Food peptides as antihypertensive agents

Bioactive Food Proteins and Peptides: Applications in Human Health

Volumn , Issue , 2011, Pages 131-180

  Aleixandre, Amaya ^a   Miguel, Marta ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; ENZYMES;

BIOACTIVE PEPTIDES; FOOD PROTEINS; IN-VITRO; IN-VIVO;

PEPTIDES;

EID: 85028715435     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (264)

1. Abubakar, A., Saito, T., Kitazawa, H., Kawai, Y., and Itoh, T. 1998. Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion. J. Dairy Sci. 81: 3131-3138.
2. Addeo, F., Chianese, L., Sacchi, R., Musso, S.S., Ferranti, P., and Malorni, A. 1994. Characterization of the oligopeptides of Parmigiano-Reggiano cheese soluble in 120 g trichloroacetic acid/l. J. Dairy Res. 61: 365-374.
3. Adson, A., Raub, T.J., Burton, P.S. et al. 1994. Quantitative approaches to delineate paracellular diffusion in cultured epithelial cell monolayers. J. Pharm. Sci. 83: 1529-1536.
4. Aihara, K., Kajimoto, O., Hirata, H., Takahashi, R., and Nakamura, Y. 2005. Effect of powdered fermented milk with Lactobacillus helveticus on subjects with high-normal blood pressure or mild hypertension. J. Am. Coll. Nutr. 24: 257-265.
5. Almeida, A.P., Frabregas, B.C., Madureira, M.M., Santos, R.J., Campagnole-Santos, M.J., and Santos, R.A. 2000. Angiotensin-(1-7) potentiates the coronary vasodilatatory effect of bradykinin in the isolated rat heart. Braz. J. Med. Biol. Res. 33: 709-713.
6. Alting, A.C., Meijer, R J.G.M., and Van Beresteijn, E.C.H. 1997. Incomplete elimination of the ABBOS epitope of bovine serum albumin under simulated gastrointestinal conditions of infants. Diabetes Care 20: 875-880.
7. Ames, B.N., Shigenaga, M.K., and Hagen, T.M. 1993. Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci. 90: 7915-7922.
8. Anderson, J.W., Smith, B.M., and Washnock, C.S. 1999. Cardiovascular and renal benefits of dry bean and soybean intake. Am. J. Clin. Nutr. 70: 464S-474S.
9. Appel, L.J., Moore, T.J., Obarzanek, E. et al. 1997. A clinical trial of the effects of dietary patterns on blood pressure. New Engl. J. Med. 336: 1117-1124.
10. Astwood, L.D., Leach, J.N., and Fuschs, R.L. 1996. Stability of food allergens to digestion in vitro. Nat. Biotechnol. 14: 1269-1273.
11. Baykal, Y., Yilmaz, M.I., Celik, T. et al. 2003. Effects of antihypertensive agents, alpha receptor blockers, beta blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and calcium channel blockers, on oxidative stress. J. Hypertens. 21: 1207-1211.
12. Bernier, S.G., Haldar, S., and Michel, T. 2000. Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric-oxide synthase. J. Biol. Chem. 275: 30707-30715.
13. Bree, F., Hamon, G., and Tillement, J.P. 1992. Evidence for two binding sites on membrane-bound angiotensin-converting enzymes (ACE) for exogenous inhibitors except in testis. Life Sci. 51: 787-794.
14. Buñag, R.D. 1973. Validation in awake rats of a tail-cuff method for measuring systolic pressure. J. Appl. Physiol. 34: 279-282.
15. Buñag, R.D. and Butterfield, J. 1982. Tail-cuff blood-pressure measurement without external preheating in awake rats. Hypertension 4: 898-903.
16. Burton, P.S., Conradi, R.A., Hilgers, A.R., Ho, N.F.H., and Maggiora, L.L. 1992. The relationship between peptide structure and transport across epithelial cell monolayers. J. Control Release 19: 87-98.
17. Bütikofer, U., Meyer, J., Sieber, R., Walther, B., and Wechsler, D. 2008. Occurrence of the angiotensin-converting enzyme inhibiting tripeptides Val-Pro-Pro and Ile-Pro-Pro in different cheese varieties of Swiss origin. J. Dairy Sci. 91: 29-38.
18. Byun, H. and Kim, S. 2001. Purification and characterization of angiotensin I converting enzyme (ACE) inhibitory peptides from Alaska Pollack (Theragra chalcogramma) skin. Process Biochem. 36: 1155-1162.
19. Cadee, J.A., Chang, C.Y., Chen, C.W., Huang, C.N., Chen, S.L., and Wang, C.K. 2007. Bovine casein hydrolysate (c12 Peptide) reduces blood pressure in prehypertensive subjects. Am. J. Hypertens. 20: 1-5.
20. CDER/FDA. 2000. Guidance for industry: Waiver of in vivo bioavailability and bioequivalence studies for immediate-release solid oral dosage form based on a biopharmaceutical classification system (August).
21. Cervato, G., Cazzola, R., and Cestaro, B. 1999. Studies on the antioxidant activity of milk caseins. Int. J. Food Sci. Nutr. 50: 291-296.
22. Cha, M. and Park, J.R. 2005. Production and characterization of a soy protein-derived angiotensin I-converting enzyme inhibitory hydrolysate. J. Med. Food 8: 305-310.
23. Chabance, B., Marterua, P., Rambaud, J.C. et al. 1998. Casein peptide release and passage to the blood in humans during digestion of milk or yogurt. Biochimie 80: 155-165.
24. Chang, K.J., Lillian, A., Hazum, E., and Cuatrecasas, P. 1981. Morphicetin: A potent and specific agonist for morphine (μ) receptors. Science 212: 75-77.
25. Chen, H.M., Muramoto, K., Yamauchi, F., and Nokihara, K. 1996. Antioxidant activity of peptides designed based on the antioxidative peptide isolated from digests of a soybean protein. J. Agric. Food Chem. 44: 2619-2623.
26. Chen, J.R., Yang, S.C., Suetsuna, K., and Chao, J.C.J. 2004. Soybean protein-derived hydrolysate affects blood pressure in spontaneously hypertensive rats. J. Food Biochem. 28: 61-73.
27. Cheung, H.S., Wang, F.L., Ondetti, M.A., Sabo, E.F., and Cushman, D.W. 1980. Binding of peptides substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem. 25: 401-407.
28. Chiba, H., Tani, F., and Yoshikawa, M. 1989. Opioid antagonist peptides derived from κ-casein. J. Dairy Res. 56: 363-366.
29. Chobert, J.M., El-Zahar, K., Sitohy, M. et al. 2005. Angiotensin I-converting-enzyme (ACE)-inhibitory activity of tryptic peptides of ovine beta-lactoglobulin and of milk yoghurts obtained by using different starters. Lait 85: 141-152.
30. Clemente, A. 2000. Enzymatic protein hydrolysates in human nutrition. Trends Food Sci. 11: 254-262.
31. Collins, R., Peto, R., MacMahon, S. et al. 1990. Blood pressure, stroke, and coronary heart disease. Part 2, Short-term reductions in blood pressure: Overview of randomised drug trials in their epidemiological context. Lancet 335: 827-838.
32. Conradi, R.A., Hilgers, A.R., Ho, N.F.H., and Burton, P.S. 1992. The influence of pep­tide structure on transport across Caco-2 cells. II. Peptide bond modification which results in improved permeability. Pharm. Res. 9: 435-439.
33. Conradi, R.A., Wilkinson, K.F., Rush, B.D., Hilgers, A.R., Ruwart, M.J., and Burton, P.S. 1993. In vitro/in vivo models for peptide oral absorption: Comparison of Caco-2 cell permeability with rat intestinal absorption of renin inhibitory peptides. Pharm. Res. 10: 1790-1792.
34. Cushman, D.W. and Cheung, H.S. 1971. Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung. Biochem. Pharmacol. 20: 1637-1648.
