Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids

New England Journal of Medicine

Volumn 362, Issue 11, 2010, Pages 975-985

  Lemanske Jr , Robert F ^a   Mauger, David T ^b   Sorkness, Christine A ^a   Jackson, Daniel J ^a   Boehmer, Susan J ^b   Martinez, Fernando D ^c   Strunk, Robert C ^d   Szefler, Stanley J ^e   Zeiger, Robert S ^f,g   Bacharier, Leonard B ^d   Covar, Ronina A ^e   Guilbert, Theresa W ^a   Larsen, Gary ^e   Morgan, Wayne J ^c   Moss, Mark H ^a   Spahn, Joseph D ^e   Taussig, Lynn M ^e  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

^d WASHINGTON UNIVERSITY   (United States)

^e UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^g KAISER PERMANENTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLOVENT DISKUS; FLUTICASONE PROPIONATE; FLUTICASONE PROPIONATE PLUS SALMETEROL; LONG ACTING DRUG; MONTELUKAST; PREDNISONE; SALBUTAMOL; UNCLASSIFIED DRUG; VENTOLIN HFA;

ADOLESCENT; AFRICAN AMERICAN; APPENDICITIS; ARTICLE; ASTHMA; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISEASE EXACERBATION; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; ECZEMA; EUROPEAN AMERICAN; FEMALE; FORCED EXPIRATORY VOLUME; HISPANIC; HUMAN; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PATIENT COMPLIANCE; PREDICTION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROBABILITY; RACE DIFFERENCE; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SCORING SYSTEM; THRUSH; TREATMENT DURATION; TREATMENT FAILURE; TREATMENT RESPONSE;

EID: 77949576423     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1001278     Document Type: Article

References (23)

1. Sorkness CA, Lemanske RF Jr, Mauger DT, et al. Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller Trial. J Allergy Clin Immunol 2007;119:64-72.
2. Verberne AA, Frost C, Duiverman EJ, Grol MH, Kerrebijn KF. Addition of salmeterol versus doubling the dose of beclomethasone in children with asthma. Am J Respir Crit Care Med 1998;158:213-9.
3. Bensch G, Berger WE, Blokhin BM, et al. One-year efficacy and safety of inhaled formoterol dry powder in children with persistent asthma. Ann Allergy Asthma Immunol 2002;89:180-90.
4. de Blic J, Ogorodova L, Klink R, et al. Salmeterol/fluticasone propionate vs. double dose fluticasone propionate on lung function and asthma control in children. Pediatr Allergy Immunol 2009;20:763-71.
5. Gappa M, Zachgo W, von Berg A, Kamin W, Stern-Sträter C, Steinkamp G. Add-on salmeterol compared to double dose fluticasone in pediatric asthma: a double-blind, randomized trial (VIAPAED). Pediatr Pulmonol 2009;44:1132-42.
6. Tal A, Simon G, Vermeulen JH, et al. Budesonide/formoterol in a single inhaler versus inhaled corticosteroids alone in the treatment of asthma. Pediatr Pulmonol 2002;34:342-50.
7. Ni Chroinin M, Lasserson TJ, Greenstone I, Ducharme FM. Addition of longacting beta-agonists to inhaled corticosteroids for chronic asthma in children. Cochrane Database Syst Rev 2009;3: CD007949.
8. Simons FE, Villa JR, Lee BW, et al. Montelukast added to budesonide in children with persistent asthma: a randomized, double-blind, crossover study. J Pediatr 2001;138:694-8.
9. National Asthma Education and Prevention Program. Expert Panel Report 3 (EPR-3): guidelines for the diagnosis and management of asthma: summary report 2007. J Allergy Clin Immunol 2007;120: Suppl:S94-S138.
10. Strunk RC, Szefler SJ, Phillips BR, et al. Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in children. J Allergy Clin Immunol 2003;112:883-92.
11. Juniper EF, Guyatt GH, Feeny DH, Ferrie PJ, Griffith LE, Townsend M. Measuring quality of life in children with asthma. Qual Life Res 1996;5:35-46.
12. Nathan RA, Sorkness CA, Kosinski M, et al. Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol 2004;113:59-65.
13. Schatz M, Kosinski M, Yarlas AS, Hanlon J, Watson ME, Jhingran P. The minimally important difference of the Asthma Control Test. J Allergy Clin Immunol 2009;124:719-23.
14. Liu AH, Zeiger R, Sorkness C, et al. Development and cross-sectional validation of the Childhood Asthma Control Test. J Allergy Clin Immunol 2007;119: 817-25.
15. Marden JI. Analyzing and modeling rank data. London: Chapman & Hall, 1995.
16. Knuffman JE, Sorkness CA, Lemanske RF Jr, et al. Phenotypic predictors of long-term response to inhaled corticosteroid and leukotriene modifier therapies in pediatric asthma. J Allergy Clin Immunol 2009;123:411-6.
17. Naqvi M, Thyne S, Choudhry S, et al. Ethnic-specific differences in bronchodilator responsiveness among African Americans, Puerto Ricans, and Mexicans with asthma. J Asthma 2007;44:639-48.
18. Naqvi M, Tcheurekdjian H, DeBoard JA, et al. Inhaled corticosteroids and augmented bronchodilator responsiveness in Latino and African American asthmatic patients. Ann Allergy Asthma Immunol 2008;100:551-7.
19. Moore PE, Ryckman KK, Williams SM, Patel N, Summar ML, Sheller JR. Genetic variants of GSNOR and ADRB2 influence response to albuterol in African-American children with severe asthma. Pediatr Pulmonol 2009;44:649-54.
20. Corvol H, De Giacomo A, Eng C, et al. Genetic ancestry modifies pharmacogenetic gene-gene interaction for asthma. Pharmacogenet Genomics 2009;19:489-96.
21. Kramer JM. Balancing the benefits and risks of inhaled long-acting beta-agonists - the influence of values. N Engl J Med 2009;360:1592-5.
22. Lazarus SC, Boushey HA, Fahy JV, et al. Long-acting beta2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial. JAMA 2001;285:2583-93.
23. Lemanske RF Jr, Sorkness CA, Mauger EA, et al. Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial. JAMA 2001;285: 2594-603.