Increased airway smooth muscle in preschool wheezers who have asthma at school age

Journal of Allergy and Clinical Immunology

Volumn 131, Issue 4, 2013, Pages

  O'Reilly, Ruth ^a,b   Ullmann, Nicola ^a,b   Irving, Samantha ^a,b   Bossley, Cara J ^a,b   Sonnappa, Samatha ^c   Zhu, Jie ^a   Oates, Timothy ^b   Banya, Winston ^a   Jeffery, Peter K ^a   Bush, Andrew ^a,b   Saglani, Sejal ^a,b  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

airway smooth muscle; asthma; pathology; pediatric; Preschool wheeze

Indexed keywords

AIRWAY SMOOTH MUSCLE; ARTICLE; ASTHMA; BRONCHOSCOPY; BRONCHUS BIOPSY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOBRONCHIAL BIOPSY; EOSINOPHIL; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; INFANT; MALE; MAST CELL; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SMOOTH MUSCLE; WHEEZING;

EID: 84875732224     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2012.08.044     Document Type: Article

References (61)

1. P.K. Jeffery Remodeling in asthma and chronic obstructive lung disease Am J Respir Crit Care Med 164 suppl 2001 S28 S38
2. L. Benayoun, A. Druilhe, M.C. Dombret, M. Aubier, and M. Pretolani Airway structural alterations selectively associated with severe asthma Am J Respir Crit Care Med 167 2003 1360 1368 (Pubitemid 36609720)
3. N. Regamey, M. Ochs, T.N. Hilliard, C. Muhlfeld, N. Cornish, and L. Fleming Increased airway smooth muscle mass in children with asthma, cystic fibrosis, and non-cystic fibrosis bronchiectasis Am J Respir Crit Care Med 177 2008 837 843 (Pubitemid 351600661)
4. A. Gupta, A. Sjoukes, D. Richards, W. Banya, C. Hawrylowicz, and A. Bush Relationship between serum vitamin d, disease severity, and airway remodeling in children with asthma Am J Respir Crit Care Med 184 2011 1342 1349
5. N. Tsurikisawa, C. Oshikata, T. Tsuburai, H. Saito, K. Sekiya, and H. Tanimoto Bronchial hyperresponsiveness to histamine correlates with airway remodelling in adults with asthma Respir Med 104 2010 1271 1277
6. M. Kaminska, S. Foley, K. Maghni, C. Storness-Bliss, H. Coxson, and H. Ghezzo Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction J Allergy Clin Immunol 124 2009 45 51
7. A.L. James, T.R. Bai, T. Mauad, M.J. Abramson, M. Dolhnikoff, and K.O. McKay Airway smooth muscle thickness in asthma is related to severity but not duration of asthma Eur Respir J 34 2009 1040 1045
8. C.E. Brightling, P. Bradding, F.A. Symon, S.T. Holgate, A.J. Wardlaw, and I.D. Pavord Mast-cell infiltration of airway smooth muscle in asthma N Engl J Med 346 2002 1699 1705 (Pubitemid 34547483)
9. S. Siddiqui, V. Mistry, C. Doe, K. Roach, A. Morgan, and A. Wardlaw Airway hyperresponsiveness is dissociated from airway wall structural remodeling J Allergy Clin Immunol 122 2008 335 341
10. D. Kaur, R. Saunders, F. Hollins, L. Woodman, C. Doe, and S. Siddiqui Mast cell fibroblastoid differentiation mediated by airway smooth muscle in asthma J Immunol 185 2010 6105 6114
11. F.D. Martinez, A.L. Wright, L.M. Taussig, C.J. Holberg, M. Halonen, and W.J. Morgan Asthma and wheezing in the first six years of life. The Group Health Medical Associates N Engl J Med 332 1995 133 138
12. W.J. Morgan, D.A. Stern, D.L. Sherrill, S. Guerra, C.J. Holberg, and T.W. Guilbert Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence Am J Respir Crit Care Med 172 2005 1253 1258 (Pubitemid 43076563)
