-
1
-
-
84925546187
-
Type 2 inflammation in asthma—present in most, absent in many
-
1 Fahy, JV, Type 2 inflammation in asthma—present in most, absent in many. Nat Rev Immunol 15 (2015), 57–65.
-
(2015)
Nat Rev Immunol
, vol.15
, pp. 57-65
-
-
Fahy, J.V.1
-
2
-
-
76149146032
-
Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program
-
2 Moore, WC, Meyers, DA, Wenzel, SE, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med 181 (2010), 315–323.
-
(2010)
Am J Respir Crit Care Med
, vol.181
, pp. 315-323
-
-
Moore, W.C.1
Meyers, D.A.2
Wenzel, S.E.3
-
3
-
-
79957920754
-
Inflammatory links between obesity and metabolic disease
-
3 Lumeng, CN, Saltiel, AR, Inflammatory links between obesity and metabolic disease. J Clin Invest 121 (2011), 2111–2117.
-
(2011)
J Clin Invest
, vol.121
, pp. 2111-2117
-
-
Lumeng, C.N.1
Saltiel, A.R.2
-
4
-
-
0029005689
-
Circulating interleukin-6 levels in patients with bronchial asthma
-
4 Yokoyama, A, Kohno, N, Fujino, S, et al. Circulating interleukin-6 levels in patients with bronchial asthma. Am J Respir Crit Care Med 151 (1995), 1354–1358.
-
(1995)
Am J Respir Crit Care Med
, vol.151
, pp. 1354-1358
-
-
Yokoyama, A.1
Kohno, N.2
Fujino, S.3
-
5
-
-
80052721297
-
Identification of IL-6R and chromosome 11q13.5 as risk loci for asthma
-
5 Ferreira, MA, Matheson, MC, Duffy, DL, et al. Identification of IL-6R and chromosome 11q13.5 as risk loci for asthma. Lancet 378 (2011), 1006–1014.
-
(2011)
Lancet
, vol.378
, pp. 1006-1014
-
-
Ferreira, M.A.1
Matheson, M.C.2
Duffy, D.L.3
-
6
-
-
84893513577
-
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
-
6 Chung, KF, Wenzel, SE, Brozek, JL, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J 43 (2014), 343–373.
-
(2014)
Eur Respir J
, vol.43
, pp. 343-373
-
-
Chung, K.F.1
Wenzel, S.E.2
Brozek, J.L.3
-
7
-
-
71949093013
-
-
Third edition Clinical and Laboratory Standards Institute Wayne, PA
-
7 Clinical & Laboratory Standards Institute, Horowitz, GL, Altaie, S, Boyd, JC, et al. Defining, establishing, and verifying reference intervals in the clinical laboratory: approved guideline, Third edition, 2008, Clinical and Laboratory Standards Institute, Wayne, PA.
-
(2008)
Defining, establishing, and verifying reference intervals in the clinical laboratory: approved guideline
-
-
Horowitz, G.L.1
Altaie, S.2
Boyd, J.C.3
-
8
-
-
0025228036
-
Acute-phase response of human hepatocytes: regulation of acute-phase protein synthesis by interleukin-6
-
8 Castell, JV, Gomez-Lechon, MJ, David, M, Fabra, R, Trullenque, R, Heinrich, PC, Acute-phase response of human hepatocytes: regulation of acute-phase protein synthesis by interleukin-6. Hepatology 12 (1990), 1179–1186.
-
(1990)
Hepatology
, vol.12
, pp. 1179-1186
-
-
Castell, J.V.1
Gomez-Lechon, M.J.2
David, M.3
Fabra, R.4
Trullenque, R.5
Heinrich, P.C.6
-
9
-
-
0029854203
-
Comparison of two methods of collecting induced sputum in asthmatic subjects
-
9 Gershman, NH, Wong, HH, Liu, JT, Mahlmeister, MJ, Fahy, JV, Comparison of two methods of collecting induced sputum in asthmatic subjects. Eur Respir J 9 (1996), 2448–2453.
-
(1996)
Eur Respir J
, vol.9
, pp. 2448-2453
-
-
Gershman, N.H.1
Wong, H.H.2
Liu, J.T.3
Mahlmeister, M.J.4
Fahy, J.V.5
-
10
-
-
84882896337
-
Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects
-
10 Hastie, AT, Moore, WC, Li, H, et al. Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects. J Allergy Clin Immunol 132 (2013), 72–80.
