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Volumn 102, Issue 2, 2017, Pages 369-380

Energy metabolic pathways control the fate and function of myeloid immune cells

Author keywords

Dendritic cell; Macrophage; MDSC; Neutrophil

Indexed keywords

ADAPTIVE IMMUNITY; BONE MARROW CELL; CELL DIFFERENTIATION; CELL FATE; CELL FUNCTION; CELL METABOLISM; CELLULAR IMMUNITY; DENDRITIC CELL; ENERGY METABOLISM; HUMAN; IMMUNOCOMPETENT CELL; INNATE IMMUNITY; MACROPHAGE; MYELOID-DERIVED SUPPRESSOR CELL; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; CYTOLOGY; IMMUNOLOGY; METABOLISM;

EID: 85026760035     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.1VMR1216-535R     Document Type: Review
Times cited : (45)

References (157)
  • 1
    • 84896905991 scopus 로고    scopus 로고
    • Metabolic regulation of immune responses
    • Ganeshan, K., Chawla, A. (2014) Metabolic regulation of immune responses. Annu. Rev. Immunol. 32, 609–634.
    • (2014) Annu. Rev. Immunol. , vol.32 , pp. 609-634
    • Ganeshan, K.1    Chawla, A.2
  • 2
    • 84960399221 scopus 로고    scopus 로고
    • Immunometabolism governs dendritic cell and macrophage function
    • O’Neill, L. A., Pearce, E. J. (2016) Immunometabolism governs dendritic cell and macrophage function. J. Exp. Med. 213, 15–23.
    • (2016) J. Exp. Med. , vol.213 , pp. 15-23
    • O’Neill, L.A.1    Pearce, E.J.2
  • 4
    • 84876758617 scopus 로고    scopus 로고
    • Metabolic pathways in immune cell activation and quiescence
    • Pearce, E. L., Pearce, E. J. (2013) Metabolic pathways in immune cell activation and quiescence. Immunity 38, 633–643.
    • (2013) Immunity , vol.38 , pp. 633-643
    • Pearce, E.L.1    Pearce, E.J.2
  • 5
    • 84885670616 scopus 로고    scopus 로고
    • Fueling immunity: Insights into metabolism and lymphocyte function
    • Pearce, E. L., Poffenberger, M. C., Chang, C. H., Jones, R. G. (2013) Fueling immunity: insights into metabolism and lymphocyte function. Science 342, 1242454.
    • (2013) Science , vol.342
    • Pearce, E.L.1    Poffenberger, M.C.2    Chang, C.H.3    Jones, R.G.4
  • 6
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden, M. G., Cantley, L. C., Thompson, C. B. (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324, 1029–1033.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 7
    • 0001221508 scopus 로고
    • On respiratory impairment in cancer cells
    • Warburg, O. (1956) On respiratory impairment in cancer cells. Science 124, 269–270.
    • (1956) Science , vol.124 , pp. 269-270
    • Warburg, O.1
  • 9
    • 85011588765 scopus 로고    scopus 로고
    • The NADPH oxidase and microbial killing by neutrophils, with a particular emphasis on the proposed antimicrobial role of myeloperoxidase within the phagocytic vacuole
    • MCHD-0018-2015
    • Levine, A. P., Segal, A. W. (2016) The NADPH oxidase and microbial killing by neutrophils, with a particular emphasis on the proposed antimicrobial role of myeloperoxidase within the phagocytic vacuole. Microbiol. Spectr. 4, MCHD-0018-2015.
    • (2016) Microbiol. Spectr. , vol.4
    • Levine, A.P.1    Segal, A.W.2
  • 10
    • 0000054142 scopus 로고
    • The biochemical basis of phagocytosis. I. Metabolic changes during the ingestion of particles by polymorphonuclear leukocytes
    • Sbarra, A. J., Karnovsky, M. L. (1959) The biochemical basis of phagocytosis. I. Metabolic changes during the ingestion of particles by polymorphonuclear leukocytes. J. Biol. Chem. 234, 1355–1362.
    • (1959) J. Biol. Chem. , vol.234 , pp. 1355-1362
    • Sbarra, A.J.1    Karnovsky, M.L.2
  • 11
    • 0344521566 scopus 로고
    • Biochemical studies on leucocytes. I. Phosphatase activity in health, leucocytosis, and myelocytic leucemia
    • Valentine, W. N., Beck, W. S. (1951) Biochemical studies on leucocytes. I. Phosphatase activity in health, leucocytosis, and myelocytic leucemia. J. Lab. Clin. Med. 38, 39–55.
    • (1951) J. Lab. Clin. Med. , vol.38 , pp. 39-55
    • Valentine, W.N.1    Beck, W.S.2
  • 12
    • 84878533006 scopus 로고    scopus 로고
    • Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human blood
    • Chacko, B. K., Kramer, P. A., Ravi, S., Johnson, M. S., Hardy, R. W., Ballinger, S. W., Darley-Usmar, V. M. (2013) Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human blood. Lab. Invest. 93, 690–700.
    • (2013) Lab. Invest. , vol.93 , pp. 690-700
    • Chacko, B.K.1    Kramer, P.A.2    Ravi, S.3    Johnson, M.S.4    Hardy, R.W.5    Ballinger, S.W.6    Darley-Usmar, V.M.7
  • 13
    • 0037442128 scopus 로고    scopus 로고
    • The mitochondrial network of human neutrophils: Role in chemotaxis, phagocytosis, respiratory burst activation, and commitment to apoptosis
    • Fossati, G., Moulding, D. A., Spiller, D. G., Moots, R. J., White, M. R., Edwards, S. W. (2003) The mitochondrial network of human neutrophils: role in chemotaxis, phagocytosis, respiratory burst activation, and commitment to apoptosis. J. Immunol. 170, 1964–1972.
    • (2003) J. Immunol. , vol.170 , pp. 1964-1972
    • Fossati, G.1    Moulding, D.A.2    Spiller, D.G.3    Moots, R.J.4    White, M.R.5    Edwards, S.W.6
  • 14
    • 84893196785 scopus 로고    scopus 로고
    • A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: Implications for their use as bioenergetic biomarkers
    • Kramer, P. A., Ravi, S., Chacko, B., Johnson, M. S., Darley-Usmar, V. M. (2014) A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: implications for their use as bioenergetic biomarkers. Redox Biol. 2, 206–210.
