-
1
-
-
84896905991
-
Metabolic regulation of immune responses
-
Ganeshan, K., Chawla, A. (2014) Metabolic regulation of immune responses. Annu. Rev. Immunol. 32, 609–634.
-
(2014)
Annu. Rev. Immunol.
, vol.32
, pp. 609-634
-
-
Ganeshan, K.1
Chawla, A.2
-
2
-
-
84960399221
-
Immunometabolism governs dendritic cell and macrophage function
-
O’Neill, L. A., Pearce, E. J. (2016) Immunometabolism governs dendritic cell and macrophage function. J. Exp. Med. 213, 15–23.
-
(2016)
J. Exp. Med.
, vol.213
, pp. 15-23
-
-
O’Neill, L.A.1
Pearce, E.J.2
-
3
-
-
84978148203
-
A guide to immunometabolism for immunologists
-
O’Neill, L. A., Kishton, R. J., Rathmell, J. (2016) A guide to immunometabolism for immunologists. Nat. Rev. Immunol. 16, 553–565.
-
(2016)
Nat. Rev. Immunol.
, vol.16
, pp. 553-565
-
-
O’Neill, L.A.1
Kishton, R.J.2
Rathmell, J.3
-
4
-
-
84876758617
-
Metabolic pathways in immune cell activation and quiescence
-
Pearce, E. L., Pearce, E. J. (2013) Metabolic pathways in immune cell activation and quiescence. Immunity 38, 633–643.
-
(2013)
Immunity
, vol.38
, pp. 633-643
-
-
Pearce, E.L.1
Pearce, E.J.2
-
5
-
-
84885670616
-
Fueling immunity: Insights into metabolism and lymphocyte function
-
Pearce, E. L., Poffenberger, M. C., Chang, C. H., Jones, R. G. (2013) Fueling immunity: insights into metabolism and lymphocyte function. Science 342, 1242454.
-
(2013)
Science
, vol.342
-
-
Pearce, E.L.1
Poffenberger, M.C.2
Chang, C.H.3
Jones, R.G.4
-
6
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
Vander Heiden, M. G., Cantley, L. C., Thompson, C. B. (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324, 1029–1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
7
-
-
0001221508
-
On respiratory impairment in cancer cells
-
Warburg, O. (1956) On respiratory impairment in cancer cells. Science 124, 269–270.
-
(1956)
Science
, vol.124
, pp. 269-270
-
-
Warburg, O.1
-
8
-
-
85014308052
-
Neutrophil extracellular traps and its implications in inflammation: An overview
-
Delgado-Rizo, V., Martínez-Guzmán, M. A., Iñiguez-Gutierrez, L., García-Orozco, A., Alvarado-Navarro, A., Fafutis-Morris, M. (2017) Neutrophil extracellular traps and its implications in inflammation: an overview. Front. Immunol. 8, 81.
-
(2017)
Front. Immunol.
, vol.8
, pp. 81
-
-
Delgado-Rizo, V.1
Martínez-Guzmán, M.A.2
Iñiguez-Gutierrez, L.3
García-Orozco, A.4
Alvarado-Navarro, A.5
Fafutis-Morris, M.6
-
9
-
-
85011588765
-
The NADPH oxidase and microbial killing by neutrophils, with a particular emphasis on the proposed antimicrobial role of myeloperoxidase within the phagocytic vacuole
-
MCHD-0018-2015
-
Levine, A. P., Segal, A. W. (2016) The NADPH oxidase and microbial killing by neutrophils, with a particular emphasis on the proposed antimicrobial role of myeloperoxidase within the phagocytic vacuole. Microbiol. Spectr. 4, MCHD-0018-2015.
-
(2016)
Microbiol. Spectr.
, vol.4
-
-
Levine, A.P.1
Segal, A.W.2
-
10
-
-
0000054142
-
The biochemical basis of phagocytosis. I. Metabolic changes during the ingestion of particles by polymorphonuclear leukocytes
-
Sbarra, A. J., Karnovsky, M. L. (1959) The biochemical basis of phagocytosis. I. Metabolic changes during the ingestion of particles by polymorphonuclear leukocytes. J. Biol. Chem. 234, 1355–1362.
-
(1959)
J. Biol. Chem.
, vol.234
, pp. 1355-1362
-
-
Sbarra, A.J.1
Karnovsky, M.L.2
-
11
-
-
0344521566
-
Biochemical studies on leucocytes. I. Phosphatase activity in health, leucocytosis, and myelocytic leucemia
-
Valentine, W. N., Beck, W. S. (1951) Biochemical studies on leucocytes. I. Phosphatase activity in health, leucocytosis, and myelocytic leucemia. J. Lab. Clin. Med. 38, 39–55.
-
(1951)
J. Lab. Clin. Med.
, vol.38
, pp. 39-55
-
-
Valentine, W.N.1
Beck, W.S.2
-
12
-
-
84878533006
-
Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human blood
-
Chacko, B. K., Kramer, P. A., Ravi, S., Johnson, M. S., Hardy, R. W., Ballinger, S. W., Darley-Usmar, V. M. (2013) Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human blood. Lab. Invest. 93, 690–700.
-
(2013)
Lab. Invest.
, vol.93
, pp. 690-700
-
-
Chacko, B.K.1
Kramer, P.A.2
Ravi, S.3
Johnson, M.S.4
Hardy, R.W.5
Ballinger, S.W.6
Darley-Usmar, V.M.7
-
13
-
-
0037442128
-
The mitochondrial network of human neutrophils: Role in chemotaxis, phagocytosis, respiratory burst activation, and commitment to apoptosis
-
Fossati, G., Moulding, D. A., Spiller, D. G., Moots, R. J., White, M. R., Edwards, S. W. (2003) The mitochondrial network of human neutrophils: role in chemotaxis, phagocytosis, respiratory burst activation, and commitment to apoptosis. J. Immunol. 170, 1964–1972.
-
(2003)
J. Immunol.
, vol.170
, pp. 1964-1972
-
-
Fossati, G.1
Moulding, D.A.2
Spiller, D.G.3
Moots, R.J.4
White, M.R.5
Edwards, S.W.6
-
14
-
-
84893196785
-
A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: Implications for their use as bioenergetic biomarkers
-
Kramer, P. A., Ravi, S., Chacko, B., Johnson, M. S., Darley-Usmar, V. M. (2014) A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: implications for their use as bioenergetic biomarkers. Redox Biol. 2, 206–210.
-
(2014)
Redox Biol
, vol.2
, pp. 206-210
-
-
Kramer, P.A.1
Ravi, S.2
Chacko, B.3
Johnson, M.S.4
Darley-Usmar, V.M.5
-
15
-
-
33750350859
-
Mitochondria in neutrophil apoptosis
-
Van Raam, B. J., Verhoeven, A. J., Kuijpers, T. W. (2006) Mitochondria in neutrophil apoptosis. Int. J. Hematol. 84, 199–204.
-
(2006)
Int. J. Hematol.
, vol.84
, pp. 199-204
-
-
Van Raam, B.J.1
Verhoeven, A.J.2
Kuijpers, T.W.3
-
16
-
-
0019969614
-
Energy metabolism of human neutrophils during phagocytosis
-
Borregaard, N., Herlin, T. (1982) Energy metabolism of human neutrophils during phagocytosis. J. Clin. Invest. 70, 550–557.
-
(1982)
J. Clin. Invest.
, vol.70
, pp. 550-557
-
-
Borregaard, N.1
Herlin, T.2
-
17
-
-
0021684935
-
Priming of neutrophils for enhanced release of oxygen metabolites by bacterial lipopolysaccharide. Evidence for increased activity of the superoxide-producing enzyme
-
Guthrie, L. A., McPhail, L. C., Henson, P. M., Johnston, R. B. Jr. (1984) Priming of neutrophils for enhanced release of oxygen metabolites by bacterial lipopolysaccharide. Evidence for increased activity of the superoxide-producing enzyme. J. Exp. Med. 160, 1656–1671.
-
(1984)
J. Exp. Med.
, vol.160
, pp. 1656-1671
-
-
Guthrie, L.A.1
McPhail, L.C.2
Henson, P.M.3
Johnston, R.B.4
-
18
-
-
84861034431
-
The impact of various reactive oxygen species on the formation of neutrophil extracellular traps
-
Kirchner, T., Möller, S., Klinger, M., Solbach, W., Laskay, T., Behnen, M. (2012) The impact of various reactive oxygen species on the formation of neutrophil extracellular traps. Mediators Inflamm. 2012, 849136.
-
(2012)
Mediators Inflamm
, vol.2012
-
-
Kirchner, T.1
Möller, S.2
Klinger, M.3
Solbach, W.4
Laskay, T.5
Behnen, M.6
-
19
-
-
84929658566
-
Metabolic requirements for neutrophil extracellular traps formation
-
Rodríguez-Espinosa, O., Rojas-Espinosa, O., Moreno-Altamirano, M. M., López-Villegas, E. O., Sánchez-García, F. J. (2015) Metabolic requirements for neutrophil extracellular traps formation. Immunology 145, 213–224.
-
(2015)
Immunology
, vol.145
, pp. 213-224
-
-
Rodríguez-Espinosa, O.1
Rojas-Espinosa, O.2
Moreno-Altamirano, M.M.3
López-Villegas, E.O.4
Sánchez-García, F.J.5
-
20
-
-
44349150953
-
Mitochondrial membrane potential in human neutrophils is maintained by complex III activity in the absence of supercomplex organisation
-
Van Raam, B. J., Sluiter, W., de Wit, E., Roos, D., Verhoeven, A. J., Kuijpers, T. W. (2008) Mitochondrial membrane potential in human neutrophils is maintained by complex III activity in the absence of supercomplex organisation. PLoS One 3, e2013.
-
(2008)
Plos One
, vol.3
-
-
Van Raam, B.J.1
Sluiter, W.2
De Wit, E.3
Roos, D.4
Verhoeven, A.J.5
Kuijpers, T.W.6
-
21
-
-
0037423948
-
HIF-1alpha is essential for myeloid cell-mediated inflammation
-
Cramer, T., Yamanishi, Y., Clausen, B. E., Förster, I., Pawlinski, R., Mackman, N., Haase, V. H., Jaenisch, R., Corr, M., Nizet, V., Firestein, G. S., Gerber, H. P., Ferrara, N., Johnson, R. S. (2003) HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell 112, 645–657.
-
(2003)
Cell
, vol.112
, pp. 645-657
-
-
Cramer, T.1
Yamanishi, Y.2
Clausen, B.E.3
Förster, I.4
Pawlinski, R.5
Mackman, N.6
Haase, V.H.7
Jaenisch, R.8
Corr, M.9
Nizet, V.10
Firestein, G.S.11
Gerber, H.P.12
Ferrara, N.13
Johnson, R.S.14
-
22
-
-
22144492953
-
HIF-1alpha expression regulates the bactericidal capacity of phagocytes
-
Peyssonnaux, C., Datta, V., Cramer, T., Doedens, A., Theodorakis, E. A., Gallo, R. L., Hurtado-Ziola, N., Nizet, V., Johnson, R. S. (2005) HIF-1alpha expression regulates the bactericidal capacity of phagocytes. J. Clin. Invest. 115, 1806–1815.
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 1806-1815
-
-
Peyssonnaux, C.1
Datta, V.2
Cramer, T.3
Doedens, A.4
Theodorakis, E.A.5
Gallo, R.L.6
Hurtado-Ziola, N.7
Nizet, V.8
Johnson, R.S.9
-
23
-
-
19944432390
-
Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity
-
Walmsley, S. R., Print, C., Farahi, N., Peyssonnaux, C., Johnson, R. S., Cramer, T., Sobolewski, A., Condliffe, A. M., Cowburn, A. S., Johnson, N., Chilvers, E. R. (2005) Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity. J. Exp. Med. 201, 105–115.
