Fish oil-derived fatty acids in pregnancy and wheeze and asthma in offspring

New England Journal of Medicine

Volumn 375, Issue 26, 2016, Pages 2530-2539

  Bisgaard, Hans ^a   Stokholm, Jakob ^a,c   Chawes, Bo L ^a   Vissing, Nadja H ^a   Bjarnadóttir, Elin ^a,c   Schoos, Ann Marie M ^a   Wolsk, Helene M ^a   Pedersen, Tine M ^a,c   Vinding, Rebecca K ^a,c   Thorsteinsdóttir, Sunna ^a   Følsgaard, Nilofar V ^a   Fink, Nadia R ^a   Thorsen, Jonathan ^a   Pedersen, Anders G ^d   Waage, Johannes ^a   Rasmussen, Morten A ^a   Stark, Ken D ^e   Olsen, Sjurdur F ^b,f   Bønnelykke, Klaus ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b STATENS SERUM INSTITUT   (Denmark)

^c NAESTVED HOSPITAL   (Denmark)

^d TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^e UNIVERSITY OF WATERLOO   (Canada)

^f HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLECALCIFEROL; DOCOSAHEXAENOIC ACID; FISH OIL; ICOSAPENTAENOIC ACID; OLIVE OIL; OMEGA 3 FATTY ACID; PLACEBO;

ALLERGIC DISEASE; ARTICLE; ASTHMA; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE EXACERBATION; DOCOSAHEXAENOIC ACID BLOOD LEVEL; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG MEGADOSE; DRUG POTENTIATION; ECZEMA; EICOSAPENTAENOIC ACID BLOOD LEVEL; FATTY ACID BLOOD LEVEL; FEMALE; FOLLOW UP; GESTATION PERIOD; HUMAN; INFECTION RISK; LOWER RESPIRATORY TRACT INFECTION; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; PARALLEL DESIGN; PATIENT COMPLIANCE; PHENOTYPE; POPULATION RESEARCH; PREGNANT WOMAN; PRESCHOOL CHILD; PRIORITY JOURNAL; PROGENY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; SCHOOL CHILD; SENSITIZATION; THIRD TRIMESTER PREGNANCY; TREATMENT RESPONSE; WHEEZING; ABNORMAL RESPIRATORY SOUND; BLOOD; DIETARY SUPPLEMENT; DRUG EFFECTS; KAPLAN MEIER METHOD; MALE; MEDICATION COMPLIANCE; PREGNANCY; RESPIRATORY TRACT INFECTIONS; RISK;

ASTHMA; CHILD, PRESCHOOL; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FATTY ACIDS, OMEGA-3; FEMALE; FISH OILS; FOLLOW-UP STUDIES; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MEDICATION ADHERENCE; OLIVE OIL; PREGNANCY; PREGNANCY TRIMESTER, THIRD; RESPIRATORY SOUNDS; RESPIRATORY TRACT INFECTIONS; RISK;

EID: 85007378118     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1503734     Document Type: Article

References (35)

