Quadrupling the dose of inhaled corticosteroid to prevent asthma exacerbations: A randomized, double-blind, placebo-controlled, parallel-group clinical trial

American Journal of Respiratory and Critical Care Medicine

Volumn 180, Issue 7, 2009, Pages 598-602

  Oborne, Janet ^a,b   Mortimer, Kevin ^a   Hubbard, Richard B ^a   Tattersfield, Anne E ^a   Harrison, Tim W ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b NOTTINGHAM CITY HOSPITAL   (United Kingdom)

Author keywords

Asthma management; Fourfold; Steroids

Indexed keywords

BECLOMETASONE DIPROPIONATE; CORTICOSTEROID; PLACEBO; PREDNISONE;

ADOLESCENT; ADULT; ARTICLE; ASTHMA; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DISEASE CONTROL; DISEASE EXACERBATION; DOUBLE BLIND PROCEDURE; DRUG DOSE ESCALATION; FEMALE; GLOSSITIS; HEADACHE; HEALTH CARE POLICY; HUMAN; INGESTION; INHALER; LARYNGITIS; MAJOR CLINICAL STUDY; MALE; NAUSEA; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SELF CARE; SIDE EFFECT; SINGLE BLIND PROCEDURE; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME; UPPER RESPIRATORY TRACT INFECTION;

ADMINISTRATION, INHALATION; ADRENAL CORTEX HORMONES; ANTI-ASTHMATIC AGENTS; ASTHMA; BECLOMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; METERED DOSE INHALERS; MIDDLE AGED; RESPIRATORY FUNCTION TESTS; TREATMENT OUTCOME;

EID: 70349446758     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.200904-0616OC     Document Type: Article

References (13)

1. British Thoracic Society Scottish Intercollegiate Guidelines Network. British Guideline on the Management of Asthma. Accessed 2009 Aug 19. Available from: http://www.brit-thoracic.org.uk/ClinicalInformation/Asthma/ AsthmaGuidelines/tabid/83/Default.aspx
2. Global Initiative For Asthma Guidelines. http://www.ginasthma.com/ GuidelineList.asp?l1=2&l2=1
3. National Heart Lung and Blood Institute. Guidelines for the diagnosis and management of asthma. http://www.nhlbi.nih.gov/guidelines/asthma/asthgdln.htm
4. National Asthma Council Australia. Asthma management handbook. http://www.nationalasthma.org.au/html/management/home/index.asp
5. Harrison TW, Oborne J, Newton S, Tattersfield AE. Doubling the dose of inhaled corticosteroid to prevent asthma exacerbations: randomised controlled trial. Lancet 2004;363:271-275. (Pubitemid 38142409)
6. Fitzgerald JM, Becker A, Sears MR, Mink S, Chung K, Lee J, and the Canadian Asthma Exacerbation Study Group. Doubling the dose of budesonide versus maintenance treatment in asthma exacerbations. Thorax 2004;59:550-556.
7. Oborne J, Mortimer K, Hubbard RB, Tattersfield AE, Harrison TW. Can acute exacerbations of asthma be prevented with a four-fold increase in inhaled corticosteroid use [abstract]? Am J Respir Crit Care Med 2009;179:A2794.
8. Foresi A, Morelli MC, Catena E on behalf of the Italian Study Group. Low-dose budesonide with the addition of an increased dose during exacerbations is effective in long-term asthma control. Chest 2000;117:440-446.
9. Pauwels RA, Löfdahl CG, Postma DS, Tattersfield AE, O'Byrne P, Barnes PJ, Ullman A for the Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group. N Engl J Med 1997;337:1405-1411.
10. Powell H, Gibson PG. Options for self-management education for adults with asthma. Cochrane Database of Syst Rev 2003;(1):CD004107.
11. FitzGerald JM, Shragge D, Haddon J, Jennings B, Lee J, Bai T, Pare P, Kassen D, Grunfeld A. A randomized, controlled trial of high dose, inhaled budesonide versus oral prednisone in patients discharged from the emergency department following an acute asthma exacerbation. Can Respir J 2000;7:61-67.
12. Levy ML, Stevenson C, Maslen T. Comparison of short courses of oral prednisolone and fluticasone propionate in the treatment of adults with acute exacerbations of asthma in primary care. Thorax 1996;51:1087-1092. (Pubitemid 26402819)
13. O'Byrne PM, Barnes PJ, Rodriguez-Roisin R, Runnerstrom E, Sandstrom T, Svennson K, Tattersfield A. Low dose inhaled budesonide and formoterol in mild persistent asthma. Am J Respir Crit Care Med 2001;164:1392-1397.