    • (2014) Redox Biol , vol.2 , pp. 206-210
    • Kramer, P.A.1    Ravi, S.2    Chacko, B.3    Johnson, M.S.4    Darley-Usmar, V.M.5
  • 16
    • 0019969614 scopus 로고
    • Energy metabolism of human neutrophils during phagocytosis
    • Borregaard, N., Herlin, T. (1982) Energy metabolism of human neutrophils during phagocytosis. J. Clin. Invest. 70, 550–557.
    • (1982) J. Clin. Invest. , vol.70 , pp. 550-557
    • Borregaard, N.1    Herlin, T.2
  • 17
    • 0021684935 scopus 로고
    • Priming of neutrophils for enhanced release of oxygen metabolites by bacterial lipopolysaccharide. Evidence for increased activity of the superoxide-producing enzyme
    • Guthrie, L. A., McPhail, L. C., Henson, P. M., Johnston, R. B. Jr. (1984) Priming of neutrophils for enhanced release of oxygen metabolites by bacterial lipopolysaccharide. Evidence for increased activity of the superoxide-producing enzyme. J. Exp. Med. 160, 1656–1671.
    • (1984) J. Exp. Med. , vol.160 , pp. 1656-1671
    • Guthrie, L.A.1    McPhail, L.C.2    Henson, P.M.3    Johnston, R.B.4
  • 18
    • 84861034431 scopus 로고    scopus 로고
    • The impact of various reactive oxygen species on the formation of neutrophil extracellular traps
    • Kirchner, T., Möller, S., Klinger, M., Solbach, W., Laskay, T., Behnen, M. (2012) The impact of various reactive oxygen species on the formation of neutrophil extracellular traps. Mediators Inflamm. 2012, 849136.
    • (2012) Mediators Inflamm , vol.2012
    • Kirchner, T.1    Möller, S.2    Klinger, M.3    Solbach, W.4    Laskay, T.5    Behnen, M.6
  • 20
    • 44349150953 scopus 로고    scopus 로고
    • Mitochondrial membrane potential in human neutrophils is maintained by complex III activity in the absence of supercomplex organisation
    • Van Raam, B. J., Sluiter, W., de Wit, E., Roos, D., Verhoeven, A. J., Kuijpers, T. W. (2008) Mitochondrial membrane potential in human neutrophils is maintained by complex III activity in the absence of supercomplex organisation. PLoS One 3, e2013.
    • (2008) Plos One , vol.3
    • Van Raam, B.J.1    Sluiter, W.2    De Wit, E.3    Roos, D.4    Verhoeven, A.J.5    Kuijpers, T.W.6
  • 24
    • 84873743410 scopus 로고    scopus 로고
    • M1 and M2 macrophages: Oracles of health and disease
    • Mills, C. D. (2012) M1 and M2 macrophages: oracles of health and disease. Crit. Rev. Immunol. 32, 463–488.
    • (2012) Crit. Rev. Immunol. , vol.32 , pp. 463-488
    • Mills, C.D.1
  • 25
    • 84876800337 scopus 로고    scopus 로고
    • Macrophage biology in development, homeostasis and disease
    • Wynn, T. A., Chawla, A., Pollard, J. W. (2013) Macrophage biology in development, homeostasis and disease. Nature 496, 445–455.
    • (2013) Nature , vol.496 , pp. 445-455
    • Wynn, T.A.1    Chawla, A.2    Pollard, J.W.3
  • 26
    • 76249095169 scopus 로고    scopus 로고
    • Development of monocytes, macrophages, and dendritic cells
    • Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., Ley, K. (2010) Development of monocytes, macrophages, and dendritic cells. Science 327, 656–661.
    • (2010) Science , vol.327 , pp. 656-661
    • Geissmann, F.1    Manz, M.G.2    Jung, S.3    Sieweke, M.H.4    Merad, M.5    Ley, K.6
  • 30
    • 56149103896 scopus 로고    scopus 로고
    • Macrophage polarization in bacterial infections
    • Benoit, M., Desnues, B., Mege, J. L. (2008) Macrophage polarization in bacterial infections. J. Immunol. 181, 3733–3739.
    • (2008) J. Immunol. , vol.181 , pp. 3733-3739
    • Benoit, M.1    Desnues, B.2    Mege, J.L.3
  • 31
    • 84871076444 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization in tissue repair and remodelling
    • Mantovani, A., Biswas, S. K., Galdiero, M. R., Sica, A., Locati, M. (2013) Macrophage plasticity and polarization in tissue repair and remodelling. J. Pathol. 229, 176–185.
    • (2013) J. Pathol. , vol.229 , pp. 176-185
    • Mantovani, A.1    Biswas, S.K.2    Galdiero, M.R.3    Sica, A.4    Locati, M.5
  • 32
    • 80355131976 scopus 로고    scopus 로고
    • Protective and pathogenic functions of macrophage subsets
    • Murray, P. J., Wynn, T. A. (2011) Protective and pathogenic functions of macrophage subsets. Nat. Rev. Immunol. 11, 723–737.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 723-737
    • Murray, P.J.1    Wynn, T.A.2
  • 33
    • 79751496064 scopus 로고    scopus 로고
    • Alternative macrophage activation and metabolism
    • Odegaard, J. I., Chawla, A. (2011) Alternative macrophage activation and metabolism. Annu. Rev. Pathol. 6, 275–297.
    • (2011) Annu. Rev. Pathol. , vol.6 , pp. 275-297
    • Odegaard, J.I.1    Chawla, A.2
  • 34
    • 0035576207 scopus 로고    scopus 로고
    • Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: Granulomatous pathology is shaped by the pattern of L-arginine metabolism
    • Hesse, M., Modolell, M., La Flamme, A. C., Schito, M., Fuentes, J. M., Cheever, A. W., Pearce, E. J., Wynn, T. A. (2001) Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism. J. Immunol. 167, 6533–6544.