13. S. Saglani, D.N. Payne, J. Zhu, Z. Wang, A.G. Nicholson, and A. Bush Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers Am J Respir Crit Care Med 176 2007 858 864 (Pubitemid 350097074)
14. R. O'Reilly, T. Oates, J. Zhu, P.K. Jeffery, A. Bush, and S. Saglani Increased reticular basement membrane thickness but not airway smooth muscle in endobronchial biopsies of severe preschool wheezers [abstract] Thorax 65 2010 A2
15. O'Reilly R, Oates T, Zhu J, Jeffery PK, Bush A, Saglani S. More airway smooth muscle in preschool children increases risk of future asthma [abstract]. Presented at the European Respiratory Society Annual Congress, September 2011, Amsterdam, 1407.
16. S. Saglani, S.A. McKenzie, A. Bush, and D.N. Payne A video questionnaire identifies upper airway abnormalities in preschool children with reported wheeze Arch Dis Child 90 2005 961 964 (Pubitemid 41232351)
17. M.I. Asher, U. Keil, H.R. Anderson, R. Beasley, J. Crane, and F. Martinez International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods Eur Respir J 8 1995 483 491
18. S. Illi, M.E. von, S. Lau, R. Nickel, C. Gruber, and B. Niggemann The natural course of atopic dermatitis from birth to age 7 years and the association with asthma J Allergy Clin Immunol 113 2004 925 931 (Pubitemid 38608603)
19. J.C. Celedon, D.K. Milton, C.D. Ramsey, A.A. Litonjua, L. Ryan, and T.A. Platts-Mills Exposure to dust mite allergen and endotoxin in early life and asthma and atopy in childhood J Allergy Clin Immunol 120 2007 144 149 (Pubitemid 46990490)
20. S.H. Arshad, R.J. Kurukulaaratchy, M. Fenn, and S. Matthews Early life risk factors for current wheeze, asthma, and bronchial hyperresponsiveness at 10 years of age Chest 127 2005 502 508 (Pubitemid 40229309)
21. C.D. Ramsey, D.R. Gold, A.A. Litonjua, D.L. Sredl, L. Ryan, and J.C. Celedon Respiratory illnesses in early life and asthma and atopy in childhood J Allergy Clin Immunol 119 2007 150 156 (Pubitemid 46037807)
22. B.A. Raby, J.C. Celedon, A.A. Litonjua, W. Phipatanakul, D. Sredl, and E. Oken Low-normal gestational age as a predictor of asthma at 6 years of age Pediatrics 114 2004 e327 e332
23. J.C. Celedon, R.J. Wright, A.A. Litonjua, D. Sredl, L. Ryan, and S.T. Weiss Day care attendance in early life, maternal history of asthma, and asthma at the age of 6 years Am J Respir Crit Care Med 167 2003 1239 1243 (Pubitemid 36555096)
24. R.S. Cane, and S.A. McKenzie Parents' interpretations of children's respiratory symptoms on video Arch Dis Child 84 2001 31 34 (Pubitemid 32060133)
25. J.A. Castro-Rodriguez, C.J. Holberg, A.L. Wright, and F.D. Martinez A clinical index to define risk of asthma in young children with recurrent wheezing Am J Respir Crit Care Med 162 2000 1403 1406
26. C.S. Devulapalli, K.C. Carlsen, G. Haland, M.C. Munthe-Kaas, M. Pettersen, and P. Mowinckel Severity of obstructive airways disease by age 2 years predicts asthma at 10 years of age Thorax 63 2008 8 13
27. M.R. Miller, J. Hankinson, V. Brusasco, F. Burgos, R. Casaburi, and A. Coates Standardisation of spirometry Eur Respir J 26 2005 319 338 (Pubitemid 41079078)
28. K.A. Macleod, A.R. Horsley, N.J. Bell, A.P. Greening, J.A. Innes, and S. Cunningham Ventilation heterogeneity in children with well controlled asthma with normal spirometry indicates residual airways disease Thorax 64 2009 33 37