35. Cushman, D.W., Cheung, H.S., Sabo, E.F., and Ondetti, M.A. 1977. Design of potent competitive inhibitors of angiotensin-converting enzyme. Carboxyalkanoyl and mercaptoalkanoyl amino acids. Biochemistry 16: 5484-5491.
36. Cushman, D.W., Pluscec, J., Williams, N.J. et al. 1973. Inhibition of angiotensin-converting enzyme by analogs of peptides from Bothrops jaraca venom. Experientia 29: 1032-1035.
37. D’Alvise, N., Lesueur-Lambert, C., Ferin, B., Dhulster, P., and Guillochon, D. 2000. Hydrolysis and large scale ultrafiltration study of alfalfa protein concentrate enzymatic hydrolysate. Enzyme Microb. Tech. 27: 286-294.
38. Daniel, H., Morse, E.L., and Adibi, S.A. 1992. Determinants of substrate affinity for the oligopeptide/H+ symporter in the renal brush border membrane. J. Biol. Chem. 267: 9565-9573.
39. Dávalos, A., Gómez-Cordovés, C., and Bartolomé, B. 2004a. Extending applicability of the oxygen radical absorbance capacity (ORAC-fluorescein) assay. J. Food Prot. 67: 1939-1944.
40. Dávalos, A., Miguel, M., Bartolomé, B., and López-Fandiño, R. 2004b. Antioxidant activity of peptides derived from egg white proteins by enzymatic hydrolysis. J. Food Prot. 67: 1939-1944.
41. Deddish, P.A., Marcic, B., Jackman, H.L., Wang, H.Z., Skidgel, R.A., and Erdös, E.G. 1998. N-domain-specific substrate and C-domain inhibitors of angiotensin-converting enzyme: angiotensin-(1-7) and keto-ACE. Hypertension 31: 912-917.
42. Deddish, P.A., Wang, L.X., Jackman, H.L. et al. 1996. Single-domain angiotensin I converting enzyme (kininase II): Characterization and properties. J. Pharmacol. Exp. Ther. 279(3): 1582-1589.
43. Donoghue, M., Hsieh, F., Baronas, E. et al. 2000. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ. Res. 87: E1-E9.
44. Dzau, V.J. 2001. Theodore Cooper lecture: Tissue angiotensin and pathobiology of vascular disease: a unifying hypothesis. Hypertension 37: 1047-1052.
45. Engberink, M.F., Schouten, E.G., Kok, F.J., van Mierlo, L.A., Brouwer, I.A., and Geleijnse, J.M. 2008. Lactotripeptides show no effect on human blood pressure: Results from a double-blind randomized controlled trial. Hypertension 51: 399-405.
46. Erdös, E.G. 1976. Conversion of angiotensin I to angiotensin II. Am. J. Med. 60: 749-759.
47. Fazel, A. 1998. Nutritional and health benefits of yogurt and fermented milks. Functional peptides. Danone World News.
48. FDA. 1999. Guidance for industry waiver of in vivo bioavailability and bioequivalence studies base don Biopharmaceutics Classification system. CDER draft - January.
49. Fiat, A.M., Migliore-Samour, D., Jollès, P., Drouet, L., Bal dit Sollier, C., and Caen, J. 1993. Biologically active peptides from milk proteins with emphasis on two examples concerning antithrombotic and immunomodulating activities. J. Dairy Sci. 76: 301-310.
50. Fischer, M.A. and Avorn, J. 2004. Economic implications of evidence-based prescribing for hypertension: Can better care cost less? JAMA 291: 1850-1856.
51. Fitzgerald, R.J., Murria, B.A., and Walsh, G.J. 2004. Hypotensive peptides from milk proteins. J. Nutr. 134: 980S-988S.
52. Fujita, H., Sasaki, R., and Yoshikawa, M. 1995b. Potentiation of the antihyperten­sive activity of orally administered Ovokinin, a vasorelaxing peptide derived from ovalbumin, by emulsification in egg phosphatidyl-choline. Biosci. Biotech. Biochem. 59: 2344-2345.
53. Fujita, H., Usui, H., Kurahashi, K., and Yoshikawa, M. 1995a. Isolation and characterization of Ovokinin, a bradykinin B1 agonist peptide derived from ovalbumin. Peptides 16: 785-790.
54. Fujita, H., Yamagami, T., and Ohshima, K. 2001. Effects of an ACE-inhibitory agent, katsuobushi oligopeptide, in the spontaneously hypertensive rat and in borderline and mildly hypertensive subjects. Nutr. Res. 21: 1149-1158.
55. Fujita, H., Yasumoto, R., Hasegawa, M., and Ohshima, K. 1997a. Human volunteers study on antihypertensive effect of “Katsuobushi Oligopeptide” (I). Jpn. Pharmacol. Ther. 25: 147-151.
56. Fujita, H., Yasumoto, R., Hasegawa, M., and Ohshima, K. 1997b. Human volunteers study on antihypertensive effect of “Katsuobushi Oligopeptide” (II) - A placebo-controlled study on the effect of “peptide soup” on blood pressure in borderline and hypertensive subjects. Jpn. Pharmacol. Ther. 25: 153-157.
57. Fujita, H., Yokoyama, K., and Yoshikawa, M. 2000. Classification and antihyperten­sive activity of angiotensin I-converting enzyme inhibitory peptides derived from food proteins. J. Food Sci. 65: 564-569.
58. Fujita, H., Yokoyama, K., Yaumoto, R., and Yoshikawa, M. 1995c. Antihypertensive effect of thermolysin digest of dried bonito in spontaneously hypertensive rat. Clin. Exp. Pharmacol. Physiol. Suppl 22: S304-S305.
59. Fujita, H. and Yoshikawa, M. 1999. LKPNM: a prodrug-type ACE-inhibitory peptide derived from fish protein. Immunopharmacology 44: 123-127.
60. Ganapathy, V. and Leibach, F.H. 1985. Is intestinal peptide transport energized by a proton gradient? Am. J. Physiol. 249: G153-G160.
61. García Del Río, C., Smellie, W.S., and Morton, J.J. 1981. Des-Asp-angiotensin I: Its identification in rat blood and confirmation as a substrate for converting enzyme. Endocrinology 108: 406-412.
62. Gardiner, S.M., Kemp, P.A., March, J.E., and Bennett, T. 1993. Regional haemodynamic effects of angiotensin II (3-8) in conscious rats. Br. J. Pharmacol. 110: 159-162.
63. Gardner, M.I.G. 1994. Absorption of intact proteins and peptides. In Physiology of the Gastrointestinal Tract (L.R. Johnson, Ed.), New York: Raven Press, pp. 1795-1820.
64. Garrison, E.A., Santiago, J.A., Osei, S.Y., and Kadowitz, P.J. 1995. Analysis of responses to angiotensin peptides in the hindquarters vascular bed of the cat. Am. J. Physiol. 268: H2418-H2425.
65. Gaynes, R.P., Szidon, J.P., and Oparil, S. 1978. In vivo and in vitro conversion of des-1-Asp angiotensin I to angiotensin III. Biochem. Pharmacol. 27: 2871-2877.
66. Gobbetti, M., Ferranti, P., Smacchi, E., and Goffredi, F. 2000. Production of angiotensin I-converting peptides in fermented milks started by Lactobacillus delbruckii subsp bulgaricus SS1 and Lactococcus lactis subsp cremoris FT5. Appl. Environ. Microbiol. 66: 3898-3904.
67. Gómez-Ruiz, J.A., Ramos, M., and Recio, I. 2003. Angiotensin-converting enzyme-inhibitory peptides in Manchego cheeses manufactured with different starter cultures. Int. Dairy J. 12: 697-706.
68. Gómez-Ruiz, J.A., Ramos, M., and Recio, I. 2004a. Angiotensin-converting enzyme-inhibitory peptides isolated from Manchego cheeses. Stability under simulated gastrointestinal digestion. Int. Dairy J. 14: 1075-1080.
