Lactobacillus helveticus fermented milk lowers blood pressure in hypertensive subjects in 24-h ambulatory blood pressure measurement

American Journal of Hypertension

Volumn 18, Issue 12, 2005, Pages 1600-1605

  Jauhiainen, Tiina ^a,b   Vapaatalo, Heikki ^a   Poussa, Tuija ^c   Kyrönpalo, Sinikka ^d   Rasmussen, Martin ^d   Korpela, Riitta ^a,b,e  

^a UNIVERSITY OF HELSINKI   (Finland)

^b VALIO LTD   (Finland)

^c STAT Consulting   (Finland)

^d Department of Social Services and Health Care ^*  (Finland)

^e FOUNDATION FOR NUTRITION RESEARCH   (Finland)

Author keywords

Ambulatory blood pressure measurement; Biologically active tripeptides; Fermented milk; Hypertension; Lactobacillus helveticus

Indexed keywords

ISOLEUCYLPROLYLPROLINE; MILK PROTEIN; PLACEBO; TRIPEPTIDE; UNCLASSIFIED DRUG; VALYLPROYLPROLINE;

ADULT; ARTICLE; BLOATING; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE REGULATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DIASTOLIC BLOOD PRESSURE; DIET THERAPY; DOUBLE BLIND PROCEDURE; FERMENTED PRODUCT; FLATULENCE; FOOD SAFETY; GYNECOLOGIC DISEASE; HUMAN; HYPERTENSION; INFLAMMATION; INFLUENZA; KNEE PAIN; LACTOBACILLUS HELVETICUS; MAJOR CLINICAL STUDY; MILK; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; STOMACH PAIN; SYSTOLIC BLOOD PRESSURE; URINARY TRACT DISEASE;

ANALYSIS OF VARIANCE; ANIMALS; BLOOD PRESSURE; BLOOD PRESSURE MONITORING, AMBULATORY; CIRCADIAN RHYTHM; DOUBLE-BLIND METHOD; FEMALE; FERMENTATION; HUMANS; HYPERTENSION; LACTOBACILLUS HELVETICUS; MALE; MILK; MILK PROTEINS; OFFICE VISITS; OLIGOPEPTIDES;

EID: 29144450330     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjhyper.2005.06.006     Document Type: Article

References (16)

1. Y. Nakamura, N. Yamamoto, K. Sakai, T. Takano Antihypertensive effect of sour milk and peptides isolated from it that are inhibitors to angiotensin I-converting enzyme J Dairy Sci 78 1995 1253 1257
2. M. Sipola, P. Finckenberg, R. Korpela, H. Vapaatalo, M.L. Nurminen Effect of long-term intake of milk products on blood pressure in hypertensive rats J Dairy Res 69 2002 103 111
3. M. Sipola, P. Finckenberg, J. Santisteban, R. Korpela, H. Vapaatalo, M.L. Nurminen Long-term intake of milk peptides attenuates development of hypertension in spontaneously hypertensive rats J Physiol Pharmacol 52 2001 745 754
4. L. Seppo, T. Jauhiainen, T. Poussa, R. Korpela A fermented milk high in bioactive peptides has a blood pressure lowering effect in hypertensive subjects Am J Clin Nutr 77 2003 326 330
5. L. Seppo, O. Kerojoki, T. Suomalainen, R. Korpela The effect of a Lactobacillus helveticus LBK-16H fermented milk on hypertension - a pilot study on humans Milk Sci Int 57 2002 124 127
6. O. Masuda, Y. Nakamura, T. Takano Antihypertensive peptides are present in aorta after oral administration of sour milk containing these peptides to spontaneously hypertensive rats J Nutr 126 1996 3063 3068
7. Y. Nakamura, O. Masuda, T. Takano Decrease of tissue angiotensin I-converting enzyme activity upon feeding sour milk in spontaneously hypertensive rats Biosci Biotechnol Biochem 60 1996 488 489
8. G. Beevers, G.Y. Lip, E. O'Brien ABC of hypertension. Blood pressure measurement. Part I - sphygmomanometry factors common to all techniques BMJ 322 2001 981 985
9. W.T. Friedewald, R.I. Levy, D.S. Fredrickson Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge Clin Chem 18 1972 499 502
10. S. MacMahon, A. Rodgers, B. Neal, J. Chalmers Blood pressure lowering for the secondary prevention of myocardial infarction and stroke Hypertension 29 1997 537 538
11. M. Satake, M. Enjoh, Y. Nakamura, T. Takano, Y. Kawamura, S. Arai, M. Shimizu Transepithelial transport of the bioactive tripeptide, Val-Pro-Pro, in human intestinal Caco-2 cell monolayers Biosci Biotechnol Biochem 66 2002 378 384
12. L.E. Griffith, G.H. Guyatt, R.J. Cook, H.C. Bucher, D.J. Cook The influence of dietary and nondietary calcium supplementation on blood pressure an updated meta-analysis of randomized controlled trials Am J Hypertens 12 1999 84 92
13. P.K. Whelton, J. He, J.A. Cutler, F.L. Brancati, L.J. Appel, D. Follmann, M.J. Klag Effects of oral potassium on blood pressure Meta-analysis of randomized controlled clinical trials JAMA 277 1997 1624 1632
14. M. Narva, R. Nevala, T. Poussa, R. Korpela The effect of Lactobacillus helveticus fermented milk on acute changes in calcium metabolism in postmenopausal women Eur J Nutr 43 2004 61 68
15. 45Ca disappearance and temporal systolic blood pressure in spontaneously hypertensive rats Br J Nutr 68 1992 765 781
16. H.D. Sesso, J.E. Buring, N. Rifai, G.J. Blake, J.M. Gaziano, P.M. Ridker C-reactive protein and the risk of developing hypertension JAMA 290 2003 2945 2951