29. A.R. Horsley, P.M. Gustafsson, K.A. Macleod, C. Saunders, A.P. Greening, and D.J. Porteous Lung clearance index is a sensitive, repeatable and practical measure of airways disease in adults with cystic fibrosis Thorax 63 2008 135 140 (Pubitemid 351236478)
30. N. Beydon, S.D. Davis, E. Lombardi, J.L. Allen, H.G. Arets, and P. Aurora An official American Thoracic Society/European Respiratory Society statement: pulmonary function testing in preschool children Am J Respir Crit Care Med 175 2007 1304 1345 (Pubitemid 46905757)
31. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005 Am J Respir Crit Care Med 171 2005 912 930
32. S.K. Weiland, B. Bjorksten, B. Brunekreef, W.O. Cookson, M.E. von, and D.P. Strachan Phase II of the International Study of Asthma and Allergies in Childhood (ISAAC II): rationale and methods Eur Respir J 24 2004 406 412 (Pubitemid 39232263)
33. P. Sullivan, D. Stephens, T. Ansari, J. Costello, and P. Jeffery Variation in the measurements of basement membrane thickness and inflammatory cell number in bronchial biopsies Eur Respir J 12 1998 811 815 (Pubitemid 28491649)
34. A. Niimi, A. Torrego, A.G. Nicholson, B.G. Cosio, T.B. Oates, and K.F. Chung Nature of airway inflammation and remodeling in chronic cough J Allergy Clin Immunol 116 2005 565 570 (Pubitemid 41267129)
35. D. Caudri, A. Wijga, C.M. AS, M. Hoekstra, D.S. Postma, and G.H. Koppelman Predicting the long-term prognosis of children with symptoms suggestive of asthma at preschool age J Allergy Clin Immunol 124 2009 903 910
36. J. Henderson, R. Granell, J. Heron, A. Sherriff, A. Simpson, and A. Woodcock Associations of wheezing phenotypes in the first 6 years of life with atopy, lung function and airway responsiveness in mid-childhood Thorax 63 2008 974 980
37. R.J. Kurukulaaratchy, S. Matthews, S.T. Holgate, and S.H. Arshad Predicting persistent disease among children who wheeze during early life Eur Respir J 22 2003 767 771 (Pubitemid 37369565)
38. K.C. Lodrup Carlsen, G. Haland, C.S. Devulapalli, M. Munthe-Kaas, M. Pettersen, and B. Granum Asthma in every fifth child in Oslo, Norway: a 10-year follow up of a birth cohort study Allergy 61 2006 454 460 (Pubitemid 43334115)
39. P.G. Woodruff, G.M. Dolganov, R.E. Ferrando, S. Donnelly, S.R. Hays, and O.D. Solberg Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression Am J Respir Crit Care Med 169 2004 1001 1006 (Pubitemid 38543637)
40. A.A. Hislop, and S.G. Haworth Airway size and structure in the normal fetal and infant lung and the effect of premature delivery and artificial ventilation Am Rev Respir Dis 140 1989 1717 1726 (Pubitemid 20041059)
41. A. James, and N. Carroll Airway smooth muscle in health and disease; methods of measurement and relation to function Eur Respir J 15 2000 782 789 (Pubitemid 30196310)
42. S. Sonnappa, C.M. Bastardo, A. Wade, S. Saglani, S.A. McKenzie, and A. Bush Symptom-pattern phenotype and pulmonary function in preschool wheezers J Allergy Clin Immunol 126 2010 519 526
43. C. Keen, A.C. Olin, G. Wennergren, and P. Gustafsson Small airway function, exhaled NO and airway hyper-responsiveness in paediatric asthma Respir Med 105 2011 1476 1484