-
(2005)
J. Exp. Med.
, vol.201
, pp. 105-115
-
-
Walmsley, S.R.1
Print, C.2
Farahi, N.3
Peyssonnaux, C.4
Johnson, R.S.5
Cramer, T.6
Sobolewski, A.7
Condliffe, A.M.8
Cowburn, A.S.9
Johnson, N.10
Chilvers, E.R.11
-
24
-
-
84873743410
-
M1 and M2 macrophages: Oracles of health and disease
-
Mills, C. D. (2012) M1 and M2 macrophages: oracles of health and disease. Crit. Rev. Immunol. 32, 463–488.
-
(2012)
Crit. Rev. Immunol.
, vol.32
, pp. 463-488
-
-
Mills, C.D.1
-
25
-
-
84876800337
-
Macrophage biology in development, homeostasis and disease
-
Wynn, T. A., Chawla, A., Pollard, J. W. (2013) Macrophage biology in development, homeostasis and disease. Nature 496, 445–455.
-
(2013)
Nature
, vol.496
, pp. 445-455
-
-
Wynn, T.A.1
Chawla, A.2
Pollard, J.W.3
-
26
-
-
76249095169
-
Development of monocytes, macrophages, and dendritic cells
-
Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., Ley, K. (2010) Development of monocytes, macrophages, and dendritic cells. Science 327, 656–661.
-
(2010)
Science
, vol.327
, pp. 656-661
-
-
Geissmann, F.1
Manz, M.G.2
Jung, S.3
Sieweke, M.H.4
Merad, M.5
Ley, K.6
-
27
-
-
84876775203
-
Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes
-
Hashimoto, D., Chow, A., Noizat, C., Teo, P., Beasley, M. B., Leboeuf, M., Becker, C. D., See, P., Price, J., Lucas, D., Greter, M., Mortha, A., Boyer, S. W., Forsberg, E. C., Tanaka, M., van Rooijen, N., García-Sastre, A., Stanley, E. R., Ginhoux, F., Frenette, P. S., Merad, M. (2013) Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity 38, 792–804.
-
(2013)
Immunity
, vol.38
, pp. 792-804
-
-
Hashimoto, D.1
Chow, A.2
Noizat, C.3
Teo, P.4
Beasley, M.B.5
Leboeuf, M.6
Becker, C.D.7
See, P.8
Price, J.9
Lucas, D.10
Greter, M.11
Mortha, A.12
Boyer, S.W.13
Forsberg, E.C.14
Tanaka, M.15
Van Rooijen, N.16
García-Sastre, A.17
Stanley, E.R.18
Ginhoux, F.19
Frenette, P.S.20
Merad, M.21
more..
-
28
-
-
79958715229
-
Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation
-
Jenkins, S. J., Ruckerl, D., Cook, P. C., Jones, L. H., Finkelman, F. D., van Rooijen, N., MacDonald, A. S., Allen, J. E. (2011) Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation. Science 332, 1284–1288.
-
(2011)
Science
, vol.332
, pp. 1284-1288
-
-
Jenkins, S.J.1
Ruckerl, D.2
Cook, P.C.3
Jones, L.H.4
Finkelman, F.D.5
Van Rooijen, N.6
Macdonald, A.S.7
Allen, J.E.8
-
29
-
-
84859508307
-
A lineage of myeloid cells independent of Myb and hematopoietic stem cells
-
Schulz, C., Gomez Perdiguero, E., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E., Pollard, J. W., Frampton, J., Liu, K. J., Geissmann, F. (2012) A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science 336, 86–90.
-
(2012)
Science
, vol.336
, pp. 86-90
-
-
Schulz, C.1
Gomez Perdiguero, E.2
Chorro, L.3
Szabo-Rogers, H.4
Cagnard, N.5
Kierdorf, K.6
Prinz, M.7
Wu, B.8
Jacobsen, S.E.9
Pollard, J.W.10
Frampton, J.11
Liu, K.J.12
Geissmann, F.13
-
30
-
-
56149103896
-
Macrophage polarization in bacterial infections
-
Benoit, M., Desnues, B., Mege, J. L. (2008) Macrophage polarization in bacterial infections. J. Immunol. 181, 3733–3739.
-
(2008)
J. Immunol.
, vol.181
, pp. 3733-3739
-
-
Benoit, M.1
Desnues, B.2
Mege, J.L.3
-
31
-
-
84871076444
-
Macrophage plasticity and polarization in tissue repair and remodelling
-
Mantovani, A., Biswas, S. K., Galdiero, M. R., Sica, A., Locati, M. (2013) Macrophage plasticity and polarization in tissue repair and remodelling. J. Pathol. 229, 176–185.
-
(2013)
J. Pathol.
, vol.229
, pp. 176-185
-
-
Mantovani, A.1
Biswas, S.K.2
Galdiero, M.R.3
Sica, A.4
Locati, M.5
-
32
-
-
80355131976
-
Protective and pathogenic functions of macrophage subsets
-
Murray, P. J., Wynn, T. A. (2011) Protective and pathogenic functions of macrophage subsets. Nat. Rev. Immunol. 11, 723–737.
-
(2011)
Nat. Rev. Immunol.
, vol.11
, pp. 723-737
-
-
Murray, P.J.1
Wynn, T.A.2
-
33
-
-
79751496064
-
Alternative macrophage activation and metabolism
-
Odegaard, J. I., Chawla, A. (2011) Alternative macrophage activation and metabolism. Annu. Rev. Pathol. 6, 275–297.
-
(2011)
Annu. Rev. Pathol.
, vol.6
, pp. 275-297
-
-
Odegaard, J.I.1
Chawla, A.2
-
34
-
-
0035576207
-
Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: Granulomatous pathology is shaped by the pattern of L-arginine metabolism
-
Hesse, M., Modolell, M., La Flamme, A. C., Schito, M., Fuentes, J. M., Cheever, A. W., Pearce, E. J., Wynn, T. A. (2001) Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism. J. Immunol. 167, 6533–6544.
-
(2001)
J. Immunol.
, vol.167
, pp. 6533-6544
-
-
Hesse, M.1
Modolell, M.2
La Flamme, A.C.3
Schito, M.4
Fuentes, J.M.5
Cheever, A.W.6
Pearce, E.J.7
Wynn, T.A.8
-
35
-
-
0035727293
-
Macrophage arginine metabolism to ornithine/urea or nitric oxide/citrulline: A life or death issue
-
Mills, C. D. (2001) Macrophage arginine metabolism to ornithine/urea or nitric oxide/citrulline: a life or death issue. Crit. Rev. Immunol. 21, 399–425.
-
(2001)
Crit. Rev. Immunol.
, vol.21
, pp. 399-425
-
-
Mills, C.D.1
-
36
-
-
0032102990
-
Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/ arginase balance: competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype
-
Munder, M., Eichmann, K., Modolell, M. (1998) Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/ arginase balance: competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype. J. Immunol. 160, 5347–5354.
-
(1998)
J. Immunol
, vol.160
, pp. 5347-5354
-
-
Munder, M.1
Eichmann, K.2
Modolell, M.3
-
37
-
-
0014736780
-
Some biochemical aspects of the immune macrophage
-
Hard, G. C. (1970) Some biochemical aspects of the immune macrophage. Br. J. Exp. Pathol. 51, 97–105.
-
(1970)
Br. J. Exp. Pathol.
, vol.51
, pp. 97-105
-
-
Hard, G.C.1
-
38
-
-
0023029455
-
Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages
-
Newsholme, P., Curi, R., Gordon, S., Newsholme, E. A. (1986) Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages. Biochem. J. 239, 121–125.
-
(1986)
Biochem. J.
, vol.239
, pp. 121-125
-
-
Newsholme, P.1
Curi, R.2
Gordon, S.3
Newsholme, E.A.4
-
39
-
-
77956213727
-
Substrate fate in activated macrophages: A comparison between innate, classic, and alternative activation
-
Rodríguez-Prados, J. C., Través, P. G., Cuenca, J., Rico, D., Aragonés, J., Martín-Sanz, P., Cascante, M., Boscá, L. (2010) Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation. J. Immunol. 185, 605–614.
-
(2010)
J. Immunol.
, vol.185
, pp. 605-614
-
-
Rodríguez-Prados, J.C.1
Través, P.G.2
Cuenca, J.3
Rico, D.4
Aragonés, J.5
Martín-Sanz, P.6
Cascante, M.7
Boscá, L.8
-
40
-
-
84862016400
-
The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism
-
Haschemi, A., Kosma, P., Gille, L., Evans, C. R., Burant, C. F., Starkl, P., Knapp, B., Haas, R., Schmid, J. A., Jandl, C., Amir, S., Lubec, G., Park, J., Esterbauer, H., Bilban, M., Brizuela, L., Pospisilik, J. A., Otterbein, L. E., Wagner, O. (2012) The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism. Cell Metab. 15, 813–826.
-
(2012)
Cell Metab
, vol.15
, pp. 813-826
-
-
Haschemi, A.1
Kosma, P.2
Gille, L.3
Evans, C.R.4
Burant, C.F.5
Starkl, P.6
Knapp, B.7
Haas, R.8
Schmid, J.A.9
Jandl, C.10
Amir, S.11
Lubec, G.12
Park, J.13
Esterbauer, H.14
Bilban, M.15
Brizuela, L.16
Pospisilik, J.A.17
Otterbein, L.E.18
Wagner, O.19
-
41
-
-
77649177217
-
Differential activation and antagonistic function of HIF-alpha isoforms in macrophages are essential for NO homeostasis
-
Takeda, N., O’Dea, E. L., Doedens, A., Kim, J. W., Weidemann, A., Stockmann, C., Asagiri, M., Simon, M. C., Hoffmann, A., Johnson, R. S. (2010) Differential activation and antagonistic function of HIF-alpha isoforms in macrophages are essential for NO homeostasis. Genes Dev. 24, 491–501.
-
(2010)
Genes Dev
, vol.24
, pp. 491-501
-
-
Takeda, N.1
O’Dea, E.L.2
Doedens, A.3
Kim, J.W.4
Weidemann, A.5
Stockmann, C.6
Asagiri, M.7
Simon, M.C.8
Hoffmann, A.9
Johnson, R.S.10
-
42
-
-
33644614520
-
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
-
Kim, J. W., Tchernyshyov, I., Semenza, G. L., Dang, C. V. (2006) HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 3, 177–185.
-
(2006)
Cell Metab
, vol.3
, pp. 177-185
-
-
Kim, J.W.1
Tchernyshyov, I.2
Semenza, G.L.3
Dang, C.V.4
-
43
-
-
33644622570
-
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
-
Papandreou, I., Cairns, R. A., Fontana, L., Lim, A. L., Denko, N. C. (2006) HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab. 3, 187–197.
-
(2006)
Cell Metab
, vol.3
, pp. 187-197
-
-
Papandreou, I.1
Cairns, R.A.2
Fontana, L.3
Lim, A.L.4
Denko, N.C.5
-
44
-
-
79955532516
-
TLR signalling augments macrophage bactericidal activity through mitochondrial ROS
-
West, A. P., Brodsky, I. E., Rahner, C., Woo, D. K., Erdjument-Bromage, H., Tempst, P., Walsh, M. C., Choi, Y., Shadel, G. S., Ghosh, S. (2011) TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 472, 476–480.
