-
1
-
-
80052245860
-
A call to reform the taxonomy of human disease
-
Kola, I, Bell, J, A call to reform the taxonomy of human disease. Nat Rev Drug Discov 10 (2011), 641–642.
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 641-642
-
-
Kola, I.1
Bell, J.2
-
2
-
-
0000606763
-
Treatment of chronic asthma with prednisolone; significance of eosinophils in the sputum
-
Brown, HM, Treatment of chronic asthma with prednisolone; significance of eosinophils in the sputum. Lancet 2 (1958), 1245–1247.
-
(1958)
Lancet
, vol.2
, pp. 1245-1247
-
-
Brown, H.M.1
-
3
-
-
84937039082
-
Evidence for the efficacy and safety of anti-interleukin-5 treatment in the management of refractory eosinophilic asthma
-
Hilvering, B, Xue, L, Pavord, ID, Evidence for the efficacy and safety of anti-interleukin-5 treatment in the management of refractory eosinophilic asthma. Ther Adv Respir Dis 9 (2015), 135–145.
-
(2015)
Ther Adv Respir Dis
, vol.9
, pp. 135-145
-
-
Hilvering, B.1
Xue, L.2
Pavord, I.D.3
-
4
-
-
6444222929
-
New drugs for asthma
-
Barnes, PJ, New drugs for asthma. Nat Rev Drug Discov 3 (2004), 831–844.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 831-844
-
-
Barnes, P.J.1
-
5
-
-
0030811544
-
The use of induced sputum to investigate airway inflammation
-
Pavord, ID, Pizzichini, MM, Pizzichini, E, Hargreave, FE, The use of induced sputum to investigate airway inflammation. Thorax 52 (1997), 498–501.
-
(1997)
Thorax
, vol.52
, pp. 498-501
-
-
Pavord, I.D.1
Pizzichini, M.M.2
Pizzichini, E.3
Hargreave, F.E.4
-
6
-
-
52049089924
-
Inflammometry to assess airway diseases
-
Pavord, ID, Shaw, DE, Gibson, PG, Taylor, DR, Inflammometry to assess airway diseases. Lancet 372 (2008), 1017–1019.
-
(2008)
Lancet
, vol.372
, pp. 1017-1019
-
-
Pavord, I.D.1
Shaw, D.E.2
Gibson, P.G.3
Taylor, D.R.4
-
7
-
-
84922375817
-
Asthma phenotypes and the use of biologic medications in asthma and allergic disease: the next steps toward personalized care
-
Fajt, ML, Wenzel, SE, Asthma phenotypes and the use of biologic medications in asthma and allergic disease: the next steps toward personalized care. J Allergy Clin Immunol 135 (2015), 299–310.
-
(2015)
J Allergy Clin Immunol
, vol.135
, pp. 299-310
-
-
Fajt, M.L.1
Wenzel, S.E.2
-
8
-
-
84925546187
-
Type 2 inflammation in asthma–present in most, absent in many
-
Fahy, JV, Type 2 inflammation in asthma–present in most, absent in many. Nat Rev Immunol 15 (2015), 57–65.
-
(2015)
Nat Rev Immunol
, vol.15
, pp. 57-65
-
-
Fahy, J.V.1
-
9
-
-
84891685199
-
Combination corticosteroid/β-agonist inhaler as reliever therapy: a solution for intermittent and mild asthma?
-
Beasley, R, Weatherall, M, Shirtcliffe, P, Hancox, R, Reddel, HK, Combination corticosteroid/β-agonist inhaler as reliever therapy: a solution for intermittent and mild asthma?. J Allergy Clin Immunol 133 (2014), 39–41.
-
(2014)
J Allergy Clin Immunol
, vol.133
, pp. 39-41
-
-
Beasley, R.1
Weatherall, M.2
Shirtcliffe, P.3
Hancox, R.4
Reddel, H.K.5
-
10
-
-
0037202790
-
Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial
-
Green, RH, Brightling, CE, McKenna, S, et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet 360 (2002), 1715–1721.
-
(2002)
Lancet
, vol.360
, pp. 1715-1721
-
-
Green, R.H.1
Brightling, C.E.2
McKenna, S.3
-
11
-
-
33344476409
-
Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations
-
Jayaram, L, Pizzichini, MM, Cook, RJ, et al. Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations. Eur Respir J 27 (2006), 483–494.
-
(2006)
Eur Respir J
, vol.27
, pp. 483-494
-
-
Jayaram, L.1
Pizzichini, M.M.2
Cook, R.J.3
-
12
-
-
84865145614
-
Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial
-
Pavord, ID, Korn, S, Howarth, P, et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet 380 (2012), 651–659.
-
(2012)
Lancet
, vol.380
, pp. 651-659
-
-
Pavord, I.D.1
Korn, S.2
Howarth, P.3
-
13
-
-
33646911140
-
Anti-IgE: lessons learned from effects on airway inflammation and asthma exacerbation
-
Fahy, JV, Anti-IgE: lessons learned from effects on airway inflammation and asthma exacerbation. J Allergy Clin Immunol 117 (2006), 1230–1232.
-
(2006)
J Allergy Clin Immunol
, vol.117
, pp. 1230-1232
-
-
Fahy, J.V.1
-
14
-
-
0024961405
-
Thoracic society of Australia and New Zealand. Asthma management plan, 1989
-
Woolcock, A, Rubinfeld, AR, Seale, JP, et al. Thoracic society of Australia and New Zealand. Asthma management plan, 1989. Med J Aust 151 (1989), 650–653.
-
(1989)
Med J Aust
, vol.151
, pp. 650-653
-
-
Woolcock, A.1
Rubinfeld, A.R.2
Seale, J.P.3
-
15
-
-
0025316781
-
The assessment and treatment of asthma: a conference report
-
Hargreave, FE, Dolovich, J, Newhouse, MT, The assessment and treatment of asthma: a conference report. J Allergy Clin Immunol 85 (1990), 1098–1111.
-
(1990)
J Allergy Clin Immunol
, vol.85
, pp. 1098-1111
-
-
Hargreave, F.E.1
Dolovich, J.2
Newhouse, M.T.3
-
16
-
-
0025141037
-
Guidelines for management of asthma in adults: I—Chronic persistent asthma. Statement by the British Thoracic Society, Research Unit of the Royal College of Physicians of London, King's Fund Centre, National Asthma Campaign
-
Guidelines for management of asthma in adults: I—Chronic persistent asthma. Statement by the British Thoracic Society, Research Unit of the Royal College of Physicians of London, King's Fund Centre, National Asthma Campaign. BMJ 301 (1990), 651–653.
-
(1990)
BMJ
, vol.301
, pp. 651-653
-
-
-
17
-
-
0024402294
-
Management of asthma: a consensus statement
-
Warner, JO, Götz, M, Landau, LI, et al. Management of asthma: a consensus statement. Arch Dis Child 64 (1989), 1065–1079.
-
(1989)
Arch Dis Child
, vol.64
, pp. 1065-1079
-
-
Warner, J.O.1
Götz, M.2
Landau, L.I.3
-
19
-
-
85027129810
-
Trends in international asthma mortality: analysis of data from the WHO Mortality Database from 46 countries (1993–2012)
-
published online Aug 7.
-
Ebmeier, S, Thayabaran, D, Braithwaite, I, Bénamara, C, Weatherall, M, Beasley, R, Trends in international asthma mortality: analysis of data from the WHO Mortality Database from 46 countries (1993–2012). Lancet, 2017 published online Aug 7. DOI:10.1016/S0140-6736(17)31448-4.
-
(2017)
Lancet
-
-
Ebmeier, S.1
Thayabaran, D.2
Braithwaite, I.3
Bénamara, C.4
Weatherall, M.5
Beasley, R.6
-
21
-
-
84928999108
-
Barriers to new drug development in respiratory disease
-
Barnes, PJ, Bonini, S, Seeger, W, Belvisi, MG, Ward, B, Holmes, A, Barriers to new drug development in respiratory disease. Eur Respir J 45 (2015), 1197–1207.
-
(2015)
Eur Respir J
, vol.45
, pp. 1197-1207
-
-
Barnes, P.J.1
Bonini, S.2
Seeger, W.3
Belvisi, M.G.4
Ward, B.5
Holmes, A.6
-
22
-
-
84921279756
-
CON: encouraging resistance to rule-based medicine is essential to improving outcomes
-
Rosenthal, M, CON: encouraging resistance to rule-based medicine is essential to improving outcomes. Thorax 70 (2015), 112–114.
-
(2015)
Thorax
, vol.70
, pp. 112-114
-
-
Rosenthal, M.1
-
23
-
-
85055064275
-
Ciba Guest Symposium. Terminology, definitions and classifications of chronic pulmonary emphysema and related conditions
-
Ciba Guest Symposium. Terminology, definitions and classifications of chronic pulmonary emphysema and related conditions. Thorax, 14, 1959, 13.
-
(1959)
Thorax
, vol.14
, pp. 13
-
-
-
24
-
-
33747772780
-
A plea to abandon asthma as a disease concept
-
A plea to abandon asthma as a disease concept. Lancet, 368, 2006, 705.
-
(2006)
Lancet
, vol.368
, pp. 705
-
-
-
25
-
-
48249085691
-
Cluster analysis and clinical asthma phenotypes
-
Haldar, P, Pavord, ID, Shaw, DE, et al. Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med 178 (2008), 218–224.
-
(2008)
Am J Respir Crit Care Med
, vol.178
, pp. 218-224
-
-
Haldar, P.1
Pavord, I.D.2
Shaw, D.E.3
-
26
-
-
34248206610
-
Eosinophilic airway inflammation and exacerbations of COPD: a randomised controlled trial
-
Siva, R, Green, RH, Brightling, CE, et al. Eosinophilic airway inflammation and exacerbations of COPD: a randomised controlled trial. Eur Respir J 29 (2007), 906–913.
-
(2007)
Eur Respir J
, vol.29
, pp. 906-913
-
-
Siva, R.1
Green, R.H.2
Brightling, C.E.3
-
27
-
-
80052755474
-
Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial
-
Powell, H, Murphy, VE, Taylor, DR, et al. Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial. Lancet 378 (2011), 983–990.
-
(2011)
Lancet
, vol.378
, pp. 983-990
-
-
Powell, H.1
Murphy, V.E.2
Taylor, D.R.3
-
28
-
-
61849086181
-
Mepolizumab and exacerbations of refractory eosinophilic asthma
-
Haldar, P, Brightling, CE, Hargadon, B, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 360 (2009), 973–984.
-
(2009)
N Engl J Med
, vol.360
, pp. 973-984
-
-
Haldar, P.1
Brightling, C.E.2
Hargadon, B.3
-
29
-
-
84879401471
-
Dupilumab in persistent asthma with elevated eosinophil levels
-
Wenzel, S, Ford, L, Pearlman, D, et al. Dupilumab in persistent asthma with elevated eosinophil levels. N Engl J Med 368 (2013), 2455–2466.
-
(2013)
N Engl J Med
, vol.368
, pp. 2455-2466
-
-
Wenzel, S.1
Ford, L.2
Pearlman, D.3
-
30
-
-
84940733208
-
Lebrikizumab in moderate-to-severe asthma: pooled data from two randomised placebo-controlled studies
-
Hanania, NA, Noonan, M, Corren, J, et al. Lebrikizumab in moderate-to-severe asthma: pooled data from two randomised placebo-controlled studies. Thorax 70 (2015), 748–756.
-
(2015)
Thorax
, vol.70
, pp. 748-756
-
-
Hanania, N.A.1
Noonan, M.2
Corren, J.3
-
31
-
-
80053084755
-
Lebrikizumab treatment in adults with asthma
-
Corren, J, Lemanske, RF, Hanania, NA, et al. Lebrikizumab treatment in adults with asthma. N Engl J Med 365 (2011), 1088–1098.
-
(2011)
N Engl J Med
, vol.365
, pp. 1088-1098
-
-
Corren, J.1
Lemanske, R.F.2
Hanania, N.A.3
-
32
-
-
33747756534
-
Asthma: defining of the persistent adult phenotypes
-
Wenzel, SE, Asthma: defining of the persistent adult phenotypes. Lancet 368 (2006), 804–813.
-
(2006)
Lancet
, vol.368
, pp. 804-813
-
-
Wenzel, S.E.1
-
35
-
-
85021827402
-
2017 GINA report, global strategy for asthma management and prevention
-
(accessed June 5, 2017).
-
Global Initiative for Asthma. 2017 GINA report, global strategy for asthma management and prevention. http://ginasthma.org/2017-gina-report-global-strategy-for-asthma-management-and-prevention/ (accessed June 5, 2017).
-
-
-
-
36
-
-
0029401223
-
Sir John Floyer (1649–1734) British physician and pioneer clinical investigator
-
Cohen, SG, Sir John Floyer (1649–1734) British physician and pioneer clinical investigator. Allergy Proc 16 (1995), 328–329.
-
(1995)
Allergy Proc
, vol.16
, pp. 328-329
-
-
Cohen, S.G.1
-
37
-
-
0022307020
-
Henry Hyde Salter (1823–71): a biographical sketch
-
Sakula, A, Henry Hyde Salter (1823–71): a biographical sketch. Thorax 40 (1985), 887–888.
-
(1985)
Thorax
, vol.40
, pp. 887-888
-
-
Sakula, A.1
-
38
-
-
0345675905
-
A clinical survey of 1074 patients with asthma followed for two years
-
Rackemann, FM, A clinical survey of 1074 patients with asthma followed for two years. J Lab Clin Med 12 (1927), 1185–1197.
-
(1927)
J Lab Clin Med
, vol.12
, pp. 1185-1197
-
-
Rackemann, F.M.1
-
39
-
-
79955064074
-
Thorax
-
RB Todd Longmans London
-
Hutchinson, J, Thorax. Todd, RB, (eds.) The cylopaedia of anatomy and physiology, 1852, Longmans, London, 1016–1087.
-
(1852)
The cylopaedia of anatomy and physiology
, pp. 1016-1087
-
-
Hutchinson, J.1
-
40
-
-
77049301707
-
Etude des facteurs alvéolaires et bronchiques de la ventilation pulmonaire
-
Tiffeneau, R, Drutel, P, Etude des facteurs alvéolaires et bronchiques de la ventilation pulmonaire. J Fr Med Chir Thorac 3 (1949), 401–431.
-
(1949)
J Fr Med Chir Thorac
, vol.3
, pp. 401-431
-
-
Tiffeneau, R.1
Drutel, P.2
-
41
-
-
84864008138
-
Bronchodilator responsiveness: interpret with caution
-
Fingleton, J, Weatherall, M, Beasley, R, Bronchodilator responsiveness: interpret with caution. Thorax 67 (2012), 667–668.
-
(2012)
Thorax
, vol.67
, pp. 667-668
-
-
Fingleton, J.1
Weatherall, M.2
Beasley, R.3
-
42
-
-
49749169555
-
Controlled trial of effects of cortisone acetate in status asthmaticus; report to the Medical Research Council by the subcommittee on clinical trials in asthma
-
Controlled trial of effects of cortisone acetate in status asthmaticus; report to the Medical Research Council by the subcommittee on clinical trials in asthma. Lancet 271 (1956), 803–806.
-
(1956)
Lancet
, vol.271
, pp. 803-806
-
-
-
43
-
-
34250638232
-
How the first effective inhaled corticosteroid was almost discarded as useless
-
Brown, HM, How the first effective inhaled corticosteroid was almost discarded as useless. Ann Allergy Asthma Immunol 98 (2007), 602–603.
-
(2007)
Ann Allergy Asthma Immunol
, vol.98
, pp. 602-603
-
-
Brown, H.M.1
-
44
-
-
0015493603
-
Beclomethasone dipropionate: a new steroid aerosol for the treatment of allergic asthma
-
Brown, HM, Storey, G, George, WH, Beclomethasone dipropionate: a new steroid aerosol for the treatment of allergic asthma. BMJ 1 (1972), 585–590.
-
(1972)
BMJ
, vol.1
, pp. 585-590
-
-
Brown, H.M.1
Storey, G.2
George, W.H.3
-
45
-
-
84980109753
-
Asthmatic Symptoms in the First Year of Life
-
Selander, PER, Asthmatic Symptoms in the First Year of Life. Acta Paediatr 49 (1960), 265–269.
-
(1960)
Acta Paediatr
, vol.49
, pp. 265-269
-
-
Selander, P.E.R.1
-
46
-
-
84965343615
-
“Acute Wheezy Chests”
-
Fry, J, “Acute Wheezy Chests”. BMJ 1 (1961), 227–232.
-
(1961)
BMJ
, vol.1
, pp. 227-232
-
-
Fry, J.1
-
47
-
-
0025783580
-
Natural history of asthma in childhood–a birth cohort study
-
Sporik, R, Holgate, ST, Cogswell, JJ, Natural history of asthma in childhood–a birth cohort study. Arch Dis Child 66 (1991), 1050–1053.
-
(1991)
Arch Dis Child
, vol.66
, pp. 1050-1053
-
-
Sporik, R.1
Holgate, S.T.2
Cogswell, J.J.3
-
48
-
-
0017144256
-
The wheezy child
-
Cogswell, JJ, The wheezy child. Practitioner 217 (1976), 371–376.
-
(1976)
Practitioner
, vol.217
, pp. 371-376
-
-
Cogswell, J.J.1
-
49
-
-
84905913759
-
The association between childhood asthma and adult chronic obstructive pulmonary disease
-
Tai, A, Tran, H, Roberts, M, Clarke, N, Wilson, J, Robertson, CF, The association between childhood asthma and adult chronic obstructive pulmonary disease. Thorax 69 (2014), 805–810.
-
(2014)
Thorax
, vol.69
, pp. 805-810
-
-
Tai, A.1
Tran, H.2
Roberts, M.3
Clarke, N.4
Wilson, J.5
Robertson, C.F.6
-
50
-
-
0027742658
-
Out of the mouths of babes and sucklings: lessons from early childhood asthma
-
Silverman, M, Out of the mouths of babes and sucklings: lessons from early childhood asthma. Thorax 48 (1993), 1200–1204.
-
(1993)
Thorax
, vol.48
, pp. 1200-1204
-
-
Silverman, M.1
-
51
-
-
0028870592
-
Asthma and wheezing in the first six years of life
-
Martinez, FD, Wright, AL, Taussig, LM, Holberg, CJ, Halonen, M, Morgan, WJ, the The Group Health Medical Associates. Asthma and wheezing in the first six years of life. N Engl J Med 332 (1995), 133–138.
-
(1995)
N Engl J Med
, vol.332
, pp. 133-138
-
-
Martinez, F.D.1
Wright, A.L.2
Taussig, L.M.3
Holberg, C.J.4
Halonen, M.5
Morgan, W.J.6
-
52
-
-
79957811992
-
Comparison of childhood wheezing phenotypes in 2 birth cohorts: ALSPAC and PIAMA
-
e14.
-
Savenije, OE, Granell, R, Caudri, D, et al. Comparison of childhood wheezing phenotypes in 2 birth cohorts: ALSPAC and PIAMA. J Allergy Clin Immunol 127 (2011), 1505–1512 e14.
