P2X3 receptor antagonist (AF-219) in refractory chronic cough: A randomised, double-blind, placebo-controlled phase 2 study

The Lancet

Volumn 385, Issue 9974, 2015, Pages 1198-1205

  Abdulqawi, Rayid ^a,b   Dockry, Rachel ^a,b   Holt, Kimberley ^a,b   Layton, Gary ^c   Mccarthy, Bruce G ^d   Ford, Anthony P ^d   Smith, Jaclyn A ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

^c ParamStat Ltd   (United Kingdom)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AF 219; ANTITUSSIVE AGENT; PLACEBO; PURINERGIC P2X3 RECEPTOR; UNCLASSIFIED DRUG; AF-219; PURINERGIC P2X RECEPTOR ANTAGONIST; PYRIMIDINE DERIVATIVE;

ADULT; AGED; AMBULATORY MONITORING; ANOSMIA; ARTICLE; BLURRED VISION; CHRONIC COUGH; CLINICAL ARTICLE; COMPARATIVE EFFECTIVENESS; CONSTIPATION; CONTROLLED STUDY; COUGHING; DEPRESSION; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG WITHDRAWAL; DYSGEUSIA; FEMALE; GASTROESOPHAGEAL REFLUX; GLOSSODYNIA; HEADACHE; HUMAN; HYPERSALIVATION; HYPOGEUSIA; INTENTION TO TREAT ANALYSIS; MALE; NAUSEA; OROPHARYNX PAIN; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; TASTE DISORDER; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; CHRONIC DISEASE; CIRCADIAN RHYTHM; CLINICAL TRIAL; COUGH; CROSSOVER PROCEDURE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

ADULT; AGED; ANTITUSSIVE AGENTS; CHRONIC DISEASE; CIRCADIAN RHYTHM; COUGH; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; PURINERGIC P2X RECEPTOR ANTAGONISTS; PYRIMIDINES; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84925967760     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(14)61255-1     Document Type: Article

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