    • (2001) J. Immunol. , vol.167 , pp. 6533-6544
    • Hesse, M.1    Modolell, M.2    La Flamme, A.C.3    Schito, M.4    Fuentes, J.M.5    Cheever, A.W.6    Pearce, E.J.7    Wynn, T.A.8
  • 35
    • 0035727293 scopus 로고    scopus 로고
    • Macrophage arginine metabolism to ornithine/urea or nitric oxide/citrulline: A life or death issue
    • Mills, C. D. (2001) Macrophage arginine metabolism to ornithine/urea or nitric oxide/citrulline: a life or death issue. Crit. Rev. Immunol. 21, 399–425.
    • (2001) Crit. Rev. Immunol. , vol.21 , pp. 399-425
    • Mills, C.D.1
  • 36
    • 0032102990 scopus 로고    scopus 로고
    • Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/ arginase balance: competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype
    • Munder, M., Eichmann, K., Modolell, M. (1998) Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/ arginase balance: competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype. J. Immunol. 160, 5347–5354.
    • (1998) J. Immunol , vol.160 , pp. 5347-5354
    • Munder, M.1    Eichmann, K.2    Modolell, M.3
  • 37
    • 0014736780 scopus 로고
    • Some biochemical aspects of the immune macrophage
    • Hard, G. C. (1970) Some biochemical aspects of the immune macrophage. Br. J. Exp. Pathol. 51, 97–105.
    • (1970) Br. J. Exp. Pathol. , vol.51 , pp. 97-105
    • Hard, G.C.1
  • 38
    • 0023029455 scopus 로고
    • Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages
    • Newsholme, P., Curi, R., Gordon, S., Newsholme, E. A. (1986) Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages. Biochem. J. 239, 121–125.
    • (1986) Biochem. J. , vol.239 , pp. 121-125
    • Newsholme, P.1    Curi, R.2    Gordon, S.3    Newsholme, E.A.4
  • 42
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
    • Kim, J. W., Tchernyshyov, I., Semenza, G. L., Dang, C. V. (2006) HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 3, 177–185.
    • (2006) Cell Metab , vol.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 43
    • 33644622570 scopus 로고    scopus 로고
    • HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
    • Papandreou, I., Cairns, R. A., Fontana, L., Lim, A. L., Denko, N. C. (2006) HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab. 3, 187–197.
    • (2006) Cell Metab , vol.3 , pp. 187-197
    • Papandreou, I.1    Cairns, R.A.2    Fontana, L.3    Lim, A.L.4    Denko, N.C.5
  • 45
    • 79952184583 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)
    • Bulua, A. C., Simon, A., Maddipati, R., Pelletier, M., Park, H., Kim, K. Y., Sack, M. N., Kastner, D. L., Siegel, R. M. (2011) Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS). J. Exp. Med. 208, 519–533.
    • (2011) J. Exp. Med. , vol.208 , pp. 519-533
    • Bulua, A.C.1    Simon, A.2    Maddipati, R.3    Pelletier, M.4    Park, H.5    Kim, K.Y.6    Sack, M.N.7    Kastner, D.L.8    Siegel, R.M.9
  • 46
    • 78651393239 scopus 로고    scopus 로고
    • A role for mitochondria in NLRP3 inflammasome activation
    • Zhou, R., Yazdi, A. S., Menu, P., Tschopp, J. (2011) A role for mitochondria in NLRP3 inflammasome activation. Nature 469, 221–225.
    • (2011) Nature , vol.469 , pp. 221-225
    • Zhou, R.1    Yazdi, A.S.2    Menu, P.3    Tschopp, J.4
  • 49
    • 84939625498 scopus 로고    scopus 로고
    • Metformin inhibits the production of reactive oxygen species from NADH:Ubiquinone oxidoreductase to limit induction of interleukin-1β (IL-1β) and boosts interleukin-10 (IL-10) in lipopolysaccharide (LPS)-activated macrophages
    • Kelly, B., Tannahill, G. M., Murphy, M. P., O’Neill, L. A. (2015) Metformin inhibits the production of reactive oxygen species from NADH:Ubiquinone oxidoreductase to limit induction of interleukin-1β (IL-1β) and boosts interleukin-10 (IL-10) in lipopolysaccharide (LPS)-activated macrophages. J. Biol. Chem. 290, 20348–20359.
    • (2015) J. Biol. Chem. , vol.290 , pp. 20348-20359
    • Kelly, B.1    Tannahill, G.M.2    Murphy, M.P.3    O’Neill, L.A.4
  • 53
    • 84899473768 scopus 로고    scopus 로고
    • Succinate: A metabolic signal in inflammation
    • Mills, E., O’Neill, L. A. (2014) Succinate: a metabolic signal in inflammation. Trends Cell Biol. 24, 313–320.
    • (2014) Trends Cell Biol , vol.24 , pp. 313-320
    • Mills, E.1    O’Neill, L.A.2
  • 58
    • 44349112305 scopus 로고    scopus 로고
    • Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity
    • Kang, K., Reilly, S. M., Karabacak, V., Gangl, M. R., Fitzgerald, K., Hatano, B., Lee, C. H. (2008) Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab. 7, 485–495.
    • (2008) Cell Metab , vol.7 , pp. 485-495
    • Kang, K.1    Reilly, S.M.2    Karabacak, V.3    Gangl, M.R.4    Fitzgerald, K.5    Hatano, B.6    Lee, C.H.7
  • 61
    • 84872576236 scopus 로고    scopus 로고
    • Metabolism of inflammation limited by AMPK and pseudo-starvation
    • O’Neill, L. A., Hardie, D. G. (2013) Metabolism of inflammation limited by AMPK and pseudo-starvation. Nature 493, 346–355.
    • (2013) Nature , vol.493 , pp. 346-355
    • O’Neill, L.A.1    Hardie, D.G.2
  • 62
    • 58849115949 scopus 로고    scopus 로고
    • Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype
    • Sag, D., Carling, D., Stout, R. D., Suttles, J. (2008) Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype. J. Immunol. 181, 8633–8641.