-
(2011)
Nature
, vol.472
, pp. 476-480
-
-
West, A.P.1
Brodsky, I.E.2
Rahner, C.3
Woo, D.K.4
Erdjument-Bromage, H.5
Tempst, P.6
Walsh, M.C.7
Choi, Y.8
Shadel, G.S.9
Ghosh, S.10
-
45
-
-
79952184583
-
Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)
-
Bulua, A. C., Simon, A., Maddipati, R., Pelletier, M., Park, H., Kim, K. Y., Sack, M. N., Kastner, D. L., Siegel, R. M. (2011) Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS). J. Exp. Med. 208, 519–533.
-
(2011)
J. Exp. Med.
, vol.208
, pp. 519-533
-
-
Bulua, A.C.1
Simon, A.2
Maddipati, R.3
Pelletier, M.4
Park, H.5
Kim, K.Y.6
Sack, M.N.7
Kastner, D.L.8
Siegel, R.M.9
-
46
-
-
78651393239
-
A role for mitochondria in NLRP3 inflammasome activation
-
Zhou, R., Yazdi, A. S., Menu, P., Tschopp, J. (2011) A role for mitochondria in NLRP3 inflammasome activation. Nature 469, 221–225.
-
(2011)
Nature
, vol.469
, pp. 221-225
-
-
Zhou, R.1
Yazdi, A.S.2
Menu, P.3
Tschopp, J.4
-
47
-
-
79951642032
-
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
-
Nakahira, K., Haspel, J. A., Rathinam, V. A., Lee, S. J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., Fitzgerald, K. A., Ryter, S. W., Choi, A. M. (2011) Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat. Immunol. 12, 222–230.
-
(2011)
Nat. Immunol.
, vol.12
, pp. 222-230
-
-
Nakahira, K.1
Haspel, J.A.2
Rathinam, V.A.3
Lee, S.J.4
Dolinay, T.5
Lam, H.C.6
Englert, J.A.7
Rabinovitch, M.8
Cernadas, M.9
Kim, H.P.10
Fitzgerald, K.A.11
Ryter, S.W.12
Choi, A.M.13
-
48
-
-
84862777872
-
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
-
Shimada, K., Crother, T. R., Karlin, J., Dagvadorj, J., Chiba, N., Chen, S., Ramanujan, V. K., Wolf, A. J., Vergnes, L., Ojcius, D. M., Rentsendorj, A., Vargas, M., Guerrero, C., Wang, Y., Fitzgerald, K. A., Underhill, D. M., Town, T., Arditi, M. (2012) Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 36, 401–414.
-
(2012)
Immunity
, vol.36
, pp. 401-414
-
-
Shimada, K.1
Crother, T.R.2
Karlin, J.3
Dagvadorj, J.4
Chiba, N.5
Chen, S.6
Ramanujan, V.K.7
Wolf, A.J.8
Vergnes, L.9
Ojcius, D.M.10
Rentsendorj, A.11
Vargas, M.12
Guerrero, C.13
Wang, Y.14
Fitzgerald, K.A.15
Underhill, D.M.16
Town, T.17
Arditi, M.18
-
49
-
-
84939625498
-
Metformin inhibits the production of reactive oxygen species from NADH:Ubiquinone oxidoreductase to limit induction of interleukin-1β (IL-1β) and boosts interleukin-10 (IL-10) in lipopolysaccharide (LPS)-activated macrophages
-
Kelly, B., Tannahill, G. M., Murphy, M. P., O’Neill, L. A. (2015) Metformin inhibits the production of reactive oxygen species from NADH:Ubiquinone oxidoreductase to limit induction of interleukin-1β (IL-1β) and boosts interleukin-10 (IL-10) in lipopolysaccharide (LPS)-activated macrophages. J. Biol. Chem. 290, 20348–20359.
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 20348-20359
-
-
Kelly, B.1
Tannahill, G.M.2
Murphy, M.P.3
O’Neill, L.A.4
-
50
-
-
84924935721
-
Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization
-
Jha, A. K., Huang, S. C., Sergushichev, A., Lampropoulou, V., Ivanova, Y., Loginicheva, E., Chmielewski, K., Stewart, K. M., Ashall, J., Everts, B., Pearce, E. J., Driggers, E. M., Artyomov, M. N. (2015) Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization. Immunity 42, 419–430.
-
(2015)
Immunity
, vol.42
, pp. 419-430
-
-
Jha, A.K.1
Huang, S.C.2
Sergushichev, A.3
Lampropoulou, V.4
Ivanova, Y.5
Loginicheva, E.6
Chmielewski, K.7
Stewart, K.M.8
Ashall, J.9
Everts, B.10
Pearce, E.J.11
Driggers, E.M.12
Artyomov, M.N.13
-
51
-
-
84877343356
-
Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production
-
Michelucci, A., Cordes, T., Ghelfi, J., Pailot, A., Reiling, N., Goldmann, O., Binz, T., Wegner, A., Tallam, A., Rausell, A., Buttini, M., Linster, C. L., Medina, E., Balling, R., Hiller, K. (2013) Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Proc. Natl. Acad. Sci. USA 110, 7820–7825.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 7820-7825
-
-
Michelucci, A.1
Cordes, T.2
Ghelfi, J.3
Pailot, A.4
Reiling, N.5
Goldmann, O.6
Binz, T.7
Wegner, A.8
Tallam, A.9
Rausell, A.10
Buttini, M.11
Linster, C.L.12
Medina, E.13
Balling, R.14
Hiller, K.15
-
53
-
-
84899473768
-
Succinate: A metabolic signal in inflammation
-
Mills, E., O’Neill, L. A. (2014) Succinate: a metabolic signal in inflammation. Trends Cell Biol. 24, 313–320.
-
(2014)
Trends Cell Biol
, vol.24
, pp. 313-320
-
-
Mills, E.1
O’Neill, L.A.2
-
54
-
-
84876285741
-
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
-
Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., Zheng, L., Gardet, A., Tong, Z., Jany, S. S., Corr, S. C., Haneklaus, M., Caffrey, B. E., Pierce, K., Walmsley, S., Beasley, F. C., Cummins, E., Nizet, V., Whyte, M., Taylor, C. T., Lin, H., Masters, S. L., Gottlieb, E., Kelly, V. P., Clish, C., Auron, P. E., Xavier, R. J., O’Neill, L. A. (2013) Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature 496, 238–242.
-
(2013)
Nature
, vol.496
, pp. 238-242
-
-
Tannahill, G.M.1
Curtis, A.M.2
Adamik, J.3
Palsson-McDermott, E.M.4
McGettrick, A.F.5
Goel, G.6
Frezza, C.7
Bernard, N.J.8
Kelly, B.9
Foley, N.H.10
Zheng, L.11
Gardet, A.12
Tong, Z.13
Jany, S.S.14
Corr, S.C.15
Haneklaus, M.16
Caffrey, B.E.17
Pierce, K.18
Walmsley, S.19
Beasley, F.C.20
Cummins, E.21
Nizet, V.22
Whyte, M.23
Taylor, C.T.24
Lin, H.25
Masters, S.L.26
Gottlieb, E.27
Kelly, V.P.28
Clish, C.29
Auron, P.E.30
Xavier, R.J.31
O’Neill, L.A.32
more..
-
55
-
-
84990845578
-
Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages
-
Mills, E. L., Kelly, B., Logan, A., Costa, A. S., Varma, M., Bryant, C. E., Tourlomousis, P., Däbritz, J. H., Gottlieb, E., Latorre, I., Corr, S. C., McManus, G., Ryan, D., Jacobs, H. T., Szibor, M., Xavier, R. J., Braun, T., Frezza, C., Murphy, M. P., O’Neill, L. A. (2016) Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages. Cell 167, 457–470.e13.
-
(2016)
Cell
, vol.167
, pp. 457-470
-
-
Mills, E.L.1
Kelly, B.2
Logan, A.3
Costa, A.S.4
Varma, M.5
Bryant, C.E.6
Tourlomousis, P.7
Däbritz, J.H.8
Gottlieb, E.9
Latorre, I.10
Corr, S.C.11
McManus, G.12
Ryan, D.13
Jacobs, H.T.14
Szibor, M.15
Xavier, R.J.16
Braun, T.17
Frezza, C.18
Murphy, M.P.19
O’Neill, L.A.20
more..
-
56
-
-
33745428666
-
Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation
-
Vats, D., Mukundan, L., Odegaard, J. I., Zhang, L., Smith, K. L., Morel, C. R., Wagner, R. A., Greaves, D. R., Murray, P. J., Chawla, A. (2006) Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation. Cell Metab. 4, 13–24.
-
(2006)
Cell Metab
, vol.4
, pp. 13-24
-
-
Vats, D.1
Mukundan, L.2
Odegaard, J.I.3
Zhang, L.4
Smith, K.L.5
Morel, C.R.6
Wagner, R.A.7
Greaves, D.R.8
Murray, P.J.9
Chawla, A.10
-
57
-
-
84906319549
-
Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages
-
Huang, S. C., Everts, B., Ivanova, Y., O’Sullivan, D., Nascimento, M., Smith, A. M., Beatty, W., Love-Gregory, L., Lam, W. Y., O’Neill, C. M., Yan, C., Du, H., Abumrad, N. A., Urban, J. F. Jr., Artyomov, M. N., Pearce, E. L., Pearce, E. J. (2014) Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages. Nat. Immunol. 15, 846–855.
-
(2014)
Nat. Immunol.
, vol.15
, pp. 846-855
-
-
Huang, S.C.1
Everts, B.2
Ivanova, Y.3
O’Sullivan, D.4
Nascimento, M.5
Smith, A.M.6
Beatty, W.7
Love-Gregory, L.8
Lam, W.Y.9
O’Neill, C.M.10
Yan, C.11
Du, H.12
Abumrad, N.A.13
Urban, J.F.14
Artyomov, M.N.15
Pearce, E.L.16
Pearce, E.J.17
-
58
-
-
44349112305
-
Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity
-
Kang, K., Reilly, S. M., Karabacak, V., Gangl, M. R., Fitzgerald, K., Hatano, B., Lee, C. H. (2008) Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab. 7, 485–495.
-
(2008)
Cell Metab
, vol.7
, pp. 485-495
-
-
Kang, K.1
Reilly, S.M.2
Karabacak, V.3
Gangl, M.R.4
Fitzgerald, K.5
Hatano, B.6
Lee, C.H.7
-
59
-
-
34347354309
-
Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance
-
Odegaard, J. I., Ricardo-Gonzalez, R. R., Goforth, M. H., Morel, C. R., Subramanian, V., Mukundan, L., Red Eagle, A., Vats, D., Brombacher, F., Ferrante, A. W., Chawla, A. (2007) Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature 447, 1116–1120.
-
(2007)
Nature
, vol.447
, pp. 1116-1120
-
-
Odegaard, J.I.1
Ricardo-Gonzalez, R.R.2
Goforth, M.H.3
Morel, C.R.4
Subramanian, V.5
Mukundan, L.6
Red Eagle, A.7
Vats, D.8
Brombacher, F.9
Ferrante, A.W.10
Chawla, A.11
-
60
-
-
44349161098
-
Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance
-
Odegaard, J. I., Ricardo-Gonzalez, R. R., Red Eagle, A., Vats, D., Morel, C. R., Goforth, M. H., Subramanian, V., Mukundan, L., Ferrante, A. W., Chawla, A. (2008) Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. Cell Metab. 7, 496–507.