-
(2011)
J Allergy Clin Immunol
, vol.127
, pp. 1505-1512
-
-
Savenije, O.E.1
Granell, R.2
Caudri, D.3
-
53
-
-
84891739052
-
Transient early wheeze and lung function in early childhood associated with chronic obstructive pulmonary disease genes
-
e1–4.
-
Kerkhof, M, Boezen, HM, Granell, R, et al. Transient early wheeze and lung function in early childhood associated with chronic obstructive pulmonary disease genes. J Allergy Clin Immunol 133 (2014), 68–76 e1–4.
-
(2014)
J Allergy Clin Immunol
, vol.133
, pp. 68-76
-
-
Kerkhof, M.1
Boezen, H.M.2
Granell, R.3
-
54
-
-
0142027213
-
Relationship among pulmonary function, bronchial reactivity, and exhaled nitric oxide in a large group of asthmatic patients
-
Langley, SJ, Goldthorpe, S, Custovic, A, Woodcock, A, Relationship among pulmonary function, bronchial reactivity, and exhaled nitric oxide in a large group of asthmatic patients. Ann Allergy Asthma Immunol 91 (2003), 398–404.
-
(2003)
Ann Allergy Asthma Immunol
, vol.91
, pp. 398-404
-
-
Langley, S.J.1
Goldthorpe, S.2
Custovic, A.3
Woodcock, A.4
-
55
-
-
84905375210
-
Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21: a population-based birth cohort study
-
Semic-Jusufagic, A, Belgrave, D, Pickles, A, et al. Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21: a population-based birth cohort study. Lancet Respir Med 2 (2014), 621–630.
-
(2014)
Lancet Respir Med
, vol.2
, pp. 621-630
-
-
Semic-Jusufagic, A.1
Belgrave, D.2
Pickles, A.3
-
56
-
-
0141639949
-
A longitudinal, population-based, cohort study of childhood asthma followed to adulthood
-
Sears, MR, Greene, JM, Willan, AR, et al. A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. N Engl J Med 349 (2003), 1414–1422.
-
(2003)
N Engl J Med
, vol.349
, pp. 1414-1422
-
-
Sears, M.R.1
Greene, J.M.2
Willan, A.R.3
-
57
-
-
84899799291
-
Trajectories of lung function during childhood
-
Belgrave, DC, Buchan, I, Bishop, C, Lowe, L, Simpson, A, Custovic, A, Trajectories of lung function during childhood. Am J Respir Crit Care Med 189 (2014), 1101–1109.
-
(2014)
Am J Respir Crit Care Med
, vol.189
, pp. 1101-1109
-
-
Belgrave, D.C.1
Buchan, I.2
Bishop, C.3
Lowe, L.4
Simpson, A.5
Custovic, A.6
-
58
-
-
80053421998
-
The introduction of allergenic foods and the development of reported wheezing and eczema in childhood: the Generation R study
-
Tromp, II, Kiefte-de Jong, JC, Lebon, A, et al. The introduction of allergenic foods and the development of reported wheezing and eczema in childhood: the Generation R study. Arch Pediatr Adolesc Med 165 (2011), 933–938.
-
(2011)
Arch Pediatr Adolesc Med
, vol.165
, pp. 933-938
-
-
Tromp, I.I.1
Kiefte-de Jong, J.C.2
Lebon, A.3
-
59
-
-
44949128015
-
Dimensions of respiratory symptoms in preschool children: population-based birth cohort study
-
Smith, JA, Drake, R, Simpson, A, Woodcock, A, Pickles, A, Custovic, A, Dimensions of respiratory symptoms in preschool children: population-based birth cohort study. Am J Respir Crit Care Med 177 (2008), 1358–1363.
-
(2008)
Am J Respir Crit Care Med
, vol.177
, pp. 1358-1363
-
-
Smith, J.A.1
Drake, R.2
Simpson, A.3
Woodcock, A.4
Pickles, A.5
Custovic, A.6
-
60
-
-
1142309482
-
Parental asthma as a risk factor for the development of early skin test sensitization in children
-
Crestani, E, Guerra, S, Wright, AL, Halonen, M, Martinez, FD, Parental asthma as a risk factor for the development of early skin test sensitization in children. J Allergy Clin Immunol 113 (2004), 284–290.
-
(2004)
J Allergy Clin Immunol
, vol.113
, pp. 284-290
-
-
Crestani, E.1
Guerra, S.2
Wright, A.L.3
Halonen, M.4
Martinez, F.D.5
-
61
-
-
0025266711
-
Maternal smoking and childhood asthma
-
Weitzman, M, Gortmaker, S, Walker, DK, Sobol, A, Maternal smoking and childhood asthma. Pediatrics 85 (1990), 505–511.
-
(1990)
Pediatrics
, vol.85
, pp. 505-511
-
-
Weitzman, M.1
Gortmaker, S.2
Walker, D.K.3
Sobol, A.4
-
62
-
-
47649120494
-
Cesarean section and risk of severe childhood asthma: a population-based cohort study
-
Tollånes, MC, Moster, D, Daltveit, AK, Irgens, LM, Cesarean section and risk of severe childhood asthma: a population-based cohort study. J Pediatr 153 (2008), 112–116.
-
(2008)
J Pediatr
, vol.153
, pp. 112-116
-
-
Tollånes, M.C.1
Moster, D.2
Daltveit, A.K.3
Irgens, L.M.4
-
63
-
-
0025763770
-
Is low birth weight a risk factor for asthma during adolescence?
-
Seidman, DS, Laor, A, Gale, R, Stevenson, DK, Danon, YL, Is low birth weight a risk factor for asthma during adolescence?. Arch Dis Child 66 (1991), 584–587.
-
(1991)
Arch Dis Child
, vol.66
, pp. 584-587
-
-
Seidman, D.S.1
Laor, A.2
Gale, R.3
Stevenson, D.K.4
Danon, Y.L.5
-
64
-
-
0023708533
-
Diminished lung function as a predisposing factor for wheezing respiratory illness in infants
-
Martinez, FD, Morgan, WJ, Wright, AL, Holberg, CJ, Taussig, LM, Diminished lung function as a predisposing factor for wheezing respiratory illness in infants. N Engl J Med 319 (1988), 1112–1117.
-
(1988)
N Engl J Med
, vol.319
, pp. 1112-1117
-
-
Martinez, F.D.1
Morgan, W.J.2
Wright, A.L.3
Holberg, C.J.4
Taussig, L.M.5
-
65
-
-
11144356329
-
The relationship between infant airway function, childhood airway responsiveness, and asthma
-
Turner, SW, Palmer, LJ, Rye, PJ, et al. The relationship between infant airway function, childhood airway responsiveness, and asthma. Am J Respir Crit Care Med 169 (2004), 921–927.
-
(2004)
Am J Respir Crit Care Med
, vol.169
, pp. 921-927
-
-
Turner, S.W.1
Palmer, L.J.2
Rye, P.J.3
-
66
-
-
0029023287
-
Bronchial responsiveness in the neonatal period as a risk factor for wheezing in infancy
-
Clarke, JR, Salmon, B, Silverman, M, Bronchial responsiveness in the neonatal period as a risk factor for wheezing in infancy. Am J Respir Crit Care Med 151 (1995), 1434–1440.
-
(1995)
Am J Respir Crit Care Med
, vol.151
, pp. 1434-1440
-
-
Clarke, J.R.1
Salmon, B.2
Silverman, M.3
-
67
-
-
0035148756
-
Airway responsiveness in early infancy predicts asthma, lung function, and respiratory symptoms by school age
-
Palmer, LJ, Rye, PJ, Gibson, NA, Burton, PR, Landau, LI, Lesouëf, PN, Airway responsiveness in early infancy predicts asthma, lung function, and respiratory symptoms by school age. Am J Respir Crit Care Med 163 (2001), 37–42.
-
(2001)
Am J Respir Crit Care Med
, vol.163
, pp. 37-42
-
-
Palmer, L.J.1
Rye, P.J.2
Gibson, N.A.3
Burton, P.R.4
Landau, L.I.5
Lesouëf, P.N.6
-
68
-
-
84861764332
-
Interaction between asthma and lung function growth in early life
-
Bisgaard, H, Jensen, SM, Bønnelykke, K, Interaction between asthma and lung function growth in early life. Am J Respir Crit Care Med 185 (2012), 1183–1189.
-
(2012)
Am J Respir Crit Care Med
, vol.185
, pp. 1183-1189
-
-
Bisgaard, H.1
Jensen, S.M.2
Bønnelykke, K.3
-
69
-
-
79951972586
-
Exposure to environmental microorganisms and childhood asthma
-
Ege, MJ, Mayer, M, Normand, A-C, et al., the GABRIELA Transregio 22 Study Group. Exposure to environmental microorganisms and childhood asthma. N Engl J Med 364 (2011), 701–709.
-
(2011)
N Engl J Med
, vol.364
, pp. 701-709
-
-
Ege, M.J.1
Mayer, M.2
Normand, A.-C.3
-
70
-
-
0042530449
-
Exposure and sensitization to indoor allergens: association with lung function, bronchial reactivity, and exhaled nitric oxide measures in asthma
-
Langley, SJ, Goldthorpe, S, Craven, M, Morris, J, Woodcock, A, Custovic, A, Exposure and sensitization to indoor allergens: association with lung function, bronchial reactivity, and exhaled nitric oxide measures in asthma. J Allergy Clin Immunol 112 (2003), 362–368.
-
(2003)
J Allergy Clin Immunol
, vol.112
, pp. 362-368
-
-
Langley, S.J.1
Goldthorpe, S.2
Craven, M.3
Morris, J.4
Woodcock, A.5
Custovic, A.6
-
71
-
-
33747143424
-
Endotoxin exposure, CD14, and allergic disease: an interaction between genes and the environment
-
Simpson, A, John, SL, Jury, F, et al. Endotoxin exposure, CD14, and allergic disease: an interaction between genes and the environment. Am J Respir Crit Care Med 174 (2006), 386–392.
-
(2006)
Am J Respir Crit Care Med
, vol.174
, pp. 386-392
-
-
Simpson, A.1
John, S.L.2
Jury, F.3
-
72
-
-
84874947907
-
Pediatric asthma and development of atopy
-
Custovic, A, Lazic, N, Simpson, A, Pediatric asthma and development of atopy. Curr Opin Allergy Clin Immunol 13 (2013), 173–180.
-
(2013)
Curr Opin Allergy Clin Immunol
, vol.13
, pp. 173-180
-
-
Custovic, A.1
Lazic, N.2
Simpson, A.3
-
73
-
-
77952762424
-
Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study
-
Simpson, A, Tan, VY, Winn, J, et al. Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study. Am J Respir Crit Care Med 181 (2010), 1200–1206.
-
(2010)
Am J Respir Crit Care Med
, vol.181
, pp. 1200-1206
-
-
Simpson, A.1
Tan, V.Y.2
Winn, J.3
-
74
-
-
33646488054
-
Long-term inhaled corticosteroids in preschool children at high risk for asthma
-
Guilbert, TW, Morgan, WJ, Zeiger, RS, et al. Long-term inhaled corticosteroids in preschool children at high risk for asthma. N Engl J Med 354 (2006), 1985–1997.
-
(2006)
N Engl J Med
, vol.354
, pp. 1985-1997
-
-
Guilbert, T.W.1
Morgan, W.J.2
Zeiger, R.S.3
-
75
-
-
33646480059
-
Intermittent inhaled corticosteroids in infants with episodic wheezing
-
Bisgaard, H, Hermansen, MN, Loland, L, Halkjaer, LB, Buchvald, F, Intermittent inhaled corticosteroids in infants with episodic wheezing. N Engl J Med 354 (2006), 1998–2005.
-
(2006)
N Engl J Med
, vol.354
, pp. 1998-2005
-
-
Bisgaard, H.1
Hermansen, M.N.2
Loland, L.3
Halkjaer, L.B.4
Buchvald, F.5
-
76
-
-
33747758047
-
Secondary prevention of asthma by the use of Inhaled Fluticasone propionate in Wheezy INfants (IFWIN): double-blind, randomised, controlled study
-
Murray, CS, Woodcock, A, Langley, SJ, Morris, J, Custovic, A, for the IFWIN study team. Secondary prevention of asthma by the use of Inhaled Fluticasone propionate in Wheezy INfants (IFWIN): double-blind, randomised, controlled study. Lancet 368 (2006), 754–762.
-
(2006)
Lancet
, vol.368
, pp. 754-762
-
-
Murray, C.S.1
Woodcock, A.2
Langley, S.J.3
Morris, J.4
Custovic, A.5
-
77
-
-
36049007283
-
Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers
-
Saglani, S, Payne, DN, Zhu, J, et al. Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers. Am J Respir Crit Care Med 176 (2007), 858–864.
-
(2007)
Am J Respir Crit Care Med
, vol.176
, pp. 858-864
-
-
Saglani, S.1
Payne, D.N.2
Zhu, J.3
-
78
-
-
33750685972
-
Comparison of asthma treatment given in addition to inhaled corticosteroids on airway inflammation and responsiveness
-
Green, RH, Brightling, CE, McKenna, S, et al. Comparison of asthma treatment given in addition to inhaled corticosteroids on airway inflammation and responsiveness. Eur Respir J 27 (2006), 1144–1151.
-
(2006)
Eur Respir J
, vol.27
, pp. 1144-1151
-
-
Green, R.H.1
Brightling, C.E.2
McKenna, S.3
-
79
-
-
0025797080
-
Prescribed fenoterol and death from asthma in New Zealand, 1981–7: a further case-control study
-
Grainger, J, Woodman, K, Pearce, N, et al. Prescribed fenoterol and death from asthma in New Zealand, 1981–7: a further case-control study. Thorax 46 (1991), 105–111.
-
(1991)
Thorax
, vol.46
, pp. 105-111
-
-
Grainger, J.1
Woodman, K.2
Pearce, N.3
-
80
-
-
0024515162
-
Prescribed fenoterol and death from asthma in New Zealand, 1981–83: case-control study
-
Crane, J, Pearce, N, Flatt, A, et al. Prescribed fenoterol and death from asthma in New Zealand, 1981–83: case-control study. Lancet 1 (1989), 917–922.
-
(1989)
Lancet
, vol.1
, pp. 917-922
-
-
Crane, J.1
Pearce, N.2
Flatt, A.3
-
81
-
-
0015348479
-
Asthma mortality. Why the United States was spared an epidemic of deaths due to asthma
-
Stolley, PD, Asthma mortality. Why the United States was spared an epidemic of deaths due to asthma. Am Rev Respir Dis 105 (1972), 883–890.
-
(1972)
Am Rev Respir Dis
, vol.105
, pp. 883-890
-
-
Stolley, P.D.1
-
82
-
-
0028214757
-
A cohort analysis of excess mortality in asthma and the use of inhaled beta-agonists
-
Suissa, S, Ernst, P, Boivin, JF, et al. A cohort analysis of excess mortality in asthma and the use of inhaled beta-agonists. Am J Respir Crit Care Med 149 (1994), 604–610.
-
(1994)
Am J Respir Crit Care Med
, vol.149
, pp. 604-610
-
-
Suissa, S.1
Ernst, P.2
Boivin, J.F.3
-
83
-
-
0024545977
-
Cellular events in the bronchi in mild asthma and after bronchial provocation
-
Beasley, R, Roche, WR, Roberts, JA, Holgate, ST, Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis 139 (1989), 806–817.
-
(1989)
Am Rev Respir Dis
, vol.139
, pp. 806-817
-
-
Beasley, R.1
Roche, W.R.2
Roberts, J.A.3
Holgate, S.T.4
-
84
-
-
84923148787
-
Asthma deaths: what now?
-
Levy, ML, Winter, R, Asthma deaths: what now?. Thorax 70 (2015), 209–210.
-
(2015)
Thorax
, vol.70
, pp. 209-210
-
-
Levy, M.L.1
Winter, R.2
-
85
-
-
71049144979
-
Corticosteroid responsiveness and clinical characteristics in childhood difficult asthma
-
Bossley, CJ, Saglani, S, Kavanagh, C, et al. Corticosteroid responsiveness and clinical characteristics in childhood difficult asthma. Eur Respir J 34 (2009), 1052–1059.
-
(2009)
Eur Respir J
, vol.34
, pp. 1052-1059
-
-
Bossley, C.J.1
Saglani, S.2
Kavanagh, C.3
-
86
-
-
0028264310
-
Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid. Allen & Hanburys Limited UK Study Group
-
Greening, AP, Ind, PW, Northfield, M, Shaw, G, Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid. Allen & Hanburys Limited UK Study Group. Lancet 344 (1994), 219–224.
-
(1994)
Lancet
, vol.344
, pp. 219-224
-
-
Greening, A.P.1
Ind, P.W.2
Northfield, M.3
Shaw, G.4
-
87
-
-
1842370350
-
Effect of inhaled formoterol and budesonide on exacerbations of asthma
-
Pauwels, RA, Löfdahl, CG, Postma, DS, et al., the Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group. Effect of inhaled formoterol and budesonide on exacerbations of asthma. N Engl J Med 337 (1997), 1405–1411.
-
(1997)
N Engl J Med
, vol.337
, pp. 1405-1411
-
-
Pauwels, R.A.1
Löfdahl, C.G.2
Postma, D.S.3
-
88
-
-
77956378654
-
Call for withdrawal of LABA single-therapy inhaler in asthma
-
Beasley, R, Perrin, K, Weatherall, M, Wijesinghe, M, Call for withdrawal of LABA single-therapy inhaler in asthma. Lancet 376 (2010), 750–751.
-
(2010)
Lancet
, vol.376
, pp. 750-751
-
-
Beasley, R.1
Perrin, K.2
Weatherall, M.3
Wijesinghe, M.4
-
89
-
-
0032565364
-
Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC
-
Beasley, R, Keil, U, von Mutius, E, et al., the The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. Lancet 351 (1998), 1225–1232.
-
(1998)
Lancet
, vol.351
, pp. 1225-1232
-
-
Beasley, R.1
Keil, U.2
von Mutius, E.3
-
90
-
-
84918780392
-
The global asthma report
-
(accessed Feb 26, 2017).
-
Global Asthma Network. The global asthma report. http://www.globalasthmareport.org, 2014 (accessed Feb 26, 2017).
-
(2014)
-
-
-
91
-
-
84858304153
-
Global asthma prevalence in adults: findings from the cross-sectional world health survey
-
To, T, Stanojevic, S, Moores, G, et al. Global asthma prevalence in adults: findings from the cross-sectional world health survey. BMC Public Health, 12, 2012, 204.
-
(2012)
BMC Public Health
, vol.12
, pp. 204
-
-
To, T.1
Stanojevic, S.2
Moores, G.3
-
92
-
-
84873742940
-
Follow-up of the Finnish Asthma Programme 2000-2010: reduction of hospital burden needs risk group rethinking
-
Kauppi, P, Linna, M, Martikainen, J, Mäkelä MJ, Haahtela, T, Follow-up of the Finnish Asthma Programme 2000-2010: reduction of hospital burden needs risk group rethinking. Thorax 68 (2013), 292–293.