-
(2013)
J Allergy Clin Immunol
, vol.132
, pp. 72-80
-
-
Hastie, A.T.1
Moore, W.C.2
Li, H.3
-
11
-
-
84895064176
-
Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma
-
11 Peters, MC, Mekonnen, ZK, Yuan, S, Bhakta, NR, Woodruff, PG, Fahy, JV, Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma. J Allergy Clin Immunol 133 (2014), 388–394.
-
(2014)
J Allergy Clin Immunol
, vol.133
, pp. 388-394
-
-
Peters, M.C.1
Mekonnen, Z.K.2
Yuan, S.3
Bhakta, N.R.4
Woodruff, P.G.5
Fahy, J.V.6
-
12
-
-
80053084755
-
Lebrikizumab treatment in adults with asthma
-
12 Corren, J, Lemanske, RF, Hanania, NA, et al. Lebrikizumab treatment in adults with asthma. N Engl J Med 365 (2011), 1088–1098.
-
(2011)
N Engl J Med
, vol.365
, pp. 1088-1098
-
-
Corren, J.1
Lemanske, R.F.2
Hanania, N.A.3
-
13
-
-
69249150516
-
T-helper type 2-driven inflammation defines major subphenotypes of asthma
-
13 Woodruff, PG, Modrek, B, Choy, DF, et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med 180 (2009), 388–395.
-
(2009)
Am J Respir Crit Care Med
, vol.180
, pp. 388-395
-
-
Woodruff, P.G.1
Modrek, B.2
Choy, D.F.3
-
14
-
-
1842842014
-
Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition
-
14 Grundy, SM, Brewer, HB Jr, Cleeman, JI, National Heart, Lung, and Blood Institute, et al. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Arterioscler Thromb Vasc Biol 24 (2004), e13–e18.
-
(2004)
Arterioscler Thromb Vasc Biol
, vol.24
, pp. e13-e18
-
-
Grundy, S.M.1
Brewer, H.B.2
Cleeman, J.I.3
National Heart, Lung, and Blood Institute,4
-
15
-
-
33847191784
-
Association of peripheral total and differential leukocyte counts with metabolic syndrome and risk of ischemic cardiovascular diseases in patients with type 2 diabetes mellitus
-
15 Tsai, JC, Sheu, SH, Chiu, HC, et al. Association of peripheral total and differential leukocyte counts with metabolic syndrome and risk of ischemic cardiovascular diseases in patients with type 2 diabetes mellitus. Diabetes Metab Res Rev 23 (2007), 111–118.
-
(2007)
Diabetes Metab Res Rev
, vol.23
, pp. 111-118
-
-
Tsai, J.C.1
Sheu, S.H.2
Chiu, H.C.3
-
16
-
-
23844457439
-
CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: overview
-
16 Pearson, TA, Mensah, GA, Hong, Y, Smith, SC Jr CDC, AHA. CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: overview. Circulation 110 (2004), e543–e544.
-
(2004)
Circulation
, vol.110
, pp. e543-e544
-
-
Pearson, T.A.1
Mensah, G.A.2
Hong, Y.3
Smith, S.C.4
-
17
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
17 Weisberg, SP, McCann, D, Desai, M, Rosenbaum, M, Leibel, RL, Ferrante, AW Jr, Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112 (2003), 1796–1808.
-
(2003)
J Clin Invest
, vol.112
, pp. 1796-1808
-
-
Weisberg, S.P.1
McCann, D.2
Desai, M.3
Rosenbaum, M.4
Leibel, R.L.5
Ferrante, A.W.6
-
18
-
-
68149183241
-
IL-6 is required for airway mucus production induced by inhaled fungal allergens
-
18 Neveu, WA, Allard, JB, Dienz, O, et al. IL-6 is required for airway mucus production induced by inhaled fungal allergens. J Immunol 183 (2009), 1732–1738.
-
(2009)
J Immunol
, vol.183
, pp. 1732-1738
-
-
Neveu, W.A.1
Allard, J.B.2
Dienz, O.3
-
19
-
-
81555209757
-
The many faces of interleukin-6: the role of IL-6 in inflammation, vasculopathy, and fibrosis in systemic sclerosis
-
19 Barnes, TC, Anderson, ME, Moots, RJ, The many faces of interleukin-6: the role of IL-6 in inflammation, vasculopathy, and fibrosis in systemic sclerosis. Int J Rheumatol, 2011, 2011, 721608.