-
(2008)
Cell Metab
, vol.7
, pp. 496-507
-
-
Odegaard, J.I.1
Ricardo-Gonzalez, R.R.2
Red Eagle, A.3
Vats, D.4
Morel, C.R.5
Goforth, M.H.6
Subramanian, V.7
Mukundan, L.8
Ferrante, A.W.9
Chawla, A.10
-
61
-
-
84872576236
-
Metabolism of inflammation limited by AMPK and pseudo-starvation
-
O’Neill, L. A., Hardie, D. G. (2013) Metabolism of inflammation limited by AMPK and pseudo-starvation. Nature 493, 346–355.
-
(2013)
Nature
, vol.493
, pp. 346-355
-
-
O’Neill, L.A.1
Hardie, D.G.2
-
62
-
-
58849115949
-
Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype
-
Sag, D., Carling, D., Stout, R. D., Suttles, J. (2008) Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype. J. Immunol. 181, 8633–8641.
-
(2008)
J. Immunol.
, vol.181
, pp. 8633-8641
-
-
Sag, D.1
Carling, D.2
Stout, R.D.3
Suttles, J.4
-
63
-
-
84994797642
-
Metabolic reprogramming mediated by the mTORC2-IRF4 signaling axis is essential for macrophage alternative activation
-
Huang, S. C., Smith, A. M., Everts, B., Colonna, M., Pearce, E. L., Schilling, J. D., Pearce, E. J. (2016) Metabolic reprogramming mediated by the mTORC2-IRF4 signaling axis is essential for macrophage alternative activation. Immunity 45, 817–830.
-
(2016)
Immunity
, vol.45
, pp. 817-830
-
-
Huang, S.C.1
Smith, A.M.2
Everts, B.3
Colonna, M.4
Pearce, E.L.5
Schilling, J.D.6
Pearce, E.J.7
-
64
-
-
84902136675
-
Proteomic characterization of human proinflammatory M1 and anti-inflammatory M2 macrophages and their response to Candida albicans
-
Reales-Calderón, J. A., Aguilera-Montilla, N., Corbí, A. L., Molero, G., Gil, C. (2014) Proteomic characterization of human proinflammatory M1 and anti-inflammatory M2 macrophages and their response to Candida albicans. Proteomics 14, 1503–1518.
-
(2014)
Proteomics
, vol.14
, pp. 1503-1518
-
-
Reales-Calderón, J.A.1
Aguilera-Montilla, N.2
Corbí, A.L.3
Molero, G.4
Gil, C.5
-
65
-
-
84962617442
-
Cutting edge: Mycobacterium tuberculosis induces aerobic glycolysis in human alveolar macrophages that is required for control of intracellular bacillary replication
-
Gleeson, L. E., Sheedy, F. J., Palsson-McDermott, E. M., Triglia, D., O’Leary, S. M., O’Sullivan, M. P., O’Neill, L. A., Keane, J. (2016) Cutting edge: Mycobacterium tuberculosis induces aerobic glycolysis in human alveolar macrophages that is required for control of intracellular bacillary replication. J. Immunol. 196, 2444–2449.
-
(2016)
J. Immunol.
, vol.196
, pp. 2444-2449
-
-
Gleeson, L.E.1
Sheedy, F.J.2
Palsson-McDermott, E.M.3
Triglia, D.4
O’Leary, S.M.5
O’Sullivan, M.P.6
O’Neill, L.A.7
Keane, J.8
-
66
-
-
84903957169
-
Fatty acid oxidation is dispensable for human macrophage IL-4-induced polarization
-
Namgaladze, D., Brüne, B. (2014) Fatty acid oxidation is dispensable for human macrophage IL-4-induced polarization. Biochim. Biophys. Acta 1841, 1329–1335.
-
(2014)
Biochim. Biophys. Acta
, vol.1841
, pp. 1329-1335
-
-
Namgaladze, D.1
Brüne, B.2
-
67
-
-
78149277909
-
How tolerogenic dendritic cells induce regulatory T cells
-
Maldonado, R. A., von Andrian, U. H. (2010) How tolerogenic dendritic cells induce regulatory T cells. Adv. Immunol. 108, 111–165.
-
(2010)
Adv. Immunol.
, vol.108
, pp. 111-165
-
-
Maldonado, R.A.1
Von Andrian, U.H.2
-
68
-
-
0015619335
-
Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution
-
Steinman, R. M., Cohn, Z. A. (1973) Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J. Exp. Med. 137, 1142–1162.
-
(1973)
J. Exp. Med.
, vol.137
, pp. 1142-1162
-
-
Steinman, R.M.1
Cohn, Z.A.2
-
69
-
-
33750934617
-
Dendritic cells: Translating innate to adaptive immunity
-
Steinman, R. M., Hemmi, H. (2006) Dendritic cells: translating innate to adaptive immunity. Curr. Top. Microbiol. Immunol. 311, 17–58.
-
(2006)
Curr. Top. Microbiol. Immunol.
, vol.311
, pp. 17-58
-
-
Steinman, R.M.1
Hemmi, H.2
-
70
-
-
84900461408
-
Development and function of dendritic cell subsets
-
Mildner, A., Jung, S. (2014) Development and function of dendritic cell subsets. Immunity 40, 642–656.
-
(2014)
Immunity
, vol.40
, pp. 642-656
-
-
Mildner, A.1
Jung, S.2
-
71
-
-
77349093500
-
Harnessing human dendritic cell subsets for medicine
-
Ueno, H., Schmitt, N., Klechevsky, E., Pedroza-Gonzalez, A., Matsui, T., Zurawski, G., Oh, S., Fay, J., Pascual, V., Banchereau, J., Palucka, K. (2010) Harnessing human dendritic cell subsets for medicine. Immunol. Rev. 234, 199–212.
-
(2010)
Immunol. Rev.
, vol.234
, pp. 199-212
-
-
Ueno, H.1
Schmitt, N.2
Klechevsky, E.3
Pedroza-Gonzalez, A.4
Matsui, T.5
Zurawski, G.6
Oh, S.7
Fay, J.8
Pascual, V.9
Banchereau, J.10
Palucka, K.11
-
72
-
-
44449117540
-
Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function
-
Jantsch, J., Chakravortty, D., Turza, N., Prechtel, A. T., Buchholz, B., Gerlach, R. G., Volke, M., Gläsner, J., Warnecke, C., Wiesener, M. S., Eckardt, K. U., Steinkasserer, A., Hensel, M., Willam, C. (2008) Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function. J. Immunol. 180, 4697–4705.
-
(2008)
J. Immunol.
, vol.180
, pp. 4697-4705
-
-
Jantsch, J.1
Chakravortty, D.2
Turza, N.3
Prechtel, A.T.4
Buchholz, B.5
Gerlach, R.G.6
Volke, M.7
Gläsner, J.8
Warnecke, C.9
Wiesener, M.S.10
Eckardt, K.U.11
Steinkasserer, A.12
Hensel, M.13
Willam, C.14
-
73
-
-
77954735369
-
Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation
-
Krawczyk, C. M., Holowka, T., Sun, J., Blagih, J., Amiel, E., DeBerardinis, R. J., Cross, J. R., Jung, E., Thompson, C. B., Jones, R. G., Pearce, E. J. (2010) Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. Blood 115, 4742–4749.
-
(2010)
Blood
, vol.115
, pp. 4742-4749
-
-
Krawczyk, C.M.1
Holowka, T.2
Sun, J.3
Blagih, J.4
Amiel, E.5
Deberardinis, R.J.6
Cross, J.R.7
Jung, E.8
Thompson, C.B.9
Jones, R.G.10
Pearce, E.J.11
-
74
-
-
84907543940
-
MTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity
-
Cheng, S. C., Quintin, J., Cramer, R. A., Shepardson, K. M., Saeed, S., Kumar, V., Giamarellos-Bourboulis, E. J., Martens, J. H., Rao, N. A., Aghajanirefah, A., Manjeri, G. R., Li, Y., Ifrim, D. C., Arts, R. J., van der Veer, B. M., Deen, P. M., Logie, C., O’Neill, L. A., Willems, P., van de Veerdonk, F. L., van der Meer, J. W., Ng, A., Joosten, L. A., Wijmenga, C., Stunnenberg, H. G., Xavier, R. J., Netea, M. G. (2014) mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity. Science 345, 1250684.
-
(2014)
Science
, vol.345
-
-
Cheng, S.C.1
Quintin, J.2
Cramer, R.A.3
Shepardson, K.M.4
Saeed, S.5
Kumar, V.6
Giamarellos-Bourboulis, E.J.7
Martens, J.H.8
Rao, N.A.9
Aghajanirefah, A.10
Manjeri, G.R.11
Li, Y.12
Ifrim, D.C.13
Arts, R.J.14
Van Der Veer, B.M.15
Deen, P.M.16
Logie, C.17
O’Neill, L.A.18
Willems, P.19
Van De Veerdonk, F.L.20
Van Der Meer, J.W.21
Ng, A.22
Joosten, L.A.23
Wijmenga, C.24
Stunnenberg, H.G.25
Xavier, R.J.26
Netea, M.G.27
more..
-
75
-
-
34547134517
-
Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (MTOR) via an mTOR signaling motif
-
Land, S. C., Tee, A. R. (2007) Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif. J. Biol. Chem. 282, 20534–20543.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 20534-20543
-
-
Land, S.C.1
Tee, A.R.2
-
76
-
-
84865435212
-
Inhibition of mechanistic target of rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice
-
Amiel, E., Everts, B., Freitas, T. C., King, I. L., Curtis, J. D., Pearce, E. L., Pearce, E. J. (2012) Inhibition of mechanistic target of rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice. J. Immunol. 189, 2151–2158.
-
(2012)
J. Immunol.
, vol.189
, pp. 2151-2158
-
-
Amiel, E.1
Everts, B.2
Freitas, T.C.3
King, I.L.4
Curtis, J.D.5
Pearce, E.L.6
Pearce, E.J.7
-
77
-
-
84886257842
-
Rapamycin has suppressive and stimulatory effects on human plasmacytoid dendritic cell functions
-
Boor, P. P., Metselaar, H. J., Mancham, S., van der Laan, L. J., Kwekkeboom, J. (2013) Rapamycin has suppressive and stimulatory effects on human plasmacytoid dendritic cell functions. Clin. Exp. Immunol. 174, 389–401.
-
(2013)
Clin. Exp. Immunol.
, vol.174
, pp. 389-401
-
-
Boor, P.P.1
Metselaar, H.J.2
Mancham, S.3
Van Der Laan, L.J.4
Kwekkeboom, J.5
-
78
-
-
77958126087
-
A versatile role of mammalian target of rapamycin in human dendritic cell function and differentiation
-
Haidinger, M., Poglitsch, M., Geyeregger, R., Kasturi, S., Zeyda, M., Zlabinger, G. J., Pulendran, B., Hörl, W. H., Säemann, M. D., Weichhart, T. (2010) A versatile role of mammalian target of rapamycin in human dendritic cell function and differentiation. J. Immunol. 185, 3919–3931.
-
(2010)
J. Immunol.
, vol.185
, pp. 3919-3931
-
-
Haidinger, M.1
Poglitsch, M.2
Geyeregger, R.3
Kasturi, S.4
Zeyda, M.5
Zlabinger, G.J.6
Pulendran, B.7
Hörl, W.H.8
Säemann, M.D.9
Weichhart, T.10
-
79
-
-
0034687662
-
The effect of nitric oxide on cell respiration: A key to understanding its role in cell survival or death
-
Beltrán, B., Mathur, A., Duchen, M. R., Erusalimsky, J. D., Moncada, S. (2000) The effect of nitric oxide on cell respiration: a key to understanding its role in cell survival or death. Proc. Natl. Acad. Sci. USA 97, 14602–14607.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 14602-14607
-
-
Beltrán, B.1
Mathur, A.2
Duchen, M.R.3
Erusalimsky, J.D.4
Moncada, S.5
-
80
-
-
28044464985
-
Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases
-
Cleeter, M. W., Cooper, J. M., Darley-Usmar, V. M., Moncada, S., Schapira, A. H. (1994) Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases. FEBS Lett. 345, 50–54.
