loren J ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DALHOUSIE UNIVERSITY   (Canada)

^d UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOLOGY; GENETIC ALGORITHMS; MEDICAL IMAGING; MUSCULOSKELETAL SYSTEM; NEUROLOGY; PHYSIOLOGICAL MODELS; TISSUE;

MAMMALIAN HEART; PHENOTYPES; REGENERATIVE CAPACITY;

CELL CULTURE;

MEDICINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL FATE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC PROCEDURES; HEART GRAFT; HEART INFARCTION; HEART MUSCLE CELL; HEMATOPOIETIC STEM CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REPORTER GENE; TRANSGENE;

ANIMALS; CELL COUNT; CELL DIFFERENTIATION; CELL LINEAGE; CELLS, CULTURED; COCULTURE TECHNIQUES; FEMALE; GENES, REPORTER; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; MALE; MICE; MICE, TRANSGENIC; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; ORGAN SPECIFICITY; REGENERATION; TISSUE THERAPY; TRANSGENES;

ANIMALIA; MAMMALIA;

EID: 11144356049     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02446     Document Type: Article

References (31)

1. Mallory, G. K., White, P. D. & Salcedo-Salgar, J. The speed of healing of myocardial infarction: A study of the pathologic anatomy in 72 cases. Am. Heart J. 18, 647-671 (1939).
2. Ferrari, G. et al. Muscle regeneration by bone marrow-derived myogenic progenitors. Science 279, 1528-1530 (1998); erratum Science 281, 923 (1998).
3. Ferrari, G. et al. Muscle regeneration by bone marrow-derived myogenic progenitors. Science 279, 1528-1530 (1998); erratum Science 281, 923 (1998).
4. Gussoni, E. et al. Dystrophin expression in the mdx mouse restored by stem cell transplantation. Nature 401, 390-394 (1999).
5. Lagasse, E. et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nature Med. 6, 1229-1234 (2000).
6. Krause, D. S. et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105, 369-377 (2001).
7. Mezey, E., Chandross, K. J., Harta, G., Maki, R. A. & McKercher, S. R. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 290, 1779-1782 (2000).
8. Brazelton, T. R., Rossi, F. M., Keshet, G. I. & Blau, H. M. From marrow to brain: expression of neuronal phenotypes in adult mice. Science 290, 1775-1779 (2000).
9. Jackson, K. A. et al. Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J. Clin. Invest. 107, 1395-1402 (2001).
10. Orlic, D. et al. Bone marrow cells regenerate infarcted myocardium. Nature 410, 701-705 (2001).
11. Laflamme, M. A., Myerson, D., Saffitz, J. E. & Murry, C. E. Evidence for cardiomyocyte repopulation by extracardiac progenitors in transplanted human hearts. Circ. Res. 90, 634-640 (2002).
12. Quaini, F. et al. Chimerism of the transplanted heart. N. Engl. J. Med. 346, 5-15 (2002).
13. Muller, P. et al. Cardiomyocytes of noncardiac origin in myocardial biopsies of human transplanted hearts. Circulation 106, 31-35 (2002).
14. Bittner, R. E. et al. Recruitment of bone-marrow-derived cells by skeletal and cardiac muscle in adult dystrophic mdx mice. Anat. Embryol. (Berl.) 199, 391-396 (1999).
15. Alvarez-Dolado, M. et al. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 425, 968-973 (2003).
16. Deb, A. et al. Bone marrow-derived cardiomyocytes are present in adult human heart: A study of gender-mismatched bone marrow transplantation patients. Circulation 107, 1247-1249 (2003).
17. Strauer, B. E. et al. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 106, 1913-1918 (2002).
18. Assmus, B. et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI). Circulation 106, 3009-3017 (2002).
19. Soonpaa, M. H., Koh, G. Y., Klug, M. G. & Field, L. J. Formation of nascent intercalated disks between grafted fetal cardiomyocytes and host myocardium. Science 264, 98-101 (1994).
20. Virag, J. I. & Murry, C. E. Myofibroblast and endothelial cell proliferation during murine myocardial infarct repair. Am. J. Pathol. 163, 2433-2440 (2003).
21. Soonpaa, M. H. & Field, L. J. Assessment of cardiomyocyte DNA synthesis in normal and injured adult mouse hearts. Am. J. Physiol. 272, H220-H226 (1997).
22. Dowell, J. D., Rubart, M., Pasumarthi, K. B., Soonpaa, M. H. & Field, L. J. Myocyte and myogenic stem cell transplantation in the heart. Cardiovasc. Res. 58, 336-350 (2003).
23. Clarke, D. L. et al. Generalized potential of adult neural stem cells. Science 288, 1660-1663 (2000).
24. Badorff, C. et al. Transdifferentiation of blood-derived human adult endothelial progenitor cells into functionally active cardiomyocytes. Circulation 107, 1024-1032 (2003).
25. Rubart, M. et al. Physiological coupling of donor and host cardiomyocytes after cellular transplantation. Circ. Res. 92, 1217-1224 (2003).
26. Stripecke, R. et al. Immune response to green fluorescent protein: implications for gene therapy. Gene Ther. 6, 1305-1312 (1999).
27. Oh, H. et al. Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc. Natl Acad. Sci. USA 100, 12313-12318 (2003).
28. Kuramochi, Y. et al. Cardiomyocyte regeneration from circulating bone marrow cells in mice. Pediatr. Res. 54, 319-325 (2003).
29. Kudo, M. et al. Implantation of bone marrow stem cells reduces the infarction and fibrosis in ischemic mouse heart. J. Mol. Cell. Cardiol. 35, 1113-1119 (2003).
30. Reinecke, H. & Murry, C. E. Cell grafting for cardiac repair. Methods Mol. Biol. 219, 97-112 (2003).
31. Reinecke, H., Poppa, V. & Murry, C. E. Skeletal muscle stem cells do not transdifferentiate into cardiomyocytes after cardiac grafting. J. Mol. Cell. Cardiol. 34, 241-249 (2002).