-
(2013)
Thorax
, vol.68
, pp. 292-293
-
-
Kauppi, P.1
Linna, M.2
Martikainen, J.3
Mäkelä, M.J.4
Haahtela, T.5
-
93
-
-
84906932841
-
The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial
-
Djukanović R, Harrison, T, Johnston, SL, et al., the INTERCIA Study Group. The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial. Am J Respir Crit Care Med 190 (2014), 145–154.
-
(2014)
Am J Respir Crit Care Med
, vol.190
, pp. 145-154
-
-
Djukanović, R.1
Harrison, T.2
Johnston, S.L.3
-
94
-
-
0036208838
-
A comparison of the validity of different diagnostic tests in adults with asthma
-
Hunter, CJ, Brightling, CE, Woltmann, G, Wardlaw, AJ, Pavord, ID, A comparison of the validity of different diagnostic tests in adults with asthma. Chest 121 (2002), 1051–1057.
-
(2002)
Chest
, vol.121
, pp. 1051-1057
-
-
Hunter, C.J.1
Brightling, C.E.2
Woltmann, G.3
Wardlaw, A.J.4
Pavord, I.D.5
-
95
-
-
0029963172
-
Prior diagnosis and treatment of patients with normal results of methacholine challenge and unexplained respiratory symptoms
-
Joyce, DP, Chapman, KR, Kesten, S, Prior diagnosis and treatment of patients with normal results of methacholine challenge and unexplained respiratory symptoms. Chest 109 (1996), 697–701.
-
(1996)
Chest
, vol.109
, pp. 697-701
-
-
Joyce, D.P.1
Chapman, K.R.2
Kesten, S.3
-
96
-
-
84866418072
-
A cross-sectional study of patterns of airway dysfunction, symptoms and morbidity in primary care asthma
-
Shaw, D, Green, R, Berry, M, et al. A cross-sectional study of patterns of airway dysfunction, symptoms and morbidity in primary care asthma. Prim Care Respir J 21 (2012), 283–287.
-
(2012)
Prim Care Respir J
, vol.21
, pp. 283-287
-
-
Shaw, D.1
Green, R.2
Berry, M.3
-
97
-
-
84873956600
-
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary
-
Vestbo, J, Hurd, SS, Agustí AG, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 187 (2013), 347–365.
-
(2013)
Am J Respir Crit Care Med
, vol.187
, pp. 347-365
-
-
Vestbo, J.1
Hurd, S.S.2
Agustí, A.G.3
-
98
-
-
51249109930
-
Proportional classifications of COPD phenotypes
-
Marsh, SE, Travers, J, Weatherall, M, et al. Proportional classifications of COPD phenotypes. Thorax 63 (2008), 761–767.
-
(2008)
Thorax
, vol.63
, pp. 761-767
-
-
Marsh, S.E.1
Travers, J.2
Weatherall, M.3
-
99
-
-
84941176876
-
The asthma-COPD overlap syndrome: towards a revised taxonomy of chronic airways diseases?
-
Bateman, ED, Reddel, HK, van Zyl-Smit, RN, Agusti, A, The asthma-COPD overlap syndrome: towards a revised taxonomy of chronic airways diseases?. Lancet Respir Med 3 (2015), 719–728.
-
(2015)
Lancet Respir Med
, vol.3
, pp. 719-728
-
-
Bateman, E.D.1
Reddel, H.K.2
van Zyl-Smit, R.N.3
Agusti, A.4
-
100
-
-
84939424142
-
Two Lovely Black Eyes; Oh, what a surprise!
-
Pavord, I, Bush, A, Two Lovely Black Eyes; Oh, what a surprise!. Thorax 70 (2015), 609–610.
-
(2015)
Thorax
, vol.70
, pp. 609-610
-
-
Pavord, I.1
Bush, A.2
-
101
-
-
84939231736
-
Asthma-COPD overlap 2015: now we are six
-
Gibson, PG, McDonald, VM, Asthma-COPD overlap 2015: now we are six. Thorax 70 (2015), 683–691.
-
(2015)
Thorax
, vol.70
, pp. 683-691
-
-
Gibson, P.G.1
McDonald, V.M.2
-
102
-
-
84943428582
-
Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank
-
Wain, LV, Shrine, N, Miller, S, et al. the UK Brain Expression Consortium (UKBEC), the OxGSK Consortium. Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. Lancet Respir Med 3 (2015), 769–781.
-
(2015)
Lancet Respir Med
, vol.3
, pp. 769-781
-
-
Wain, L.V.1
Shrine, N.2
Miller, S.3
-
103
-
-
77950901497
-
Mepolizumab in refractory eosinophilic asthma
-
Pavord, ID, Haldar, P, Bradding, P, Wardlaw, AJ, Mepolizumab in refractory eosinophilic asthma. Thorax, 65, 2010, 370.
-
(2010)
Thorax
, vol.65
, pp. 370
-
-
Pavord, I.D.1
Haldar, P.2
Bradding, P.3
Wardlaw, A.J.4
-
104
-
-
0036795111
-
Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids
-
Green, RH, Brightling, CE, Woltmann, G, Parker, D, Wardlaw, AJ, Pavord, ID, Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax 57 (2002), 875–879.
-
(2002)
Thorax
, vol.57
, pp. 875-879
-
-
Green, R.H.1
Brightling, C.E.2
Woltmann, G.3
Parker, D.4
Wardlaw, A.J.5
Pavord, I.D.6
-
105
-
-
84884905728
-
Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects
-
e1–5.
-
Malinovschi, A, Fonseca, JA, Jacinto, T, Alving, K, Janson, C, Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects. J Allergy Clin Immunol 132 (2013), 821–827 e1–5.
-
(2013)
J Allergy Clin Immunol
, vol.132
, pp. 821-827
-
-
Malinovschi, A.1
Fonseca, J.A.2
Jacinto, T.3
Alving, K.4
Janson, C.5
-
106
-
-
84930866341
-
Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trials
-
Pascoe, S, Locantore, N, Dransfield, MT, Barnes, NC, Pavord, ID, Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trials. Lancet Respir Med 3 (2015), 435–442.
-
(2015)
Lancet Respir Med
, vol.3
, pp. 435-442
-
-
Pascoe, S.1
Locantore, N.2
Dransfield, M.T.3
Barnes, N.C.4
Pavord, I.D.5
-
107
-
-
23644431748
-
Exhaled nitric oxide: a predictor of steroid response
-
Smith, AD, Cowan, JO, Brassett, KP, et al. Exhaled nitric oxide: a predictor of steroid response. Am J Respir Crit Care Med 172 (2005), 453–459.
-
(2005)
Am J Respir Crit Care Med
, vol.172
, pp. 453-459
-
-
Smith, A.D.1
Cowan, J.O.2
Brassett, K.P.3
-
108
-
-
33644773052
-
The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma
-
Berry, MA, Shaw, DE, Green, RH, Brightling, CE, Wardlaw, AJ, Pavord, ID, The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma. Clin Exp Allergy 35 (2005), 1175–1179.
-
(2005)
Clin Exp Allergy
, vol.35
, pp. 1175-1179
-
-
Berry, M.A.1
Shaw, D.E.2
Green, R.H.3
Brightling, C.E.4
Wardlaw, A.J.5
Pavord, I.D.6
-
109
-
-
84876883293
-
Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study
-
Hanania, NA, Wenzel, S, Rosén, K, et al. Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study. Am J Respir Crit Care Med 187 (2013), 804–811.
-
(2013)
Am J Respir Crit Care Med
, vol.187
, pp. 804-811
-
-
Hanania, N.A.1
Wenzel, S.2
Rosén, K.3
-
110
-
-
84961382219
-
Biomarkers in the clinical development of asthma therapies
-
Staton, TL, Choy, DF, Arron, JR, Biomarkers in the clinical development of asthma therapies. Biomarkers Med 10 (2016), 165–176.
-
(2016)
Biomarkers Med
, vol.10
, pp. 165-176
-
-
Staton, T.L.1
Choy, D.F.2
Arron, J.R.3
-
111
-
-
84887503251
-
The yin and the yang of immunosuppression with inhaled corticosteroids
-
Sabroe, I, Postma, D, Heijink, I, Dockrell, DH, The yin and the yang of immunosuppression with inhaled corticosteroids. Thorax 68 (2013), 1085–1087.
-
(2013)
Thorax
, vol.68
, pp. 1085-1087
-
-
Sabroe, I.1
Postma, D.2
Heijink, I.3
Dockrell, D.H.4
-
112
-
-
6644229440
-
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
-
Leckie, MJ, ten Brinke, A, Khan, J, et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 356 (2000), 2144–2148.
-
(2000)
Lancet
, vol.356
, pp. 2144-2148
-
-
Leckie, M.J.1
ten Brinke, A.2
Khan, J.3
-
113
-
-
0037590906
-
Anti-interleukin-5 monoclonal antibodies: preclinical and clinical evidence in asthma models
-
Leckie, MJ, Anti-interleukin-5 monoclonal antibodies: preclinical and clinical evidence in asthma models. Am J Respir Med 2 (2003), 245–259.
-
(2003)
Am J Respir Med
, vol.2
, pp. 245-259
-
-
Leckie, M.J.1
-
114
-
-
36749065556
-
A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma
-
Flood-Page, P, Swenson, C, Faiferman, I, et al., the International Mepolizumab Study Group. A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma. Am J Respir Crit Care Med 176 (2007), 1062–1071.
-
(2007)
Am J Respir Crit Care Med
, vol.176
, pp. 1062-1071
-
-
Flood-Page, P.1
Swenson, C.2
Faiferman, I.3
-
115
-
-
36849086388
-
The demise of anti IL-5 for asthma, or not
-
O'Byrne, PM, The demise of anti IL-5 for asthma, or not. Am J Respir Crit Care Med 176 (2007), 1059–1060.
-
(2007)
Am J Respir Crit Care Med
, vol.176
, pp. 1059-1060
-
-
O'Byrne, P.M.1
-
116
-
-
61849155730
-
Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
-
Nair, P, Pizzichini, MM, Kjarsgaard, M, et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med 360 (2009), 985–993.
-
(2009)
N Engl J Med
, vol.360
, pp. 985-993
-
-
Nair, P.1
Pizzichini, M.M.2
Kjarsgaard, M.3
-
117
-
-
84875467652
-
Efficacy of anti-interleukin-5 therapy with mepolizumab in patients with asthma: a meta-analysis of randomized placebo-controlled trials
-
Liu, Y, Zhang, S, Li, DW, Jiang, SJ, Efficacy of anti-interleukin-5 therapy with mepolizumab in patients with asthma: a meta-analysis of randomized placebo-controlled trials. PLoS One, 8, 2013, e59872.
-
(2013)
PLoS One
, vol.8
, pp. e59872
-
-
Liu, Y.1
Zhang, S.2
Li, D.W.3
Jiang, S.J.4
-
118
-
-
84907423833
-
Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma
-
Bel, EH, Wenzel, SE, Thompson, PJ, et al., the SIRIUS Investigators. Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma. N Engl J Med 371 (2014), 1189–1197.
-
(2014)
N Engl J Med
, vol.371
, pp. 1189-1197
-
-
Bel, E.H.1
Wenzel, S.E.2
Thompson, P.J.3
-
119
-
-
84907424177
-
Mepolizumab treatment in patients with severe eosinophilic asthma
-
Ortega, HG, Liu, MC, Pavord, ID, et al., the MENSA Investigators. Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med 371 (2014), 1198–1207.
-
(2014)
N Engl J Med
, vol.371
, pp. 1198-1207
-
-
Ortega, H.G.1
Liu, M.C.2
Pavord, I.D.3
-
120
-
-
84919382915
-
Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study
-
Castro, M, Wenzel, SE, Bleecker, ER, et al. Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study. Lancet Respir Med 2 (2014), 879–890.
-
(2014)
Lancet Respir Med
, vol.2
, pp. 879-890
-
-
Castro, M.1
Wenzel, S.E.2
Bleecker, E.R.3
-
121
-
-
84929026123
-
Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials
-
Castro, M, Zangrilli, J, Wechsler, ME, et al. Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials. Lancet Respir Med 3 (2015), 355–366.
-
(2015)
Lancet Respir Med
, vol.3
, pp. 355-366
-
-
Castro, M.1
Zangrilli, J.2
Wechsler, M.E.3
-
122
-
-
84964573673
-
Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial
-
Wenzel, S, Castro, M, Corren, J, et al. Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial. Lancet 388 (2016), 31–44.
-
(2016)
Lancet
, vol.388
, pp. 31-44
-
-
Wenzel, S.1
Castro, M.2
Corren, J.3
-
123
-
-
52049087356
-
Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease
-
Anderson, GP, Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. Lancet 372 (2008), 1107–1119.
-
(2008)
Lancet
, vol.372
, pp. 1107-1119
-
-
Anderson, G.P.1
-
124
-
-
84973557274
-
Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts
-
Peters, MC, McGrath, KW, Hawkins, GA, et al., the National Heart, Lung and Blood Institute Severe Asthma Research Program. Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts. Lancet Respir Med 4 (2016), 574–584.
-
(2016)
Lancet Respir Med
, vol.4
, pp. 574-584
-
-
Peters, M.C.1
McGrath, K.W.2
Hawkins, G.A.3
-
125
-
-
84880041974
-
Complex airway disease: an approach to assessment and management
-
Pavord, ID, Complex airway disease: an approach to assessment and management. Lancet Respir Med 1 (2013), 84–90.
-
(2013)
Lancet Respir Med
, vol.1
, pp. 84-90
-
-
Pavord, I.D.1
-
127
-
-
84958073595
-
Treatable traits: toward precision medicine of chronic airway diseases
-
Agusti, A, Bel, E, Thomas, M, et al. Treatable traits: toward precision medicine of chronic airway diseases. Eur Respir J 47 (2016), 410–419.
-
(2016)
Eur Respir J
, vol.47
, pp. 410-419
-
-
Agusti, A.1
Bel, E.2
Thomas, M.3
-
128
-
-
84892645769
-
Challenges in interpreting wheeze phenotypes: the clinical implications of statistical learning techniques
-
Belgrave, D, Simpson, A, Custovic, A, Challenges in interpreting wheeze phenotypes: the clinical implications of statistical learning techniques. Am J Respir Crit Care Med 189 (2014), 121–123.
-
(2014)
Am J Respir Crit Care Med
, vol.189
, pp. 121-123
-
-
Belgrave, D.1
Simpson, A.2
Custovic, A.3
-
129
-
-
70350318929
-
The definition and diagnosis of asthma
-
Hargreave, FE, Nair, P, The definition and diagnosis of asthma. Clin Exp Allergy 39 (2009), 1652–1658.
-
(2009)
Clin Exp Allergy
, vol.39
, pp. 1652-1658
-
-
Hargreave, F.E.1
Nair, P.2
-
130
-
-
84875732224
-
Increased airway smooth muscle in preschool wheezers who have asthma at school age
-
e1–16.
-
O'Reilly, R, Ullmann, N, Irving, S, et al. Increased airway smooth muscle in preschool wheezers who have asthma at school age. J Allergy Clin Immunol 131 (2013), 1024–1032 e1–16.
-
(2013)
J Allergy Clin Immunol
, vol.131
, pp. 1024-1032
-
-
O'Reilly, R.1
Ullmann, N.2
Irving, S.3
-
131
-
-
84860502407
-
Prenatal nicotine exposure alters lung function and airway geometry through α7 nicotinic receptors
-
Wongtrakool, C, Wang, N, Hyde, DM, Roman, J, Spindel, ER, Prenatal nicotine exposure alters lung function and airway geometry through α7 nicotinic receptors. Am J Respir Cell Mol Biol 46 (2012), 695–702.
-
(2012)
Am J Respir Cell Mol Biol
, vol.46
, pp. 695-702
-
-
Wongtrakool, C.1
Wang, N.2
Hyde, D.M.3
Roman, J.4
Spindel, E.R.5
-
132
-
-
0037336954
-
Airway hyperresponsiveness
-
O'Byrne, PM, Inman, MD, Airway hyperresponsiveness. Chest 123:suppl (2003), 411S–416S.
-
(2003)
Chest
, vol.123
, pp. 411S-416S
-
-
O'Byrne, P.M.1
Inman, M.D.2
-
133
-
-
0028911427
-
Bronchoprotective role for endogenous prostaglandin E2
-
Pavord, ID, Tattersfield, AE, Bronchoprotective role for endogenous prostaglandin E2. Lancet 345 (1995), 436–438.
-
(1995)
Lancet
, vol.345
, pp. 436-438
-
-
Pavord, I.D.1
Tattersfield, A.E.2
-
134
-
-
84922595423
-
Airway smooth muscle in asthma: linking contraction and mechanotransduction to disease pathogenesis and remodelling
-
Noble, PB, Pascoe, CD, Lan, B, et al. Airway smooth muscle in asthma: linking contraction and mechanotransduction to disease pathogenesis and remodelling. Pulm Pharmacol Ther 29 (2014), 96–107.
-
(2014)
Pulm Pharmacol Ther
, vol.29
, pp. 96-107
-
-
Noble, P.B.1
Pascoe, C.D.2
Lan, B.3
-
135
-
-
84878287868
-
Early life influences on the development of chronic obstructive pulmonary disease
-
Stocks, J, Sonnappa, S, Early life influences on the development of chronic obstructive pulmonary disease. Ther Adv Respir Dis 7 (2013), 161–173.
-
(2013)
Ther Adv Respir Dis
, vol.7
, pp. 161-173
-
-
Stocks, J.1
Sonnappa, S.2
-
136
-
-
84922277110
-
The child is father of the man: the importance of early life influences on lung development
-
Henderson, AJ, The child is father of the man: the importance of early life influences on lung development. Thorax 69 (2014), 976–977.
-
(2014)
Thorax
, vol.69
, pp. 976-977
-
-
Henderson, A.J.1
-
137
-
-
84937605398
-
Birth weight, early childhood growth and lung function in middle to early old age: 1946 British birth cohort
-
Cai, Y, Shaheen, SO, Hardy, R, Kuh, D, Hansell, AL, Birth weight, early childhood growth and lung function in middle to early old age: 1946 British birth cohort. Thorax 71 (2016), 916–922.
-
(2016)
Thorax
, vol.71
, pp. 916-922
-
-
Cai, Y.1
Shaheen, S.O.2
Hardy, R.3
Kuh, D.4
Hansell, A.L.5
-
138
-
-
84944153210
-
Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease
-
Lange, P, Celli, B, Agustí A, et al. Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease. N Engl J Med 373 (2015), 111–122.
-
(2015)
N Engl J Med
, vol.373
, pp. 111-122
-
-
Lange, P.1
Celli, B.2
Agustí, A.3
-
139
-
-
33750077292
-
Reduced lung function at birth and the risk of asthma at 10 years of age
-
Håland, G, Carlsen, KC, Sandvik, L, et al., the ORAACLE. Reduced lung function at birth and the risk of asthma at 10 years of age. N Engl J Med 355 (2006), 1682–1689.
