Antihypertensive effect of peptides obtained from Enterococcus faecalis-fermented milk in rats

Journal of Dairy Science

Volumn 89, Issue 9, 2006, Pages 3352-3359

  Miguel, M ^a   Recio, I ^a   Ramos, M ^a   Delgado, M A ^b   Aleixandre, M A ^c  

^a INSTITUTO DE FERMENTACIONES INDUSTRIALES CSIC   (Spain)

^b Grupo Leche Pascual   (Spain)

^c SCHOOL OF MEDICINE   (Spain)

Author keywords

Angiotensin I converting enzyme inhibitory peptide; Antihypertensive peptide; Arterial blood pressure; Spontaneously hypertensive rat

Indexed keywords

ANIMALIA; ENTEROCOCCUS FAECALIS;

EID: 33748110443     PISSN: 00220302     EISSN: None     Source Type: Journal    
DOI: 10.3168/jds.S0022-0302(06)72372-4     Document Type: Article

References (33)

1. Aleixandre, A., M. Miguel, I. Recio, M. Ramos, B. Muguerza, and M. A. Delgado. 2004. Effect of different angiotensin-converting enzyme-inhibitory peptides obtained from fermented milk containing Enterococcus faecalis in SHR and WKY rats. Fund. Clin. Pharmacol 18(Suppl. 1):78.
2. Akpaffiong, M. J., and A. A. Taylor. 1998. Antihypertensive and vasodilator actions of antioxidants in spontaneously hypertensive rats. Am. J. Hypertens. 11:1450-1460.
3. Atherton, E., and R. C. Sheppard. 1989. Pages 131-140 in Solid Phase Synthesis: A Practical Approach. IRL Press, Oxford, UK.
4. Buñag, R. D. 1973. Validation in awake rats of a tail-cuff method for measuring systolic pressure. J. Appl. Physiol. 34:279-282.
5. Cheung, H. S., F. L. Wang, M. A. Ondetti, E. F. Sabo, and D. W. Cushman. 1980. Binding of peptides substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem. 25:401-407.
6. Cushman, D. W., and H. S. Cheung. 1971. Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung. Biochem. Pharmacol. 20:1637-1648.
7. Cushman, D. W., H. S. Cheung, E. F. Sabo, and M. A. Ondetti. 1977. Design of potent competitive inhibitors of angiotensin-converting enzyme. Carboxyalkanoyl and mercaptoalkanoyl amino acids. Biochemistry 16:5484-5491.
8. Dávalos, A., M. Miguel, B. Bartolomé, and R. López-Fandino. 2004. Antioxidant activity of peptides derived from egg white proteins by enzymatic hydrolysis. J. Food Prot. 67:1939-1944.
9. Fujita, H., R. Sasaki, and M. Yoshikawa. 1995. Potentiation of the antihypertensive activity of orally administered ovokinin, a vaso-relaxing peptide derived from ovalbumin, by emulsification in egg phosphatidyl-choline. Biosci. Biotechnol. Biochem. 59:2344-2345.
10. Fujita, H., H. Suganuma, H. Usui, K. Kurahashi, R. Nakagiri, R. Sasaki, and M. Yoshikawa. 1996. Vasorelaxation by casomokinin L, a derivative of β-casomorphin and casoxin D, is mediated by NK1 receptor. Peptides 17:635-639.
11. Fujita, H., and M. Yoshikawa. 1999. LKPNM: A prodrug-type ACE-inhibitory peptide derived from fish protein. Immunopharmacology 44:123-127.
12. Gómez-Ruiz, J. A., M. Ramos, and I. Recio. 2003. Angiotensin-converting enzyme-inhibitory peptides in Manchego cheeses manufactured with different starter cultures. Int. Dairy J. 12:697-706.
13. Hata, Y., M. Yamamoto, M. Ohni, K. Nakajima, Y. Nakamura, and T. Takano. 1996. A placebo-controlled study of the effect of sour milk on blood pressure in hypertensive subjects. Am. J. Clin. Nutr. 64:767-771.
14. Kato, M., Y. Fujiwara, A. Okamoto, M. Yoshikawa, H. Chiba, and S. Udaka. 1995. Efficient production of casoxin D, a bradykinin agonist peptide derived from human casein, by Bacillus brevis, Biosci. Biotechnol. Biochem. 59:2056-2059.
15. Kawasaki, T., C. J. Jun, Y. Fukushina, K. Kegai, E. Seki, K. Osajima, K. Itoh, T. Matsui, and K. Matsumoto. 2002. Antihypertensive effect and safety evaluation of vegetable drink with peptides derived from sardine protein hydrolysates on mild hypertensive, high-normal and normal blood pressure subjects. Fukuoka Igaku Zasshi 93:208-218.