-
(1994)
FEBS Lett
, vol.345
, pp. 50-54
-
-
Cleeter, M.W.1
Cooper, J.M.2
Darley-Usmar, V.M.3
Moncada, S.4
Schapira, A.H.5
-
81
-
-
84865197492
-
Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells
-
Everts, B., Amiel, E., van der Windt, G. J., Freitas, T. C., Chott, R., Yarasheski, K. E., Pearce, E. L., Pearce, E. J. (2012) Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells. Blood 120, 1422–1431.
-
(2012)
Blood
, vol.120
, pp. 1422-1431
-
-
Everts, B.1
Amiel, E.2
Van Der Windt, G.J.3
Freitas, T.C.4
Chott, R.5
Yarasheski, K.E.6
Pearce, E.L.7
Pearce, E.J.8
-
82
-
-
84893804974
-
Direct type I IFN but not MDA5/TLR3 activation of dendritic cells is required for maturation and metabolic shift to glycolysis after poly IC stimulation
-
Pantel, A., Teixeira, A., Haddad, E., Wood, E. G., Steinman, R. M., Longhi, M. P. (2014) Direct type I IFN but not MDA5/TLR3 activation of dendritic cells is required for maturation and metabolic shift to glycolysis after poly IC stimulation. PLoS Biol. 12, e1001759.
-
(2014)
Plos Biol
, vol.12
-
-
Pantel, A.1
Teixeira, A.2
Haddad, E.3
Wood, E.G.4
Steinman, R.M.5
Longhi, M.P.6
-
83
-
-
84896654124
-
TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation
-
Everts, B., Amiel, E., Huang, S. C., Smith, A. M., Chang, C. H., Lam, W. Y., Redmann, V., Freitas, T. C., Blagih, J., van der Windt, G. J., Artyomov, M. N., Jones, R. G., Pearce, E. L., Pearce, E. J. (2014) TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation. Nat. Immunol. 15, 323–332.
-
(2014)
Nat. Immunol.
, vol.15
, pp. 323-332
-
-
Everts, B.1
Amiel, E.2
Huang, S.C.3
Smith, A.M.4
Chang, C.H.5
Lam, W.Y.6
Redmann, V.7
Freitas, T.C.8
Blagih, J.9
Van Der Windt, G.J.10
Artyomov, M.N.11
Jones, R.G.12
Pearce, E.L.13
Pearce, E.J.14
-
84
-
-
0042971652
-
Tolerogenic dendritic cells
-
Steinman, R. M., Hawiger, D., Nussenzweig, M. C. (2003) Tolerogenic dendritic cells. Annu. Rev. Immunol. 21, 685–711.
-
(2003)
Annu. Rev. Immunol.
, vol.21
, pp. 685-711
-
-
Steinman, R.M.1
Hawiger, D.2
Nussenzweig, M.C.3
-
85
-
-
84929646104
-
High mitochondrial respiration and glycolytic capacity represent a metabolic phenotype of human tolerogenic dendritic cells
-
Malinarich, F., Duan, K., Hamid, R. A., Bijin, A., Lin, W. X., Poidinger, M., Fairhurst, A. M., Connolly, J. E. (2015) High mitochondrial respiration and glycolytic capacity represent a metabolic phenotype of human tolerogenic dendritic cells. J. Immunol. 194, 5174–5186.
-
(2015)
J. Immunol.
, vol.194
, pp. 5174-5186
-
-
Malinarich, F.1
Duan, K.2
Hamid, R.A.3
Bijin, A.4
Lin, W.X.5
Poidinger, M.6
Fairhurst, A.M.7
Connolly, J.E.8
-
86
-
-
0034672472
-
Peroxisome proliferator-activated receptor gamma activators inhibit interleukin-12 production in murine dendritic cells
-
Faveeuw, C., Fougeray, S., Angeli, V., Fontaine, J., Chinetti, G., Gosset, P., Delerive, P., Maliszewski, C., Capron, M., Staels, B., Moser, M., Trottein, F. (2000) Peroxisome proliferator-activated receptor gamma activators inhibit interleukin-12 production in murine dendritic cells. FEBS Lett. 486, 261–266.
-
(2000)
FEBS Lett
, vol.486
, pp. 261-266
-
-
Faveeuw, C.1
Fougeray, S.2
Angeli, V.3
Fontaine, J.4
Chinetti, G.5
Gosset, P.6
Delerive, P.7
Maliszewski, C.8
Capron, M.9
Staels, B.10
Moser, M.11
Trottein, F.12
-
87
-
-
0034777941
-
Peroxisome proliferator-activated receptor gamma activators affect the maturation of human monocyte-derived dendritic cells
-
Gosset, P., Charbonnier, A. S., Delerive, P., Fontaine, J., Staels, B., Pestel, J., Tonnel, A. B., Trottein, F. (2001) Peroxisome proliferator-activated receptor gamma activators affect the maturation of human monocyte-derived dendritic cells. Eur. J. Immunol. 31, 2857–2865.
-
(2001)
Eur. J. Immunol.
, vol.31
, pp. 2857-2865
-
-
Gosset, P.1
Charbonnier, A.S.2
Delerive, P.3
Fontaine, J.4
Staels, B.5
Pestel, J.6
Tonnel, A.B.7
Trottein, F.8
-
88
-
-
33846902589
-
Peroxisome proliferator-activated receptor gamma control of dendritic cell function contributes to development of CD4+ T cell anergy
-
Klotz, L., Dani, I., Edenhofer, F., Nolden, L., Evert, B., Paul, B., Kolanus, W., Klockgether, T., Knolle, P., Diehl, L. (2007) Peroxisome proliferator-activated receptor gamma control of dendritic cell function contributes to development of CD4+ T cell anergy. J. Immunol. 178, 2122–2131.
-
(2007)
J. Immunol.
, vol.178
, pp. 2122-2131
-
-
Klotz, L.1
Dani, I.2
Edenhofer, F.3
Nolden, L.4
Evert, B.5
Paul, B.6
Kolanus, W.7
Klockgether, T.8
Knolle, P.9
Diehl, L.10
-
89
-
-
0036681640
-
Dendritic cell immunogenicity is regulated by peroxisome proliferator-activated receptor gamma
-
Nencioni, A., Grünebach, F., Zobywlaski, A., Denzlinger, C., Brugger, W., Brossart, P. (2002) Dendritic cell immunogenicity is regulated by peroxisome proliferator-activated receptor gamma. J. Immunol. 169, 1228–1235.
-
(2002)
J. Immunol.
, vol.169
, pp. 1228-1235
-
-
Nencioni, A.1
Grünebach, F.2
Zobywlaski, A.3
Denzlinger, C.4
Brugger, W.5
Brossart, P.6
-
90
-
-
77955344402
-
Lipid accumulation and dendritic cell dysfunction in cancer
-
Herber, D. L., Cao, W., Nefedova, Y., Novitskiy, S. V., Nagaraj, S., Tyurin, V. A., Corzo, A., Cho, H. I., Celis, E., Lennox, B., Knight, S. C., Padhya, T., McCaffrey, T. V., McCaffrey, J. C., Antonia, S., Fishman, M., Ferris, R. L., Kagan, V. E., Gabrilovich, D. I. (2010) Lipid accumulation and dendritic cell dysfunction in cancer. Nat. Med. 16, 880–886.
-
(2010)
Nat. Med.
, vol.16
, pp. 880-886
-
-
Herber, D.L.1
Cao, W.2
Nefedova, Y.3
Novitskiy, S.V.4
Nagaraj, S.5
Tyurin, V.A.6
Corzo, A.7
Cho, H.I.8
Celis, E.9
Lennox, B.10
Knight, S.C.11
Padhya, T.12
McCaffrey, T.V.13
McCaffrey, J.C.14
Antonia, S.15
Fishman, M.16
Ferris, R.L.17
Kagan, V.E.18
Gabrilovich, D.I.19
-
91
-
-
84897506146
-
Oxidized lipids block antigen cross-presentation by dendritic cells in cancer
-
Ramakrishnan, R., Tyurin, V. A., Veglia, F., Condamine, T., Amoscato, A., Mohammadyani, D., Johnson, J. J., Zhang, L. M., Klein-Seetharaman, J., Celis, E., Kagan, V. E., Gabrilovich, D. I. (2014) Oxidized lipids block antigen cross-presentation by dendritic cells in cancer. J. Immunol. 192, 2920–2931.
-
(2014)
J. Immunol.
, vol.192
, pp. 2920-2931
-
-
Ramakrishnan, R.1
Tyurin, V.A.2
Veglia, F.3
Condamine, T.4
Amoscato, A.5
Mohammadyani, D.6
Johnson, J.J.7
Zhang, L.M.8
Klein-Seetharaman, J.9
Celis, E.10
Kagan, V.E.11
Gabrilovich, D.I.12
-
92
-
-
84931569761
-
ER stress sensor XBP1 controls anti-tumor immunity by disrupting dendritic cell homeostasis
-
Cubillos-Ruiz, J. R., Silberman, P. C., Rutkowski, M. R., Chopra, S., Perales-Puchalt, A., Song, M., Zhang, S., Bettigole, S. E., Gupta, D., Holcomb, K., Ellenson, L. H., Caputo, T., Lee, A. H., Conejo-Garcia, J. R., Glimcher, L. H. (2015) ER stress sensor XBP1 controls anti-tumor immunity by disrupting dendritic cell homeostasis. Cell 161, 1527–1538.
-
(2015)
Cell
, vol.161
, pp. 1527-1538
-
-
Cubillos-Ruiz, J.R.1
Silberman, P.C.2
Rutkowski, M.R.3
Chopra, S.4
Perales-Puchalt, A.5
Song, M.6
Zhang, S.7
Bettigole, S.E.8
Gupta, D.9
Holcomb, K.10
Ellenson, L.H.11
Caputo, T.12
Lee, A.H.13
Conejo-Garcia, J.R.14
Glimcher, L.H.15
-
93
-
-
84922625184
-
Immune-mediated antitumor effect by type 2 diabetes drug, metformin
-
Eikawa, S., Nishida, M., Mizukami, S., Yamazaki, C., Nakayama, E., Udono, H. (2015) Immune-mediated antitumor effect by type 2 diabetes drug, metformin. Proc. Natl. Acad. Sci. USA 112, 1809–1814.
-
(2015)
Proc. Natl. Acad. Sci. USA
, vol.112
, pp. 1809-1814
-
-
Eikawa, S.1
Nishida, M.2
Mizukami, S.3
Yamazaki, C.4
Nakayama, E.5
Udono, H.6
-
94
-
-
77954582720
-
Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer
-
Schwartz, D. L., Bankson, J. A., Lemos, R. Jr., Lai, S. Y., Thittai, A. K., He, Y., Hostetter, G., Demeure, M. J., Von Hoff, D. D., Powis, G. (2010) Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer. Mol. Cancer Ther. 9, 2057–2067.
-
(2010)
Mol. Cancer Ther.