-
(2006)
N Engl J Med
, vol.355
, pp. 1682-1689
-
-
Håland, G.1
Carlsen, K.C.2
Sandvik, L.3
-
140
-
-
84858148726
-
Febrile respiratory illnesses in infancy and atopy are risk factors for persistent asthma and wheeze
-
Kusel, MM, Kebadze, T, Johnston, SL, Holt, PG, Sly, PD, Febrile respiratory illnesses in infancy and atopy are risk factors for persistent asthma and wheeze. Eur Respir J 39 (2012), 876–882.
-
(2012)
Eur Respir J
, vol.39
, pp. 876-882
-
-
Kusel, M.M.1
Kebadze, T.2
Johnston, S.L.3
Holt, P.G.4
Sly, P.D.5
-
141
-
-
85009788213
-
Lung Function in African Infants in the Drakenstein Child Health Study. Impact of Lower Respiratory Tract Illness
-
Gray, DM, Turkovic, L, Willemse, L, et al. Lung Function in African Infants in the Drakenstein Child Health Study. Impact of Lower Respiratory Tract Illness. Am J Respir Crit Care Med 195 (2017), 212–220.
-
(2017)
Am J Respir Crit Care Med
, vol.195
, pp. 212-220
-
-
Gray, D.M.1
Turkovic, L.2
Willemse, L.3
-
142
-
-
84919772609
-
Traffic-related air pollution: an avoidable exposure to improve respiratory health
-
Sly, PD, Traffic-related air pollution: an avoidable exposure to improve respiratory health. Thorax 70 (2015), 3–4.
-
(2015)
Thorax
, vol.70
, pp. 3-4
-
-
Sly, P.D.1
-
143
-
-
84859233105
-
Smoking during pregnancy: lessons learned from epidemiological studies and experimental studies using animal models
-
Abbott, LC, Winzer-Serhan, UH, Smoking during pregnancy: lessons learned from epidemiological studies and experimental studies using animal models. Crit Rev Toxicol 42 (2012), 279–303.
-
(2012)
Crit Rev Toxicol
, vol.42
, pp. 279-303
-
-
Abbott, L.C.1
Winzer-Serhan, U.H.2
-
144
-
-
0030593843
-
Effects of maternal smoking during pregnancy and a family history of asthma on respiratory function in newborn infants
-
Stick, SM, Burton, PR, Gurrin, L, Sly, PD, LeSouëf, PN, Effects of maternal smoking during pregnancy and a family history of asthma on respiratory function in newborn infants. Lancet 348 (1996), 1060–1064.
-
(1996)
Lancet
, vol.348
, pp. 1060-1064
-
-
Stick, S.M.1
Burton, P.R.2
Gurrin, L.3
Sly, P.D.4
LeSouëf, P.N.5
-
145
-
-
20144387227
-
Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction
-
Saglani, S, Malmström, K, Pelkonen, AS, et al. Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction. Am J Respir Crit Care Med 171 (2005), 722–727.
-
(2005)
Am J Respir Crit Care Med
, vol.171
, pp. 722-727
-
-
Saglani, S.1
Malmström, K.2
Pelkonen, A.S.3
-
146
-
-
84939226814
-
Lung consequences in adults born prematurely
-
Bolton, CE, Bush, A, Hurst, JR, Kotecha, S, McGarvey, L, Lung consequences in adults born prematurely. Thorax 70 (2015), 574–580.
-
(2015)
Thorax
, vol.70
, pp. 574-580
-
-
Bolton, C.E.1
Bush, A.2
Hurst, J.R.3
Kotecha, S.4
McGarvey, L.5
-
147
-
-
84882238835
-
Eosinophils in the spotlight: Eosinophilic airway inflammation in nonallergic asthma
-
Brusselle, GG, Maes, T, Bracke, KR, Eosinophils in the spotlight: Eosinophilic airway inflammation in nonallergic asthma. Nat Med 19 (2013), 977–979.
-
(2013)
Nat Med
, vol.19
, pp. 977-979
-
-
Brusselle, G.G.1
Maes, T.2
Bracke, K.R.3
-
148
-
-
34247485053
-
Noneosinophilic asthma: a distinct clinical and pathologic phenotype
-
Haldar, P, Pavord, ID, Noneosinophilic asthma: a distinct clinical and pathologic phenotype. J Allergy Clin Immunol 119 (2007), 1043–1052.
-
(2007)
J Allergy Clin Immunol
, vol.119
, pp. 1043-1052
-
-
Haldar, P.1
Pavord, I.D.2
-
149
-
-
0036310908
-
Non-eosinophilic asthma: importance and possible mechanisms
-
Douwes, J, Gibson, P, Pekkanen, J, Pearce, N, Non-eosinophilic asthma: importance and possible mechanisms. Thorax 57 (2002), 643–648.
-
(2002)
Thorax
, vol.57
, pp. 643-648
-
-
Douwes, J.1
Gibson, P.2
Pekkanen, J.3
Pearce, N.4
-
150
-
-
84875219719
-
Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial
-
Brusselle, GG, Vanderstichele, C, Jordens, P, et al. Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial. Thorax 68 (2013), 322–329.
-
(2013)
Thorax
, vol.68
, pp. 322-329
-
-
Brusselle, G.G.1
Vanderstichele, C.2
Jordens, P.3
-
151
-
-
38348998987
-
Clarithromycin targets neutrophilic airway inflammation in refractory asthma
-
Simpson, JL, Powell, H, Boyle, MJ, Scott, RJ, Gibson, PG, Clarithromycin targets neutrophilic airway inflammation in refractory asthma. Am J Respir Crit Care Med 177 (2008), 148–155.
-
(2008)
Am J Respir Crit Care Med
, vol.177
, pp. 148-155
-
-
Simpson, J.L.1
Powell, H.2
Boyle, M.J.3
Scott, R.J.4
Gibson, P.G.5
-
152
-
-
84862519263
-
Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial
-
Nair, P, Gaga, M, Zervas, E, et al., the Study Investigators. Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial. Clin Exp Allergy 42 (2012), 1097–1103.
-
(2012)
Clin Exp Allergy
, vol.42
, pp. 1097-1103
-
-
Nair, P.1
Gaga, M.2
Zervas, E.3
-
153
-
-
84989916843
-
Efficacy and safety of a CXCR2 antagonist, AZD5069, in patients with uncontrolled persistent asthma: a randomised, double-blind, placebo-controlled trial
-
O'Byrne, PM, Metev, H, Puu, M, et al. Efficacy and safety of a CXCR2 antagonist, AZD5069, in patients with uncontrolled persistent asthma: a randomised, double-blind, placebo-controlled trial. Lancet Respir Med 4 (2016), 797–806.
-
(2016)
Lancet Respir Med
, vol.4
, pp. 797-806
-
-
O'Byrne, P.M.1
Metev, H.2
Puu, M.3
-
154
-
-
84928985245
-
CXCR2 Antagonist MK-7123. A phase 2 proof-of-concept trial for chronic obstructive pulmonary disease
-
Rennard, SI, Dale, DC, Donohue, JF, et al. CXCR2 Antagonist MK-7123. A phase 2 proof-of-concept trial for chronic obstructive pulmonary disease. Am J Respir Crit Care Med 191 (2015), 1001–1011.
-
(2015)
Am J Respir Crit Care Med
, vol.191
, pp. 1001-1011
-
-
Rennard, S.I.1
Dale, D.C.2
Donohue, J.F.3
-
155
-
-
84902665590
-
Predictors of chronic obstructive pulmonary disease exacerbation reduction in response to daily azithromycin therapy
-
Han, MK, Tayob, N, Murray, S, et al. Predictors of chronic obstructive pulmonary disease exacerbation reduction in response to daily azithromycin therapy. Am J Respir Crit Care Med 189 (2014), 1503–1508.
-
(2014)
Am J Respir Crit Care Med
, vol.189
, pp. 1503-1508
-
-
Han, M.K.1
Tayob, N.2
Murray, S.3
-
156
-
-
85006932870
-
Intraepithelial neutrophils in pediatric severe asthma are associated with better lung function
-
Andersson, CK, Adams, A, Nagakumar, P, et al. Intraepithelial neutrophils in pediatric severe asthma are associated with better lung function. J Allergy Clin Immunol 139 (2016), 1819–1829.
-
(2016)
J Allergy Clin Immunol
, vol.139
, pp. 1819-1829
-
-
Andersson, C.K.1
Adams, A.2
Nagakumar, P.3
-
157
-
-
84895069337
-
A randomized double blind, placebo controlled phase 2 trial of BIIL 284 BS (an LTB4 receptor antagonist) for the treatment of lung disease in children and adults with cystic fibrosis
-
Konstan, MW, Döring, G, Heltshe, SL, et al., the Investigators and Coordinators of BI Trial 543.45. A randomized double blind, placebo controlled phase 2 trial of BIIL 284 BS (an LTB4 receptor antagonist) for the treatment of lung disease in children and adults with cystic fibrosis. J Cyst Fibros 13 (2014), 148–155.
-
(2014)
J Cyst Fibros
, vol.13
, pp. 148-155
-
-
Konstan, M.W.1
Döring, G.2
Heltshe, S.L.3
-
158
-
-
84890026323
-
Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma
-
Busse, WW, Holgate, S, Kerwin, E, et al. Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma. Am J Respir Crit Care Med 188 (2013), 1294–1302.
-
(2013)
Am J Respir Crit Care Med
, vol.188
, pp. 1294-1302
-
-
Busse, W.W.1
Holgate, S.2
Kerwin, E.3
-
159
-
-
62549084077
-
A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma
-
Wenzel, SE, Barnes, PJ, Bleecker, ER, et al., the T03 Asthma Investigators. A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. Am J Respir Crit Care Med 179 (2009), 549–558.
-
(2009)
Am J Respir Crit Care Med
, vol.179
, pp. 549-558
-
-
Wenzel, S.E.1
Barnes, P.J.2
Bleecker, E.R.3
-
160
-
-
32644490529
-
Evidence of a role of tumor necrosis factor alpha in refractory asthma
-
Berry, MA, Hargadon, B, Shelley, M, et al. Evidence of a role of tumor necrosis factor alpha in refractory asthma. N Engl J Med 354 (2006), 697–708.
-
(2006)
N Engl J Med
, vol.354
, pp. 697-708
-
-
Berry, M.A.1
Hargadon, B.2
Shelley, M.3
-
161
-
-
77956354206
-
Role of viral respiratory infections in asthma and asthma exacerbations
-
Busse, WW, Lemanske, RF Jr, Gern, JE, Role of viral respiratory infections in asthma and asthma exacerbations. Lancet 376 (2010), 826–834.
-
(2010)
Lancet
, vol.376
, pp. 826-834
-
-
Busse, W.W.1
Lemanske, R.F.2
Gern, J.E.3
-
162
-
-
77952695527
-
The role of viruses in acute exacerbations of asthma
-
quiz 1188–89.
-
Jackson, DJ, Johnston, SL, The role of viruses in acute exacerbations of asthma. J Allergy Clin Immunol 125 (2010), 1178–1187 quiz 1188–89.
-
(2010)
J Allergy Clin Immunol
, vol.125
, pp. 1178-1187
-
-
Jackson, D.J.1
Johnston, S.L.2
-
163
-
-
0033932501
-
The role of bacterial infections in asthma
-
Kraft, M, The role of bacterial infections in asthma. Clin Chest Med 21 (2000), 301–313.
-
(2000)
Clin Chest Med
, vol.21
, pp. 301-313
-
-
Kraft, M.1
-
164
-
-
42149110813
-
Management of chronic cough
-
Pavord, ID, Chung, KF, Management of chronic cough. Lancet 371 (2008), 1375–1384.
-
(2008)
Lancet
, vol.371
, pp. 1375-1384
-
-
Pavord, I.D.1
Chung, K.F.2
-
165
-
-
0032798777
-
Eosinophilic bronchitis is an important cause of chronic cough
-
Brightling, CE, Ward, R, Goh, KL, Wardlaw, AJ, Pavord, ID, Eosinophilic bronchitis is an important cause of chronic cough. Am J Respir Crit Care Med 160 (1999), 406–410.
-
(1999)
Am J Respir Crit Care Med
, vol.160
, pp. 406-410
-
-
Brightling, C.E.1
Ward, R.2
Goh, K.L.3
Wardlaw, A.J.4
Pavord, I.D.5
-
166
-
-
84925967760
-
P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study
-
Abdulqawi, R, Dockry, R, Holt, K, et al. P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study. Lancet 385 (2015), 1198–1205.
-
(2015)
Lancet
, vol.385
, pp. 1198-1205
-
-
Abdulqawi, R.1
Dockry, R.2
Holt, K.3
-
167
-
-
2442430704
-
Quality control for spirometry in preschool children with and without lung disease
-
Aurora, P, Stocks, J, Oliver, C, et al., the London Cystic Fibrosis Collaboration. Quality control for spirometry in preschool children with and without lung disease. Am J Respir Crit Care Med 169 (2004), 1152–1159.
-
(2004)
Am J Respir Crit Care Med
, vol.169
, pp. 1152-1159
-
-
Aurora, P.1
Stocks, J.2
Oliver, C.3
-
168
-
-
33645280587
-
Lung function tests in neonates and infants with chronic lung disease: lung and chest-wall mechanics
-
Gappa, M, Pillow, JJ, Allen, J, Mayer, O, Stocks, J, Lung function tests in neonates and infants with chronic lung disease: lung and chest-wall mechanics. Pediatr Pulmonol 41 (2006), 291–317.
-
(2006)
Pediatr Pulmonol
, vol.41
, pp. 291-317
-
-
Gappa, M.1
Pillow, J.J.2
Allen, J.3
Mayer, O.4
Stocks, J.5
-
169
-
-
0036606112
-
Specific airway resistance in 3-year-old children: a prospective cohort study
-
Lowe, L, Murray, CS, Custovic, A, Simpson, BM, Kissen, PM, Woodcock, A, the NAC Manchester Asthma and Allergy Study Group. Specific airway resistance in 3-year-old children: a prospective cohort study. Lancet 359 (2002), 1904–1908.
-
(2002)
Lancet
, vol.359
, pp. 1904-1908
-
-
Lowe, L.1
Murray, C.S.2
Custovic, A.3
Simpson, B.M.4
Kissen, P.M.5
Woodcock, A.6
-
170
-
-
9844254026
-
Straight and crooked thinking in medicine
-
Asher, R, Straight and crooked thinking in medicine. BMJ 2 (1954), 460–462.
-
(1954)
BMJ
, vol.2
, pp. 460-462
-
-
Asher, R.1
-
171
-
-
0020369647
-
Control of the end-tidal PCO2 in the hyperventilation syndrome: effects of biofeedback and breathing instructions compared
-
Doorn, PV, Folgering, HTM, Colla, P, Control of the end-tidal PCO2 in the hyperventilation syndrome: effects of biofeedback and breathing instructions compared. Bull Eur Physiopathol Respir 18 (1982), 829–836.
-
(1982)
Bull Eur Physiopathol Respir
, vol.18
, pp. 829-836
-
-
Doorn, P.V.1
Folgering, H.T.M.2
Colla, P.3
-
172
-
-
84879411561
-
Multidimensional assessment and tailored interventions for COPD: respiratory utopia or common sense?
-
McDonald, VM, Higgins, I, Wood, LG, Gibson, PG, Multidimensional assessment and tailored interventions for COPD: respiratory utopia or common sense?. Thorax 68 (2013), 691–694.
-
(2013)
Thorax
, vol.68
, pp. 691-694
-
-
McDonald, V.M.1
Higgins, I.2
Wood, L.G.3
Gibson, P.G.4
-
173
-
-
84924407907
-
Symptom- and fraction of exhaled nitric oxide-driven strategies for asthma control: A cluster-randomized trial in primary care
-
e11.
-
Honkoop, PJ, Loijmans, RJ, Termeer, EH, et al., the Asthma Control Cost-Utility Randomized Trial Evaluation (ACCURATE) Study Group. Symptom- and fraction of exhaled nitric oxide-driven strategies for asthma control: A cluster-randomized trial in primary care. J Allergy Clin Immunol 135 (2015), 682–688 e11.
-
(2015)
J Allergy Clin Immunol
, vol.135
, pp. 682-688
-
-
Honkoop, P.J.1
Loijmans, R.J.2
Termeer, E.H.3
-
174
-
-
14744284491
-
British guideline on the management of asthma
-
(accessed Aug 3, 2017).
-
British Thoracic Society and Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma. https://www.brit-thoracic.org.uk/document-library/clinical-information/asthma/btssign-asthma-guideline-2016/, 2016 (accessed Aug 3, 2017).
-
(2016)
-
-
-
175
-
-
5144221336
-
Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study
-
Bateman, ED, Boushey, HA, Bousquet, J, et al., the GOAL Investigators Group. Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study. Am J Respir Crit Care Med 170 (2004), 836–844.
-
(2004)
Am J Respir Crit Care Med
, vol.170
, pp. 836-844
-
-
Bateman, E.D.1
Boushey, H.A.2
Bousquet, J.3
-
176
-
-
84924363129
-
Fraction of exhaled nitric oxide measurements and asthma control: Are the numbers starting to add up?
-
e1.
-
Fleming, L, Bush, A, Fraction of exhaled nitric oxide measurements and asthma control: Are the numbers starting to add up?. J Allergy Clin Immunol 135 (2015), 689–690 e1.
-
(2015)
J Allergy Clin Immunol
, vol.135
, pp. 689-690
-
-
Fleming, L.1
Bush, A.2
-
177
-
-
33947579183
-
External validity of randomised controlled trials in asthma: to whom do the results of the trials apply?
-
Travers, J, Marsh, S, Williams, M, et al. External validity of randomised controlled trials in asthma: to whom do the results of the trials apply?. Thorax 62 (2007), 219–223.
-
(2007)
Thorax
, vol.62
, pp. 219-223
-
-
Travers, J.1
Marsh, S.2
Williams, M.3
-
178
-
-
80052438246
-
An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications
-
Dweik, RA, Boggs, PB, Erzurum, SC, et al., the American Thoracic Society Committee on Interpretation of Exhaled Nitric Oxide Levels (FENO) for Clinical Applications. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med 184 (2011), 602–615.
-
(2011)
Am J Respir Crit Care Med
, vol.184
, pp. 602-615
-
-
Dweik, R.A.1
Boggs, P.B.2
Erzurum, S.C.3
-
179
-
-
14744284491
-
British guideline on the management of asthma
-
(accessed June 5, 2017).
-
British Thoracic Society and Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma. www.brit-thoracic.org.uk/document-library/clinical-information/asthma/btssign-asthma-guideline-2014/, 2014 (accessed June 5, 2017).
-
(2014)
-
-
-
180
-
-
84922020947
-
Burden of asthma and chronic obstructive pulmonary disease and access to essential medicines in low-income and middle-income countries
-
Beran, D, Zar, HJ, Perrin, C, Menezes, AM, Burney, P, the Forum of International Respiratory Societies working group collaboration. Burden of asthma and chronic obstructive pulmonary disease and access to essential medicines in low-income and middle-income countries. Lancet Respir Med 3 (2015), 159–170.