69. Gómez-Ruiz, J.A., Recio, I., and Belloque, J. 2004b. ACE-Inhibitory activity and structural properties of peptide Asp-Lys-Ile-His-Pro [β-CN f(47-51)]. Study of the peptide forms synthesized by different methods. J. Agric. Food Chem. 52: 6315-6319.
70. Goodwin, J.T., Mao, B., Vidmar, T.J., Conradi, R.A., and Burton, P.S. 1999. Strategies toward predicting peptide cellular permeability from computed molecular descriptors. J. Pept. Res. 53: 355-369.
71. Gurer, H., Neal, R., Yang, P., Oztezcan, S., and Ercal, N. 1999. Captopril as an antioxidant in lead-exposed Fisher 344 rats. Hum. Exp. Toxicol. 18: 27-32.
72. Haileselassie, S.S., Lee, B.H., and Gibbs, B.F. 1999. Purification and identification of potentially bioactive peptides from enzyme-modified cheese. J. Dairy Sci. 82: 1612-1617.
73. Hai-Lun, H., Xiu-Lan, C., Cai-Yun, S., Yu-Zhong, Z., and Bai-Cheng, Z. 2006. Analysis of novel angiotensin-I-converting enzyme inhibitory peptides from protease-hydrolyzed marine shrimp Acetes chinensis. J. Pept. Sci. 12: 726-733.
74. Hata, Y., Yamamoto, M., Ohni, M., Nakajima, K., Nakamura, Y., and Takano, T. 1996. A placebo-controlled study of the effect of sour milk on blood pressure in hypertensive subjects. Am. J. Clin. Nutr. 64: 767-771.
75. He, G.Q., Xuan, G.D., Ruan, H., Chen, Q.H., and Xu, Y. 2005. Optimization of angiotensin I-converting enzyme (ACE) inhibition by rice dregs hydrolysates using response surface methodology. J. Zhejiang Univ. Sci. B 6: 508-513.
76. He, H., Chen, X., Sun, C., Zhang, Y., and Gao, P. 2006. Preparation and functional evaluation of oligopeptide-enriched hydrolysate from shrimp (Acetes chinensis) treated with crude protease from Bacillus sp. SM98011. Bioresour. Technol. 97: 385-390.
77. Hernández-Ledesma, B., Miguel, M., Amigo, L., Aleixandre, M.A., and Recio, I. 2007. Effect of simulated gastrointestinal digestion on the antihypertensive properties of β-lactoglobulin peptides. J. Dairy Res. 74: 336-339.
78. Hernández-Ledesma, B., Recio, I., Ramos, M., and Amigo, L. 2002. Preparation of ovine and caprine β-lactoglobulin hydrolysates with ACE-inhibitory activity. Identification of active peptides from caprine β-lactoglobulin hydrolysed with thermolysin. Int. Dairy J. 12: 805-812.
79. Heyman, M. and Desjeux, J.F. 1992. Significance of intestinal food protein transport. J. Pediat. Gastroent. Nutr. 15: 48-57.
80. Hidalgo, I.J., Raub, T.J., and Borchardt, R.T. 1989. Characterization of the human coloncarcinoma cell line (Caco-2) as a model system form intestinal epithelial permeability. Gastroenterology 96: 736-749.
81. Hilgers, A.R., Conradi, R.A., and Burton, P.S. 1990. Caco-2 cell monolayers as a model for drug transport across the intestinal mucosa. Pharm. Res. 7: 902-910.
82. Hirota, T., Ohki, K., Kawagishi, R., Kajimoto, Y., Mizuno, S., Nakamura, Y., and Kitakaze, M. 2007. Casein hydrolysate containing the antihypertensive tripeptides Val-Pro-Pro and Ile-Pro-Pro improves vascular endothelial function inde­pendent of blood pressure-lowering effects: contribution of the inhibitory action of angiotensin-converting enzyme. Hypertens. Res. 30: 489-496.
83. Hughes, J., Kosterlitz, H.W., and Smith, T.W. 1977. The distribution of methionine-enkephalin and leucine-enkephalin in the brain and peripheral tissues. Br. J. Pharmacol. 61: 639-647.
84. Husain, A. 1993. The chymase-angiotensin system in humans. J. Hypertens. 11: 1155-1159.
85. Hyoung Lee, D., Ho Kim, J., Sik Park, J., Jun Choi, Y., and Soo Lee, J. 2004. Isolation and characterization of a novel angiotensin I-converting enzyme inhibitory peptide derived from the edible mushroom Tricholoma giganteum. Peptides 25: 621-627.
86. Ijäs, H., Collin, M., Finchenberg, P. et al. 2004. Antihypertensive opioid-like milk peptide alpha-lactorphin: Lack of effect on behavioural test in mice. Int. Dairy J. 14: 201-205.
87. Jauhiainen, T. and Korpela, R. 2007. Milk peptides and blood pressure. J. Nutr. 137: 825S-829S.
88. Jauhiainen, T., Vapaatalo, H., Poussa, T., Kyronpalo, S., Rasmussen, M., and Korpela, R. 2005. Lactobacillus helveticus fermented milk lowers blood pressure in hypertensive subjects in 24-h ambulatory blood pressure measurement. Am. J. Hypertens. 18: 1600-1605.
89. Je, J.Y., Park, P.J., Kwon, J.Y., and Kim, S.K. 2004. A novel angiotensin I converting enzyme inhibitory peptide from Alaska pollack (Theragra chalcogramma) frame protein hydrolysate. J. Agric. Food Chem. 52: 7842-7845.
90. Jiang, H., Grieve, P.A., Marschke, R.J., Wood, A.F., Dionysius, D.A., and Alewood, P.F. 1998. Application of tandem mass spectrometry in the characterisation of flavour and bioactive peptides. Aust. J. Dairy Technol. 53: 119.
91. Karaki, H., Doi, K., Sugano, S. et al. 1990. Antihypertensive effect of tryptic hydroly­sate of milk casein in spontaneously hypertensive rats. Comp. Biochem. Physiol. 96C: 367-371.
92. Karaki, H., Kuwahara, M., Sugano, S. et al. 1993. Oral administration of peptides derived from bonito bowels decreases blood pressure in spontaneously hypertensive rats by inhibiting angiotensin converting enzyme. Comp. Biochem. Physiol. C 104: 351-353.
93. Kawasaki, T., Jun, C.J., Fukushina, Y. et al. 2002. Antihypertensive effect and safety evaluation of vegetable drink with peptides derived from sardine protein hydrolysates on mild hypertensive, high-normal, and normal blood pressure subjects. Fukuoka Igaku Zasshi 93: 208-218.
94. Kawasaki, T., Seki, E., Osajima, K. et al. 2000. Antihypertensive effect of Valyl-tyrosine, a short chain peptide derived of sardine muscle hydrolyzate, on mild hypertensive subjects. J. Hum. Hypertens. 14: 519-523.
95. Kawase, M., Hashimoto, H., Hosada, M., Morita, H., and Hosono, A. 2000. Effect of administration of fermented milk containing whey proteins concentrate to rats and healthy men on serum lipids and blood pressure. J. Dairy Sci. 83: 255-263.
96. Kim, D.C., Burton, P.S., and Borchardt, R.T.A. 1993. A correlation between the permeability characteristics of a series of peptides using an in vitro cell culture model (Caco-2) and those using an in situ perfused rat ileum model of the intestinal mucosa. Pharm. Res. 10: 1701-1714.
97. Kim, S.K., Byun, H.G., Park, P.J, and Shahidi, F. 2001. Angiotensin I converting enzyme inhibitory peptides purified from bovine skin gelatin hydrolysate. J. Agric. Food Chem. 49: 2992-2997.