    • (2008) J. Immunol. , vol.181 , pp. 8633-8641
    • Sag, D.1    Carling, D.2    Stout, R.D.3    Suttles, J.4
  • 63
    • 84994797642 scopus 로고    scopus 로고
    • Metabolic reprogramming mediated by the mTORC2-IRF4 signaling axis is essential for macrophage alternative activation
    • Huang, S. C., Smith, A. M., Everts, B., Colonna, M., Pearce, E. L., Schilling, J. D., Pearce, E. J. (2016) Metabolic reprogramming mediated by the mTORC2-IRF4 signaling axis is essential for macrophage alternative activation. Immunity 45, 817–830.
    • (2016) Immunity , vol.45 , pp. 817-830
    • Huang, S.C.1    Smith, A.M.2    Everts, B.3    Colonna, M.4    Pearce, E.L.5    Schilling, J.D.6    Pearce, E.J.7
  • 64
    • 84902136675 scopus 로고    scopus 로고
    • Proteomic characterization of human proinflammatory M1 and anti-inflammatory M2 macrophages and their response to Candida albicans
    • Reales-Calderón, J. A., Aguilera-Montilla, N., Corbí, A. L., Molero, G., Gil, C. (2014) Proteomic characterization of human proinflammatory M1 and anti-inflammatory M2 macrophages and their response to Candida albicans. Proteomics 14, 1503–1518.
    • (2014) Proteomics , vol.14 , pp. 1503-1518
    • Reales-Calderón, J.A.1    Aguilera-Montilla, N.2    Corbí, A.L.3    Molero, G.4    Gil, C.5
  • 65
    • 84962617442 scopus 로고    scopus 로고
    • Cutting edge: Mycobacterium tuberculosis induces aerobic glycolysis in human alveolar macrophages that is required for control of intracellular bacillary replication
    • Gleeson, L. E., Sheedy, F. J., Palsson-McDermott, E. M., Triglia, D., O’Leary, S. M., O’Sullivan, M. P., O’Neill, L. A., Keane, J. (2016) Cutting edge: Mycobacterium tuberculosis induces aerobic glycolysis in human alveolar macrophages that is required for control of intracellular bacillary replication. J. Immunol. 196, 2444–2449.
    • (2016) J. Immunol. , vol.196 , pp. 2444-2449
    • Gleeson, L.E.1    Sheedy, F.J.2    Palsson-McDermott, E.M.3    Triglia, D.4    O’Leary, S.M.5    O’Sullivan, M.P.6    O’Neill, L.A.7    Keane, J.8
  • 66
    • 84903957169 scopus 로고    scopus 로고
    • Fatty acid oxidation is dispensable for human macrophage IL-4-induced polarization
    • Namgaladze, D., Brüne, B. (2014) Fatty acid oxidation is dispensable for human macrophage IL-4-induced polarization. Biochim. Biophys. Acta 1841, 1329–1335.
    • (2014) Biochim. Biophys. Acta , vol.1841 , pp. 1329-1335
    • Namgaladze, D.1    Brüne, B.2
  • 67
    • 78149277909 scopus 로고    scopus 로고
    • How tolerogenic dendritic cells induce regulatory T cells
    • Maldonado, R. A., von Andrian, U. H. (2010) How tolerogenic dendritic cells induce regulatory T cells. Adv. Immunol. 108, 111–165.
    • (2010) Adv. Immunol. , vol.108 , pp. 111-165
    • Maldonado, R.A.1    Von Andrian, U.H.2
  • 68
    • 0015619335 scopus 로고
    • Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution
    • Steinman, R. M., Cohn, Z. A. (1973) Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J. Exp. Med. 137, 1142–1162.
    • (1973) J. Exp. Med. , vol.137 , pp. 1142-1162
    • Steinman, R.M.1    Cohn, Z.A.2
  • 69
    • 33750934617 scopus 로고    scopus 로고
    • Dendritic cells: Translating innate to adaptive immunity
    • Steinman, R. M., Hemmi, H. (2006) Dendritic cells: translating innate to adaptive immunity. Curr. Top. Microbiol. Immunol. 311, 17–58.
    • (2006) Curr. Top. Microbiol. Immunol. , vol.311 , pp. 17-58
    • Steinman, R.M.1    Hemmi, H.2
  • 70
    • 84900461408 scopus 로고    scopus 로고
    • Development and function of dendritic cell subsets
    • Mildner, A., Jung, S. (2014) Development and function of dendritic cell subsets. Immunity 40, 642–656.
    • (2014) Immunity , vol.40 , pp. 642-656
    • Mildner, A.1    Jung, S.2
  • 75
    • 34547134517 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (MTOR) via an mTOR signaling motif
    • Land, S. C., Tee, A. R. (2007) Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif. J. Biol. Chem. 282, 20534–20543.
    • (2007) J. Biol. Chem. , vol.282 , pp. 20534-20543
    • Land, S.C.1    Tee, A.R.2
  • 76
    • 84865435212 scopus 로고    scopus 로고
    • Inhibition of mechanistic target of rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice
    • Amiel, E., Everts, B., Freitas, T. C., King, I. L., Curtis, J. D., Pearce, E. L., Pearce, E. J. (2012) Inhibition of mechanistic target of rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice. J. Immunol. 189, 2151–2158.
    • (2012) J. Immunol. , vol.189 , pp. 2151-2158
    • Amiel, E.1    Everts, B.2    Freitas, T.C.3    King, I.L.4    Curtis, J.D.5    Pearce, E.L.6    Pearce, E.J.7
  • 77
    • 84886257842 scopus 로고    scopus 로고
    • Rapamycin has suppressive and stimulatory effects on human plasmacytoid dendritic cell functions
    • Boor, P. P., Metselaar, H. J., Mancham, S., van der Laan, L. J., Kwekkeboom, J. (2013) Rapamycin has suppressive and stimulatory effects on human plasmacytoid dendritic cell functions. Clin. Exp. Immunol. 174, 389–401.