-
(2015)
Lancet Respir Med
, vol.3
, pp. 159-170
-
-
Beran, D.1
Zar, H.J.2
Perrin, C.3
Menezes, A.M.4
Burney, P.5
-
181
-
-
84969802875
-
Blood eosinophil count: a biomarker of an important treatable trait in patients with airway disease
-
Pavord, ID, Agusti, A, Blood eosinophil count: a biomarker of an important treatable trait in patients with airway disease. Eur Respir J 47 (2016), 1299–1303.
-
(2016)
Eur Respir J
, vol.47
, pp. 1299-1303
-
-
Pavord, I.D.1
Agusti, A.2
-
182
-
-
34250215651
-
Nonatopic asthma is associated with helminth infections and bronchiolitis in poor children
-
Pereira, MU, Sly, PD, Pitrez, PM, et al. Nonatopic asthma is associated with helminth infections and bronchiolitis in poor children. Eur Respir J 29 (2007), 1154–1160.
-
(2007)
Eur Respir J
, vol.29
, pp. 1154-1160
-
-
Pereira, M.U.1
Sly, P.D.2
Pitrez, P.M.3
-
183
-
-
46849111610
-
Intestinal helminth infestation is associated with increased bronchial responsiveness in children
-
da Silva, ER, Sly, PD, de Pereira, MU, et al. Intestinal helminth infestation is associated with increased bronchial responsiveness in children. Pediatr Pulmonol 43 (2008), 662–665.
-
(2008)
Pediatr Pulmonol
, vol.43
, pp. 662-665
-
-
da Silva, E.R.1
Sly, P.D.2
de Pereira, M.U.3
-
184
-
-
84864022085
-
Sputum inflammatory phenotypes are not stable in children with asthma
-
Fleming, L, Tsartsali, L, Wilson, N, Regamey, N, Bush, A, Sputum inflammatory phenotypes are not stable in children with asthma. Thorax 67 (2012), 675–681.
-
(2012)
Thorax
, vol.67
, pp. 675-681
-
-
Fleming, L.1
Tsartsali, L.2
Wilson, N.3
Regamey, N.4
Bush, A.5
-
185
-
-
69249150516
-
T-helper type 2-driven inflammation defines major subphenotypes of asthma
-
Woodruff, PG, Modrek, B, Choy, DF, et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med 180 (2009), 388–395.
-
(2009)
Am J Respir Crit Care Med
, vol.180
, pp. 388-395
-
-
Woodruff, P.G.1
Modrek, B.2
Choy, D.F.3
-
186
-
-
77950481806
-
The FDA and safe use of long-acting beta-agonists in the treatment of asthma
-
Chowdhury, BA, Dal Pan, G, The FDA and safe use of long-acting beta-agonists in the treatment of asthma. N Engl J Med 362 (2010), 1169–1171.
-
(2010)
N Engl J Med
, vol.362
, pp. 1169-1171
-
-
Chowdhury, B.A.1
Dal Pan, G.2
-
187
-
-
85007500726
-
Should recommendations about starting inhaled corticosteroid treatment for mild asthma be based on symptom frequency: a post-hoc efficacy analysis of the START study
-
Reddel, HK, Busse, WW, Pedersen, S, et al. Should recommendations about starting inhaled corticosteroid treatment for mild asthma be based on symptom frequency: a post-hoc efficacy analysis of the START study. Lancet 389 (2017), 157–166.
-
(2017)
Lancet
, vol.389
, pp. 157-166
-
-
Reddel, H.K.1
Busse, W.W.2
Pedersen, S.3
-
188
-
-
3543134378
-
Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys
-
Rabe, KF, Adachi, M, Lai, CKW, et al. Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys. J Allergy Clin Immunol 114 (2004), 40–47.
-
(2004)
J Allergy Clin Immunol
, vol.114
, pp. 40-47
-
-
Rabe, K.F.1
Adachi, M.2
Lai, C.K.W.3
-
189
-
-
9644291519
-
Relationship between adherence to inhaled corticosteroids and poor outcomes among adults with asthma
-
Williams, LK, Pladevall, M, Xi, H, et al. Relationship between adherence to inhaled corticosteroids and poor outcomes among adults with asthma. J Allergy Clin Immunol 114 (2004), 1288–1293.
-
(2004)
J Allergy Clin Immunol
, vol.114
, pp. 1288-1293
-
-
Williams, L.K.1
Pladevall, M.2
Xi, H.3
-
190
-
-
0342419450
-
Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial
-
Lemanske, RF Jr, Sorkness, CA, Mauger, EA, et al., the Asthma Clinical Research Network for the National Heart, Lung, and Blood Institute. Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial. JAMA 285 (2001), 2594–2603.
-
(2001)
JAMA
, vol.285
, pp. 2594-2603
-
-
Lemanske, R.F.1
Sorkness, C.A.2
Mauger, E.A.3
-
191
-
-
77956026534
-
Single maintenance and reliever therapy (SMART) of asthma: a critical appraisal
-
Chapman, KR, Barnes, NC, Greening, AP, Jones, PW, Pedersen, S, Single maintenance and reliever therapy (SMART) of asthma: a critical appraisal. Thorax 65 (2010), 747–752.
-
(2010)
Thorax
, vol.65
, pp. 747-752
-
-
Chapman, K.R.1
Barnes, N.C.2
Greening, A.P.3
Jones, P.W.4
Pedersen, S.5
-
192
-
-
34249021521
-
Rescue use of beclomethasone and albuterol in a single inhaler for mild asthma
-
Papi, A, Canonica, GW, Maestrelli, P, et al., the BEST Study Group. Rescue use of beclomethasone and albuterol in a single inhaler for mild asthma. N Engl J Med 356 (2007), 2040–2052.
-
(2007)
N Engl J Med
, vol.356
, pp. 2040-2052
-
-
Papi, A.1
Canonica, G.W.2
Maestrelli, P.3
-
193
-
-
79951812951
-
Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma (TREXA): a randomised, double-blind, placebo-controlled trial
-
Martinez, FD, Chinchilli, VM, Morgan, WJ, et al. Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma (TREXA): a randomised, double-blind, placebo-controlled trial. Lancet 377 (2011), 650–657.
-
(2011)
Lancet
, vol.377
, pp. 650-657
-
-
Martinez, F.D.1
Chinchilli, V.M.2
Morgan, W.J.3
-
194
-
-
12144270425
-
Budesonide/formoterol combination therapy as both maintenance and reliever medication in asthma
-
O'Byrne, PM, Bisgaard, H, Godard, PP, et al. Budesonide/formoterol combination therapy as both maintenance and reliever medication in asthma. Am J Respir Crit Care Med 171 (2005), 129–136.
-
(2005)
Am J Respir Crit Care Med
, vol.171
, pp. 129-136
-
-
O'Byrne, P.M.1
Bisgaard, H.2
Godard, P.P.3
-
195
-
-
33747761653
-
Effect of budesonide in combination with formoterol for reliever therapy in asthma exacerbations: a randomised controlled, double-blind study
-
Rabe, KF, Atienza, T, Magyar, P, Larsson, P, Jorup, C, Lalloo, UG, Effect of budesonide in combination with formoterol for reliever therapy in asthma exacerbations: a randomised controlled, double-blind study. Lancet 368 (2006), 744–753.
-
(2006)
Lancet
, vol.368
, pp. 744-753
-
-
Rabe, K.F.1
Atienza, T.2
Magyar, P.3
Larsson, P.4
Jorup, C.5
Lalloo, U.G.6
-
196
-
-
84866129261
-
Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial
-
Calhoun, WJ, Ameredes, BT, King, TS, et al., the Asthma Clinical Research Network of the National Heart, Lung, and Blood Institute. Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial. JAMA 308 (2012), 987–997.
-
(2012)
JAMA
, vol.308
, pp. 987-997
-
-
Calhoun, W.J.1
Ameredes, B.T.2
King, T.S.3
-
197
-
-
37849028688
-
Poor adherence with inhaled corticosteroids for asthma: can using a single inhaler containing budesonide and formoterol help?
-
Sovani, MP, Whale, CI, Oborne, J, et al. Poor adherence with inhaled corticosteroids for asthma: can using a single inhaler containing budesonide and formoterol help?. Br J Gen Pract 58 (2008), 37–43.
-
(2008)
Br J Gen Pract
, vol.58
, pp. 37-43
-
-
Sovani, M.P.1
Whale, C.I.2
Oborne, J.3
-
198
-
-
0035806738
-
Dose-response relation of inhaled fluticasone propionate in adolescents and adults with asthma: meta-analysis
-
Holt, S, Suder, A, Weatherall, M, Cheng, S, Shirtcliffe, P, Beasley, R, Dose-response relation of inhaled fluticasone propionate in adolescents and adults with asthma: meta-analysis. BMJ 323 (2001), 253–256.
-
(2001)
BMJ
, vol.323
, pp. 253-256
-
-
Holt, S.1
Suder, A.2
Weatherall, M.3
Cheng, S.4
Shirtcliffe, P.5
Beasley, R.6
-
199
-
-
3843105981
-
High dose versus low dose inhaled corticosteroids as initial starting dose for asthma in adults and children
-
CD004109.
-
Powell, H, Gibson, P, High dose versus low dose inhaled corticosteroids as initial starting dose for asthma in adults and children. Cochrane Database Syst Rev, 2004 CD004109.
-
(2004)
Cochrane Database Syst Rev
-
-
Powell, H.1
Gibson, P.2
-
200
-
-
77949576423
-
Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids
-
Lemanske, RF Jr, Mauger, DT, Sorkness, CA, et al., the Childhood Asthma Research and Education (CARE) Network of the National Heart, Lung, and Blood Institute. Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids. N Engl J Med 362 (2010), 975–985.
-
(2010)
N Engl J Med
, vol.362
, pp. 975-985
-
-
Lemanske, R.F.1
Mauger, D.T.2
Sorkness, C.A.3
-
201
-
-
70349446758
-
Quadrupling the dose of inhaled corticosteroid to prevent asthma exacerbations: a randomized, double-blind, placebo-controlled, parallel-group clinical trial
-
Oborne, J, Mortimer, K, Hubbard, RB, Tattersfield, AE, Harrison, TW, Quadrupling the dose of inhaled corticosteroid to prevent asthma exacerbations: a randomized, double-blind, placebo-controlled, parallel-group clinical trial. Am J Respir Crit Care Med 180 (2009), 598–602.
-
(2009)
Am J Respir Crit Care Med
, vol.180
, pp. 598-602
-
-
Oborne, J.1
Mortimer, K.2
Hubbard, R.B.3
Tattersfield, A.E.4
Harrison, T.W.5
-
202
-
-
0037340272
-
Plasma concentrations of fluticasone propionate and budesonide following inhalation from dry powder inhalers by healthy and asthmatic subjects
-
Harrison, TW, Tattersfield, AE, Plasma concentrations of fluticasone propionate and budesonide following inhalation from dry powder inhalers by healthy and asthmatic subjects. Thorax 58 (2003), 258–260.
-
(2003)
Thorax
, vol.58
, pp. 258-260
-
-
Harrison, T.W.1
Tattersfield, A.E.2
-
203
-
-
84869488072
-
Internet-based self-management compared with usual care in adolescents with asthma: a randomized controlled trial
-
Rikkers-Mutsaerts, ER, Winters, AE, Bakker, MJ, et al., the SMASHING Study Group. Internet-based self-management compared with usual care in adolescents with asthma: a randomized controlled trial. Pediatr Pulmonol 47 (2012), 1170–1179.
-
(2012)
Pediatr Pulmonol
, vol.47
, pp. 1170-1179
-
-
Rikkers-Mutsaerts, E.R.1
Winters, A.E.2
Bakker, M.J.3
-
204
-
-
80055088365
-
Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy
-
van Nimwegen, FA, Penders, J, Stobberingh, EE, et al. Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy. J Allergy Clin Immunol 128 (2011), 948–955.
-
(2011)
J Allergy Clin Immunol
, vol.128
, pp. 948-955
-
-
van Nimwegen, F.A.1
Penders, J.2
Stobberingh, E.E.3
-
205
-
-
0036606187
-
Childhood experiences take away your breath as a young adult
-
von Mutius, E, Childhood experiences take away your breath as a young adult. Am J Respir Crit Care Med 165 (2002), 1467–1468.
-
(2002)
Am J Respir Crit Care Med
, vol.165
, pp. 1467-1468
-
-
von Mutius, E.1
-
206
-
-
84984832210
-
The Early Development of Wheeze. Environmental Determinants and Genetic Susceptibility at 17q21
-
Loss, GJ, Depner, M, Hose, AJ, et al., the PASTURE (Protection against Allergy Study in Rural Environments) Study Group. The Early Development of Wheeze. Environmental Determinants and Genetic Susceptibility at 17q21. Am J Respir Crit Care Med 193 (2016), 889–897.
-
(2016)
Am J Respir Crit Care Med
, vol.193
, pp. 889-897
-
-
Loss, G.J.1
Depner, M.2
Hose, A.J.3
-
207
-
-
33847723104
-
Moisture damage and childhood asthma: a population-based incident case-control study
-
Pekkanen, J, Hyvärinen, A, Haverinen-Shaughnessy, U, Korppi, M, Putus, T, Nevalainen, A, Moisture damage and childhood asthma: a population-based incident case-control study. Eur Respir J 29 (2007), 509–515.
-
(2007)
Eur Respir J
, vol.29
, pp. 509-515
-
-
Pekkanen, J.1
Hyvärinen, A.2
Haverinen-Shaughnessy, U.3
Korppi, M.4
Putus, T.5
Nevalainen, A.6
-
208
-
-
84858121141
-
Obesity and childhood asthma—mechanisms and manifestations
-
Jensen, ME, Wood, LG, Gibson, PG, Obesity and childhood asthma—mechanisms and manifestations. Curr Opin Allergy Clin Immunol 12 (2012), 186–192.
-
(2012)
Curr Opin Allergy Clin Immunol
, vol.12
, pp. 186-192
-
-
Jensen, M.E.1
Wood, L.G.2
Gibson, P.G.3
-
209
-
-
2442626779
-
Early-life environmental risk factors for asthma: findings from the Children's Health Study
-
Salam, MT, Li, YF, Langholz, B, Gilliland, FD, the Children's Health Study. Early-life environmental risk factors for asthma: findings from the Children's Health Study. Environ Health Perspect 112 (2004), 760–765.
-
(2004)
Environ Health Perspect
, vol.112
, pp. 760-765
-
-
Salam, M.T.1
Li, Y.F.2
Langholz, B.3
Gilliland, F.D.4
-
210
-
-
78650471025
-
Early menarche predicts incidence of asthma in early adulthood
-
Al-Sahab, B, Hamadeh, MJ, Ardern, CI, Tamim, H, Early menarche predicts incidence of asthma in early adulthood. Am J Epidemiol 173 (2011), 64–70.
-
(2011)
Am J Epidemiol
, vol.173
, pp. 64-70
-
-
Al-Sahab, B.1
Hamadeh, M.J.2
Ardern, C.I.3
Tamim, H.4
-
211
-
-
84966480721
-
Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma
-
McGeachie, MJ, Yates, KP, Zhou, X, et al., the CAMP Research Group. Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma. N Engl J Med 374 (2016), 1842–1852.
-
(2016)
N Engl J Med
, vol.374
, pp. 1842-1852
-
-
McGeachie, M.J.1
Yates, K.P.2
Zhou, X.3
-
212
-
-
33847172367
-
Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease
-
Calverley, PM, Anderson, JA, Celli, B, et al., the TORCH investigators. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N Engl J Med 356 (2007), 775–789.
-
(2007)
N Engl J Med
, vol.356
, pp. 775-789
-
-
Calverley, P.M.1
Anderson, J.A.2
Celli, B.3
-
213
-
-
84970046732
-
Symptoms and lung function decline in a middle-aged cohort of males and females in Australia
-
Abramson, MJ, Kaushik, S, Benke, GP, et al. Symptoms and lung function decline in a middle-aged cohort of males and females in Australia. Int J Chron Obstruct Pulmon Dis 11 (2016), 1097–1103.
-
(2016)
Int J Chron Obstruct Pulmon Dis
, vol.11
, pp. 1097-1103
-
-
Abramson, M.J.1
Kaushik, S.2
Benke, G.P.3
-
214
-
-
84899784758
-
Should we view chronic obstructive pulmonary disease differently after ECLIPSE? A clinical perspective from the study team
-
Vestbo, J, Agusti, A, Wouters, EF, et al., the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints Study Investigators. Should we view chronic obstructive pulmonary disease differently after ECLIPSE? A clinical perspective from the study team. Am J Respir Crit Care Med 189 (2014), 1022–1030.
-
(2014)
Am J Respir Crit Care Med
, vol.189
, pp. 1022-1030
-
-
Vestbo, J.1
Agusti, A.2
Wouters, E.F.3
-
215
-
-
58349121851
-
Severe exacerbations and decline in lung function in asthma
-
O'Byrne, PM, Pedersen, S, Lamm, CJ, Tan, WC, Busse, WW, the START Investigators Group. Severe exacerbations and decline in lung function in asthma. Am J Respir Crit Care Med 179 (2009), 19–24.
-
(2009)
Am J Respir Crit Care Med
, vol.179
, pp. 19-24
-
-
O'Byrne, P.M.1
Pedersen, S.2
Lamm, C.J.3
Tan, W.C.4
Busse, W.W.5
-
216
-
-
84937023870
-
Association between respiratory infections in early life and later asthma is independent of virus type
-
e4.
-
Bønnelykke, K, Vissing, NH, Sevelsted, A, Johnston, SL, Bisgaard, H, Association between respiratory infections in early life and later asthma is independent of virus type. J Allergy Clin Immunol 136 (2015), 81–86 e4.
-
(2015)
J Allergy Clin Immunol
, vol.136
, pp. 81-86
-
-
Bønnelykke, K.1
Vissing, N.H.2
Sevelsted, A.3
Johnston, S.L.4
Bisgaard, H.5
-
217
-
-
84951570253
-
Recent advances in the development of subunit-based RSV vaccines
-
Jaberolansar, N, Toth, I, Young, PR, Skwarczynski, M, Recent advances in the development of subunit-based RSV vaccines. Expert Rev Vaccines 15 (2016), 53–68.
-
(2016)
Expert Rev Vaccines
, vol.15
, pp. 53-68
-
-
Jaberolansar, N.1
Toth, I.2
Young, P.R.3
Skwarczynski, M.4
-
218
-
-
85021139678
-
Palivizumab prophylaxis in preterm infants and subsequent recurrent wheezing: 6 year follow up study
-
published online Feb 2.
-
Mochizuki, H, Kusuda, S, Okada, K, Yoshihara, S, Furuya, H, Simões, EA, Palivizumab prophylaxis in preterm infants and subsequent recurrent wheezing: 6 year follow up study. Am J Respir Crit Care Med, 2017 published online Feb 2. DOI:10.1164/rccm.201609-1812OC.