-
(2011)
Int J Rheumatol
, vol.2011
, pp. 721608
-
-
Barnes, T.C.1
Anderson, M.E.2
Moots, R.J.3
-
20
-
-
34547188748
-
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
-
20 Zhou, L, Ivanov, II, Spolski, R, et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 8 (2007), 967–974.
-
(2007)
Nat Immunol
, vol.8
, pp. 967-974
-
-
Zhou, L.1
Ivanov, I.I.2
Spolski, R.3
-
21
-
-
20144375594
-
The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo
-
21 Doganci, A, Eigenbrod, T, Krug, N, et al. The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo. J Clin Invest 115 (2005), 313–325.
-
(2005)
J Clin Invest
, vol.115
, pp. 313-325
-
-
Doganci, A.1
Eigenbrod, T.2
Krug, N.3
-
22
-
-
84938741070
-
Insulin resistance, metabolic syndrome, and lung function in US adolescents with and without asthma
-
22 Forno, E, Han, YY, Muzumdar, RH, Celedon, JC, Insulin resistance, metabolic syndrome, and lung function in US adolescents with and without asthma. J Allergy Clin Immunol 136 (2015), 304–311.
-
(2015)
J Allergy Clin Immunol
, vol.136
, pp. 304-311
-
-
Forno, E.1
Han, Y.Y.2
Muzumdar, R.H.3
Celedon, J.C.4
-
23
-
-
84908020394
-
Insulin and the lung: connecting asthma and metabolic syndrome
-
23 Singh, S, Prakash, YS, Linneberg, A, Agrawal, A, Insulin and the lung: connecting asthma and metabolic syndrome. J Allergy, 2013, 2013, 627384.
-
(2013)
J Allergy
, vol.2013
, pp. 627384
-
-
Singh, S.1
Prakash, Y.S.2
Linneberg, A.3
Agrawal, A.4
-
24
-
-
84867917889
-
Interleukin-6: from an inflammatory marker to a target for inflammatory diseases
-
24 Rincon, M, Interleukin-6: from an inflammatory marker to a target for inflammatory diseases. Trends Immunol 33 (2012), 571–577.
-
(2012)
Trends Immunol
, vol.33
, pp. 571-577
-
-
Rincon, M.1
-
25
-
-
84877275257
-
Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial
-
25 Gabay, C, Emery, P, van Vollenhoven, R, et al. Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial. Lancet 381 (2013), 1541–1550.
-
(2013)
Lancet
, vol.381
, pp. 1541-1550
-
-
Gabay, C.1
Emery, P.2
van Vollenhoven, R.3
-
26
-
-
84871318830
-
Randomized trial of tocilizumab in systemic juvenile idiopathic arthritis
-
26 De Benedetti, F, Brunner, HI, Ruperto, N, et al. Randomized trial of tocilizumab in systemic juvenile idiopathic arthritis. N Engl J Med 367 (2012), 2385–2395.
-
(2012)
N Engl J Med
, vol.367
, pp. 2385-2395
-
-
De Benedetti, F.1
Brunner, H.I.2
Ruperto, N.3
-
27
-
-
18344410191
-
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo
-
27 Atreya, R, Mudter, J, Finotto, S, et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nat Med 6 (2000), 583–588.
-
(2000)
Nat Med
, vol.6
, pp. 583-588
-
-
Atreya, R.1
Mudter, J.2
Finotto, S.3
-
28
-
-
84927610492
-
Interleukin-6 as a therapeutic target
-
28 Rossi, JF, Lu, ZY, Jourdan, M, Klein, B, Interleukin-6 as a therapeutic target. Clin Cancer Res 21 (2015), 1248–1257.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 1248-1257
-
-
Rossi, J.F.1
Lu, Z.Y.2
Jourdan, M.3
Klein, B.4
-
29
-
-
84920971274
-
The environment and disease: association or causation? 1965
-
29 Hill, AB, The environment and disease: association or causation? 1965. J R Soc Med 108 (2015), 32–37.
-
(2015)
J R Soc Med
, vol.108
, pp. 32-37
-
-
Hill, A.B.1
|