16. Laragh, J. H., L. Bear, H. R. Brunner, F. G. Buhler, J. E. Ealey, and E. D. Vaughan. 1972. Renin, angiotensin and aldosterone system in pathogenesis and management of hypertensive vascular disease. Am. J. Med. 52:633-652.
17. Masuda, O., Y. Nakamura, and T. Takano. 1996. Antihypertensive peptides are present in aorta after oral administration of sour milk containing these peptides to spontaneously hypertensive rats. J. Nutr. 126:3063-3068.
18. Matoba, N., H. Usui, H. Fujita, and M. Yoshikawa. 1999. A novel anti-hypertensive peptide derived from ovalbumin induces nitric oxide-mediated vasorelaxation in an isolated SHR mesenteric artery. FEBS Lett. 452:181-184.
19. Miguel, M., B. Muguerza, E. Sánchez, M. A. Delgado, I. Recio, M. Ramos, and A. Aleixandre. 2005. Changes in arterial blood pressure in hypertensive rats caused by long-term intake of milk fermented by Enteroccocus faecalis CECT 5728. Br. J. Nutr. 93:1-9.
20. Muguerza, B., A. Delgado, A. Quirós del Bosque, I. Recio, M. Ramos, and A. Aleixandre, inventors. 2004. Cepas de Enterococcus faecalis productoras de péptidos bioactivos y sus aplicaciones. Spanish patent no. PCT/ES2004/000227.
21. Muguerza, B., M. Ramos, E. Sánchez, M. A. Manso, M. Miguel, A. Aleixandre, M. A. Delgado, and I. Recio. 2006. Antihypertensive activity of milk fermented by Enterococcus faecalis strains isolated from raw milk. Int. Dairy J. 16:61-69.
22. Nakamura, Y., O. Masuda, and T. Takano. 1996. Decrease of tissue angiotensin I-converting enzyme activity upon feeding sour milk in spontaneously hypertensive rats. Biosci. Biotechnol. Biochem. 60:488-489.
23. Nakamura, Y., N. Yamamoto, K. Sakai, A. Okubo, S. Yamazaki, and T. J. Takano. 1995a. Antihypertensive effect of sour milk and peptides isolated from it that are inhibitors to angiotensin I-converting enzyme. J. Dairy Sci. 78:1253-1257.
24. Nakamura, Y., N. Yamamoto, K. Sakai, T. Takano, A. Okubo, and S. Yamazaki. 1995b. Purification and characterization of angiotensin-converting enzyme inhibitors from sour milk. J. Dairy Sci. 78:777-783.
25. Oshima, G., H. Shimabukuro, and K. Nagasawa. 1979. Peptide inhibitors of angiotensin-I converting enzyme in digests of gelatin by bacterial collagenase. Biochim. Biophys. Acta 556:128-137.
26. Quirós, A., M. Ramos, B. Muguerza, M. A. Delgado, M. Miguel, A. Aleixandre, and I. Recio. Identification of novel antihypertensive peptides in milk fermented with Enterococcus faecalis. Int. Dairy J. (accepted)
27. Rodríguez-Iturbe, B., C. D. Zhan, Y. Quiroz, R. F. Sindhu, and N. D. Vaziri. 2003. Antioxidant-rich diet relieves hypertension and reduces renal immune infiltration in spontaneously hypertensive rats. Hypertension 41:341.
28. Sekiya, S., Y. Kobayashi, E. Kita, Y. Imamura, and S. Toyama. 1992. Antihypertensive effects of tryptic hydrolysate of casein on normotensive and hypertensive volunteers. J. Nutr. Food Sci. 45:513-517.
29. Seppo, L., T. Jauhiainen, T. Poussa, and R. Korpela. 2003. A fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects. Am. J. Clin. Nutr. 77:326-330.
30. Sipola, M. P., P. Finckenberg, R. Korpela, H. Vapaatalo, and M. A. Nurminen. 2002. Effect of long-term intake of milk products on blood pressure in hypertensive rats. J. Dairy Res. 69:103-111.
31. Sipola, M., P. Finckenberg, J. Santisteban, R. Korpela, H. Vapaatalo, and M. L. Nurminen. 2001. Long-term intake of milk peptides attenuates development of hypertension in spontaneously hypertensive rats. J. Phys. Pharm. 52:745-754.
32. Soares De Moura, R., F. S. Costa Viana, M. A. V. Souza, K. Kovary, D. C. Guedes, E. P. B. Oliveira, L. S. M. Rubenich, L. C. Carvalho, R. M. Oliveira, R. M. Tano, T. Gusmão, and M. L. Correia. 2002. Antihypertensive, vasodilator and antioxidant effects of a Vinifiera grape skin extract. J. Pharm. Pharmacol. 54:1515-1520.
33. Soffer, R. L. 1976. Angiotensin converting enzyme and the regulation of vasoactive peptides. Annu. Rev. Biochem. 45:73-94.