Importance of hedgehog interacting protein and other lung function genes in asthma

Journal of Allergy and Clinical Immunology

Volumn 127, Issue 6, 2011, Pages 1457-1465

  Li, Xingnan ^a   Howard, Timothy D ^a   Moore, Wendy C ^a   Ampleford, Elizabeth J ^a   Li, Huashi ^a   Busse, William W ^b   Calhoun, William J ^c   Castro, Mario ^d   Chung, Kian Fan ^e   Erzurum, Serpil C ^f   Fitzpatrick, Anne M ^g   Gaston, Benjamin ^h   Israel, Elliot ⁱ   Jarjour, Nizar N ^j   Teague, W Gerald ^h   Wenzel, Sally E ^k   Peters, Stephen P ^a   Hawkins, Gregory A ^a   Bleecker, Eugene R ^a   Meyers, Deborah A ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c University of Texas Medical Branch School of Medicine   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^f LERNER RESEARCH INSTITUTE   (United States)

^g EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

ⁱ HARVARD UNIVERSITY   (United States)

^j University of Wisconsin Health   (United States)

^k UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

more..

Author keywords

Asthma; asthma severity; FAM13A; FEV 1 FVC; FEV1; FVC; genetics; HHIP; meta analysis; PTCH1

Indexed keywords

BRONCHODILATING AGENT; HEDGEHOG INTERACTING PROTEIN; METHACHOLINE; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

AFRICAN AMERICAN; ARTICLE; ASTHMA; DISEASE SEVERITY; EUROPEAN AMERICAN; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; GENE FUNCTION; GENE LINKAGE DISEQUILIBRIUM; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC DIFFERENCE; GENOME ANALYSIS; HUMAN; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN FUNCTION; RACE DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM;

AFRICAN AMERICANS; ASTHMA; BRONCHIAL HYPERREACTIVITY; CARRIER PROTEINS; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LINKAGE DISEQUILIBRIUM; MEMBRANE GLYCOPROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTO-ONCOGENE PROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, NOTCH; RESPIRATORY FUNCTION TESTS; THROMBOSPONDINS;

EID: 79957850646     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2011.01.056     Document Type: Article

References (35)