98. Kodera, T. and Nio, N. 2006. Identification of an angiotensin I-converting enzyme inhibitory peptides from protein hydrolysates by a soybean protease and the antihypertensive effects of hydrolysates in spontaneously hypertensive rats models. J. Food Sci. 71: C164-C173.
99. Kohama, Y., Matsumoto, S., Oka, H., Teramoto, T., Okabe, M., and Mimura, Y. 1988. Isolation of angiotensin-converting enzyme inhibitor from tuna muscle. Biochem. Biophys. Res. Commun. 155: 332-337.
100. Kohama, Y., Oka, H., Matsumoto, S. et al. 1989. Biological properties of angiotensin converting enzyme inhibitor derived from tuna muscle. J. Pharmacobio.-Dynan 12: 566-571.
101. Kohmura, M., Nio, N., Kubo, K., Minishima, Y., Munekata, E., and Ariyoshi, Y. 1989. Inhibition of angiotensin-converting enzyme by synthetic peptides of human β-casein. Agric. Biol. Chem. 53: 2107-2114.
102. Kudoh, K., Matsumoto, M., Onodera, S., Takeda, Y., Ando, K., and Shiomi, N. 2003. Antioxidative activity and protective effect against ethanol-induced gastric mucosal damage of a potato protein hydrolysate. J. Nutr. Sci. Vitaminol. 49: 451-455.
103. Kuono, K., Hirano, S., Kuboki, H., Kasai, M., and Hatae, K. 2005. Effects of dried bonito (Katsuobushi) and captopril, an angiotensin I-converting enzyme inhibitor, on rat isolated: A possible mechanism of antihypertensive action. Biosci. Biotech. Biochem. 69: 911-915.
104. Landmesser, U. and Drexler, H. 2006. Effect of angiotensin II type 1 receptor antagonism on endothelial function: role of bradykinin and nitric oxide. J. Hypertens. Suppl. (1): S39-S43.
105. Laursen, J.B., Rajagopalan, S., Galis, Z., Tarpey, M., Freeman, B.A., and Harrison, D.G. 1997. Role of superoxide in angiotensin II-induced but catecholamine-induced hypertension. Circulation 95: 588-593.
106. Lee, J.E., Bae, I.Y., Lee, H.G., and Yang, C.B. 2006. Tyr-Pro-Lys, an angiotensin I-converting enzyme inhibitory peptide derived from broccoli (Brassica oleracea Italica). Food Chem. 99: 143-148.
107. Lee, N.Y., Cheng, J.T., Enomoto, T., and Nakano, Y. 2006a. One peptide derived from hen ovotransferrin as prodrug to inhibit angiotensin converting enzyme. J. Food Drug. Anal. 14: 31-35.
108. Lee, N.Y., Cheng, J.T., Enomoto, T., and Nakano, Y. 2006b. Antihypertensive effect of angiotensin converting enzyme inhibitory peptide obtained from hen ovotransferrin. J. Chinese Chem. Soc. 53: 495-501.
109. Lee, Y.K. and Salminen, S. 1995. The coming of age of probiotics. Trends Food Sci. Technol. 6: 241-245.
110. Lee, Y.M., Skurk, T., Hennig, M., and Hauner, H. 2007. Effect of a milk drink supplemented with whey peptides on blood pressure in patients with mild hypertension. Eur. J. Nutr. 46: 21-27.
111. Leibach, F.H. and Ganapathy, V. 1986. Peptide transporters in the intestine and the kidney. Ann. Rev. Nutr. 16: 99-119.
112. Li, C. H., Matsui, T., Matsumoto, K., Yamasaki, R., and Kawasaki, T. 2002. Latent production of angiotensin I-converting enzyme inhibitors from buckwheat protein. J. Pept. Sci. 8: 267-274.
113. Li, G.H., Liu, H., Shi, Y.H., and Le, G.W. 2005. Direct spectrophotometric measurement of Angiotensin I-converting ezyme inhibitory activity for screening bioactive peptides. J. Pharm. Biomed. Anal. 37: 219-224.
114. Li, G.H., Qu, M.R., Wan, J.Z., and You, J.M. 2007. Antihypertensive effect of rice protein hydrolysate with in vitro angiotensin I-converting enzyme inhibitory activity in spontaneously hypertensive rats. Asia Pac. J. Clin. Nutr. 16 Suppl: 275-280.
115. Li, G.H., Wan, J.Z., Le, G.W., and Shi, Y.H. 2006. Novel angiotensin I-converting enzyme inhibitory peptides isolated from Alcalase hydrolysate of mung bean protein. J. Pept. Sci. 12: 509-514.
116. Lo, W.M. and Li-Chan, E.C. 2005. Angiotensin I converting enzyme inhibitory peptides from in vitro pepsin-pancreatin digestion of soy protein. J. Agric. Food Chem. 53: 3369-3376.
117. Loufrani, L., Henrion, D., Chansel, D., Ardaillou, R., and Levy, B.I. 1999. Functional evidence for an angiotensin IV receptor in rat resistance arteries. J. Pharmacol. Exp. Ther. 291: 583-588.
118. MacMahon, S., Peto, R., Cutler, J. et al. 1990. Blood pressure, stroke, and coronary heart disease. Part 1, Prolonged differences in blood pressure: Prospective observational studies corrected for the regression dilution bias. Lancet 335: 765-774.
119. Maeno, M., Yamamoto, N., and Takano, T. 1996. Identification of an antihypertensive peptide from casein hydrolysate produced by a proteinase from Lactobacillus helveticus CP790. J. Dairy Sci. 79: 1316-1321.
120. Maes, W., Van Camp, J., Vermeirssen, V. et al. 2004. Influence of the lactokinin Ala-Leu-Pro-Met-His-Ile-Arg (ALPMHIR) on the release of endothelial cells. Regul. Pept. 18: 105-109.
121. Mallikarjun Gouda, K.G., Gowda, L.R., Rao, A.G., and Prakash, V. 2006. Angiotensin I-converting enzyme inhibitory peptide derived from glycinin, the 11S globulin of soybean (Glycine max). J. Agric. Food Chem. 54: 4568-4573.
122. Marceau, F. 1995. Kinin B1 receptors: A review. Immunopharmacology 30: 1-26.
123. Marceau, F., Larrivee, J.F., Saint-Jacques, E., and Bachvarov, D.R. 1997. The kinin B1 receptor: An inducible G protein coupled receptor. Can. J. Physiol. Pharmacol. 75: 725-730.
124. Maruyama, S., Mitachi, H., Awaya, J., Kurono, M., Tomizuka, N., and Suzuki, H. 1987a. Angiotensin I-converting enzyme inhibitory activity of the C-terminal hexapeptide of α s1-casein. Agric. Biol. Chem. 51: 2557-2561.
125. Maruyama, S., Mitachi, S., Tanaka, H., Tomizuka, N., and Suzuki, H. 1987b. Studies on the active site antihypertensive activity of angiotensin I-converting inhibitors derived from casein. Agric. Biol. Chem. 51: 1581-1586.
126. Maruyama, S., Miyoshi, S., Kaneko, T., and Tanaka, H. 1989. Angiotensin I-converting enzyme inhibitory activities of synthetic peptides related to the tandem repeated sequence of a maize endosperm protein. Agric. Biol. Chem. 53: 1077-1081.
127. Maruyama, S. and Suzuki, H. 1982. A peptide inhibitor of angiotensin-I converting enzyme in the tryptic hydrolyzate of casein. Agric. Biol. Chem. 46: 1393-1394.
128. Masuda, O., Nakamura, Y., and Takano, T. 1996. Antihypertensive peptides are present in aorta after oral administration of sour milk containing these peptides to spontaneously hypertensive rats. J. Nutr. 126: 3063-3068.
129. Matoba, N., Usui, H., Fujita, H., and Yoshikawa, M. 1999. A novel antihypertensive peptide derived from ovalbumin induces nitric oxide-mediated vasorelaxation in an isolated SHR mesenteric artery. FEBS Lett. 452: 181-184.