, vol.9
, pp. 2057-2067
-
-
Schwartz, D.L.1
Bankson, J.A.2
Lemos, R.3
Lai, S.Y.4
Thittai, A.K.5
He, Y.6
Hostetter, G.7
Demeure, M.J.8
Von Hoff, D.D.9
Powis, G.10
-
95
-
-
23044507635
-
Optimizing cancer radiotherapy with 2-deoxy-d-glucose dose escalation studies in patients with glioblastoma multiforme
-
Singh, D., Banerji, A. K., Dwarakanath, B. S., Tripathi, R. P., Gupta, J. P., Mathew, T. L., Ravindranath, T., Jain, V. (2005) Optimizing cancer radiotherapy with 2-deoxy-d-glucose dose escalation studies in patients with glioblastoma multiforme. Strahlenther. Onkol. 181, 507–514.
-
(2005)
Strahlenther. Onkol
, vol.181
, pp. 507-514
-
-
Singh, D.1
Banerji, A.K.2
Dwarakanath, B.S.3
Tripathi, R.P.4
Gupta, J.P.5
Mathew, T.L.6
Ravindranath, T.7
Jain, V.8
-
96
-
-
84858785703
-
Coordinated regulation of myeloid cells by tumours
-
Gabrilovich, D. I., Ostrand-Rosenberg, S., Bronte, V. (2012) Coordinated regulation of myeloid cells by tumours. Nat. Rev. Immunol. 12, 253–268.
-
(2012)
Nat. Rev. Immunol.
, vol.12
, pp. 253-268
-
-
Gabrilovich, D.I.1
Ostrand-Rosenberg, S.2
Bronte, V.3
-
97
-
-
41149148269
-
Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: Mechanisms and therapeutic perspectives
-
Rodríguez, P. C., Ochoa, A. C. (2008) Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives. Immunol. Rev. 222, 180–191.
-
(2008)
Immunol. Rev.
, vol.222
, pp. 180-191
-
-
Rodríguez, P.C.1
Ochoa, A.C.2
-
98
-
-
84864213428
-
MDSC: A new player in HIV immunopathogenesis
-
Macatangay, B. J., Landay, A. L., Rinaldo, C. R. (2012) MDSC: a new player in HIV immunopathogenesis. AIDS 26, 1567–1569.
-
(2012)
AIDS
, vol.26
, pp. 1567-1569
-
-
Macatangay, B.J.1
Landay, A.L.2
Rinaldo, C.R.3
-
99
-
-
84926980006
-
Pathogenic fungi regulate immunity by inducing neutrophilic myeloid-derived suppressor cells
-
Rieber, N., Singh, A., Öz, H., Carevic, M., Bouzani, M., Amich, J., Ost, M., Ye, Z., Ballbach, M., Schäfer, I., Mezger, M., Klimosch, S. N., Weber, A. N., Handgretinger, R., Krappmann, S., Liese, J., Engeholm, M., Schüle, R., Salih, H. R., Marodi, L., Speckmann, C., Grimbacher, B., Ruland, J., Brown, G. D., Beilhack, A., Loeffler, J., Hartl, D. (2015) Pathogenic fungi regulate immunity by inducing neutrophilic myeloid-derived suppressor cells. Cell Host Microbe 17, 507–514.
-
(2015)
Cell Host Microbe
, vol.17
, pp. 507-514
-
-
Rieber, N.1
Singh, A.2
Öz, H.3
Carevic, M.4
Bouzani, M.5
Amich, J.6
Ost, M.7
Ye, Z.8
Ballbach, M.9
Schäfer, I.10
Mezger, M.11
Klimosch, S.N.12
Weber, A.N.13
Handgretinger, R.14
Krappmann, S.15
Liese, J.16
Engeholm, M.17
Schüle, R.18
Salih, H.R.19
Marodi, L.20
Speckmann, C.21
Grimbacher, B.22
Ruland, J.23
Brown, G.D.24
Beilhack, A.25
Loeffler, J.26
Hartl, D.27
more..
-
100
-
-
32044439372
-
CD11b+/Gr-1+ myeloid suppressor cells cause T cell dysfunction after traumatic stress
-
Makarenkova, V. P., Bansal, V., Matta, B. M., Perez, L. A., Ochoa, J. B. (2006) CD11b+/Gr-1+ myeloid suppressor cells cause T cell dysfunction after traumatic stress. J. Immunol. 176, 2085–2094.
-
(2006)
J. Immunol.
, vol.176
, pp. 2085-2094
-
-
Makarenkova, V.P.1
Bansal, V.2
Matta, B.M.3
Perez, L.A.4
Ochoa, J.B.5
-
101
-
-
84982872436
-
Obesity-induced inflammation and desmoplasia promote pancreatic cancer progression and resistance to chemotherapy
-
Incio, J., Liu, H., Suboj, P., Chin, S. M., Chen, I. X., Pinter, M., Ng, M. R., Nia, H. T., Grahovac, J., Kao, S., Babykutty, S., Huang, Y., Jung, K., Rahbari, N. N., Han, X., Chauhan, V. P., Martin, J. D., Kahn, J., Huang, P., Desphande, V., Michaelson, J., Michelakos, T. P., Ferrone, C. R., Soares, R., Boucher, Y., Fukumura, D., Jain, R. K. (2016) Obesity-induced inflammation and desmoplasia promote pancreatic cancer progression and resistance to chemotherapy. Cancer Discov. 6, 852–869.
-
(2016)
Cancer Discov
, vol.6
, pp. 852-869
-
-
Incio, J.1
Liu, H.2
Suboj, P.3
Chin, S.M.4
Chen, I.X.5
Pinter, M.6
Ng, M.R.7
Nia, H.T.8
Grahovac, J.9
Kao, S.10
Babykutty, S.11
Huang, Y.12
Jung, K.13
Rahbari, N.N.14
Han, X.15
Chauhan, V.P.16
Martin, J.D.17
Kahn, J.18
Huang, P.19
Desphande, V.20
Michaelson, J.21
Michelakos, T.P.22
Ferrone, C.R.23
Soares, R.24
Boucher, Y.25
Fukumura, D.26
Jain, R.K.27
more..
-
102
-
-
79959538608
-
Gr-1+ CD11b+ myeloid-derived suppressor cells suppress inflammation and promote insulin sensitivity in obesity
-
Xia, S., Sha, H., Yang, L., Ji, Y., Ostrand-Rosenberg, S., Qi, L. (2011) Gr-1+ CD11b+ myeloid-derived suppressor cells suppress inflammation and promote insulin sensitivity in obesity. J. Biol. Chem. 286, 23591–23599.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 23591-23599
-
-
Xia, S.1
Sha, H.2
Yang, L.3
Ji, Y.4
Ostrand-Rosenberg, S.5
Qi, L.6
-
103
-
-
78650474985
-
Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13
-
Highfill, S. L., Rodriguez, P. C., Zhou, Q., Goetz, C. A., Koehn, B. H., Veenstra, R., Taylor, P. A., Panoskaltsis-Mortari, A., Serody, J. S., Munn, D. H., Tolar, J., Ochoa, A. C., Blazar, B. R. (2010) Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13. Blood 116, 5738–5747.
-
(2010)
Blood
, vol.116
, pp. 5738-5747
-
-
Highfill, S.L.1
Rodriguez, P.C.2
Zhou, Q.3
Goetz, C.A.4
Koehn, B.H.5
Veenstra, R.6
Taylor, P.A.7
Panoskaltsis-Mortari, A.8
Serody, J.S.9
Munn, D.H.10
Tolar, J.11
Ochoa, A.C.12
Blazar, B.R.13
-
104
-
-
38449100026
-
CD11b+Ly-6C(Hi) suppressive monocytes in experimental autoimmune encephalomyelitis
-
Zhu, B., Bando, Y., Xiao, S., Yang, K., Anderson, A. C., Kuchroo, V. K., Khoury, S. J. (2007) CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis. J. Immunol. 179, 5228–5237.
-
(2007)
J. Immunol.
, vol.179
, pp. 5228-5237
-
-
Zhu, B.1
Bando, Y.2
Xiao, S.3
Yang, K.4
Anderson, A.C.5
Kuchroo, V.K.6
Khoury, S.J.7
-
105
-
-
84977632889
-
Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
-
Bronte, V., Brandau, S., Chen, S. H., Colombo, M. P., Frey, A. B., Greten, T. F., Mandruzzato, S., Murray, P. J., Ochoa, A., Ostrand-Rosenberg, S., Rodriguez, P. C., Sica, A., Umansky, V., Vonderheide, R. H., Gabrilovich, D. I. (2016) Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards. Nat. Commun. 7, 12150.
-
(2016)
Nat. Commun.
, vol.7
-
-
Bronte, V.1
Brandau, S.2
Chen, S.H.3
Colombo, M.P.4
Frey, A.B.5
Greten, T.F.6
Mandruzzato, S.7
Murray, P.J.8
Ochoa, A.9
Ostrand-Rosenberg, S.10
Rodriguez, P.C.11
Sica, A.12
Umansky, V.13
Vonderheide, R.H.14
Gabrilovich, D.I.15
-
106
-
-
78650722060
-
Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes
-
Kowanetz, M., Wu, X., Lee, J., Tan, M., Hagenbeek, T., Qu, X., Yu, L., Ross, J., Korsisaari, N., Cao, T., Bou-Reslan, H., Kallop, D., Weimer, R., Ludlam, M. J., Kaminker, J. S., Modrusan, Z., van Bruggen, N., Peale, F. V., Carano, R., Meng, Y. G., Ferrara, N. (2010) Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes. Proc. Natl. Acad. Sci. USA 107, 21248–21255.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 21248-21255
-
-
Kowanetz, M.1
Wu, X.2
Lee, J.3
Tan, M.4
Hagenbeek, T.5
Qu, X.6
Yu, L.7
Ross, J.8
Korsisaari, N.9
Cao, T.10
Bou-Reslan, H.11
Kallop, D.12
Weimer, R.13
Ludlam, M.J.14
Kaminker, J.S.15
Modrusan, Z.16
Van Bruggen, N.17
Peale, F.V.18
Carano, R.19
Meng, Y.G.20
Ferrara, N.21
more..
-
107
-
-
0034551670
-
Identification of a CD11b(+)/ Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells
-
Bronte, V., Apolloni, E., Cabrelle, A., Ronca, R., Serafini, P., Zamboni, P., Restifo, N. P., Zanovello, P. (2000) Identification of a CD11b(+)/ Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells. Blood 96, 3838–3846.
-
(2000)
Blood
, vol.96
, pp. 3838-3846
-
-
Bronte, V.1
Apolloni, E.2
Cabrelle, A.3
Ronca, R.4
Serafini, P.5
Zamboni, P.6
Restifo, N.P.7
Zanovello, P.8
-
108
-
-
77955771348
-
GM-CSF is one of the main breast tumor-derived soluble factors involved in the differentiation of CD11b-Gr1- bone marrow progenitor cells into myeloid-derived suppressor cells
-
Morales, J. K., Kmieciak, M., Knutson, K. L., Bear, H. D., Manjili, M. H. (2010) GM-CSF is one of the main breast tumor-derived soluble factors involved in the differentiation of CD11b-Gr1- bone marrow progenitor cells into myeloid-derived suppressor cells. Breast Cancer Res. Treat. 123, 39–49.
-
(2010)
Breast Cancer Res. Treat.
, vol.123
, pp. 39-49
-
-
Morales, J.K.1
Kmieciak, M.2
Knutson, K.L.3
Bear, H.D.4
Manjili, M.H.5
-
109
-
-
29644442445
-
Inflammation induces myeloid-derived suppressor cells that facilitate tumor progression
-
Bunt, S. K., Sinha, P., Clements, V. K., Leips, J., Ostrand-Rosenberg, S. (2006) Inflammation induces myeloid-derived suppressor cells that facilitate tumor progression. J. Immunol. 176, 284–290.