1. National Asthma Education and Prevention Program. Expert Panel report 3: guidelines for the diagnosis and management of asthma. Bethesda (MD): National Heart, Lung, and Blood Institute; 2007. No. 07-4051. Available at: http://www.nhlbi.nih.gov/guidelines/asthma. Accessed June 8, 2010.
2. Global Initiative for Asthma: Global Strategy for Asthma Management and Prevention (GINA). National Institutes of Health; National Heart, Lung, and Blood Institute. Updated 2008. Available at: http://www.ginasthma.org. Accessed June 8, 2010.
3. Moore WC, Bleecker ER, Curran-Everett D, Erzurum SC, Ameredes BT, Bacharier L, et al. Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol 2007;119:405-13. (Pubitemid 46210080)
4. Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med 2010;181:315-23.
5. Miller MK, Johnson C, Miller DP, Deniz Y, Bleecker ER, Wenzel SE. Severity assessment in asthma: an evolving concept. J Allergy Clin Immunol 2005;116:990-5. (Pubitemid 41571777)
6. Hancock DB, Eijgelsheim M, Wilk JB, Gharib SA, Loehr LR, Marciante KD, et al. Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet 2010;42:45-52.
7. Repapi E, Sayers I, Wain LV, Burton PR, Johnson T, Obeidat M, et al. Genome-wide association study identifies five loci associated with lung function. Nat Genet 2010;42:36-44.
8. Weiss ST. Lung function and airway diseases. Nat Genet 2010;42:14-6.
9. Xu J, Meyers DA, Ober C, Blumenthal MN, Mellen B, Barnes KC, et al. Genome-wide screen and identification of gene-gene interactions for asthma-susceptibility loci in three U.S. populations: collaborative study on the genetics of asthma. Am J Hum Genet 2001;68:1437-46. (Pubitemid 32510619)
10. Lester LA, Rich SS, Blumenthal MN, Togias A, Murphy S, Malveaux F, et al. Ethnic differences in asthma and associated phenotypes: collaborative study on the genetics of asthma. J Allergy Clin Immunol 2001;108:357-62. (Pubitemid 32881055)
11. Dolan CM, Fraher KE, Bleecker ER, Borish L, Chipps B, Hayden ML, et al. Design and baseline characteristics of The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study: a large cohort of patients with severe or difficult-to-treat asthma. Ann Allergy Asthma Immunol 2004;92:32-9. (Pubitemid 38113629)
12. Li X, Howard TD, Zheng SL, Haselkorn T, Peters SP, Meyers DA, et al. Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions. J Allergy Clin Immunol 2010;125:328-35.
13. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007;81:559-75. (Pubitemid 47330214)
14. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 2006;38:904-9. (Pubitemid 44141658)
15. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005;21:263-5. (Pubitemid 40202029)
16. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, et al. The structure of haplotype blocks in the human genome. Science 2002;296: 2225-9. (Pubitemid 34680308)
17. Vercelli D. Discovering susceptibility genes for asthma and allergy. Nat Rev Immunol 2008;8:169-82. (Pubitemid 351323288)
18. Chuang PT, McMahon AP. Vertebrate hedgehog signalling modulated by induction of a hedgehog-binding protein. Nature 1999;397:617-21.
19. Ingham PW. Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo. Nature 1993;366:560-2. (Pubitemid 24035994)
20. Tabin CJ, McMahon AP. Recent advances in hedgehog signalling. Trends Cell Biol 1997;7:442-6. (Pubitemid 27472784)
21. Jeong J, McMahon AP. Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1. Development 2005;132:143-54. (Pubitemid 40207974)
22. Miller LA, Wert SE, Clark JC, Xu Y, Perl AK, Whitsett JA. Role of sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung. Dev Dyn 2004;231:57-71. (Pubitemid 39095197)
23. Warburton D, Bellusci S, De Langhe S, Del Moral PM, Fleury V, Mailleux A, et al. Molecular mechanisms of early lung specification and branching morphogenesis. Pediatr Res 2005;57:26R-37R.
24. Weedon MN, Lango H, Lindgren CM, Wallace C, Evans DM, Mangino M, et al. Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet 2008;40:575-83. (Pubitemid 351601210)
25. Gudbjartsson DF, Walters GB, Thorleifsson G, Stefansson H, Halldorsson BV, Zusmanovich P, et al. Many sequence variants affecting diversity of adult human height. Nat Genet 2008;40:609-15. (Pubitemid 351601211)
26. Wilk JB, Chen TH, Gottlieb DJ, Walter RE, Nagle MW, Brandler BJ, et al. A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet 2009;5:e1000429.
27. Pillai SG, Ge D, Zhu G, Kong X, Shianna KV, Need AC, et al. A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet 2009;5:e1000421.
28. Sleiman PM, Flory J, Imielinski M, Bradfield JP, Annaiah K, Willis-Owen SA, et al. Variants of DENND1B associated with asthma in children. N Engl J Med 2010;362:36-44.
29. Moffatt MF, Kabesch M, Liang L, Dixon AL, Strachan D, Heath S, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 2007;448:470-3. (Pubitemid 47123521)
30. Himes BE, Hunninghake GM, Baurley JW, Rafaels NM, Sleiman P, Strachan DP, et al. Genome-wide association analysis identifies PDE4D as an asthma susceptibility gene. Am J Hum Genet 2009;84:581-93.
31. Mathias RA, Grant AV, Rafaels N, Hand T, Gao L, Vergara C, et al. A genome-wide association study on African-ancestry populations for asthma. J Allergy Clin Immunol 2010;125:336-46, e4.
32. Cho MH, Boutaoui N, Klanderman BJ, Sylvia JS, Ziniti JP, Hersh CP, et al. Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet 2010;42:200-2.
33. Hunninghake GM, Cho MH, Tesfaigzi Y, Soto-Quiros ME, Avila L, Lasky-Su J, et al. MMP12, lung function, and COPD in high-risk populations. N Engl J Med 2009;361:2599-608.
34. Van Eerdewegh P, Little RD, Dupuis J, Del Mastro RG, Falls K, Simon J, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature 2002;418:426-30. (Pubitemid 34826843)
35. Sadeghnejad A, Ohar JA, Zheng SL, Sterling DA, Hawkins GA, Meyers DA, et al. Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers. Respir Res 2009;10:21.