130. Matoba, N., Yamada, Y., Usui, H., Nakagiri, R., and Yoshikawa, M. 2001. Designing potent derivatives of Ovokinin (2-7), an antihypertensive peptide derived from ovalbumin. Biosci. Biotech. Biochem. 65: 636-639.
131. Matsufuji, H., Matsui, T., Ohshige, S., Kawasaki, T., Osajima, K., and Osajima, T. 1995. Antihypertensive effects of angiotensin fragments in SHR. Biosci. Biotechnol. Biochem. 59: 1398-1401.
132. Matsufuji, H., Matsui, T., Seki, E., Osajima, K., Nakashima, M., and Osajima, Y. 1994. Angiotenin I-converting enzyme inhibitory peptides in an alkaline protease hydrolyzate derived from sardine muscle. Biosci. Biotechnol. Biochem. 58: 2244-2245.
133. Matsui, T., Li, C.H., and Osajima, Y. 1999. Preparation and characterization of novel bioactive peptides responsible for angiotensin I-converting enzyme inhibition from wheat germ. J. Peptide Sci. 5: 289-297.
134. Matsui, T., Matsufuji, H., Seki, E., Osajima, K., Nakashima, M., and Osajima, Y. 1993. Inhibition of angiotensin I-converting enzyme by Bacillus licheniformis alkaline protease hydrolyzates derived from sardine muscle. Biosci. Biotechnol. Biochem. 57: 922-925.
135. Matsumura, N., Fujii, M., Takeda, Y., Sugita, K., and Shimizu, T. 1993. Angiotensin I-converting enzyme inhibitory peptides derived from bonito bowels autolysate. Biosci. Biotech. Biochem. 57: 695-697.
136. Megias, C., del Mar Yust, M., Pedroche, J. et al. 2004. Purification of an ACE inhibitory peptide after hydrolysis of sunflower (Helianthus annuus L.) protein isolates. J. Agric. Food Chem. 52: 1928-1932.
137. Meisel, H. 1997. Biochemical properties of bioactive peptides derived from milk proteins: Potential nutraceuticals for food and pharmaceutical applications. Liv. Prod Sci. 50: 125-138.
138. Meisel, H. 1998. Overview on milk protein-derived peptides. Int. Dairy J. 8: 363-373.
139. Meisel, H. 2001. Bioactive peptides from milk proteins: A perspective for consumers and producers. Aust. J. Dairy Technol. 56: 83-92.
140. Messina, M. 1995. Modern applications for an ancient bean: Soybeans and the prevention and treatment of chronic disease. J. Nutr. 125: 567S-569S.
141. Messina, M. 1999. Legumes and soybeans: Overview of their nutritional profiles and health effects. Am. J. Clin. Nutr. 70: 439S-450S.
142. Mierke, D.F., Nöbner, G., Schiller, P.W., and Goodman, M. 1990. Morphicetin analogs containing 2-aminocyclopentane carboxylic acid as a peptidomimetic for proline. Int. J. Pep. Res. 35: 34-45.
143. Miguel, M. and Aleixandre, A. 2006. Antihypertensive peptides derived from egg proteins. J. Nutr. 136: 1457-1460.
144. Miguel, M., López-Fandiño, R., Ramos, M., and Aleixandre, M.A. 2005b. Short-term effect of egg white hydrolysate products on the arterial blood pressure of hypertensive rats. Br. J. Nutr. 94: 731-737.
145. Miguel, M., López-Fandiño, R., Ramos, M., and Aleixandre, M.A. 2006c. Long-term antihypertensive effect of egg white treated with pepsin in hypertensive rats. Life Sci. 78: 2960-2966.
146. Miguel, M., Muguerza, B., Sánchez, E. et al. 2005a. Changes in arterial blood pressure of milk fermented by Enterococcus faecalis CECT 5728 in spontaneously hypertensive rats. Br. J. Nutr. 93: 1-9.
147. Miguel, M., Ramos, M., Aleixandre, M.A., and López-Fandiño, R. 2006a. Antihypertensive peptides obtained from egg white proteins by enzymatic hydrolysis. Stability under simulated gastrointestinal digestion. J. Agric. Food Chem. 54: 726-731.
148. Miguel, M., Recio, I., Gómez-Ruiz, J.A., Ramos, M., and López-Fandiño, R. 2004. Angiotensin I-converting enzyme inhibitory activity of peptides derived from egg white proteins by enzymatic hydrolysis. J. Food Prot. 67: 1914-1920.
149. Miguel, M., Recio, I., Ramos, M., Delgado, M.A., and Aleixandre, M.A. 2006b. Effect of ACE-inhibitory peptides obtained from Enterococcus faecalis fermented milk in hypertensive rats. J. Dairy Sci. 89: 3352-3359.
150. Mine, Y. 1995. Recent advances in the understanding of egg white protein functional­ity. Trends Food Sci. Technol. 6: 225-232.
151. Miyoshi, S., Ishikawa, H., Kaneko, T., Fukui, F., Tanaka, H., and Maruyama, S. 1991. Structures and activity of angiotensin-converting enzyme inhibitors in an α-zein hydrolysate. Agric. Biol. Chem. 55: 1313-1771.
152. Mizuno, S., Matsura, K., Gotou, T. et al. 2005. Antihypertensive effect of casein hydrolysate in a placebo-controlled study in subjects with high-normal blood pressure and mild hypertension. Br. J. Nutr. 94: 84-91.
153. Mizushima, S., Ohshige, K., Watanabe, J. et al. 2004. Randomized controlled trial of sour milk on blood pressure in borderline hypertensive men. Am. J. Hypertens. 17: 701-706.
154. Moosmann, B. and Behl, C. 2002. Secretory peptide hormones are biochemical anti­oxidants: Structure-activity relationship. Mol. Pharmacol. 61: 260-268.
155. Motoi, H. and Kodama, T. 2003. Isolation and characterization of Angiotensin I-coverting enzyme inhibitory peptides from wheat gliadin hydrolysate. Nahrung/Food 47: 354-358.
156. Muguerza, B., Ramos, M., Sánchez, E. et al. 2006. Antihypertensive activity of milks fermented by Enterococcus faecalis strains isolated from raw milk. Int. Dairy J. 16: 61-69.
157. Mullally, M.M., Meisel, H., and FitzGerald, R. J. 1996. Synthetic peptides corresponding to α-lactalbumin and α-lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. Biol. Chem. 377: 259-260.
158. Mullally, M.M., Meisel, H., and FitzGerald, R.J. 1997a. Angiotensin-I-converting enzyme inhibitory activities of gastric and pancreatic proteinase digest of whey proteins. Int. Dairy J. 7: 299-303.
159. Mullally, M.M., Meisel, H., and FitzGerald, R.J. 1997b. Identification of a novel angiotensin-I-converting enzyme inhibitory peptide α-lactoglobulin corresponding to a tryptic fragment of bovine. FEBS Lett. 402: 99-101.
160. Murakami, M., Tonouchi, H., Takahashi, R. et al. 2004. Structural analysis of a new antihypertensive peptide (beta-lactosin B) isolated from a commercial whey product. J. Dairy Sci. 87: 1967-1974.
161. Murray, B.A., Walsh, D.J., and FitzGerald, R.J. 2004. Modification of the furanacryloyl-L-phenylalanylglycylglycine assay for determination of angiotensin-I-converting enzyme inhibitory activity. J. Biochem. Biophys. Methods 59: 127-137.
162. Nakamura, Y., Masuda, O., and Takano, T. 1996. Decrease of tissue angiotensin I-converting enzyme activity upon feeding sour milk in spontaneously hypertensive rats. Biosci. Biotech. Biochem. 60: 488-489.
163. Nakamura, Y., Yamamoto, N., Sakai, K., Okubo, A., Yamazaki, S., and Takano, T.J. 1995b. Antihypertensive effect of sour milk and peptides isolated from it that are inhibitors to angiotensin I-converting enzyme. J. Dairy Sci. 78: 1253-1257.