    • (2013) Clin. Exp. Immunol. , vol.174 , pp. 389-401
    • Boor, P.P.1    Metselaar, H.J.2    Mancham, S.3    Van Der Laan, L.J.4    Kwekkeboom, J.5
  • 79
    • 0034687662 scopus 로고    scopus 로고
    • The effect of nitric oxide on cell respiration: A key to understanding its role in cell survival or death
    • Beltrán, B., Mathur, A., Duchen, M. R., Erusalimsky, J. D., Moncada, S. (2000) The effect of nitric oxide on cell respiration: a key to understanding its role in cell survival or death. Proc. Natl. Acad. Sci. USA 97, 14602–14607.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 14602-14607
    • Beltrán, B.1    Mathur, A.2    Duchen, M.R.3    Erusalimsky, J.D.4    Moncada, S.5
  • 80
    • 28044464985 scopus 로고
    • Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases
    • Cleeter, M. W., Cooper, J. M., Darley-Usmar, V. M., Moncada, S., Schapira, A. H. (1994) Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases. FEBS Lett. 345, 50–54.
    • (1994) FEBS Lett , vol.345 , pp. 50-54
    • Cleeter, M.W.1    Cooper, J.M.2    Darley-Usmar, V.M.3    Moncada, S.4    Schapira, A.H.5
  • 82
    • 84893804974 scopus 로고    scopus 로고
    • Direct type I IFN but not MDA5/TLR3 activation of dendritic cells is required for maturation and metabolic shift to glycolysis after poly IC stimulation
    • Pantel, A., Teixeira, A., Haddad, E., Wood, E. G., Steinman, R. M., Longhi, M. P. (2014) Direct type I IFN but not MDA5/TLR3 activation of dendritic cells is required for maturation and metabolic shift to glycolysis after poly IC stimulation. PLoS Biol. 12, e1001759.
    • (2014) Plos Biol , vol.12
    • Pantel, A.1    Teixeira, A.2    Haddad, E.3    Wood, E.G.4    Steinman, R.M.5    Longhi, M.P.6
  • 85
    • 84929646104 scopus 로고    scopus 로고
    • High mitochondrial respiration and glycolytic capacity represent a metabolic phenotype of human tolerogenic dendritic cells
    • Malinarich, F., Duan, K., Hamid, R. A., Bijin, A., Lin, W. X., Poidinger, M., Fairhurst, A. M., Connolly, J. E. (2015) High mitochondrial respiration and glycolytic capacity represent a metabolic phenotype of human tolerogenic dendritic cells. J. Immunol. 194, 5174–5186.
    • (2015) J. Immunol. , vol.194 , pp. 5174-5186
    • Malinarich, F.1    Duan, K.2    Hamid, R.A.3    Bijin, A.4    Lin, W.X.5    Poidinger, M.6    Fairhurst, A.M.7    Connolly, J.E.8
  • 87
    • 0034777941 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma activators affect the maturation of human monocyte-derived dendritic cells
    • Gosset, P., Charbonnier, A. S., Delerive, P., Fontaine, J., Staels, B., Pestel, J., Tonnel, A. B., Trottein, F. (2001) Peroxisome proliferator-activated receptor gamma activators affect the maturation of human monocyte-derived dendritic cells. Eur. J. Immunol. 31, 2857–2865.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 2857-2865
    • Gosset, P.1    Charbonnier, A.S.2    Delerive, P.3    Fontaine, J.4    Staels, B.5    Pestel, J.6    Tonnel, A.B.7    Trottein, F.8
  • 88
    • 33846902589 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma control of dendritic cell function contributes to development of CD4+ T cell anergy
    • Klotz, L., Dani, I., Edenhofer, F., Nolden, L., Evert, B., Paul, B., Kolanus, W., Klockgether, T., Knolle, P., Diehl, L. (2007) Peroxisome proliferator-activated receptor gamma control of dendritic cell function contributes to development of CD4+ T cell anergy. J. Immunol. 178, 2122–2131.
    • (2007) J. Immunol. , vol.178 , pp. 2122-2131
    • Klotz, L.1    Dani, I.2    Edenhofer, F.3    Nolden, L.4    Evert, B.5    Paul, B.6    Kolanus, W.7    Klockgether, T.8    Knolle, P.9    Diehl, L.10
  • 89
    • 0036681640 scopus 로고    scopus 로고
    • Dendritic cell immunogenicity is regulated by peroxisome proliferator-activated receptor gamma
    • Nencioni, A., Grünebach, F., Zobywlaski, A., Denzlinger, C., Brugger, W., Brossart, P. (2002) Dendritic cell immunogenicity is regulated by peroxisome proliferator-activated receptor gamma. J. Immunol. 169, 1228–1235.
    • (2002) J. Immunol. , vol.169 , pp. 1228-1235
    • Nencioni, A.1    Grünebach, F.2    Zobywlaski, A.3    Denzlinger, C.4    Brugger, W.5    Brossart, P.6
  • 94
    • 77954582720 scopus 로고    scopus 로고
    • Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer
    • Schwartz, D. L., Bankson, J. A., Lemos, R. Jr., Lai, S. Y., Thittai, A. K., He, Y., Hostetter, G., Demeure, M. J., Von Hoff, D. D., Powis, G. (2010) Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer. Mol. Cancer Ther. 9, 2057–2067.
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 2057-2067
    • Schwartz, D.L.1    Bankson, J.A.2    Lemos, R.3    Lai, S.Y.4    Thittai, A.K.5    He, Y.6    Hostetter, G.7    Demeure, M.J.8    Von Hoff, D.D.9    Powis, G.10
  • 97
    • 41149148269 scopus 로고    scopus 로고
    • Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: Mechanisms and therapeutic perspectives
    • Rodríguez, P. C., Ochoa, A. C. (2008) Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives. Immunol. Rev. 222, 180–191.
    • (2008) Immunol. Rev. , vol.222 , pp. 180-191
    • Rodríguez, P.C.1    Ochoa, A.C.2
  • 98
    • 84864213428 scopus 로고    scopus 로고
    • MDSC: A new player in HIV immunopathogenesis
    • Macatangay, B. J., Landay, A. L., Rinaldo, C. R. (2012) MDSC: a new player in HIV immunopathogenesis. AIDS 26, 1567–1569.