-
(2017)
Am J Respir Crit Care Med
-
-
Mochizuki, H.1
Kusuda, S.2
Okada, K.3
Yoshihara, S.4
Furuya, H.5
Simões, E.A.6
-
219
-
-
84957950279
-
Type 2 innate lymphoid cells in induced sputum from children with severe asthma
-
Nagakumar, P, Denney, L, Fleming, L, Bush, A, Lloyd, CM, Saglani, S, Type 2 innate lymphoid cells in induced sputum from children with severe asthma. J Allergy Clin Immunol 137 (2016), 624–626.
-
(2016)
J Allergy Clin Immunol
, vol.137
, pp. 624-626
-
-
Nagakumar, P.1
Denney, L.2
Fleming, L.3
Bush, A.4
Lloyd, C.M.5
Saglani, S.6
-
220
-
-
52049088955
-
Wheezing and bronchial hyper-responsiveness in early childhood as predictors of newly diagnosed asthma in early adulthood: a longitudinal birth-cohort study
-
Stern, DA, Morgan, WJ, Halonen, M, Wright, AL, Martinez, FD, Wheezing and bronchial hyper-responsiveness in early childhood as predictors of newly diagnosed asthma in early adulthood: a longitudinal birth-cohort study. Lancet 372 (2008), 1058–1064.
-
(2008)
Lancet
, vol.372
, pp. 1058-1064
-
-
Stern, D.A.1
Morgan, W.J.2
Halonen, M.3
Wright, A.L.4
Martinez, F.D.5
-
221
-
-
0032567988
-
Effect of pneumonia and whooping cough in childhood on adult lung function
-
Johnston, IDA, Strachan, DP, Anderson, HR, Effect of pneumonia and whooping cough in childhood on adult lung function. N Engl J Med 338 (1998), 581–587.
-
(1998)
N Engl J Med
, vol.338
, pp. 581-587
-
-
Johnston, I.D.A.1
Strachan, D.P.2
Anderson, H.R.3
-
222
-
-
84930362845
-
Genotype alone does not predict the clinical course of SFTPC deficiency in paediatric patients
-
Kröner, C, Reu, S, Teusch, V, et al. Genotype alone does not predict the clinical course of SFTPC deficiency in paediatric patients. Eur Respir J 46 (2015), 197–206.
-
(2015)
Eur Respir J
, vol.46
, pp. 197-206
-
-
Kröner, C.1
Reu, S.2
Teusch, V.3
-
223
-
-
0035931973
-
A mutation in the surfactant protein C gene associated with familial interstitial lung disease
-
Nogee, LM, Dunbar, AE 3rd, Wert, SE, Askin, F, Hamvas, A, Whitsett, JA, A mutation in the surfactant protein C gene associated with familial interstitial lung disease. N Engl J Med 344 (2001), 573–579.
-
(2001)
N Engl J Med
, vol.344
, pp. 573-579
-
-
Nogee, L.M.1
Dunbar, A.E.2
Wert, S.E.3
Askin, F.4
Hamvas, A.5
Whitsett, J.A.6
-
224
-
-
0030841815
-
Airway hyperreactivity produced by short-term exposure to hyperoxia in neonatal guinea pigs
-
Schulman, SR, Canada, AT, Fryer, AD, Winsett, DW, Costa, DL, Airway hyperreactivity produced by short-term exposure to hyperoxia in neonatal guinea pigs. Am J Physiol 272 (1997), L1211–L1216.
-
(1997)
Am J Physiol
, vol.272
, pp. L1211-L1216
-
-
Schulman, S.R.1
Canada, A.T.2
Fryer, A.D.3
Winsett, D.W.4
Costa, D.L.5
-
225
-
-
79957850646
-
Importance of hedgehog interacting protein and other lung function genes in asthma
-
Li, X, Howard, TD, Moore, WC, et al. Importance of hedgehog interacting protein and other lung function genes in asthma. J Allergy Clin Immunol 127 (2011), 1457–1465.
-
(2011)
J Allergy Clin Immunol
, vol.127
, pp. 1457-1465
-
-
Li, X.1
Howard, T.D.2
Moore, W.C.3
-
226
-
-
84920991728
-
Degeneracy: Demystifying and destigmatizing a core concept in systems biology
-
Mason, PH, Degeneracy: Demystifying and destigmatizing a core concept in systems biology. Complexity 20 (2015), 12–21.
-
(2015)
Complexity
, vol.20
, pp. 12-21
-
-
Mason, P.H.1
-
227
-
-
77955371721
-
Network, degeneracy and bow tie. Integrating paradigms and architectures to grasp the complexity of the immune system
-
Tieri, P, Grignolio, A, Zaikin, A, et al. Network, degeneracy and bow tie. Integrating paradigms and architectures to grasp the complexity of the immune system. Theor Biol Med Model, 7, 2010, 32.
-
(2010)
Theor Biol Med Model
, vol.7
, pp. 32
-
-
Tieri, P.1
Grignolio, A.2
Zaikin, A.3
-
228
-
-
77952886834
-
Degeneracy as a substrate for respiratory regulation
-
Mellen, NM, Degeneracy as a substrate for respiratory regulation. Respir Physiol Neurobiol 172 (2010), 1–7.
-
(2010)
Respir Physiol Neurobiol
, vol.172
, pp. 1-7
-
-
Mellen, N.M.1
-
229
-
-
33845614415
-
Complex systems and human movement
-
Mayer-Kress, G, Liu, Y-T, Newell, KM, Complex systems and human movement. Complexity 12 (2006), 40–51.
-
(2006)
Complexity
, vol.12
, pp. 40-51
-
-
Mayer-Kress, G.1
Liu, Y.-T.2
Newell, K.M.3
-
230
-
-
84871558605
-
Non-local competition drives both rapid divergence and prolonged stasis in a model of speciation in populations with degenerate resource consumption
-
Atamas, N, Atamas, MS, Atamas, F, Atamas, SP, Non-local competition drives both rapid divergence and prolonged stasis in a model of speciation in populations with degenerate resource consumption. Theor Biol Med Model, 9, 2012, 56.
-
(2012)
Theor Biol Med Model
, vol.9
, pp. 56
-
-
Atamas, N.1
Atamas, M.S.2
Atamas, F.3
Atamas, S.P.4
-
231
-
-
84878022251
-
Multiple atopy phenotypes and their associations with asthma: similar findings from two birth cohorts
-
Lazic, N, Roberts, G, Custovic, A, et al. Multiple atopy phenotypes and their associations with asthma: similar findings from two birth cohorts. Allergy 68 (2013), 764–770.
-
(2013)
Allergy
, vol.68
, pp. 764-770
-
-
Lazic, N.1
Roberts, G.2
Custovic, A.3
-
232
-
-
84908330690
-
Developmental profiles of eczema, wheeze, and rhinitis: two population-based birth cohort studies
-
Belgrave, DC, Granell, R, Simpson, A, et al. Developmental profiles of eczema, wheeze, and rhinitis: two population-based birth cohort studies. PLoS Med, 11, 2014, e1001748.
-
(2014)
PLoS Med
, vol.11
, pp. e1001748
-
-
Belgrave, D.C.1
Granell, R.2
Simpson, A.3
-
233
-
-
84920496635
-
Systems biology of asthma and allergic diseases: a multiscale approach
-
Bunyavanich, S, Schadt, EE, Systems biology of asthma and allergic diseases: a multiscale approach. J Allergy Clin Immunol 135 (2015), 31–42.
-
(2015)
J Allergy Clin Immunol
, vol.135
, pp. 31-42
-
-
Bunyavanich, S.1
Schadt, E.E.2
-
234
-
-
84875163436
-
ADCYAP1R1 and asthma in Puerto Rican children
-
Chen, W, Boutaoui, N, Brehm, JM, et al. ADCYAP1R1 and asthma in Puerto Rican children. Am J Respir Crit Care Med 187 (2013), 584–588.
-
(2013)
Am J Respir Crit Care Med
, vol.187
, pp. 584-588
-
-
Chen, W.1
Boutaoui, N.2
Brehm, J.M.3
-
235
-
-
84949117071
-
DNA methylation and childhood asthma in the inner city
-
Yang, IV, Pedersen, BS, Liu, A, et al. DNA methylation and childhood asthma in the inner city. J Allergy Clin Immunol 136 (2015), 69–80.
-
(2015)
J Allergy Clin Immunol
, vol.136
, pp. 69-80
-
-
Yang, I.V.1
Pedersen, B.S.2
Liu, A.3
-
236
-
-
84906310245
-
Differential DNA methylation profiles of infants exposed to maternal asthma during pregnancy
-
Gunawardhana, LP, Baines, KJ, Mattes, J, Murphy, VE, Simpson, JL, Gibson, PG, Differential DNA methylation profiles of infants exposed to maternal asthma during pregnancy. Pediatr Pulmonol 49 (2014), 852–862.
-
(2014)
Pediatr Pulmonol
, vol.49
, pp. 852-862
-
-
Gunawardhana, L.P.1
Baines, K.J.2
Mattes, J.3
Murphy, V.E.4
Simpson, J.L.5
Gibson, P.G.6
-
237
-
-
84905961096
-
Immune mechanisms and development of childhood asthma
-
Raedler, D, Schaub, B, Immune mechanisms and development of childhood asthma. Lancet Respir Med 2 (2014), 647–656.
-
(2014)
Lancet Respir Med
, vol.2
, pp. 647-656
-
-
Raedler, D.1
Schaub, B.2
-
238
-
-
84982085604
-
Innate immunity and asthma risk in Amish and Hutterite farm children
-
Stein, MM, Hrusch, CL, Gozdz, J, et al. Innate immunity and asthma risk in Amish and Hutterite farm children. N Engl J Med 375 (2016), 411–421.
-
(2016)
N Engl J Med
, vol.375
, pp. 411-421
-
-
Stein, M.M.1
Hrusch, C.L.2
Gozdz, J.3
-
239
-
-
84929297936
-
Dynamics and Stabilization of the human gut microbiome during the first year of life
-
Bäckhed, F, Roswall, J, Peng, Y, et al. Dynamics and Stabilization of the human gut microbiome during the first year of life. Cell Host Microbe 17 (2015), 690–703.
-
(2015)
Cell Host Microbe
, vol.17
, pp. 690-703
-
-
Bäckhed, F.1
Roswall, J.2
Peng, Y.3
-
240
-
-
61649117011
-
Air pollution during pregnancy and lung function in newborns: a birth cohort study
-
Latzin, P, Röösli, M, Huss, A, Kuehni, CE, Frey, U, Air pollution during pregnancy and lung function in newborns: a birth cohort study. Eur Respir J 33 (2009), 594–603.
-
(2009)
Eur Respir J
, vol.33
, pp. 594-603
-
-
Latzin, P.1
Röösli, M.2
Huss, A.3
Kuehni, C.E.4
Frey, U.5
-
241
-
-
36349031124
-
Wheeze and asthma prevalence and related health-service use in white and south Asian pre-schoolchildren in the United Kingdom
-
Kuehni, CE, Strippoli, MP, Low, N, Brooke, AM, Silverman, M, Wheeze and asthma prevalence and related health-service use in white and south Asian pre-schoolchildren in the United Kingdom. Clin Exp Allergy 37 (2007), 1738–1746.
-
(2007)
Clin Exp Allergy
, vol.37
, pp. 1738-1746
-
-
Kuehni, C.E.1
Strippoli, M.P.2
Low, N.3
Brooke, A.M.4
Silverman, M.5
-
242
-
-
84956917105
-
The microbial environment and its influence on asthma prevention in early life
-
von Mutius, E, The microbial environment and its influence on asthma prevention in early life. J Allergy Clin Immunol 137 (2016), 680–689.
-
(2016)
J Allergy Clin Immunol
, vol.137
, pp. 680-689
-
-
von Mutius, E.1
-
243
-
-
84900313699
-
Asthma genetics and personalised medicine
-
Meyers, DA, Bleecker, ER, Holloway, JW, Holgate, ST, Asthma genetics and personalised medicine. Lancet Respir Med 2 (2014), 405–415.
-
(2014)
Lancet Respir Med
, vol.2
, pp. 405-415
-
-
Meyers, D.A.1
Bleecker, E.R.2
Holloway, J.W.3
Holgate, S.T.4
-
244
-
-
84858668898
-
The exposome: from concept to utility
-
Wild, CP, The exposome: from concept to utility. Int J Epidemiol 41 (2012), 24–32.
-
(2012)
Int J Epidemiol
, vol.41
, pp. 24-32
-
-
Wild, C.P.1
-
245
-
-
84939464587
-
Relation between circulating CC16 concentrations, lung function, and development of chronic obstructive pulmonary disease across the lifespan: a prospective study
-
Guerra, S, Halonen, M, Vasquez, MM, et al. Relation between circulating CC16 concentrations, lung function, and development of chronic obstructive pulmonary disease across the lifespan: a prospective study. Lancet Respir Med 3 (2015), 613–620.
-
(2015)
Lancet Respir Med
, vol.3
, pp. 613-620
-
-
Guerra, S.1
Halonen, M.2
Vasquez, M.M.3
-
246
-
-
84940770259
-
The Study Team for Early Life Asthma Research (STELAR) consortium ‘Asthma e-lab’: team science bringing data, methods and investigators together
-
Custovic, A, Ainsworth, J, Arshad, H, et al. The Study Team for Early Life Asthma Research (STELAR) consortium ‘Asthma e-lab’: team science bringing data, methods and investigators together. Thorax 70 (2015), 799–801.
-
(2015)
Thorax
, vol.70
, pp. 799-801
-
-
Custovic, A.1
Ainsworth, J.2
Arshad, H.3
-
247
-
-
84991665514
-
Genome-wide associations for birth weight and correlations with adult disease
-
Horikoshi, M, Beaumont, RN, Day, FR, et al. the CHARGE Consortium Hematology Working Group, the Early Growth Genetics (EGG) Consortium. Genome-wide associations for birth weight and correlations with adult disease. Nature 538 (2016), 248–252.
-
(2016)
Nature
, vol.538
, pp. 248-252
-
-
Horikoshi, M.1
Beaumont, R.N.2
Day, F.R.3
-
248
-
-
3242783463
-
Drug development strategies for asthma: in search of a new paradigm
-
Holt, PG, Sly, PD, Martinez, FD, et al. Drug development strategies for asthma: in search of a new paradigm. Nat Immunol 5 (2004), 695–698.
-
(2004)
Nat Immunol
, vol.5
, pp. 695-698
-
-
Holt, P.G.1
Sly, P.D.2
Martinez, F.D.3
-
249
-
-
84860666096
-
Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment
-
Holt, PG, Sly, PD, Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment. Nat Med 18 (2012), 726–735.
-
(2012)
Nat Med
, vol.18
, pp. 726-735
-
-
Holt, P.G.1
Sly, P.D.2
-
250
-
-
0033549827
-
Long-term clinical efficacy of grass-pollen immunotherapy
-
Durham, SR, Walker, SM, Varga, E-M, et al. Long-term clinical efficacy of grass-pollen immunotherapy. N Engl J Med 341 (1999), 468–475.
-
(1999)
N Engl J Med
, vol.341
, pp. 468-475
-
-
Durham, S.R.1
Walker, S.M.2
Varga, E.-M.3
-
251
-
-
77952505549
-
Omalizumab in children with inadequately controlled severe allergic (IgE-mediated) asthma
-
Kulus, M, Hébert, J, Garcia, E, Fowler Taylor, A, Fernandez Vidaurre, C, Blogg, M, Omalizumab in children with inadequately controlled severe allergic (IgE-mediated) asthma. Curr Med Res Opin 26 (2010), 1285–1293.
-
(2010)
Curr Med Res Opin
, vol.26
, pp. 1285-1293
-
-
Kulus, M.1
Hébert, J.2
Garcia, E.3
Fowler Taylor, A.4
Fernandez Vidaurre, C.5
Blogg, M.6
-
252
-
-
79952795093
-
Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children
-
Busse, WW, Morgan, WJ, Gergen, PJ, et al. Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children. N Engl J Med 364 (2011), 1005–1015.
-
(2011)
N Engl J Med
, vol.364
, pp. 1005-1015
-
-
Busse, W.W.1
Morgan, W.J.2
Gergen, P.J.3
-
253
-
-
6844250986
-
Effects of an immunostimulating agent on acute exacerbations and hospitalizations in patients with chronic obstructive pulmonary disease. The PARI-IS Study Steering Committee and Research Group. Prevention of acute respiratory infection by an immunostimulant
-
Collet, JP, Shapiro, P, Ernst, P, Renzi, T, Ducruet, T, Robinson, A, Effects of an immunostimulating agent on acute exacerbations and hospitalizations in patients with chronic obstructive pulmonary disease. The PARI-IS Study Steering Committee and Research Group. Prevention of acute respiratory infection by an immunostimulant. Am J Respir Crit Care Med 156 (1997), 1719–1724.
-
(1997)
Am J Respir Crit Care Med
, vol.156
, pp. 1719-1724
-
-
Collet, J.P.1
Shapiro, P.2
Ernst, P.3
Renzi, T.4
Ducruet, T.5
Robinson, A.6
-
254
-
-
77957783557
-
The immunostimulant OM-85 BV prevents wheezing attacks in preschool children
-
Razi, CH, Harmancı K, Abacı A, et al. The immunostimulant OM-85 BV prevents wheezing attacks in preschool children. J Allergy Clin Immunol 126 (2010), 763–769.
-
(2010)
J Allergy Clin Immunol
, vol.126
, pp. 763-769
-
-
Razi, C.H.1
Harmancı, K.2
Abacı, A.3
-
255
-
-
38349125635
-
Severity of obstructive airways disease by age 2 years predicts asthma at 10 years of age
-
Devulapalli, CS, Carlsen, KC, Håland, G, et al. Severity of obstructive airways disease by age 2 years predicts asthma at 10 years of age. Thorax 63 (2008), 8–13.
-
(2008)
Thorax
, vol.63
, pp. 8-13
-
-
Devulapalli, C.S.1
Carlsen, K.C.2
Håland, G.3
-
256
-
-
0033773993
-
A clinical index to define risk of asthma in young children with recurrent wheezing
-
Castro-Rodríguez, JA, Holberg, CJ, Wright, AL, Martinez, FD, A clinical index to define risk of asthma in young children with recurrent wheezing. Am J Respir Crit Care Med 162 (2000), 1403–1406.
-
(2000)
Am J Respir Crit Care Med
, vol.162
, pp. 1403-1406
-
-
Castro-Rodríguez, J.A.1
Holberg, C.J.2
Wright, A.L.3
Martinez, F.D.4
-
257
-
-
84921341702
-
Exhaled biomarkers and gene expression at preschool age improve asthma prediction at 6 years of age
-
Klaassen, EM, van de Kant, KD, Jöbsis, Q, et al. Exhaled biomarkers and gene expression at preschool age improve asthma prediction at 6 years of age. Am J Respir Crit Care Med 191 (2015), 201–207.