164. Nakamura, Y., Yamamoto, N., Sakai, K., Takano, T., Okubo, A., and Yamazaki, S. 1995a. Purification and characterization of angiotensin-converting enzyme inhibitors from sour milk. J. Dairy Sci. 78: 777-783.
165. Nakano, D., Ogura, K., Miyakoshi, M. et al. 2006. Antihypertensive effect of angiotensin I-converting enzyme inhibitory peptides from a sesame protein hydrolysate in spontaneously hypertensive rats. Biosci. Biotechnol. Biochem. 70: 1118-1126.
166. National Heart, Lung and Blood Institute. 2003. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. 03-5233. Bethesda, MD: National Institutes of Health.
167. Ni, A., Chao, L., and Chao, J. 1998. Transcription factor nuclear factor kappaB regulates the inducible expression of the human B1 receptor gene in inflammation. J. Biol. Chem. 273: 2784-2791.
168. Nii, Y., Fukuta, K., Yoshimoto, R., Sakai, K., and Ogawa, T. 2008. Determination of antihypertensive peptides from an izumi shrimp hydrolysate. Biosci. Biotechnol. Biochem. 72: 861-864.
169. Nurmeinin, M.L., Sipola, M., Kaarto, H. et al. 2000. Aα-Lactorphin lowers blood pressure measured by radiotelemetry in normotensive and spontaneously hypertensive rats. Life Sci. 66: 535-543.
170. Okamoto, A., Hanagata, H., Matsumoto, E., Kawamura, Y., Koizumi, Y., and Yanadiga, F. 1995. Angiotensin I converting enzyme inhibitory activities of various fermented milks. Biosci. Biotechnol. Biochem. 59: 1147-1149.
171. Okamoto, K. and Aoki, K. 1963. Development of a strain of spontaneously hypertensive rats. Japan Circ. J. 27: 282-293.
172. Okitsu, M., Morita, A., Kakitani, M., Okada, M., and Yokogoshi, H. 1995. Inhibition of the endothelin-converting enzyme by pepsin digests of food proteins. Biosci. Biotechnol. Biochem. 59: 325-326.
173. Ondetti, M.A. and Cushman, D.W. 1982. Enzymes of the renin-angiotensin system and their inhibitors. Ann. Rev. Biochem. 51: 283-308.
174. Ondetti, M.A., Rubin, B., and Cushman, D.W. 1977. Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents. Science 196: 441-444.
175. Ono, S., Hosokawa, M., Miyashita, K., and Takahashi, K. 2003. Isolation of peptides with angiotensin I-converting enzyme inhibitory effect derived from hydrolysate of upstream chum salmon muscle. J. Food Sci. 68: 1611-1614.
176. Ono, S., Hosokawa, M., Miyashita, K., and Takahashi, K. 2006. Inhibition properties of dipeptides from salmon muscle hydrolysate on angiotensin I-converting enzyme. Int. J. Food Sci. Tech. 41: 4383-386.
177. Pappenheimer, J.R., Dahl, C.E., Karnovsky, M.L., and Maggio, J.E. 1994. Intestinal absorption and excretion of octapeptides composed of D-aminoacides. Proc. Natl. Acad. Sci. USA 91: 1942-1945.
178. Patel, J.M., Martens, J.R., Li, Y.D., Gelband, C.H., Raizada, M.K., and Block, E.R. 1998. Angiotensin IV receptor-mediated activation of lung endothelial NOS is associ­ated with vasorelaxation. Am. J. Physiol. 275: L1061-L1068.
179. Pihlanto-Leppälä, A., Koskinen, P., Piilola, K., Tupasela, T., and Korhonen, H. 2000. Angiotensin I-converting enzyme inhibitory properties of whey protein digests: Concentration and characterization of active peptides. J. Dairy Res. 1: 53-64.
180. Pihlanto-Leppälä, A., Rokka, T., and Korhonen, H. 1998. Angiotensin-I-converting enzyme inhibitory peptides derived from bovine milk proteins. Int. Dairy J. 8: 325-331.
181. Pins, J.J. and Keenan, J.M. 2002. The antihypertensive effects of a hydrolysated whey protein isolate supplement (Biozate® 1). Cardiovasc. Drugs Ther. 16: 68.
182. Pins, J.J. and Keenan, J.M. 2003. The antihypertensive effects of a hydrolysated whey protein isolate supplement (Biozate® 1): A pilot study. FASEB J. 17:A1110.
183. Pins, J.J. and Keenan, J.M. 2006. Effects of whey peptides on cardiovascular risk factors. J. Clin. Hypertens. 8: 775-782.
184. Quirós, A., Ramos, M., Muguerza, B. et al. 2007. Identification of novel antihypertensive peptides in milk fermented with Enterococus faecalis. Int. Dairy J. 17: 33-41.
185. Rival, S.G., Boeriu, C.G., and Wichers, H. J. 2001b. Casein and casein hydrolysates. 2. Antioxidant properties and relevance to lipoxygenase inhibition. J. Agric. Food Chem. 49: 295-302.
186. Rival, S.G., Fornaroli, S., Boeriu, C.G., and Wichers, H.J. 2001a. Caseins and casein hydrolysates. 1. Lipoxygenase inhibitory properties. J. Agric. Food Chem. 49: 287-294.
187. Robert, M.C., Razaname, A., Mutter, M., and Juillerat, M.A. 2004. Identification of angiotensin-I-converting enzyme inhibitory peptides derived from sodium caseinate hydrolysates produced by Lactobacillus helveticus NCC 2765. J. Agric. Food Chem. 52: 6923-6931.
188. Rodicio Díaz, J. L. 2000. Comentario sobre el coste/beneficio de la hipertensión arterial. Gestión y evaluación de costes sanitarios 1: 6-10.
189. Rohrbach, M.S., Williams, E.B., and Rolstad, R.A. 1981. Purification and substrate specificity of bovine angiotensin-converting enzyme. J. Biol. Chem. 256: 225-230.
190. Rokka, T., Syvaoja, E.L., Tuominen, J., and Korhonen, H. 1997. Release of bioactive peptides by enzymatic proteolysis of Lactobacillus GC fermented UHT-milk. Milchwissenchaft 52: 675-678.
191. Ryhänen, E.L., Pilhlanto-Leppälä, A., and Pahkala, K. 2001. A new type of ripened, low-fat cheese with bioactive properties. Int. Dairy J. 11: 441-447.
192. Saeed, R.W., Stefano, G.B., Murga, J.D. et al. 2000. Expression of functional delta opioid receptors in vascular smooth muscle. Int. J. Mol. Med. 6: 673-677.
193. Saiga, A.I., Tanabe, S., and Nishimura, T. 2003. Antioxidant activity of peptides obtained from porcine myofibrillar proteins by protease treatment. J. Agric. Food Chem. 51: 3661-3667.
194. Saito, T. 2008. Antihypertensive peptides derived from bovine casein and whey proteins. Adv. Exp. Med. Biol. 606: 295-317.
195. Saito, T., Nakamura, T., Kitazawa, H., Kawai, Y., and Itoh, T. 2000. Isolation and structural analysis of antihypertensive peptides that exist naturally in Gouda cheese. J. Dairy Sci. 83: 1434-1440.
196. Sanders, M.E. 1993. Effect of consumption of lactic cultures on human health. Adv. Food Nutr. Res. 37: 67-130.
197. Satake, M., Enjho, M., Nakamura, Y., Takano, T., Kawamura, Y., and Arai, S. 2002. Transepithelial transport of the bioactive tripeptide, Val-Pro-Pro, in human intestinal Caco-2 cell monolayers. Biosci. Biotech. Biochem. 66: 378-384.
