Purification and identification of potentially bioactive peptides from enzyme-modified cheese

Journal of Dairy Science

Volumn 82, Issue 8, 1999, Pages 1612-1617

  Haileselassle, S S ^a   Lee, B H ^a,b   Gibbs, B F ^a  

^a MCGILL UNIVERSITY   (Canada)

^b FOOD RESEARCH AND DEVELOPMENT CENTRE   (Canada)

Author keywords

Antihypertensive peptide; Bioactive peptide; Enzyme modified cheese; Lactobacillus casei

Indexed keywords

LACTOBACILLUS CASEI;

AMINOPEPTIDASE; ANTIHYPERTENSIVE AGENT; BETA CASOMORPHINS; BETA-CASOMORPHINS; CASEIN; CYTOSOL AMINOPEPTIDASE; ENDORPHIN; METALLOPROTEINASE; MICROBIAL METALLOPROTEINASES; PEPTIDE;

AMINO ACID SEQUENCE; ARTICLE; CHEESE; CHEMISTRY; ENZYMOLOGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION AND PURIFICATION; LACTOBACILLUS CASEI; MASS SPECTROMETRY; MOLECULAR GENETICS;

AMINO ACID SEQUENCE; AMINOPEPTIDASES; ANTIHYPERTENSIVE AGENTS; CASEINS; CHEESE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENDORPHINS; LACTOBACILLUS CASEI; LEUCYL AMINOPEPTIDASE; MASS SPECTROMETRY; METALLOENDOPEPTIDASES; MOLECULAR SEQUENCE DATA; PEPTIDES;

EID: 0033174892     PISSN: 00220302     EISSN: None     Source Type: Journal    
DOI: 10.3168/jds.s0022-0302(99)75389-0     Document Type: Article

References (19)

1. Arora, G., and B. H. Lee. 1992. Purification and characterization of aminopeptidase from Lactobacillus casei ssp. casei LLG. J. Dairy Sci. 75:700-710.
2. Cliffe, A. J., and B. A. Law. 1990. Peptide composition of enzyme-treated Cheddar cheese slurries, determined by reverse phase high performance liquid chromatography. Food Chem. 36:73-80.
3. Covey, T. R., R. F. Bonner, B. I. Shushan, and J. Henion. 1988. The determination of protein, oligonucleotide and peptide weights by ion spray mass spectrometry. Rapid communication. Mass Spectrom. 2:249.
4. Daniel, H., M. Vohwinkel, and G. Rehner. 1990. Effect of casein and β-casomorphin on gastrointestinal motility in rats. J. Nutr. 120:252-257.
5. Harwalkar, V. R., and D. J. McMahon. 1993. Symposium: biological and food functional characteristics of milk protein hydrolysis products. Introduction. J. Dairy Sci. 76:300.
6. Kreil, G., M. Umbach, V. Brantl, and H. Teschemacher. 1983. Studies of the enzymatic degradation of β-casomorphins. Life Sci. 33:137-140.
7. Kuwabura, Y., S. Nagai, N. Yoshimutu, I. Nakagawa, Y. Watanabe, and Y. Tamai. 1995. Antihypertensive effect of the milk fermented by culturing with various lactic acid bacteria and a yeast. J. Ferment. Bioeng. 80:294-295.
8. Maeno, M., N. Yamamoto, and T. Takano. 1996. Identification of antihypertensive peptide from casein hydrolysate produced by Lactobacillus helveticus CP790. J. Dairy Sci. 79:1316-1321.
9. MaGugan, W. A. 1975. Cheddar cheese flavour: a review of current progress. J. Agric. Food Chem. 23:1047-1050.
10. Maruyama, S., and H. Suzuki. 1982. A peptide inhibitor of angiotensin I-converting enzyme in the tryptic hydrolysate of casein. Agric. Biol. Chem. 46:1393-1394.
11. Meisel, H. 1997. Biochemical properties of regulatory peptides derived from milk protein. Peptide Sci. 43:119-128.
12. Minagawa, H., S. Kobayashi, S. Shimamura, and M. Tomita. 1989. Debittering mechanism in bitter peptides of enzymatic hydrolysates from milk casein by aminopeptidase. J. Food Sci. 54:1225-1229.
13. Mullaly, M. M., H. Meisel, and R. J. FitzGerald. 1997. Angiotensin I-converting enzyme inhibitory activities of gastric and pancreatic proteinase digests of whey proteins. Int. Dairy J. 7: 299-303.
14. Nakamura, Y., N. Yamamoto, K. Sakai, A. Okubo, S. Yamazaki, and T. Takano. 1995. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J. Dairy Sci. 78:777-783.
15. Park, S. Y., B. F. Gibbs, and B. H. Lee. 1995. Effects of crude enzyme of Lactobacillus casei LLG on water-soluble peptides of enzyme-modified cheese. Food Res. Int. 28:43-49.
16. Park, S. Y., B. F. Gibbs, and B. H. Lee. 1996. Identification of peptides derived from β-casein hydrolysates by proteolytic enzymes. Korean J. Dairy Sci. 18:237-246.
17. Schlimme, E., H. Meisel, and H. Frister. 1988. Bioactive sequences in milk proteins. Pages 143-149 in Milk Proteins: Nutritional, Clinical, Functional and Technological Aspects. E. Schlimme, ed. New York, NY.
18. Yamamoto, N. 1997. Antihypertensive peptides derived from food proteins. Peptide Sci. 43:129-134.
19. Yamamoto, N., A. Akino, and T. Takano. 1994. Antihypertensive effect of the peptides derived from casein by extracellular proteinase from Lactobacillus helveticus CP790. J. Dairy Sci. 77:917-922.