-
(2015)
Am J Respir Crit Care Med
, vol.191
, pp. 201-207
-
-
Klaassen, E.M.1
van de Kant, K.D.2
Jöbsis, Q.3
-
258
-
-
84884906703
-
Prophylactic use of sublingual allergen immunotherapy in high risk children: a pilot study
-
Holt, PG, Sly, PD, Sampson, HA, et al. Prophylactic use of sublingual allergen immunotherapy in high risk children: a pilot study. J Allergy Clin Immunol 132 (2013), 991–993.
-
(2013)
J Allergy Clin Immunol
, vol.132
, pp. 991-993
-
-
Holt, P.G.1
Sly, P.D.2
Sampson, H.A.3
-
259
-
-
84923805721
-
Randomized trial of peanut consumption in infants at risk for peanut allergy
-
Du Toit, G, Roberts, G, Sayre, PH, et al., the LEAP Study Team. Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med 372 (2015), 803–813.
-
(2015)
N Engl J Med
, vol.372
, pp. 803-813
-
-
Du Toit, G.1
Roberts, G.2
Sayre, P.H.3
-
260
-
-
84947962151
-
Randomized controlled trial of primary prevention of atopy using house dust mite allergen oral immunotherapy in early childhood
-
e1, 11.
-
Zolkipli, Z, Roberts, G, Cornelius, V, et al. Randomized controlled trial of primary prevention of atopy using house dust mite allergen oral immunotherapy in early childhood. J Allergy Clin Immunol 136 (2015), 1541–1547 e1, 11.
-
(2015)
J Allergy Clin Immunol
, vol.136
, pp. 1541-1547
-
-
Zolkipli, Z.1
Roberts, G.2
Cornelius, V.3
-
261
-
-
77952181378
-
Various effects of different probiotic strains in allergic disorders: an update from laboratory and clinical data
-
Özdemir, O, Various effects of different probiotic strains in allergic disorders: an update from laboratory and clinical data. Clin Exp Immunol 160 (2010), 295–304.
-
(2010)
Clin Exp Immunol
, vol.160
, pp. 295-304
-
-
Özdemir, O.1
-
262
-
-
85007378118
-
Fish oil-derived fatty acids in pregnancy and wheeze and asthma in offspring
-
Bisgaard, H, Stokholm, J, Chawes, BL, et al. Fish oil-derived fatty acids in pregnancy and wheeze and asthma in offspring. N Engl J Med 375 (2016), 2530–2539.
-
(2016)
N Engl J Med
, vol.375
, pp. 2530-2539
-
-
Bisgaard, H.1
Stokholm, J.2
Chawes, B.L.3
-
263
-
-
84875219804
-
The novel TLR-9 agonist QbG10 shows clinical efficacy in persistent allergic asthma
-
Beeh, KM, Kanniess, F, Wagner, F, et al. The novel TLR-9 agonist QbG10 shows clinical efficacy in persistent allergic asthma. J Allergy Clin Immunol 131 (2013), 866–874.
-
(2013)
J Allergy Clin Immunol
, vol.131
, pp. 866-874
-
-
Beeh, K.M.1
Kanniess, F.2
Wagner, F.3
-
264
-
-
79956338147
-
Clinical trials and tribulations: the MASCOT study
-
Lenney, W, Perry, S, Price, D, Clinical trials and tribulations: the MASCOT study. Thorax 66 (2011), 457–458.
-
(2011)
Thorax
, vol.66
, pp. 457-458
-
-
Lenney, W.1
Perry, S.2
Price, D.3
-
265
-
-
0034534908
-
Incentive to study drugs in children and other governmental initiatives: will patients with asthma benefit?
-
Giacoia, GP, Incentive to study drugs in children and other governmental initiatives: will patients with asthma benefit?. J Allergy Clin Immunol 106:suppl 3 (2000), S118–S124.
-
(2000)
J Allergy Clin Immunol
, vol.106
, pp. S118-S124
-
-
Giacoia, G.P.1
-
266
-
-
67649805319
-
An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice
-
Reddel, HK, Taylor, DR, Bateman, ED, et al., the American Thoracic Society/European Respiratory Society Task Force on Asthma Control and Exacerbations. An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med 180 (2009), 59–99.
-
(2009)
Am J Respir Crit Care Med
, vol.180
, pp. 59-99
-
-
Reddel, H.K.1
Taylor, D.R.2
Bateman, E.D.3
-
267
-
-
0033616466
-
Differences between asthma exacerbations and poor asthma control
-
Reddel, H, Ware, S, Marks, G, Salome, C, Jenkins, C, Woolcock, A, Differences between asthma exacerbations and poor asthma control. Lancet 353 (1999), 364–369.
-
(1999)
Lancet
, vol.353
, pp. 364-369
-
-
Reddel, H.1
Ware, S.2
Marks, G.3
Salome, C.4
Jenkins, C.5
Woolcock, A.6
-
268
-
-
32644435902
-
COPD exacerbations. 1: Epidemiology
-
Donaldson, GC, Wedzicha, JA, COPD exacerbations. 1: Epidemiology. Thorax 61 (2006), 164–168.
-
(2006)
Thorax
, vol.61
, pp. 164-168
-
-
Donaldson, G.C.1
Wedzicha, J.A.2
-
269
-
-
34147215995
-
Exacerbations in cystic fibrosis. 1: Epidemiology and pathogenesis
-
Goss, CH, Burns, JL, Exacerbations in cystic fibrosis. 1: Epidemiology and pathogenesis. Thorax 62 (2007), 360–367.
-
(2007)
Thorax
, vol.62
, pp. 360-367
-
-
Goss, C.H.1
Burns, J.L.2
-
270
-
-
84883458047
-
Assessing the risk of attack in the management of asthma: a review and proposal for revision of the current control-centred paradigm
-
Blakey, JD, Woolnough, K, Fellows, J, Walker, S, Thomas, M, Pavord, ID, Assessing the risk of attack in the management of asthma: a review and proposal for revision of the current control-centred paradigm. Prim Care Respir J 22 (2013), 344–352.
-
(2013)
Prim Care Respir J
, vol.22
, pp. 344-352
-
-
Blakey, J.D.1
Woolnough, K.2
Fellows, J.3
Walker, S.4
Thomas, M.5
Pavord, I.D.6
-
271
-
-
0031768355
-
Asthma and natural colds. Inflammatory indices in induced sputum: a feasibility study
-
Pizzichini, MM, Pizzichini, E, Efthimiadis, A, et al. Asthma and natural colds. Inflammatory indices in induced sputum: a feasibility study. Am J Respir Crit Care Med 158 (1998), 1178–1184.
-
(1998)
Am J Respir Crit Care Med
, vol.158
, pp. 1178-1184
-
-
Pizzichini, M.M.1
Pizzichini, E.2
Efthimiadis, A.3
-
272
-
-
0028791194
-
Exacerbations of asthma without sputum eosinophilia
-
Turner, MO, Hussack, P, Sears, MR, Dolovich, J, Hargreave, FE, Exacerbations of asthma without sputum eosinophilia. Thorax 50 (1995), 1057–1061.
-
(1995)
Thorax
, vol.50
, pp. 1057-1061
-
-
Turner, M.O.1
Hussack, P.2
Sears, M.R.3
Dolovich, J.4
Hargreave, F.E.5
-
273
-
-
0035721532
-
Risk factors for hospitalization among adults with asthma: the influence of sociodemographic factors and asthma severity
-
Eisner, MD, Katz, PP, Yelin, EH, Shiboski, SC, Blanc, PD, Risk factors for hospitalization among adults with asthma: the influence of sociodemographic factors and asthma severity. Respir Res 2 (2001), 53–60.
-
(2001)
Respir Res
, vol.2
, pp. 53-60
-
-
Eisner, M.D.1
Katz, P.P.2
Yelin, E.H.3
Shiboski, S.C.4
Blanc, P.D.5
-
274
-
-
58749085209
-
Oral prednisolone for preschool children with acute virus-induced wheezing
-
Panickar, J, Lakhanpaul, M, Lambert, PC, et al. Oral prednisolone for preschool children with acute virus-induced wheezing. N Engl J Med 360 (2009), 329–338.
-
(2009)
N Engl J Med
, vol.360
, pp. 329-338
-
-
Panickar, J.1
Lakhanpaul, M.2
Lambert, P.C.3
-
275
-
-
67649231422
-
The effect of high dose inhaled corticosteroids on wheeze in infants after respiratory syncytial virus infection: randomised double blind placebo controlled trial
-
Ermers, MJJ, Rovers, MM, van Woensel, JB, Kimpen, JLL, Bont, LJ, The effect of high dose inhaled corticosteroids on wheeze in infants after respiratory syncytial virus infection: randomised double blind placebo controlled trial. BMJ, 338, 2009, b897.
-
(2009)
BMJ
, vol.338
, pp. b897
-
-
Ermers, M.J.J.1
Rovers, M.M.2
van Woensel, J.B.3
Kimpen, J.L.L.4
Bont, L.J.5
-
276
-
-
63149097933
-
Efficacy of inhaled corticosteroids in infants and preschoolers with recurrent wheezing and asthma: a systematic review with meta-analysis
-
Castro-Rodriguez, JA, Rodrigo, GJ, Efficacy of inhaled corticosteroids in infants and preschoolers with recurrent wheezing and asthma: a systematic review with meta-analysis. Pediatrics 123 (2009), e519–e525.
-
(2009)
Pediatrics
, vol.123
, pp. e519-e525
-
-
Castro-Rodriguez, J.A.1
Rodrigo, G.J.2
-
277
-
-
84908027796
-
Intermittent montelukast in children aged 10 months to 5 years with wheeze (WAIT trial): a multicentre, randomised, placebo-controlled trial
-
Nwokoro, C, Pandya, H, Turner, S, et al. Intermittent montelukast in children aged 10 months to 5 years with wheeze (WAIT trial): a multicentre, randomised, placebo-controlled trial. Lancet Respir Med 2 (2014), 796–803.
-
(2014)
Lancet Respir Med
, vol.2
, pp. 796-803
-
-
Nwokoro, C.1
Pandya, H.2
Turner, S.3
-
278
-
-
84899975771
-
Diagnosis, management, and prognosis of preschool wheeze
-
Ducharme, FM, Tse, SM, Chauhan, B, Diagnosis, management, and prognosis of preschool wheeze. Lancet 383 (2014), 1593–1604.
-
(2014)
Lancet
, vol.383
, pp. 1593-1604
-
-
Ducharme, F.M.1
Tse, S.M.2
Chauhan, B.3
-
279
-
-
80052936263
-
Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers
-
Bafadhel, M, McKenna, S, Terry, S, et al. Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers. Am J Respir Crit Care Med 184 (2011), 662–671.
-
(2011)
Am J Respir Crit Care Med
, vol.184
, pp. 662-671
-
-
Bafadhel, M.1
McKenna, S.2
Terry, S.3
-
280
-
-
84907216438
-
Blood eosinophil guided prednisolone therapy for exacerbations of COPD: a further analysis
-
Bafadhel, M, Davies, L, Calverley, PM, Aaron, SD, Brightling, CE, Pavord, ID, Blood eosinophil guided prednisolone therapy for exacerbations of COPD: a further analysis. Eur Respir J 44 (2014), 789–791.
-
(2014)
Eur Respir J
, vol.44
, pp. 789-791
-
-
Bafadhel, M.1
Davies, L.2
Calverley, P.M.3
Aaron, S.D.4
Brightling, C.E.5
Pavord, I.D.6
-
281
-
-
84863447204
-
Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial
-
Bafadhel, M, McKenna, S, Terry, S, et al. Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial. Am J Respir Crit Care Med 186 (2012), 48–55.
-
(2012)
Am J Respir Crit Care Med
, vol.186
, pp. 48-55
-
-
Bafadhel, M.1
McKenna, S.2
Terry, S.3
-
282
-
-
84055199162
-
Benralizumab–a humanized mAb to IL-5Rα with enhanced antibody-dependent cell-mediated cytotoxicity—a novel approach for the treatment of asthma
-
Ghazi, A, Trikha, A, Calhoun, WJ, Benralizumab–a humanized mAb to IL-5Rα with enhanced antibody-dependent cell-mediated cytotoxicity—a novel approach for the treatment of asthma. Expert Opin Biol Ther 12 (2012), 113–118.
-
(2012)
Expert Opin Biol Ther
, vol.12
, pp. 113-118
-
-
Ghazi, A.1
Trikha, A.2
Calhoun, W.J.3
-
283
-
-
84918571425
-
A randomized trial of benralizumab, an antiinterleukin 5 receptor α monoclonal antibody, after acute asthma
-
Nowak, RM, Parker, JM, Silverman, RA, et al. A randomized trial of benralizumab, an antiinterleukin 5 receptor α monoclonal antibody, after acute asthma. Am J Emerg Med 33 (2014), 14–20.
-
(2014)
Am J Emerg Med
, vol.33
, pp. 14-20
-
-
Nowak, R.M.1
Parker, J.M.2
Silverman, R.A.3
-
284
-
-
84893513577
-
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
-
Chung, KF, Wenzel, SE, Brozek, JL, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J 43 (2013), 343–373.
-
(2013)
Eur Respir J
, vol.43
, pp. 343-373
-
-
Chung, K.F.1
Wenzel, S.E.2
Brozek, J.L.3
-
285
-
-
15844363866
-
Severe asthma treatment: need for characterising patients
-
Heaney, LG, Robinson, DS, Severe asthma treatment: need for characterising patients. Lancet 365 (2005), 974–976.
-
(2005)
Lancet
, vol.365
, pp. 974-976
-
-
Heaney, L.G.1
Robinson, D.S.2
-
286
-
-
84857440098
-
Non-adherence in difficult asthma: time to take it seriously
-
Heaney, LG, Horne, R, Non-adherence in difficult asthma: time to take it seriously. Thorax 67 (2012), 268–270.
-
(2012)
Thorax
, vol.67
, pp. 268-270
-
-
Heaney, L.G.1
Horne, R.2
-
287
-
-
85015978970
-
Validation of a metered dose inhaler electronic monitoring device: implications for asthma clinical trial use
-
Pilcher, J, Holliday, M, Ebmeier, S, et al. Validation of a metered dose inhaler electronic monitoring device: implications for asthma clinical trial use. BMJ Open Respir Res, 3, 2016, e000128.
-
(2016)
BMJ Open Respir Res
, vol.3
, pp. e000128
-
-
Pilcher, J.1
Holliday, M.2
Ebmeier, S.3
-
288
-
-
84870446529
-
The utility of fractional exhaled nitric oxide suppression in the identification of nonadherence in difficult asthma
-
McNicholl, DM, Stevenson, M, McGarvey, LP, Heaney, LG, The utility of fractional exhaled nitric oxide suppression in the identification of nonadherence in difficult asthma. Am J Respir Crit Care Med 186 (2012), 1102–1108.
-
(2012)
Am J Respir Crit Care Med
, vol.186
, pp. 1102-1108
-
-
McNicholl, D.M.1
Stevenson, M.2
McGarvey, L.P.3
Heaney, L.G.4
-
289
-
-
64349113168
-
Efficacy of esomeprazole for treatment of poorly controlled asthma
-
Mastronarde, JG, Anthonisen, NR, Castro, M, et al., the American Lung Association Asthma Clinical Research Centers. Efficacy of esomeprazole for treatment of poorly controlled asthma. N Engl J Med 360 (2009), 1487–1499.
-
(2009)
N Engl J Med
, vol.360
, pp. 1487-1499
-
-
Mastronarde, J.G.1
Anthonisen, N.R.2
Castro, M.3
-
290
-
-
0033185737
-
Asthma and gastroesophageal reflux: fundoplication decreases need for systemic corticosteroids
-
Spivak, H, Smith, CD, Phichith, A, Galloway, K, Waring, JP, Hunter, JG, Asthma and gastroesophageal reflux: fundoplication decreases need for systemic corticosteroids. J Gastrointest Surg 3 (1999), 477–482.
-
(1999)
J Gastrointest Surg
, vol.3
, pp. 477-482
-
-
Spivak, H.1
Smith, C.D.2
Phichith, A.3
Galloway, K.4
Waring, J.P.5
Hunter, J.G.6
-
291
-
-
76149146032
-
Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program
-
Moore, WC, Meyers, DA, Wenzel, SE, et al., the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med 181 (2010), 315–323.
-
(2010)
Am J Respir Crit Care Med
, vol.181
, pp. 315-323
-
-
Moore, W.C.1
Meyers, D.A.2
Wenzel, S.E.3
-
292
-
-
33745736452
-
Obesity and asthma
-
Beuther, DA, Weiss, ST, Sutherland, ER, Obesity and asthma. Am J Respir Crit Care Med 174 (2006), 112–119.
-
(2006)
Am J Respir Crit Care Med
, vol.174
, pp. 112-119
-
-
Beuther, D.A.1
Weiss, S.T.2
Sutherland, E.R.3
-
293
-
-
84939231284
-
Effect of bariatric surgery on asthma control, lung function and bronchial and systemic inflammation in morbidly obese subjects with asthma
-
van Huisstede, A, Rudolphus, A, Castro Cabezas, M, et al. Effect of bariatric surgery on asthma control, lung function and bronchial and systemic inflammation in morbidly obese subjects with asthma. Thorax 70 (2015), 659–667.
-
(2015)
Thorax
, vol.70
, pp. 659-667
-
-
van Huisstede, A.1
Rudolphus, A.2
Castro Cabezas, M.3
-
294
-
-
0033606539
-
Non-eosinophilic corticosteroid unresponsive asthma
-
Pavord, ID, Brightling, CE, Woltmann, G, Wardlaw, AJ, Non-eosinophilic corticosteroid unresponsive asthma. Lancet 353 (1999), 2213–2214.
-
(1999)
Lancet
, vol.353
, pp. 2213-2214
-
-
Pavord, I.D.1
Brightling, C.E.2
Woltmann, G.3
Wardlaw, A.J.4
-
295
-
-
84857431715
-
Use of sputum eosinophil counts to guide management in children with severe asthma
-
Fleming, L, Wilson, N, Regamey, N, Bush, A, Use of sputum eosinophil counts to guide management in children with severe asthma. Thorax 67 (2012), 193–198.
-
(2012)
Thorax
, vol.67
, pp. 193-198
-
-
Fleming, L.1
Wilson, N.2
Regamey, N.3
Bush, A.4
-
296
-
-
0035061065
-
Adverse effects of oral corticosteroids in relation to dose in patients with lung disease
-
Walsh, LJ, Wong, CA, Oborne, J, et al. Adverse effects of oral corticosteroids in relation to dose in patients with lung disease. Thorax 56 (2001), 279–284.
-
(2001)
Thorax
, vol.56
, pp. 279-284
-
-
Walsh, L.J.1
Wong, C.A.2
Oborne, J.3
-
297
-
-
84962016441
-
Comorbidity in severe asthma requiring systemic corticosteroid therapy: cross-sectional data from the Optimum Patient Care Research Database and the British Thoracic Difficult Asthma Registry
-
Sweeney, J, Patterson, CC, Menzies-Gow, A, et al., the British Thoracic Society Difficult Asthma Network. Comorbidity in severe asthma requiring systemic corticosteroid therapy: cross-sectional data from the Optimum Patient Care Research Database and the British Thoracic Difficult Asthma Registry. Thorax 71 (2016), 339–346.