-
(2006)
J. Immunol.
, vol.176
, pp. 284-290
-
-
Bunt, S.K.1
Sinha, P.2
Clements, V.K.3
Leips, J.4
Ostrand-Rosenberg, S.5
-
110
-
-
35448954376
-
Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression
-
Bunt, S. K., Yang, L., Sinha, P., Clements, V. K., Leips, J., Ostrand-Rosenberg, S. (2007) Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression. Cancer Res. 67, 10019–10026.
-
(2007)
Cancer Res
, vol.67
, pp. 10019-10026
-
-
Bunt, S.K.1
Yang, L.2
Sinha, P.3
Clements, V.K.4
Leips, J.5
Ostrand-Rosenberg, S.6
-
111
-
-
0037223170
-
IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice
-
Bronte, V., Serafini, P., De Santo, C., Marigo, I., Tosello, V., Mazzoni, A., Segal, D. M., Staib, C., Lowel, M., Sutter, G., Colombo, M. P., Zanovello, P. (2003) IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice. J. Immunol. 170, 270–278.
-
(2003)
J. Immunol.
, vol.170
, pp. 270-278
-
-
Bronte, V.1
Serafini, P.2
De Santo, C.3
Marigo, I.4
Tosello, V.5
Mazzoni, A.6
Segal, D.M.7
Staib, C.8
Lowel, M.9
Sutter, G.10
Colombo, M.P.11
Zanovello, P.12
-
112
-
-
33749425534
-
Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells
-
Gallina, G., Dolcetti, L., Serafini, P., De Santo, C., Marigo, I., Colombo, M. P., Basso, G., Brombacher, F., Borrello, I., Zanovello, P., Bicciato, S., Bronte, V. (2006) Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. J. Clin. Invest. 116, 2777–2790.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 2777-2790
-
-
Gallina, G.1
Dolcetti, L.2
Serafini, P.3
De Santo, C.4
Marigo, I.5
Colombo, M.P.6
Basso, G.7
Brombacher, F.8
Borrello, I.9
Zanovello, P.10
Bicciato, S.11
Bronte, V.12
-
113
-
-
84908054077
-
HMGB1 enhances immune suppression by facilitating the differentiation and suppressive activity of myeloid-derived suppressor cells
-
Parker, K. H., Sinha, P., Horn, L. A., Clements, V. K., Yang, H., Li, J., Tracey, K. J., Ostrand-Rosenberg, S. (2014) HMGB1 enhances immune suppression by facilitating the differentiation and suppressive activity of myeloid-derived suppressor cells. Cancer Res. 74, 5723–5733.
-
(2014)
Cancer Res
, vol.74
, pp. 5723-5733
-
-
Parker, K.H.1
Sinha, P.2
Horn, L.A.3
Clements, V.K.4
Yang, H.5
Li, J.6
Tracey, K.J.7
Ostrand-Rosenberg, S.8
-
114
-
-
53349125963
-
Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cells
-
Sinha, P., Okoro, C., Foell, D., Freeze, H. H., Ostrand-Rosenberg, S., Srikrishna, G. (2008) Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cells. J. Immunol. 181, 4666–4675.
-
(2008)
J. Immunol.
, vol.181
, pp. 4666-4675
-
-
Sinha, P.1
Okoro, C.2
Foell, D.3
Freeze, H.H.4
Ostrand-Rosenberg, S.5
Srikrishna, G.6
-
115
-
-
84876921278
-
Tumor STAT1 transcription factor activity enhances breast tumor growth and immune suppression mediated by myeloid-derived suppressor cells
-
Hix, L. M., Karavitis, J., Khan, M. W., Shi, Y. H., Khazaie, K., Zhang, M. (2013) Tumor STAT1 transcription factor activity enhances breast tumor growth and immune suppression mediated by myeloid-derived suppressor cells. J. Biol. Chem. 288, 11676–11688.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 11676-11688
-
-
Hix, L.M.1
Karavitis, J.2
Khan, M.W.3
Shi, Y.H.4
Khazaie, K.5
Zhang, M.6
-
116
-
-
17044366637
-
STAT1 signaling regulates tumor-associated macrophage-mediated T cell deletion
-
Kusmartsev, S., Gabrilovich, D. I. (2005) STAT1 signaling regulates tumor-associated macrophage-mediated T cell deletion. J. Immunol. 174, 4880–4891.
-
(2005)
J. Immunol.
, vol.174
, pp. 4880-4891
-
-
Kusmartsev, S.1
Gabrilovich, D.I.2
-
117
-
-
84885029080
-
Myeloid-derived suppressor cell development is regulated by a STAT/ IRF-8 axis
-
Waight, J. D., Netherby, C., Hensen, M. L., Miller, A., Hu, Q., Liu, S., Bogner, P. N., Farren, M. R., Lee, K. P., Liu, K., Abrams, S. I. (2013) Myeloid-derived suppressor cell development is regulated by a STAT/ IRF-8 axis. J. Clin. Invest. 123, 4464–4478.
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 4464-4478
-
-
Waight, J.D.1
Netherby, C.2
Hensen, M.L.3
Miller, A.4
Hu, Q.5
Liu, S.6
Bogner, P.N.7
Farren, M.R.8
Lee, K.P.9
Liu, K.10
Abrams, S.I.11
-
118
-
-
53349099219
-
Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein
-
Cheng, P., Corzo, C. A., Luetteke, N., Yu, B., Nagaraj, S., Bui, M. M., Ortiz, M., Nacken, W., Sorg, C., Vogl, T., Roth, J., Gabrilovich, D. I. (2008) Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein. J. Exp. Med. 205, 2235–2249.
-
(2008)
J. Exp. Med.
, vol.205
, pp. 2235-2249
-
-
Cheng, P.1
Corzo, C.A.2
Luetteke, N.3
Yu, B.4
Nagaraj, S.5
Bui, M.M.6
Ortiz, M.7
Nacken, W.8
Sorg, C.9
Vogl, T.10
Roth, J.11
Gabrilovich, D.I.12
-
119
-
-
66949145484
-
Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells
-
Corzo, C. A., Cotter, M. J., Cheng, P., Cheng, F., Kusmartsev, S., Sotomayor, E., Padhya, T., McCaffrey, T. V., McCaffrey, J. C., Gabrilovich, D. I. (2009) Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells. J. Immunol. 182, 5693–5701.
-
(2009)
J. Immunol.
, vol.182
, pp. 5693-5701
-
-
Corzo, C.A.1
Cotter, M.J.2
Cheng, P.3
Cheng, F.4
Kusmartsev, S.5
Sotomayor, E.6
Padhya, T.7
McCaffrey, T.V.8
McCaffrey, J.C.9
Gabrilovich, D.I.10
-
120
-
-
77953914366
-
Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor
-
Marigo, I., Bosio, E., Solito, S., Mesa, C., Fernandez, A., Dolcetti, L., Ugel, S., Sonda, N., Bicciato, S., Falisi, E., Calabrese, F., Basso, G., Zanovello, P., Cozzi, E., Mandruzzato, S., Bronte, V. (2010) Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor. Immunity 32, 790–802.
-
(2010)
Immunity
, vol.32
, pp. 790-802
-
-
Marigo, I.1
Bosio, E.2
Solito, S.3
Mesa, C.4
Fernandez, A.5
Dolcetti, L.6
Ugel, S.7
Sonda, N.8
Bicciato, S.9
Falisi, E.10
Calabrese, F.11
Basso, G.12
Zanovello, P.13
Cozzi, E.14
Mandruzzato, S.15
Bronte, V.16
-
121
-
-
65549129226
-
Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells
-
Xin, H., Zhang, C., Herrmann, A., Du, Y., Figlin, R., Yu, H. (2009) Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells. Cancer Res. 69, 2506–2513.
-
(2009)
Cancer Res
, vol.69
, pp. 2506-2513
-
-
Xin, H.1
Zhang, C.2
Herrmann, A.3
Du, Y.4
Figlin, R.5
Yu, H.6
-
122
-
-
84875866083
-
STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients
-
Vasquez-Dunddel, D., Pan, F., Zeng, Q., Gorbounov, M., Albesiano, E., Fu, J., Blosser, R. L., Tam, A. J., Bruno, T., Zhang, H., Pardoll, D., Kim, Y. (2013) STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients. J. Clin. Invest. 123, 1580–1589.
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 1580-1589
-
-
Vasquez-Dunddel, D.1
Pan, F.2
Zeng, Q.3
Gorbounov, M.4
Albesiano, E.5
Fu, J.6
Blosser, R.L.7
Tam, A.J.8
Bruno, T.9
Zhang, H.10
Pardoll, D.11
Kim, Y.12
-
123
-
-
84908003234
-
The stress-response sensor chop regulates the function and accumulation of myeloid-derived suppressor cells in tumors
-
Thevenot, P. T., Sierra, R. A., Raber, P. L., Al-Khami, A. A., Trillo-Tinoco, J., Zarreii, P., Ochoa, A. C., Cui, Y., Del Valle, L., Rodriguez, P. C. (2014) The stress-response sensor chop regulates the function and accumulation of myeloid-derived suppressor cells in tumors. Immunity 41, 389–401.
-
(2014)
Immunity
, vol.41
, pp. 389-401
-
-
Thevenot, P.T.1
Sierra, R.A.2
Raber, P.L.3
Al-Khami, A.A.4
Trillo-Tinoco, J.5
Zarreii, P.6
Ochoa, A.C.7
Cui, Y.8
Del Valle, L.9
Rodriguez, P.C.10
-
124
-
-
84941622047
-
Tumor-induced myeloid deviation: When myeloid-derived suppressor cells meet tumor-associated macrophages
-
Ugel, S., De Sanctis, F., Mandruzzato, S., Bronte, V. (2015) Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages. J. Clin. Invest. 125, 3365–3376.
-
(2015)
J. Clin. Invest.
, vol.125
, pp. 3365-3376
-
-
Ugel, S.1
De Sanctis, F.2
Mandruzzato, S.3
Bronte, V.4
-
125
-
-
4143130091
-
Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses
-
Rodriguez, P. C., Quiceno, D. G., Zabaleta, J., Ortiz, B., Zea, A. H., Piazuelo, M. B., Delgado, A., Correa, P., Brayer, J., Sotomayor, E. M., Antonia, S., Ochoa, J. B., Ochoa, A. C. (2004) Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses. Cancer Res. 64, 5839–5849.
-
(2004)
Cancer Res
, vol.64
, pp. 5839-5849
-
-
Rodriguez, P.C.1
Quiceno, D.G.2
Zabaleta, J.3
Ortiz, B.4
Zea, A.H.5
Piazuelo, M.B.6
Delgado, A.7
Correa, P.8
Brayer, J.9
Sotomayor, E.M.10
Antonia, S.11
Ochoa, J.B.12
Ochoa, A.C.13
-
126
-
-
60549088732
-
Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes
-
Rodriguez, P. C., Ernstoff, M. S., Hernandez, C., Atkins, M., Zabaleta, J., Sierra, R., Ochoa, A. C. (2009) Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes. Cancer Res. 69, 1553–1560.