198. Sato, M., Hosokawa, T., Yamaguchi, T. et al. 2002a. Angiotensin I-converting enzyme inhibitory peptides derived from wakame (Undaria pinnatifida) and their antihypertensive effect in spontaneously hypertensive rats. J. Agric. Food Chem. 50: 6245-6252.
199. Sato, M., Oba, T., Yamaguchi, T. et al. 2002b. Antihypertensive effects of hydrolysates of wakame (Undaria pinnatifida) and their angiotensin-I-converting enzyme inhibitory activity. Ann. Nutr. Metab. 46: 259-267.
200. Scruggs, P., Filipeanu, C.M., Yang, J., Kang Chang, J., and Dun, N.J. 2004. Interaction of ovokinin (2-7) with vascular bradykinin 2 receptors. Reg. Pep. 120: 85-91.
201. Sekiya, S., Kobayashi, Y., Kita, E., Imamura, Y., and Toyama, S. 1992. Antihypertensive effects of tryptic hydrolysate of casein on normotensive and hypertensive volunteers. J. Nutr. Food Sci. 45: 513-517.
202. Seppo, L., Jauhiainen, T., Poussa, T., and Korpela, R. 2003. A fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects. Am. J. Clin. Nutr. 77: 326-330.
203. Seppo, L., Kerojoki, O., Suomalainen, T., and Korpela, R. 2002. The effect of a Lactobacillus helveticus LBK-16 H fermented milk on hypertension: A pilot study on humans. Milchwissenschaft 57: 124-127.
204. Sexton, J.M., Britton, S.L., Beierwaltes, W.H., Fiksen-Olsen, M.J., and Romero, J.C. 1979. Formation of angiotensin III from [des-Asp1] angiotensin I in the mesenteric vasculature. Am. J. Physiol. 237: H218-H223.
205. Shimizu, M., Tsunogai, M., and Arai, S. 1997. Transepithelial transport of oligopeptides in the human intestinal cell, Caco-2. Peptides 18: 681-687.
206. Shin, Z.I., Ahn, C.W., Nam, H.S., Lee, H.J., Lee, H.J., and Moon, T.H. 1995. Fraction of angiotensin converting enzyme (ACE) inhibitory peptide from soybean paste. Kor. J. Food Sci. Tech. 27: 230-234.
207. Sipola, M., Finckenberg, P., Korpela, R., Vapaatalo, H., and Nurminen, M.A. 2002. Effect of long-term intake of milk products on blood pressure in hypertensive rats. J. Dairy Res. 69: 103-111.
208. Sipola, M., Finckenberg, P., Santisteban, J., Korpela, R., Vapaatalo, H., and Nurminen, M.L. 2001. Long-term intake of milk peptides attenuates development of hypertension in spontaneously hypertensive rats. J. Phys. Pharm. 52: 745-754.
209. Sirén, A.L. and Feuerstein, G. 1992. The opioid system in circulatory control. NIPS 7: 26-30.
210. Smacchi, E. and Gobbetti, M. 1998. Peptides from several Italian cheeses inhibitory to proteolytic enzymes of acid lactic bacteria, Pseudomonas fluorescens ATCC 948 and to the angiotensin I-converting enzyme. Enzyme Microb. Technol. 22: 687-694.
211. Song, L. and Healy, D.P. 1999. Kidney aminopeptidase A and hypertension, part II: Effects of angiotensin II. Hypertension 33: 746-752.
212. Srinivas, L., Shalini, V.K., and Shylaja, M. 1992. Turmerin: A water soluble antioxidant peptide from tumeric (Curcuma longa). Arch. Biochem. Biophys. 292: 617-623.
213. Stadman, E.R. 1993. Oxidation of free amino acids and amino acid residues in proteins by radiolysis and by metal-catalyzed reactions. Ann. Rev. Biochem. 62: 797-821.
214. Stepaniak, L., Fox, P.F., Sorhaug, T., and Grabska, J. 1995. Effect of peptides from the sequence 58-72 of β-casein on the activity of endopeptidase, aminopeptidase and x-prolyldipeptidyl aminopeptidase from Lactococcus lactis ssp. lactis MG1363. J. Agric. Food Chem. 43: 849-853.
215. Suetsuna, K. 1998. Isolation and characterization of angiotensin I-converting enzyme inhibitor dipeptides derived from sardine muscle. J. Nutr. Biochem. 9: 415-419.
216. Suetsuna, K., Maekawa, K., and Chen, J.R. 2004. Antihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats. J. Nutr. Biochem. 15: 267-272.
217. Suetsuna, K. and Nakano, T. 2000. Identification of an antihypertensive peptide from peptic digests of wakame (Undaria pinnatifida). J. Nutr. Biochem. 11: 450-454.
218. Suetsuna, K. and Osajima, K. 1986. The inhibitory activities against angiotensin I-converting enzyme of basic peptides originating from sardine and hair tail meat. Bull. Jpn. Soc. Sci. Fish 5: 1981-1984.
219. Suetsuna, K. and Osajima, K. 1989. Blood pressure reduction and vasodilatory effects in vivo of peptides originating from sardine muscle. Nippon Eiyou, Shokuryou Gakkaishi 52:47-51.
220. Suetsuna, K., Ukeda, H., and Ochi, H. 2000. Isolation and characterization of free radical scavenging activities of peptides derived from casein. J. Nutr. Biochem. 11: 128-131.
221. Sugai, R. 1998. ACE inhibitors and functional foods. Bull. IDF 336: 17-20.
222. Suh, H.J. and Whang, J.H. 1999. A peptide from corn gluten hydroysate that is inhibi­tory toward angiotensin-I converting enzyme. Biotechnol. Lett. 21: 1055-1058.
223. Sun, J., He, H., and Xie, B. J. 2004. Novel antioxidant peptides from fermented mushroom Ganoderma lucidum. J. Agric. Food. Chem. 52: 6646-6652.
224. Swanson, G.N., Hanesworth, J.M., Sardinia, M.F. et al. 1992. Discovery of a distinct binding site for angiotensin II (3-8), a putative angiotensin IV receptor. Regul. Pept. 40: 409-419.
225. Tom, B., Dendorfer, A., de Vries, R., Saxena, P.R., and Jan Danser, A.H. 2002. Bradykinin potentiation by ACE inhibitors: A matter of metabolism. Br. J. Pharmacol. 137: 276-284.
226. Tong, L.M., Sasaki, S., McClements, D.J., and Decker, E.A. 2000. Mechanisms of the antioxidant activity of a high molecular weight fraction of whey. J. Agric. Food Chem. 48: 1473-1478.
227. Tonouchi, H., Suzuki, M., Uchida, M., and Oda, M. 2008. Antihypertensive effect of an angiotensin converting enzyme inhibitory peptide from enzyme modified cheese. J. Dairy Res. 75: 284-290.
228. Toshiro, M., Ueno, T., Tanaka, M., Oka, H., Miyamoto, T., Osajima, K., and Matsumoto, K. 2005. Antiproliferative action of an angiotensin I-converting enzyme inhibitory peptide, Val-Tyr, via an L-type Ca2+ channel inhibition in cultured vascular smooth muscle cells. Hypertens. Res. 28: 545-552.
229. Townsend, R.R., McFadden, C.B., Ford, V., and Cadeé, J.A. 2004. A randomized, doubled-blind, placebo controlled trial of casein protein hydrolysate (C12 peptide) in human essential hypertension. Am. J. Hyperten. 17: 1056-1058.
230. Trippodo, N.C. and Frohlich, E.D. 1981. Similarities of genetic (spontaneous) hyper­tension in man and rat. Circ. Res. 48: 09-319.
231. Tsuge, N., Eikawa, Y., Nomura, Y., Yamamoto, M., and Sugisawa, K. 1991. Antioxidative activity of peptides prepared by enzymic hydrolysis of egg-white albumin. J. Agric. Chem. Soc. Japan 65: 1635-1641.