    • (2012) AIDS , vol.26 , pp. 1567-1569
    • Macatangay, B.J.1    Landay, A.L.2    Rinaldo, C.R.3
  • 100
    • 32044439372 scopus 로고    scopus 로고
    • CD11b+/Gr-1+ myeloid suppressor cells cause T cell dysfunction after traumatic stress
    • Makarenkova, V. P., Bansal, V., Matta, B. M., Perez, L. A., Ochoa, J. B. (2006) CD11b+/Gr-1+ myeloid suppressor cells cause T cell dysfunction after traumatic stress. J. Immunol. 176, 2085–2094.
    • (2006) J. Immunol. , vol.176 , pp. 2085-2094
    • Makarenkova, V.P.1    Bansal, V.2    Matta, B.M.3    Perez, L.A.4    Ochoa, J.B.5
  • 102
    • 79959538608 scopus 로고    scopus 로고
    • Gr-1+ CD11b+ myeloid-derived suppressor cells suppress inflammation and promote insulin sensitivity in obesity
    • Xia, S., Sha, H., Yang, L., Ji, Y., Ostrand-Rosenberg, S., Qi, L. (2011) Gr-1+ CD11b+ myeloid-derived suppressor cells suppress inflammation and promote insulin sensitivity in obesity. J. Biol. Chem. 286, 23591–23599.
    • (2011) J. Biol. Chem. , vol.286 , pp. 23591-23599
    • Xia, S.1    Sha, H.2    Yang, L.3    Ji, Y.4    Ostrand-Rosenberg, S.5    Qi, L.6
  • 104
    • 38449100026 scopus 로고    scopus 로고
    • CD11b+Ly-6C(Hi) suppressive monocytes in experimental autoimmune encephalomyelitis
    • Zhu, B., Bando, Y., Xiao, S., Yang, K., Anderson, A. C., Kuchroo, V. K., Khoury, S. J. (2007) CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis. J. Immunol. 179, 5228–5237.
    • (2007) J. Immunol. , vol.179 , pp. 5228-5237
    • Zhu, B.1    Bando, Y.2    Xiao, S.3    Yang, K.4    Anderson, A.C.5    Kuchroo, V.K.6    Khoury, S.J.7
  • 107
    • 0034551670 scopus 로고    scopus 로고
    • Identification of a CD11b(+)/ Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells
    • Bronte, V., Apolloni, E., Cabrelle, A., Ronca, R., Serafini, P., Zamboni, P., Restifo, N. P., Zanovello, P. (2000) Identification of a CD11b(+)/ Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells. Blood 96, 3838–3846.
    • (2000) Blood , vol.96 , pp. 3838-3846
    • Bronte, V.1    Apolloni, E.2    Cabrelle, A.3    Ronca, R.4    Serafini, P.5    Zamboni, P.6    Restifo, N.P.7    Zanovello, P.8
  • 108
    • 77955771348 scopus 로고    scopus 로고
    • GM-CSF is one of the main breast tumor-derived soluble factors involved in the differentiation of CD11b-Gr1- bone marrow progenitor cells into myeloid-derived suppressor cells
    • Morales, J. K., Kmieciak, M., Knutson, K. L., Bear, H. D., Manjili, M. H. (2010) GM-CSF is one of the main breast tumor-derived soluble factors involved in the differentiation of CD11b-Gr1- bone marrow progenitor cells into myeloid-derived suppressor cells. Breast Cancer Res. Treat. 123, 39–49.
    • (2010) Breast Cancer Res. Treat. , vol.123 , pp. 39-49
    • Morales, J.K.1    Kmieciak, M.2    Knutson, K.L.3    Bear, H.D.4    Manjili, M.H.5
  • 109
    • 29644442445 scopus 로고    scopus 로고
    • Inflammation induces myeloid-derived suppressor cells that facilitate tumor progression
    • Bunt, S. K., Sinha, P., Clements, V. K., Leips, J., Ostrand-Rosenberg, S. (2006) Inflammation induces myeloid-derived suppressor cells that facilitate tumor progression. J. Immunol. 176, 284–290.
    • (2006) J. Immunol. , vol.176 , pp. 284-290
    • Bunt, S.K.1    Sinha, P.2    Clements, V.K.3    Leips, J.4    Ostrand-Rosenberg, S.5
  • 110
    • 35448954376 scopus 로고    scopus 로고
    • Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression
    • Bunt, S. K., Yang, L., Sinha, P., Clements, V. K., Leips, J., Ostrand-Rosenberg, S. (2007) Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression. Cancer Res. 67, 10019–10026.
    • (2007) Cancer Res , vol.67 , pp. 10019-10026
    • Bunt, S.K.1    Yang, L.2    Sinha, P.3    Clements, V.K.4    Leips, J.5    Ostrand-Rosenberg, S.6
  • 113
    • 84908054077 scopus 로고    scopus 로고
    • HMGB1 enhances immune suppression by facilitating the differentiation and suppressive activity of myeloid-derived suppressor cells
    • Parker, K. H., Sinha, P., Horn, L. A., Clements, V. K., Yang, H., Li, J., Tracey, K. J., Ostrand-Rosenberg, S. (2014) HMGB1 enhances immune suppression by facilitating the differentiation and suppressive activity of myeloid-derived suppressor cells. Cancer Res. 74, 5723–5733.
    • (2014) Cancer Res , vol.74 , pp. 5723-5733
    • Parker, K.H.1    Sinha, P.2    Horn, L.A.3    Clements, V.K.4    Yang, H.5    Li, J.6    Tracey, K.J.7    Ostrand-Rosenberg, S.8
  • 114
    • 53349125963 scopus 로고    scopus 로고
    • Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cells
    • Sinha, P., Okoro, C., Foell, D., Freeze, H. H., Ostrand-Rosenberg, S., Srikrishna, G. (2008) Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cells. J. Immunol. 181, 4666–4675.
    • (2008) J. Immunol. , vol.181 , pp. 4666-4675
    • Sinha, P.1    Okoro, C.2    Foell, D.3    Freeze, H.H.4    Ostrand-Rosenberg, S.5    Srikrishna, G.6
  • 115
    • 84876921278 scopus 로고    scopus 로고
    • Tumor STAT1 transcription factor activity enhances breast tumor growth and immune suppression mediated by myeloid-derived suppressor cells
    • Hix, L. M., Karavitis, J., Khan, M. W., Shi, Y. H., Khazaie, K., Zhang, M. (2013) Tumor STAT1 transcription factor activity enhances breast tumor growth and immune suppression mediated by myeloid-derived suppressor cells. J. Biol. Chem. 288, 11676–11688.
