Strategies toward predicting peptide cellular permeability from computed molecular descriptors

Journal of Peptide Research

Volumn 53, Issue 4, 1999, Pages 355-369

  Goodwin, Jay T ^a   Mao, B ^b   Vidmar, T J ^c   Conradi, R A ^a   Burton, P S ^a  

^a Drug Absorption and Transport   (United States)

^b NONE   (United States)

^c Pharmacia and Upjohn   (United States)

Author keywords

Cellular permeability; Computed surface areas; Hydrogen bond potential; Lipophilicity

Indexed keywords

PEPTIDE;

ARTICLE; CELL MEMBRANE PERMEABILITY; CELL MEMBRANE TRANSPORT; CELL STRAIN CACO 2; DRUG DELIVERY SYSTEM; DRUG POTENCY; DRUG SELECTIVITY; HYDROGEN BOND; LIPID BILAYER; LIPID MONOLAYER; LIPOPHILICITY; MATHEMATICAL COMPUTING; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN STRUCTURE; SOLVATION; STRUCTURE ACTIVITY RELATION;

ADENOCARCINOMA; CELL MEMBRANE PERMEABILITY; COLONIC NEOPLASMS; COMPUTER SIMULATION; DRUG DESIGN; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MONTE CARLO METHOD; PEPTIDES; TUMOR CELLS, CULTURED;

EID: 0033002003     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3011.1999.00072.x     Document Type: Article

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