-
(2016)
Thorax
, vol.71
, pp. 339-346
-
-
Sweeney, J.1
Patterson, C.C.2
Menzies-Gow, A.3
-
298
-
-
1242341925
-
Anti-IgE monoclonal antibody, omalizumab: a new treatment for allergic asthma
-
Chung, KF, Anti-IgE monoclonal antibody, omalizumab: a new treatment for allergic asthma. Expert Opin Pharmacother 5 (2004), 439–446.
-
(2004)
Expert Opin Pharmacother
, vol.5
, pp. 439-446
-
-
Chung, K.F.1
-
299
-
-
84989904460
-
Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial
-
Gonem, S, Berair, R, Singapuri, A, et al. Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial. Lancet Respir Med 4 (2016), 699–707.
-
(2016)
Lancet Respir Med
, vol.4
, pp. 699-707
-
-
Gonem, S.1
Berair, R.2
Singapuri, A.3
-
300
-
-
84901759301
-
Effects of an anti-TSLP antibody on allergen-induced asthmatic responses
-
Gauvreau, GM, O'Byrne, PM, Boulet, LP, et al. Effects of an anti-TSLP antibody on allergen-induced asthmatic responses. N Engl J Med 370 (2014), 2102–2110.
-
(2014)
N Engl J Med
, vol.370
, pp. 2102-2110
-
-
Gauvreau, G.M.1
O'Byrne, P.M.2
Boulet, L.P.3
-
301
-
-
74949090750
-
Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial
-
Castro, M, Rubin, AS, Laviolette, M, et al., the AIR2 Trial Study Group. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. Am J Respir Crit Care Med 181 (2010), 116–124.
-
(2010)
Am J Respir Crit Care Med
, vol.181
, pp. 116-124
-
-
Castro, M.1
Rubin, A.S.2
Laviolette, M.3
-
302
-
-
34047099762
-
Asthma control during the year after bronchial thermoplasty
-
Cox, G, Thomson, NC, Rubin, AS, et al., the AIR Trial Study Group. Asthma control during the year after bronchial thermoplasty. N Engl J Med 356 (2007), 1327–1337.
-
(2007)
N Engl J Med
, vol.356
, pp. 1327-1337
-
-
Cox, G.1
Thomson, N.C.2
Rubin, A.S.3
-
303
-
-
33750043741
-
Evaluation of asthma with hyperpolarized helium-3 MRI: correlation with clinical severity and spirometry
-
de Lange, EE, Altes, TA, Patrie, JT, et al. Evaluation of asthma with hyperpolarized helium-3 MRI: correlation with clinical severity and spirometry. Chest 130 (2006), 1055–1062.
-
(2006)
Chest
, vol.130
, pp. 1055-1062
-
-
de Lange, E.E.1
Altes, T.A.2
Patrie, J.T.3
-
304
-
-
84952874268
-
The Salford Lung Study protocol: a pragmatic, randomised phase III real-world effectiveness trial in asthma
-
Woodcock, A, Bakerly, ND, New, JP, et al. The Salford Lung Study protocol: a pragmatic, randomised phase III real-world effectiveness trial in asthma. BMC Pulm Med, 15, 2015, 160.
-
(2015)
BMC Pulm Med
, vol.15
, pp. 160
-
-
Woodcock, A.1
Bakerly, N.D.2
New, J.P.3
-
305
-
-
84925069231
-
Real-world research and its importance in respiratory medicine
-
Price, D, Brusselle, G, Roche, N, Freeman, D, Chisholm, A, Real-world research and its importance in respiratory medicine. Breathe 11 (2015), 26–38.
-
(2015)
Breathe
, vol.11
, pp. 26-38
-
-
Price, D.1
Brusselle, G.2
Roche, N.3
Freeman, D.4
Chisholm, A.5
-
306
-
-
84984604208
-
Building the investment case for asthma R&D: the European Asthma Research and Innovation Partnership argument
-
Walker, SM, Akdis, C, Dahlen, SE, et al. Building the investment case for asthma R&D: the European Asthma Research and Innovation Partnership argument. Clin Exp Allergy 46 (2016), 1136–1138.
-
(2016)
Clin Exp Allergy
, vol.46
, pp. 1136-1138
-
-
Walker, S.M.1
Akdis, C.2
Dahlen, S.E.3
-
307
-
-
84877093623
-
Efficacy and safety of maintenance and reliever combination budesonide-formoterol inhaler in patients with asthma at risk of severe exacerbations: a randomised controlled trial
-
Patel, M, Pilcher, J, Pritchard, A, et al., the SMART Study Group. Efficacy and safety of maintenance and reliever combination budesonide-formoterol inhaler in patients with asthma at risk of severe exacerbations: a randomised controlled trial. Lancet Respir Med 1 (2013), 32–42.
-
(2013)
Lancet Respir Med
, vol.1
, pp. 32-42
-
-
Patel, M.1
Pilcher, J.2
Pritchard, A.3
-
308
-
-
84886877358
-
Characterizing wheeze phenotypes to identify endotypes of childhood asthma, and the implications for future management
-
Belgrave, DC, Custovic, A, Simpson, A, Characterizing wheeze phenotypes to identify endotypes of childhood asthma, and the implications for future management. Expert Rev Clin Immunol 9 (2013), 921–936.
-
(2013)
Expert Rev Clin Immunol
, vol.9
, pp. 921-936
-
-
Belgrave, D.C.1
Custovic, A.2
Simpson, A.3
-
309
-
-
77954637790
-
Different definitions in childhood asthma: how dependable is the dependent variable?
-
Van Wonderen, KE, Van Der Mark, LB, Mohrs, J, Bindels, PJ, Van Aalderen, WM, Ter Riet, G, Different definitions in childhood asthma: how dependable is the dependent variable?. Eur Respir J 36 (2010), 48–56.
-
(2010)
Eur Respir J
, vol.36
, pp. 48-56
-
-
Van Wonderen, K.E.1
Van Der Mark, L.B.2
Mohrs, J.3
Bindels, P.J.4
Van Aalderen, W.M.5
Ter Riet, G.6
-
310
-
-
78650373804
-
Network medicine: a network-based approach to human disease
-
Barabási, AL, Gulbahce, N, Loscalzo, J, Network medicine: a network-based approach to human disease. Nat Rev Genet 12 (2011), 56–68.
-
(2011)
Nat Rev Genet
, vol.12
, pp. 56-68
-
-
Barabási, A.L.1
Gulbahce, N.2
Loscalzo, J.3
-
311
-
-
80052259316
-
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations
-
Torgerson, DG, Ampleford, EJ, Chiu, GY, et al. the Mexico City Childhood Asthma Study (MCAAS) the Children's Health Study (CHS) and HARBORS study the Genetics of Asthma in Latino Americans (GALA) Study Study of Genes-Environment and Admixture in Latino Americans (GALA2) Study of African Americans, Asthma, Genes & Environments (SAGE) the Childhood Asthma Research and Education (CARE) Network the Childhood Asthma Management Program (CAMP) the Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE), the Genetic Research on Asthma in African Diaspora (GRAAD) Study. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet 43 (2011), 887–892.
-
(2011)
Nat Genet
, vol.43
, pp. 887-892
-
-
Torgerson, D.G.1
Ampleford, E.J.2
Chiu, G.Y.3
-
312
-
-
79959354208
-
The genetics of asthma and allergic disease: a 21st century perspective
-
Ober, C, Yao, T-C, The genetics of asthma and allergic disease: a 21st century perspective. Immunol Rev 242 (2011), 10–30.
-
(2011)
Immunol Rev
, vol.242
, pp. 10-30
-
-
Ober, C.1
Yao, T.-C.2
-
313
-
-
77957113600
-
A large-scale, consortium-based genomewide association study of asthma
-
Moffatt, MF, Gut, IG, Demenais, F, et al., the GABRIEL Consortium. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 363 (2010), 1211–1221.
-
(2010)
N Engl J Med
, vol.363
, pp. 1211-1221
-
-
Moffatt, M.F.1
Gut, I.G.2
Demenais, F.3
-
314
-
-
40049100646
-
Discovering susceptibility genes for asthma and allergy
-
Vercelli, D, Discovering susceptibility genes for asthma and allergy. Nat Rev Immunol 8 (2008), 169–182.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 169-182
-
-
Vercelli, D.1
-
315
-
-
84891372721
-
A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations
-
Bønnelykke, K, Sleiman, P, Nielsen, K, et al. A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. Nat Genet 46 (2014), 51–55.
-
(2014)
Nat Genet
, vol.46
, pp. 51-55
-
-
Bønnelykke, K.1
Sleiman, P.2
Nielsen, K.3
-
316
-
-
84928689999
-
Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication
-
Bochkov, YA, Watters, K, Ashraf, S, et al. Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication. Proc Natl Acad Sci USA 112 (2015), 5485–5490.
-
(2015)
Proc Natl Acad Sci USA
, vol.112
, pp. 5485-5490
-
-
Bochkov, Y.A.1
Watters, K.2
Ashraf, S.3
-
317
-
-
33751213587
-
The asthma epidemic
-
Eder, W, Ege, MJ, von Mutius, E, The asthma epidemic. N Engl J Med 355 (2006), 2226–2235.
-
(2006)
N Engl J Med
, vol.355
, pp. 2226-2235
-
-
Eder, W.1
Ege, M.J.2
von Mutius, E.3
-
318
-
-
74049091745
-
The role of lipopolysaccharide in the development of atopy in humans
-
Simpson, A, Martinez, FD, The role of lipopolysaccharide in the development of atopy in humans. Clin Exp Allergy 40 (2010), 209–223.
-
(2010)
Clin Exp Allergy
, vol.40
, pp. 209-223
-
-
Simpson, A.1
Martinez, F.D.2
-
319
-
-
79551502309
-
Effect of day care attendance on sensitization and atopic wheezing differs by Toll-like receptor 2 genotype in 2 population-based birth cohort studies
-
e1–9.
-
Custovic, A, Rothers, J, Stern, D, et al. Effect of day care attendance on sensitization and atopic wheezing differs by Toll-like receptor 2 genotype in 2 population-based birth cohort studies. J Allergy Clin Immunol 127 (2011), 390–397 e1–9.
-
(2011)
J Allergy Clin Immunol
, vol.127
, pp. 390-397
-
-
Custovic, A.1
Rothers, J.2
Stern, D.3
-
320
-
-
6344221598
-
Environmental allergen exposure, sensitisation and asthma: from whole populations to individuals at risk
-
Custovic, A, Simpson, A, Environmental allergen exposure, sensitisation and asthma: from whole populations to individuals at risk. Thorax 59 (2004), 825–827.
-
(2004)
Thorax
, vol.59
, pp. 825-827
-
-
Custovic, A.1
Simpson, A.2
-
321
-
-
84869239687
-
Multifaceted allergen avoidance during infancy reduces asthma during childhood with the effect persisting until age 18 years
-
Scott, M, Roberts, G, Kurukulaaratchy, RJ, Matthews, S, Nove, A, Arshad, SH, Multifaceted allergen avoidance during infancy reduces asthma during childhood with the effect persisting until age 18 years. Thorax 67 (2012), 1046–1051.
-
(2012)
Thorax
, vol.67
, pp. 1046-1051
-
-
Scott, M.1
Roberts, G.2
Kurukulaaratchy, R.J.3
Matthews, S.4
Nove, A.5
Arshad, S.H.6
-
322
-
-
0025223381
-
Regular inhaled beta-agonist treatment in bronchial asthma
-
Sears, MR, Taylor, DR, Print, CG, et al. Regular inhaled beta-agonist treatment in bronchial asthma. Lancet 336 (1990), 1391–1396.
-
(1990)
Lancet
, vol.336
, pp. 1391-1396
-
-
Sears, M.R.1
Taylor, D.R.2
Print, C.G.3
-
323
-
-
0021930430
-
Changes in bronchial hyperreactivity induced by 4 weeks of treatment with antiasthmatic drugs in patients with allergic asthma: a comparison between budesonide and terbutaline
-
Kraan, J, Koëter, GH, vd Mark, TW, Sluiter, HJ, de Vries, K, Changes in bronchial hyperreactivity induced by 4 weeks of treatment with antiasthmatic drugs in patients with allergic asthma: a comparison between budesonide and terbutaline. J Allergy Clin Immunol 76 (1985), 628–636.
-
(1985)
J Allergy Clin Immunol
, vol.76
, pp. 628-636
-
-
Kraan, J.1
Koëter, G.H.2
vd Mark, T.W.3
Sluiter, H.J.4
de Vries, K.5
-
324
-
-
84928739516
-
The platform trial: an efficient strategy for evaluating multiple treatments
-
Berry, SM, Connor, JT, Lewis, RJ, The platform trial: an efficient strategy for evaluating multiple treatments. JAMA 313 (2015), 1619–1620.
-
(2015)
JAMA
, vol.313
, pp. 1619-1620
-
-
Berry, S.M.1
Connor, J.T.2
Lewis, R.J.3
-
326
-
-
84892466177
-
Development of a mouse model mimicking key aspects of a viral asthma exacerbation
-
Clarke, DL, Davis, NH, Majithiya, JB, et al. Development of a mouse model mimicking key aspects of a viral asthma exacerbation. Clin Sci (Lond) 126 (2014), 567–580.
-
(2014)
Clin Sci (Lond)
, vol.126
, pp. 567-580
-
-
Clarke, D.L.1
Davis, N.H.2
Majithiya, J.B.3
-
327
-
-
38949170602
-
Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation
-
Bartlett, NW, Walton, RP, Edwards, MR, et al. Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation. Nat Med 14 (2008), 199–204.
-
(2008)
Nat Med
, vol.14
, pp. 199-204
-
-
Bartlett, N.W.1
Walton, R.P.2
Edwards, M.R.3
-
328
-
-
35248851540
-
Childhood asthma after bacterial colonization of the airway in neonates
-
Bisgaard, H, Hermansen, MN, Buchvald, F, et al. Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med 357 (2007), 1487–1495.
-
(2007)
N Engl J Med
, vol.357
, pp. 1487-1495
-
-
Bisgaard, H.1
Hermansen, M.N.2
Buchvald, F.3
-
329
-
-
33748855345
-
Impaired regulatory T cell function in germ-free mice
-
Ostman, S, Rask, C, Wold, AE, Hultkrantz, S, Telemo, E, Impaired regulatory T cell function in germ-free mice. Eur J Immunol 36 (2006), 2336–2346.
-
(2006)
Eur J Immunol
, vol.36
, pp. 2336-2346
-
-
Ostman, S.1
Rask, C.2
Wold, A.E.3
Hultkrantz, S.4
Telemo, E.5
-
330
-
-
84890565793
-
Microbiota abnormalities in inflammatory airway diseases—Potential for therapy
-
Gollwitzer, ES, Marsland, BJ, Microbiota abnormalities in inflammatory airway diseases—Potential for therapy. Pharmacol Ther 141 (2014), 32–39.
-
(2014)
Pharmacol Ther
, vol.141
, pp. 32-39
-
-
Gollwitzer, E.S.1
Marsland, B.J.2
-
331
-
-
84926408953
-
Organs-on-chips at the frontiers of drug discovery
-
Esch, EW, Bahinski, A, Huh, D, Organs-on-chips at the frontiers of drug discovery. Nat Rev Drug Discov 14 (2015), 248–260.
-
(2015)
Nat Rev Drug Discov
, vol.14
, pp. 248-260
-
-
Esch, E.W.1
Bahinski, A.2
Huh, D.3
-
332
-
-
84902259662
-
Pulmonary retention of primed neutrophils: a novel protective host response, which is impaired in the acute respiratory distress syndrome
-
Summers, C, Singh, NR, White, JF, et al. Pulmonary retention of primed neutrophils: a novel protective host response, which is impaired in the acute respiratory distress syndrome. Thorax 69 (2014), 623–629.
-
(2014)
Thorax
, vol.69
, pp. 623-629
-
-
Summers, C.1
Singh, N.R.2
White, J.F.3
-
333
-
-
0026702853
-
Lipopolysaccharide (LPS) inhalation in healthy subjects increases neutrophils, lymphocytes and fibronectin levels in bronchoalveolar lavage fluid
-
Sandström, T, Bjermer, L, Rylander, R, Lipopolysaccharide (LPS) inhalation in healthy subjects increases neutrophils, lymphocytes and fibronectin levels in bronchoalveolar lavage fluid. Eur Respir J 5 (1992), 992–996.
-
(1992)
Eur Respir J
, vol.5
, pp. 992-996
-
-
Sandström, T.1
Bjermer, L.2
Rylander, R.3
-
334
-
-
0030851462
-
Asthma–time for a change of name?
-
discussion 64–65.
-
Silverman, M, Wilson, N, Asthma–time for a change of name?. Arch Dis Child 77 (1997), 62–64 discussion 64–65.
-
(1997)
Arch Dis Child
, vol.77
, pp. 62-64
-
-
Silverman, M.1
Wilson, N.2
-
335
-
-
84937119168
-
Protecting newborns against pertussis: the value of vaccinating during pregnancy
-
Vilajeliu, A, García-Basteiro, AL, Bayas, JM, Protecting newborns against pertussis: the value of vaccinating during pregnancy. Expert Rev Vaccines 14 (2015), 1051–1053.
-
(2015)
Expert Rev Vaccines
, vol.14
, pp. 1051-1053
-
-
Vilajeliu, A.1
García-Basteiro, A.L.2
Bayas, J.M.3
-
336
-
-
84990184051
-
Infection and inflammation in induced sputum from preschool children with chronic airways diseases
-
Jochmann, A, Artusio, L, Robson, K, et al. Infection and inflammation in induced sputum from preschool children with chronic airways diseases. Pediatr Pulmonol 51 (2016), 778–786.
-
(2016)
Pediatr Pulmonol
, vol.51
, pp. 778-786
-
-
Jochmann, A.1
Artusio, L.2
Robson, K.3
-
337
-
-
84961839358
-
Understanding the impact of second-hand smoke exposure on clinical outcomes in participants with COPD in the SPIROMICS cohort
-
thoraxjnl-2015-207487.
-
Putcha, N, Barr, RG, Han, MK, et al., the SPIROMICS Investigators. Understanding the impact of second-hand smoke exposure on clinical outcomes in participants with COPD in the SPIROMICS cohort. Thorax, 2016 thoraxjnl-2015-207487.
-
(2016)
Thorax
-
-
Putcha, N.1
Barr, R.G.2
Han, M.K.3
-
338
-
-
84922895251
-
Personalized respiratory medicine: exploring the horizon, addressing the issues. Summary of a BRN-AJRCCM workshop held in Barcelona on June 12, 2014
-
Agustí A, Antó JM, Auffray, C, et al. Personalized respiratory medicine: exploring the horizon, addressing the issues. Summary of a BRN-AJRCCM workshop held in Barcelona on June 12, 2014. Am J Respir Crit Care Med 191 (2015), 391–401.
-
(2015)
Am J Respir Crit Care Med
, vol.191
, pp. 391-401
-
-
Agustí, A.1
Antó, J.M.2
Auffray, C.3
|