    • (2013) J. Biol. Chem. , vol.288 , pp. 11676-11688
    • Hix, L.M.1    Karavitis, J.2    Khan, M.W.3    Shi, Y.H.4    Khazaie, K.5    Zhang, M.6
  • 116
    • 17044366637 scopus 로고    scopus 로고
    • STAT1 signaling regulates tumor-associated macrophage-mediated T cell deletion
    • Kusmartsev, S., Gabrilovich, D. I. (2005) STAT1 signaling regulates tumor-associated macrophage-mediated T cell deletion. J. Immunol. 174, 4880–4891.
    • (2005) J. Immunol. , vol.174 , pp. 4880-4891
    • Kusmartsev, S.1    Gabrilovich, D.I.2
  • 121
    • 65549129226 scopus 로고    scopus 로고
    • Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells
    • Xin, H., Zhang, C., Herrmann, A., Du, Y., Figlin, R., Yu, H. (2009) Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells. Cancer Res. 69, 2506–2513.
    • (2009) Cancer Res , vol.69 , pp. 2506-2513
    • Xin, H.1    Zhang, C.2    Herrmann, A.3    Du, Y.4    Figlin, R.5    Yu, H.6
  • 124
    • 84941622047 scopus 로고    scopus 로고
    • Tumor-induced myeloid deviation: When myeloid-derived suppressor cells meet tumor-associated macrophages
    • Ugel, S., De Sanctis, F., Mandruzzato, S., Bronte, V. (2015) Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages. J. Clin. Invest. 125, 3365–3376.
    • (2015) J. Clin. Invest. , vol.125 , pp. 3365-3376
    • Ugel, S.1    De Sanctis, F.2    Mandruzzato, S.3    Bronte, V.4
  • 126
    • 60549088732 scopus 로고    scopus 로고
    • Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes
    • Rodriguez, P. C., Ernstoff, M. S., Hernandez, C., Atkins, M., Zabaleta, J., Sierra, R., Ochoa, A. C. (2009) Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes. Cancer Res. 69, 1553–1560.
    • (2009) Cancer Res , vol.69 , pp. 1553-1560
    • Rodriguez, P.C.1    Ernstoff, M.S.2    Hernandez, C.3    Atkins, M.4    Zabaleta, J.5    Sierra, R.6    Ochoa, A.C.7
  • 128
    • 0039435292 scopus 로고    scopus 로고
    • L-Arginine regulates the expression of the T-cell receptor zeta chain (CD3zeta) in Jurkat cells
    • Taheri, F., Ochoa, J. B., Faghiri, Z., Culotta, K., Park, H. J., Lan, M. S., Zea, A. H., Ochoa, A. C. (2001) L-Arginine regulates the expression of the T-cell receptor zeta chain (CD3zeta) in Jurkat cells. Clin. Cancer Res. 7 (3: Suppl), 958s–965s.
    • (2001) Clin. Cancer Res. , vol.7 , Issue.3 , pp. 958s-965s
    • Taheri, F.1    Ochoa, J.B.2    Faghiri, Z.3    Culotta, K.4    Park, H.J.5    Lan, M.S.6    Zea, A.H.7    Ochoa, A.C.8
  • 129
    • 33846933459 scopus 로고    scopus 로고
    • L-Arginine availability regulates T-lymphocyte cell-cycle progression
    • Rodriguez, P. C., Quiceno, D. G., Ochoa, A. C. (2007) L-Arginine availability regulates T-lymphocyte cell-cycle progression. Blood 109, 1568–1573.
    • (2007) Blood , vol.109 , pp. 1568-1573
    • Rodriguez, P.C.1    Quiceno, D.G.2    Ochoa, A.C.3
  • 130
    • 78149491757 scopus 로고    scopus 로고
    • L-arginine deprivation regulates cyclin D3 mRNA stability in human T cells by controlling HuR expression
    • Rodriguez, P. C., Hernandez, C. P., Morrow, K., Sierra, R., Zabaleta, J., Wyczechowska, D. D., Ochoa, A. C. (2010) L-arginine deprivation regulates cyclin D3 mRNA stability in human T cells by controlling HuR expression. J. Immunol. 185, 5198–5204.
    • (2010) J. Immunol. , vol.185 , pp. 5198-5204
    • Rodriguez, P.C.1    Hernandez, C.P.2    Morrow, K.3    Sierra, R.4    Zabaleta, J.5    Wyczechowska, D.D.6    Ochoa, A.C.7
  • 135
    • 0035889886 scopus 로고    scopus 로고
    • Tumor-infiltrating macrophages induce apoptosis in activated CD8(+) T cells by a mechanism requiring cell contact and mediated by both the cell-associated form of TNF and nitric oxide
    • Saio, M., Radoja, S., Marino, M., Frey, A. B. (2001) Tumor-infiltrating macrophages induce apoptosis in activated CD8(+) T cells by a mechanism requiring cell contact and mediated by both the cell-associated form of TNF and nitric oxide. J. Immunol. 167, 5583–5593.
    • (2001) J. Immunol. , vol.167 , pp. 5583-5593
    • Saio, M.1    Radoja, S.2    Marino, M.3    Frey, A.B.4
  • 136
    • 0033559897 scopus 로고    scopus 로고
    • Peroxynitrite inhibits T lymphocyte activation and proliferation by promoting impairment of tyrosine phosphorylation and peroxynitrite-driven apoptotic death
    • Brito, C., Naviliat, M., Tiscornia, A. C., Vuillier, F., Gualco, G., Dighiero, G., Radi, R., Cayota, A. M. (1999) Peroxynitrite inhibits T lymphocyte activation and proliferation by promoting impairment of tyrosine phosphorylation and peroxynitrite-driven apoptotic death. J. Immunol. 162, 3356–3366.
