Analysis of induced sputum in adults with asthma: Identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids

Thorax

Volumn 57, Issue 10, 2002, Pages 875-879

  Green, Ruth H ^a   Brightling, C E ^a   Woltmann, G ^a   Parker, D ^a   Wardlaw, A J ^a   Pavord, I D ^a  

^a GLENFIELD HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; METHACHOLINE;

ADULT; AIRWAY; ARTICLE; ASTHMA; CELL COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; EOSINOPHIL; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; MALE; NEUTROPHILIA; PRACTICE GUIDELINE; PRIORITY JOURNAL; SCORING SYSTEM; SPIROMETRY; SPUTUM ANALYSIS; SYMPTOM; VISUAL ANALOG SCALE;

ADMINISTRATION, INHALATION; ADMINISTRATION, TOPICAL; ADULT; ANTI-INFLAMMATORY AGENTS; ASTHMA; BUDESONIDE; EOSINOPHILIA; FEMALE; FORCED EXPIRATORY VOLUME; GLUCOCORTICOIDS; HUMANS; INFLAMMATION; LEUKOCYTOSIS; MALE; SPUTUM; TREATMENT OUTCOME; VITAL CAPACITY;

EID: 0036795111     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thorax.57.10.875     Document Type: Article

References (30)

1. Rackemann F.M. A clinical classification of asthma. Am J Med Sci 1921;clxii:802.
2. Aas K. Heterogeneity of bronchial asthma. Sub-populations or different stages of the disease. Allergy 1981;36:3-14.
3. Humbert M, Menz G, Ying S, et al. The immunopathology of extrinsic (atopic) and intrinsic (non-atopic) asthma: more similarities than differences. Immunol Today 1999;20:528-33.
4. Humbert M, Durham SR, Ying S, et al. IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity. Am J Respir Crit Care Med 1996;154:1497-504.
5. Humbert M, Ying S, Corrigan C, et al. Bronchial mucosal expression of the genes encoding chemokines RANTES and MCP-3 in symptomatic atopic and nonatopic asthmatics: relationship to the eosinophil-active cytokines interleukin (IL)-5, granulocyte macrophage-colony-stimulating factor, and IL-3. Am J Respir Cell Mol Biol 1997;16:1-8.
6. Tang C, Rolland JM, Ward C, et al. IL-5 production by bronchoalveolar lavage and peripheral blood mononuclear cells in asthma and atopy. Eur Respir J 1997;10:624-32.
7. Bentley AM, Menz G, Storz C, et al. Identification of T lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma. Relationship to symptoms and bronchial responsiveness. Am Rev Respir Dis 1992;146:500-6.
8. Folkard SG, Westwick J, Millar AB. Production of interleukin-8, RANTES and MCP-1 in intrinsic and extrinsic asthmatics. Eur Respir J 1997;10:2097-104.
9. Bentley AM, Durham SR, Kay AB. Comparison of the immunopathology of extrinsic, intrinsic and occupational asthma. J Invest Allergol Clin Immunol 1994;4:222-32.
10. Jatakanon A, Uasuf C, Maziak W, et al. Neutrophilic inflammation in severe persistent asthma. Am J Respir Crit Care Med 1999;160:1532-9.
11. Hoskins G, McCowan C, Neville RG, et al. Risk factors and costs associated with an asthma attack. Thorax 2000;55:19-24.
12. Fahy JV, Kim KW, Liu J, et al. Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation. J Allergy Clin Immunol 1995;95:843-52.
13. British Thoracic Society. The British guidelines on asthma management. Thorax 1997;52(Suppl 1):S1-20.
14. Juniper EF, Cockcroft DW, Hargreave FE. Histamine and methacholine inhalation tests: a laboratory tidal breathing protocol. 2nd ed. Lund, Sweden: Astra Draco AB, 1994.
15. Pavord ID, Pizzichini MM, Pizzichini E, et al. The use of induced sputum to investigate airway inflammation. Thorax 1997;52:498-501.
16. Pavord ID, Brightling CE, Woltmann G, et al. Non-eosinophilic corticosteroid unresponsive asthma. Lancet 1999;353:2213-4.
17. Brightling CE, Monterio W, Green RH, et al. Induced sputum and other outcome measures in chronic obstructive pulmonary disease: safety and repeatability. Respir Med 2001;95:999-1002.
18. Belda J, Leigh R, Parameswaran K, et al. Induced sputum cell counts in healthy adults. Am J Respir Crit Care Med 2000;161:475-8.
19. Spanevello A, Confalonieri M, Sulotto F, et al. Induced sputum cellularity. Reference values and distribution in normal volunteers. Am J Respir Crit Care Med 2000;162:1172-4.
20. Gibson PG, Simpson JL, Saltos N. Heterogeneity of airway inflammation in persistent asthma: evidence of neutrophilic inflammation and increased sputum interleukin-8. Chest 2001;119:1329-36.
21. Wenzel SE, Schwartz LB, Langmack EL, et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med 1999;160:1001-8.
22. Hunter CJ, Ward R, Woltmann G, et al. The safety and success rate of sputum induction using a low output ultrasonic nebuliser. Respir Med 1999;93:345-8.
23. Barnes PJ, Grunstein M, Leff A, et al. Asthma. Philadelphia: Lippincott Raven, 1997.
24. Global Initiative for Asthma. Global strategy for asthma management and prevention. Publication no 95-3659. Bethesday, MD: National Heart, Lung and Blood Institute, 1995.
25. Crimi E, Spanevello A, Neri M, et al. Dissociation between airway inflammation and airway hyperresponsiveness in allergic asthma. Am J Respir Crit Care Med 1998;157:4-9.
26. Rosi E, Ronchi MC, Grazzini M, et al. Sputum analysis, bronchial hyperresponsiveness, and airway function in asthma: results of a factor analysis. J Allergy Clin Immunol 1999;103:232-7.
27. Adelroth E, Rosenhall L, Johansson SA, et al. Inflammatory cells and eosinophilic activity in asthmatics investigated by bronchoalveolar lavage. The effects of antiasthmatic treatment with budesonide or terbutaline. Am Rev Respir Dis 1990;142:91-9.
28. Lim S, Jatakanon A, John M, et al. Effect of inhaled budesonide on lung function and airway inflammation. Assessment by various inflammatory markers in mild asthma. Am J Respir Crit Care Med 1999;159:22-30.
29. Pizzichini E, Pizzichini MM, Efthimiadis A, et al. Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements. Am J Respir Crit Care Med 1996;154:308-17.
30. Claman DM, Boushey HA, Liu J, et al. Analysis of induced sputum to examine the effects of prednisone on airway inflammation in asthmatic subjects. J Allergy Clin Immunol 1994;94:861-9.