232. Tuomilehto, J., Lindstrom, J., Hyyrynen, J. et al. 2004. Effect of ingesting sour milk fermented using Lactobacillus helveticus bacteria producing tripeptides on blood pressure in subjects with mild hypertension. J. Hum. Hypertens. 18: 705-802.
233. Turgeon, S.L. and Gauthier, S.F. 1990. Whey peptide fractions obtained with a 2-step ultrafiltration process-Production and characterization. J. Food Sci. 55: 106-108.
234. Turner, A.J. and Hooper, N.M. 2002. The angiotensin-converting enzyme gene family: Genomics and pharmacology. Trends Pharmacol Sci 23: 177-183.
235. Urata, H., Nishimura, H., and Ganten, D. 1996. Chymase-dependent angiotensin II forming systems in humans. Am. J. Hypertens. 9: 277-284.
236. VanderJagt, D.J., Okolo, S.N., Costanza, A., Blackwell, W., and Glew, R.H. 2001. Antioxidant content of the milk of Nigerian women and the sera of their exclusively breastfed infants. Nutr. Res. 21: 121-128.
237. Vermeirssen, V., Deplancke, B., Tappenden, K.A., Van Camp, J., Gaskins, H.R., and Verstraete, W. 2002. Intestinal transport of the lactokinin Ala-Leu-Pro-Met-His-Ile-Arg through a Caco-2 monolayer. J. Pept. Sci. 8(3): 95-100.
238. Vermeirssen, V., Van Camp, J., Decroos, K., Van Wijmelbeke, L., and Verstraete, W. 2003. The impact of fermentation and in vitro digestion on the formation of angiotensin-I-converting enzyme inhibitory activity from pea and whey protein. J. Dairy Sci. 86: 429-438.
239. Vermeirssen, V., Van Camp, J., and Verstraete, W. 2002. Optimisation and validation of an angiotensin-converting enzyme inhibition assay for the screening of bioactive peptides. J Biochem. Biophys. Methods 51:75-87.
240. Vermeirssen, V., Van Camp, J., and Verstraete, W. 2004. Bioavailability of angiotensin I converting enzyme inhibitory peptides. Br. J. Nutr. 92: 357-366.
241. Visser, S., Noorman, H.J., Slangeen, C.J., and Rollema, H.S. 1989. Action of plasmin on bovine β-casein in a membrane reactor. J. Dairy Res. 56: 323-333.
242. Viveros, O.H., Diliberto, E.J., Hazum, E.L., and Chang, K.J. 1979. Opiate-like material in the adrenal medulla: evidence for storage and secretion with catecholamines. Mol. Pharmacol. 16: 1101-1108.
243. Vogt, W. 1995. Oxidation of methionyl residues in proteins: Tools, targets, and reversal. Free Radic. Biol. Med. 18: 93-105.
244. Vreeman, H.J., Both, P., and Slangen, C.J. 1994. Rapid procedure for isolating the bitter carboxyl-terminal fragment 193-209 of β-casein on a preparative-scale. Neth. Milk Dairy J. 48: 63-70.
245. Walsh, D.J., Bernard, H., and Murray, B.A. et al. 2004. In vitro generation and stability of the lactokinin beta-lactoglobulin fragment (142-148). J. Dairy Sci. 87: 3845-3857.
246. Williams, T.A., Barnes, K., Kenny, A.J., Turner, A.J., and Hooper, N.M. 1992. A comparison of the zinc contents and substrate specificities of the endothelial and testicular forms of porcine angiotensin converting enzyme and the preparation of isoenzyme-specific antisera. Biochem. J. 288: 875-881.
247. Wolf-Maier, K., Cooper, R.S., Kramer, H. et al. 2004. Hypertension treatment and control in five European countries, Canada, and the United States. Hypertension 43: 10-17.
248. Wu, J. and Ding, X. 2001. Hypotensive and physiological effect of angiotensin converting enzyme inhibitory peptides derived from soy protein on spontaneously hypertensive rats. J. Agric. Food Chem. 49: 501-506.
249. Yamada, Y., Matoba, N., Usiu, H., Onishi, K., and Yoshikawa, M. 2002. Design of a highly potent antihypertensive peptide based on Ovokinin (2-7). Biosci. Biotech. Biochem. 66: 1213-1217.
250. Yamada, Y., Yamauchi, D., Yokoo, M., Ohinata, K., Usui, H., and Yoshikawa, M. 2008. A potent hypotensive peptide, novokinin, induces relaxation by AT2-and IP-receptor-dependent mechanism in the mesenteric artery from SHRs. Biosci. Biotechnol. Biochem. 72: 257-259.
251. Yamamoto, N., Akino, A., and Takano, T. 1994. Antihypertensive effects of different kinds of fermented milk in spontaneoulsy hypertensive rats. Biosci. Biotechnol. Biochem. 58: 776-778.
252. Yanagisawa, M., Kurihara, H., Kimura, S., Goto, K., and Masaki, T. 1988. A novel peptide vasoconstrictor, endothelin, is produced by vascular endothelium and modulates smooth muscle Ca2+ channels. J. Hypertens. Suppl 6: S188-S191.
253. Yang, H.Y., Yang, S.C., Chen, J.R., Tzeng, Y.H., and Han, B.C. 2004. Soyabean protein hydrolysate prevents the development of hypertension in spontaneously hypertensive rats. Br. J. Nutr. 92: 507-512.
254. Yang, Y., Marczak, E.D., Usui, H., Kawamura, Y., and Yoshikawa, M. 2004. Antihypertensive properties of spinach leaf protein digests. J. Agric. Food Chem. 52: 2223-2225.
255. Yang, Y., Marczak, E.D., Yokoo, M., Usui, H., and Yoshikawa, M. 2003. Isolation and antihypertensive effect of ACE-inhibitory peptides from spinach rubisco. J. Agric. Food Chem. 51: 4897-4902.
256. Yee, J.J. and Shipe, W.F. 1981. Using enzymatic proteolysis to reduce copper-protein catalysis of lipid oxidation. J. Food Sci. 46: 966-969.
257. Yokoyama, K., Chiba, H., and Yoshikawa, M. 1992. Peptide inhibitors for angiotensin I-converting enzyme from thermolysin digest of dried bonito. Biosci. Biotech. Biochem. 56: 1541-1545.
258. Yoshii, H., Tachi, N., Ohba, R., Sakamura, O., Takemaya, H., and Itani, T. 2001. Antihypertensive effect of ACE inhibitory oligopeptides from chicken egg yolks. Com. Biochem. Physiol. Part C 128: 27-33.
259. Yoshikawa, M. and Chiba, H. 1990. Biologically active peptides derived from milk proteins. Japan J. Dairy Food Sci. 39: A315-A321.
260. Yoshikawa, M., Tani, F., and Chiba, H. 1988. Structure-activity relationship of opioid antagonist peptides derived from milk proteins. In Peptide Chemistry (T. Shiba, Ed.), Osaka: Protein Research Foundation, pp. 473-476.
261. Yu, R., Park, S.A., Chung, D.K., Nam, H., and Shin, Z.I. 1996. Effect of soybean hydrolysate on hypertension in spontaneously hypertensive rats. J. Korean Soc. Food Sci. Nutr. 25: 1031-1036.
262. Zárate, G., Chaia, A.P., González, S., and Oliver, G. 2000. Viability and β-galactosidase activity of dairy propionibacteria subjected to digestion by artificial gastric and intestinal fluids. J. Food Prot. 63: 1214-1221.
263. Zhu, X.L., Watanabe, K., Shiraishi, K., Ueki, T., Noda, Y., Matsui, T., and Matsumoto, K. 2008. Identification of ACE-inhibitory peptides in salt-free soy sauce that are transportable across caco-2 cell monolayers. Peptides 29: 338-344.
264. Zicha, J. and Kunes, J. 1999. Ontogenetic aspects of hypertension development: Analysis in the rat. Physiol. Rev. 79: 1227-1282.