    • (1999) J. Immunol. , vol.162 , pp. 3356-3366
    • Brito, C.1    Naviliat, M.2    Tiscornia, A.C.3    Vuillier, F.4    Gualco, G.5    Dighiero, G.6    Radi, R.7    Cayota, A.M.8
  • 141
    • 85014398925 scopus 로고    scopus 로고
    • Arginine metabolism in myeloid cells shapes innate and adaptive immunity
    • Rodriguez, P. C., Ochoa, A. C., Al-Khami, A. A. (2017) Arginine metabolism in myeloid cells shapes innate and adaptive immunity. Front. Immunol. 8, 93.
    • (2017) Front. Immunol. , vol.8 , pp. 93
    • Rodriguez, P.C.1    Ochoa, A.C.2    Al-Khami, A.A.3
  • 142
    • 84959542771 scopus 로고    scopus 로고
    • The nature of myeloid-derived suppressor cells in the tumor microenvironment
    • Kumar, V., Patel, S., Tcyganov, E., Gabrilovich, D. I. (2016) The nature of myeloid-derived suppressor cells in the tumor microenvironment. Trends Immunol. 37, 208–220.
    • (2016) Trends Immunol , vol.37 , pp. 208-220
    • Kumar, V.1    Patel, S.2    Tcyganov, E.3    Gabrilovich, D.I.4
  • 144
    • 84875462761 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells suppress antitumor immune responses through IDO expression and correlate with lymph node metastasis in patients with breast cancer
    • Yu, J., Du, W., Yan, F., Wang, Y., Li, H., Cao, S., Yu, W., Shen, C., Liu, J., Ren, X. (2013) Myeloid-derived suppressor cells suppress antitumor immune responses through IDO expression and correlate with lymph node metastasis in patients with breast cancer. J. Immunol. 190, 3783–3797.
    • (2013) J. Immunol. , vol.190 , pp. 3783-3797
    • Yu, J.1    Du, W.2    Yan, F.3    Wang, Y.4    Li, H.5    Cao, S.6    Yu, W.7    Shen, C.8    Liu, J.9    Ren, X.10
  • 145
    • 19344377474 scopus 로고    scopus 로고
    • GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase
    • Munn, D. H., Sharma, M. D., Baban, B., Harding, H. P., Zhang, Y., Ron, D., Mellor, A. L. (2005) GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. Immunity 22, 633–642.
    • (2005) Immunity , vol.22 , pp. 633-642
    • Munn, D.H.1    Sharma, M.D.2    Baban, B.3    Harding, H.P.4    Zhang, Y.5    Ron, D.6    Mellor, A.L.7
  • 146
    • 75149123468 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine
    • Srivastava, M. K., Sinha, P., Clements, V. K., Rodriguez, P., Ostrand-Rosenberg, S. (2010) Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine. Cancer Res. 70, 68–77.
    • (2010) Cancer Res , vol.70 , pp. 68-77
    • Srivastava, M.K.1    Sinha, P.2    Clements, V.K.3    Rodriguez, P.4    Ostrand-Rosenberg, S.5
  • 147
    • 84863224448 scopus 로고    scopus 로고
    • Immunosuppressive activity enhances central carbon metabolism and bioenergetics in myeloid-derived suppressor cells in vitro models
    • Hammami, I., Chen, J., Murschel, F., Bronte, V., De Crescenzo, G., Jolicoeur, M. (2012) Immunosuppressive activity enhances central carbon metabolism and bioenergetics in myeloid-derived suppressor cells in vitro models. BMC Cell Biol. 13, 18.
    • (2012) BMC Cell Biol , vol.13 , pp. 18
    • Hammami, I.1    Chen, J.2    Murschel, F.3    Bronte, V.4    De Crescenzo, G.5    Jolicoeur, M.6
  • 148
    • 84893873953 scopus 로고    scopus 로고
    • SIRT1 limits the function and fate of myeloid-derived suppressor cells in tumors by orchestrating HIF-1α-dependent glycolysis
    • Liu, G., Bi, Y., Shen, B., Yang, H., Zhang, Y., Wang, X., Liu, H., Lu, Y., Liao, J., Chen, X., Chu, Y. (2014) SIRT1 limits the function and fate of myeloid-derived suppressor cells in tumors by orchestrating HIF-1α-dependent glycolysis. Cancer Res. 74, 727–737.
    • (2014) Cancer Res , vol.74 , pp. 727-737
    • Liu, G.1    Bi, Y.2    Shen, B.3    Yang, H.4    Zhang, Y.5    Wang, X.6    Liu, H.7    Lu, Y.8    Liao, J.9    Chen, X.10    Chu, Y.11
  • 150
    • 84899753178 scopus 로고    scopus 로고
    • PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
    • Noman, M. Z., Desantis, G., Janji, B., Hasmim, M., Karray, S., Dessen, P., Bronte, V., Chouaib, S. (2014) PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation. J. Exp. Med. 211, 781–790.
    • (2014) J. Exp. Med. , vol.211 , pp. 781-790
    • Noman, M.Z.1    Desantis, G.2    Janji, B.3    Hasmim, M.4    Karray, S.5    Dessen, P.6    Bronte, V.7    Chouaib, S.8
  • 152
    • 84979993733 scopus 로고    scopus 로고
    • Metabolic reprogramming of myeloid-derived suppressor cells (MDSC) in cancer
    • Al-Khami, A. A., Rodriguez, P. C., Ochoa, A. C. (2016) Metabolic reprogramming of myeloid-derived suppressor cells (MDSC) in cancer. OncoImmunology 5, e1200771.
    • (2016) Oncoimmunology , vol.5
    • Al-Khami, A.A.1    Rodriguez, P.C.2    Ochoa, A.C.3
  • 156
    • 84880648196 scopus 로고    scopus 로고
    • Tumor-derived lactate modifies antitumor immune response: Effect on myeloid-derived suppressor cells and NK cells
    • Husain, Z., Huang, Y., Seth, P., Sukhatme, V. P. (2013) Tumor-derived lactate modifies antitumor immune response: effect on myeloid-derived suppressor cells and NK cells. J. Immunol. 191, 1486–1495.
    • (2013) J. Immunol. , vol.191 , pp. 1486-1495
    • Husain, Z.1    Huang, Y.2    Seth, P.3    Sukhatme, V.P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.