44. K.E. Van Wonderen, L.B. Van Der Mark, J. Mohrs, P.J. Bindels, W.M. van Aalderen, and R.G. Ter Different definitions in childhood asthma: how dependable is the dependent variable? Eur Respir J 36 2010 48 56
45. P.D. Phelan, C.F. Robertson, and A. Olinsky The Melbourne Asthma Study: 1964-1999 J Allergy Clin Immunol 109 2002 189 194 (Pubitemid 34158282)
46. A. Bush, and S. Saglani Management of severe asthma in children Lancet 376 2010 814 825
47. A.L. James, J.G. Elliot, R.L. Jones, M.L. Carroll, T. Mauad, and T.R. Bai Airway smooth muscle hypertrophy and hyperplasia in asthma Am J Respir Crit Care Med 185 2012 1058 1064
48. M.F. Moffatt, I.G. Gut, F. Demenais, D.P. Strachan, E. Bouzigon, and S. Heath A large-scale, consortium-based genomewide association study of asthma N Engl J Med 363 2010 1211 1221
49. D. Kaur, C. Doe, L. Woodman, H. Wan, A. Sutcliffe, and F. Hollins Mast cell-airway smooth muscle crosstalk: the role of thymic stromal lymphopoietin Chest 2011 [Epub ahead of print]
50. B. Yeganeh, C. Xia, H. Movassagh, C. Koziol-White, Y. Chang, and L. Al-Alwan Emerging mediators of airway smooth muscle dysfunction in asthma Pulm Pharmacol Ther 2012 [Epub ahead of print]
51. S. Saglani, D.N. Payne, J. Zhu, Z. Wang, A.G. Nicholson, and A. Bush Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers Am J Respir Crit Care Med 176 2007 858 864 (Pubitemid 350097074)
52. P.E. Silkoff, S. Wakita, J. Chatkin, K. Ansarin, C. Gutierrez, and M. Caramori Exhaled nitric oxide after beta2-agonist inhalation and spirometry in asthma Am J Respir Crit Care Med 159 1999 940 944 (Pubitemid 29137800)
53. M.R. Miller, J. Hankinson, V. Brusasco, F. Burgos, R. Casaburi, and A. Coates Standardisation of spirometry Eur Respir J 26 2005 319 338 (Pubitemid 41079078)
54. S. Stanojevic, A. Wade, J. Stocks, J. Hankinson, A.L. Coates, and H. Pan Reference ranges for spirometry across all ages: a new approach Am J Respir Crit Care Med 177 2008 253 260 (Pubitemid 351198367)
55. M.I. Asher, U. Keil, H.R. Anderson, R. Beasley, J. Crane, and F. Martinez International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods Eur Respir J 8 1995 483 491
56. R.S. Cane, and S.A. McKenzie Parents' interpretations of children's respiratory symptoms on video Arch Dis Child 84 2001 31 34 (Pubitemid 32060133)
57. C.J. Bossley, L. Fleming, A. Gupta, N. Regamey, J. Frith, and T. Oates Pediatric severe asthma is characterized by eosinophilia and remodeling without T(H)2 cytokines J Allergy Clin Immunol 129 2012 974 982
58. J.A. Castro-Rodriguez, C.J. Holberg, A.L. Wright, and F.D. Martinez A clinical index to define risk of asthma in young children with recurrent wheezing Am J Respir Crit Care Med 162 2000 1403 1406
59. C.S. Devulapalli, K.C. Carlsen, G. Haland, M.C. Munthe-Kaas, M. Pettersen, and P. Mowinckel Severity of obstructive airways disease by age 2 years predicts asthma at 10 years of age Thorax 63 2008 8 13
60. P. Sullivan, D. Stephens, T. Ansari, J. Costello, and P. Jeffery Variation in the measurements of basement membrane thickness and inflammatory cell number in bronchial biopsies Eur Respir J 12 1998 811 815 (Pubitemid 28491649)
61. N. Regamey, M. Ochs, T.N. Hilliard, C. Muhlfeld, N. Cornish, and L. Fleming Increased airway smooth muscle mass in children with asthma, cystic fibrosis, and non-cystic fibrosis bronchiectasis Am J Respir Crit Care Med 177 2008 837 843 (Pubitemid 351600661)