1. Eder W, Ege MJ, von Mutius E. The asthma epidemic. N Engl J Med 2006; 355: 2226-35.
2. Masoli M, Fabian D, Holt S, Beasley R. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 2004; 59: 469-78.
3. Bisgaard H, Szefler S. Prevalence of asthma-like symptoms in young children. Pediatr Pulmonol 2007; 42: 723-8.
4. Leaf A, Weber PC. A new era for science in nutrition. Am J Clin Nutr 1987; 45: 1048-53.
5. Blümer N, Renz H. Consumption of omega3-fatty acids during perinatal life: role in immuno-modulation and allergy prevention. J Perinat Med 2007; 35: Suppl 1: S12-8.
6. Willers SM, Devereux G, Craig LCA, et al. Maternal food consumption during pregnancy and asthma, respiratory and atopic symptoms in 5-year-old children. Thorax 2007; 62: 773-9.
7. Dunstan JA, Mori TA, Barden A, et al. Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: a randomized, controlled trial. J Allergy Clin Immunol 2003; 112: 1178-84.
8. Furuhjelm C, Warstedt K, Larsson J, et al. Fish oil supplementation in pregnancy and lactation may decrease the risk of infant allergy. Acta Paediatr 2009; 98: 1461-7.
9. Palmer DJ, Sullivan T, Gold MS, et al. Randomized controlled trial of fish oil supplementation in pregnancy on childhood allergies. Allergy 2013; 68: 1370-6.
10. Hansen S, Strøm M, Maslova E, et al. Fish oil supplementation during pregnancy and allergic respiratory disease in the adult offspring. J Allergy Clin Immunol 2016 April 25 (Epub ahead of print).
11. Bisgaard H, Vissing NH, Carson CG, et al. Deep phenotyping of the unselected COPSAC2010 birth cohort study. Clin Exp Allergy 2013; 43: 1384-94.
12. Chawes BL, Bønnelykke K, Stokholm J, et al. Effect of vitamin D3 supplementation during pregnancy on risk of persistent wheeze in the offspring: a randomized clinical trial. JAMA 2016; 315: 353-61.
13. Bischoff AL, Følsgaard NV, Carson CG, et al. Altered response to A(H1N1)pnd09 vaccination in pregnant women: a single blinded randomized controlled trial. PLoS One 2013; 8(4): e56700.
14. Stokholm J, Chawes BL, Vissing NH, et al. Azithromycin for episodes with asthma-like symptoms in young children aged 1-3 years: a randomised, double-blind, placebo-controlled trial. Lancet Respir Med 2016; 4: 19-26.
15. Olsen SF, Mikkelsen TB, Knudsen VK, et al. Data collected on maternal dietary exposures in the Danish National Birth Cohort. Paediatr Perinat Epidemiol 2007; 21: 76-86.
16. Mikkelsen TB, Olsen SF, Rasmussen SE, Osler M. Relative validity of fruit and vegetable intake estimated by the Food Frequency Questionnaire used in the Danish National Birth Cohort. Scand J Public Health 2007; 35: 172-9.
17. Mikkelsen TB, Osler M, Olsen SF. Validity of protein, retinol, folic acid and n-3 fatty acid intakes estimated from the Food-Frequency Questionnaire used in the Danish National Birth Cohort. Public Health Nutr 2006; 9: 771-8.
18. Armstrong JM, Metherel AH, Stark KD. Direct microwave transesterification of fingertip prick blood samples for fatty acid determinations. Lipids 2008; 43: 187-96.
19. Metherel AH, Taha AY, Izadi H, Stark KD. The application of ultrasound energy to increase lipid extraction throughput of solid matrix samples (flaxseed). Prostaglandins Leukot Essent Fatty Acids 2009; 81: 417-23.
20. Bisgaard H, Hermansen MN, Loland L, Halkjaer LB, Buchvald F. Intermittent inhaled corticosteroids in infants with episodic wheezing. N Engl J Med 2006; 354: 1998-2005.
21. Bisgaard H, Hermansen MN, Buchvald F, et al. Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med 2007; 357: 1487-95.
22. Bisgaard H, Hermansen MN, Bønnelykke K, et al. Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study. BMJ 2010; 341: c4978.
23. Vissing NH, Chawes BLK, Bisgaard H. Increased risk of pneumonia and bronchiolitis after bacterial colonization of the airways as neonates. Am J Respir Crit Care Med 2013; 188: 1246-52.
24. Chawes BL, Poorisrisak P, Johnston SL, Bisgaard H. Neonatal bronchial hyperresponsiveness precedes acute severe viral bronchiolitis in infants. J Allergy Clin Immunol 2012; 130(2): 354-61.e3.
25. Hanifin J, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol (Stockh) 1980; 92:Suppl: 44-7.
26. Bisgaard H, Halkjaer LB, Hinge R, et al. Risk analysis of early childhood eczema. J Allergy Clin Immunol 2009; 123(6): 1355-60.e5.
27. Halkjaer LB, Loland L, Buchvald FF, et al. Development of atopic dermatitis during the first 3 years of life: the Copenhagen Prospective Study on Asthma in Childhood cohort study in high-risk children. Arch Dermatol 2006; 142: 561-6.
28. Steer CD, Hibbeln JR, Golding J, Davey Smith G. Polyunsaturated fatty acid levels in blood during pregnancy, at birth and at 7 years: their associations with two common FADS2 polymorphisms. Hum Mol Genet 2012; 21: 1504-12.
29. Olsen SF, Hansen HS, Sandström B, Jensen B. Erythrocyte levels compared with reported dietary intake of marine n-3 fatty acids in pregnant women. Br J Nutr 1995; 73: 387-95.
30. Denomme J, Stark KD, Holub BJ. Directly quantitated dietary (n-3) fatty acid intakes of pregnant Canadian women are lower than current dietary recommendations. J Nutr 2005; 135: 206-11.
31. Stark KD, Beblo S, Murthy M, et al. Comparison of bloodstream fatty acid composition from African-American women at gestation, delivery, and postpartum. J Lipid Res 2005; 46: 516-25.
32. Lemaitre RN, Tanaka T, Tang W, et al. Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. PLoS Genet 2011; 7(7): e1002193.
33. Lands B. Historical perspectives on the impact of n-3 and n-6 nutrients on health. Prog Lipid Res 2014; 55: 17-29.
34. McDade TW. Early environments and the ecology of inflammation. Proc Natl Acad Sci U S A 2012; 109: Suppl 2: 17281-8.
35. Micha R, Khatibzadeh S, Shi P, et al. Global, regional, and national consumption levels of dietary fats and oils in 1990 and 2010: a systematic analysis including 266 country-specific nutrition surveys. BMJ 2014; 348: g2272.