-
(2009)
Cancer Res
, vol.69
, pp. 1553-1560
-
-
Rodriguez, P.C.1
Ernstoff, M.S.2
Hernandez, C.3
Atkins, M.4
Zabaleta, J.5
Sierra, R.6
Ochoa, A.C.7
-
127
-
-
19544389638
-
L-Arginine modulates CD3zeta expression and T cell function in activated human T lymphocytes
-
Zea, A. H., Rodriguez, P. C., Culotta, K. S., Hernandez, C. P., DeSalvo, J., Ochoa, J. B., Park, H. J., Zabaleta, J., Ochoa, A. C. (2004) L-Arginine modulates CD3zeta expression and T cell function in activated human T lymphocytes. Cell. Immunol. 232, 21–31.
-
(2004)
Cell. Immunol.
, vol.232
, pp. 21-31
-
-
Zea, A.H.1
Rodriguez, P.C.2
Culotta, K.S.3
Hernandez, C.P.4
Desalvo, J.5
Ochoa, J.B.6
Park, H.J.7
Zabaleta, J.8
Ochoa, A.C.9
-
128
-
-
0039435292
-
L-Arginine regulates the expression of the T-cell receptor zeta chain (CD3zeta) in Jurkat cells
-
Taheri, F., Ochoa, J. B., Faghiri, Z., Culotta, K., Park, H. J., Lan, M. S., Zea, A. H., Ochoa, A. C. (2001) L-Arginine regulates the expression of the T-cell receptor zeta chain (CD3zeta) in Jurkat cells. Clin. Cancer Res. 7 (3: Suppl), 958s–965s.
-
(2001)
Clin. Cancer Res.
, vol.7
, Issue.3
, pp. 958s-965s
-
-
Taheri, F.1
Ochoa, J.B.2
Faghiri, Z.3
Culotta, K.4
Park, H.J.5
Lan, M.S.6
Zea, A.H.7
Ochoa, A.C.8
-
129
-
-
33846933459
-
L-Arginine availability regulates T-lymphocyte cell-cycle progression
-
Rodriguez, P. C., Quiceno, D. G., Ochoa, A. C. (2007) L-Arginine availability regulates T-lymphocyte cell-cycle progression. Blood 109, 1568–1573.
-
(2007)
Blood
, vol.109
, pp. 1568-1573
-
-
Rodriguez, P.C.1
Quiceno, D.G.2
Ochoa, A.C.3
-
130
-
-
78149491757
-
L-arginine deprivation regulates cyclin D3 mRNA stability in human T cells by controlling HuR expression
-
Rodriguez, P. C., Hernandez, C. P., Morrow, K., Sierra, R., Zabaleta, J., Wyczechowska, D. D., Ochoa, A. C. (2010) L-arginine deprivation regulates cyclin D3 mRNA stability in human T cells by controlling HuR expression. J. Immunol. 185, 5198–5204.
-
(2010)
J. Immunol.
, vol.185
, pp. 5198-5204
-
-
Rodriguez, P.C.1
Hernandez, C.P.2
Morrow, K.3
Sierra, R.4
Zabaleta, J.5
Wyczechowska, D.D.6
Ochoa, A.C.7
-
131
-
-
84920939262
-
L-Arginine depletion blunts antitumor T-cell responses by inducing myeloid-derived suppressor cells
-
Fletcher, M., Ramirez, M. E., Sierra, R. A., Raber, P., Thevenot, P., Al-Khami, A. A., Sanchez-Pino, D., Hernandez, C., Wyczechowska, D. D., Ochoa, A. C., Rodriguez, P. C. (2015) L-Arginine depletion blunts antitumor T-cell responses by inducing myeloid-derived suppressor cells. Cancer Res. 75, 275–283.
-
(2015)
Cancer Res
, vol.75
, pp. 275-283
-
-
Fletcher, M.1
Ramirez, M.E.2
Sierra, R.A.3
Raber, P.4
Thevenot, P.5
Al-Khami, A.A.6
Sanchez-Pino, D.7
Hernandez, C.8
Wyczechowska, D.D.9
Ochoa, A.C.10
Rodriguez, P.C.11
-
132
-
-
84992478733
-
L-Arginine modulates T cell metabolism and enhances survival and anti-tumor activity
-
Geiger, R., Rieckmann, J. C., Wolf, T., Basso, C., Feng, Y., Fuhrer, T., Kogadeeva, M., Picotti, P., Meissner, F., Mann, M., Zamboni, N., Sallusto, F., Lanzavecchia, A. (2016) L-Arginine modulates T cell metabolism and enhances survival and anti-tumor activity. Cell 167, 829–842.e13.
-
(2016)
Cell
, vol.167
, pp. 829-842
-
-
Geiger, R.1
Rieckmann, J.C.2
Wolf, T.3
Basso, C.4
Feng, Y.5
Fuhrer, T.6
Kogadeeva, M.7
Picotti, P.8
Meissner, F.9
Mann, M.10
Zamboni, N.11
Sallusto, F.12
Lanzavecchia, A.13
-
133
-
-
84897992390
-
Subpopulations of myeloid-derived suppressor cells impair T cell responses through independent nitric oxide-related pathways
-
Raber, P. L., Thevenot, P., Sierra, R., Wyczechowska, D., Halle, D., Ramirez, M. E., Ochoa, A. C., Fletcher, M., Velasco, C., Wilk, A., Reiss, K., Rodriguez, P. C. (2014) Subpopulations of myeloid-derived suppressor cells impair T cell responses through independent nitric oxide-related pathways. Int. J. Cancer 134, 2853–2864.
-
(2014)
Int. J. Cancer
, vol.134
, pp. 2853-2864
-
-
Raber, P.L.1
Thevenot, P.2
Sierra, R.3
Wyczechowska, D.4
Halle, D.5
Ramirez, M.E.6
Ochoa, A.C.7
Fletcher, M.8
Velasco, C.9
Wilk, A.10
Reiss, K.11
Rodriguez, P.C.12
-
134
-
-
0037080021
-
Myeloid suppressor lines inhibit T cell responses by an NO-dependent mechanism
-
Mazzoni, A., Bronte, V., Visintin, A., Spitzer, J. H., Apolloni, E., Serafini, P., Zanovello, P., Segal, D. M. (2002) Myeloid suppressor lines inhibit T cell responses by an NO-dependent mechanism. J. Immunol. 168, 689–695.
-
(2002)
J. Immunol.
, vol.168
, pp. 689-695
-
-
Mazzoni, A.1
Bronte, V.2
Visintin, A.3
Spitzer, J.H.4
Apolloni, E.5
Serafini, P.6
Zanovello, P.7
Segal, D.M.8
-
135
-
-
0035889886
-
Tumor-infiltrating macrophages induce apoptosis in activated CD8(+) T cells by a mechanism requiring cell contact and mediated by both the cell-associated form of TNF and nitric oxide
-
Saio, M., Radoja, S., Marino, M., Frey, A. B. (2001) Tumor-infiltrating macrophages induce apoptosis in activated CD8(+) T cells by a mechanism requiring cell contact and mediated by both the cell-associated form of TNF and nitric oxide. J. Immunol. 167, 5583–5593.
-
(2001)
J. Immunol.
, vol.167
, pp. 5583-5593
-
-
Saio, M.1
Radoja, S.2
Marino, M.3
Frey, A.B.4
-
136
-
-
0033559897
-
Peroxynitrite inhibits T lymphocyte activation and proliferation by promoting impairment of tyrosine phosphorylation and peroxynitrite-driven apoptotic death
-
Brito, C., Naviliat, M., Tiscornia, A. C., Vuillier, F., Gualco, G., Dighiero, G., Radi, R., Cayota, A. M. (1999) Peroxynitrite inhibits T lymphocyte activation and proliferation by promoting impairment of tyrosine phosphorylation and peroxynitrite-driven apoptotic death. J. Immunol. 162, 3356–3366.
-
(1999)
J. Immunol.
, vol.162
, pp. 3356-3366
-
-
Brito, C.1
Naviliat, M.2
Tiscornia, A.C.3
Vuillier, F.4
Gualco, G.5
Dighiero, G.6
Radi, R.7
Cayota, A.M.8
-
137
-
-
80053421470
-
Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice
-
Lu, T., Ramakrishnan, R., Altiok, S., Youn, J. I., Cheng, P., Celis, E., Pisarev, V., Sherman, S., Sporn, M. B., Gabrilovich, D. (2011) Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice. J. Clin. Invest. 121, 4015–4029.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 4015-4029
-
-
Lu, T.1
Ramakrishnan, R.2
Altiok, S.3
Youn, J.I.4
Cheng, P.5
Celis, E.6
Pisarev, V.7
Sherman, S.8
Sporn, M.B.9
Gabrilovich, D.10
-
138
-
-
34447118098
-
Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer
-
Nagaraj, S., Gupta, K., Pisarev, V., Kinarsky, L., Sherman, S., Kang, L., Herber, D. L., Schneck, J., Gabrilovich, D. I. (2007) Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer. Nat. Med. 13, 828–835.
-
(2007)
Nat. Med.
, vol.13
, pp. 828-835
-
-
Nagaraj, S.1
Gupta, K.2
Pisarev, V.3
Kinarsky, L.4
Sherman, S.5
Kang, L.6
Herber, D.L.7
Schneck, J.8
Gabrilovich, D.I.9
-
139
-
-
84895528474
-
The emerging immunological role of post-translational modifications by reactive nitrogen species in cancer microenvironment
-
De Sanctis, F., Sandri, S., Ferrarini, G., Pagliarello, I., Sartoris, S., Ugel, S., Marigo, I., Molon, B., Bronte, V. (2014) The emerging immunological role of post-translational modifications by reactive nitrogen species in cancer microenvironment. Front. Immunol. 5, 69.
-
(2014)
Front. Immunol.
, vol.5
, pp. 69
-
-
De Sanctis, F.1
Sandri, S.2
Ferrarini, G.3
Pagliarello, I.4
Sartoris, S.5
Ugel, S.6
Marigo, I.7
Molon, B.8
Bronte, V.9
-
140
-
-
80054694464
-
Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells
-
Molon, B., Ugel, S., Del Pozzo, F., Soldani, C., Zilio, S., Avella, D., De Palma, A., Mauri, P., Monegal, A., Rescigno, M., Savino, B., Colombo, P., Jonjic, N., Pecanic, S., Lazzarato, L., Fruttero, R., Gasco, A., Bronte, V., Viola, A. (2011) Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells. J. Exp. Med. 208, 1949–1962.
-
(2011)
J. Exp. Med.
, vol.208
, pp. 1949-1962
-
-
Molon, B.1
Ugel, S.2
Del Pozzo, F.3
Soldani, C.4
Zilio, S.5
Avella, D.6
De Palma, A.7
Mauri, P.8
Monegal, A.9
Rescigno, M.10
Savino, B.11
Colombo, P.12
Jonjic, N.13
Pecanic, S.14
Lazzarato, L.15
Fruttero, R.16
Gasco, A.17
Bronte, V.18
Viola, A.19
-
141
-
-
85014398925
-
Arginine metabolism in myeloid cells shapes innate and adaptive immunity
-
Rodriguez, P. C., Ochoa, A. C., Al-Khami, A. A. (2017) Arginine metabolism in myeloid cells shapes innate and adaptive immunity. Front. Immunol. 8, 93.
-
(2017)
Front. Immunol.
, vol.8
, pp. 93
-
-
Rodriguez, P.C.1
Ochoa, A.C.2
Al-Khami, A.A.3
-
142
-
-
84959542771
-
The nature of myeloid-derived suppressor cells in the tumor microenvironment
-
Kumar, V., Patel, S., Tcyganov, E., Gabrilovich, D. I. (2016) The nature of myeloid-derived suppressor cells in the tumor microenvironment. Trends Immunol. 37, 208–220.
-
(2016)
Trends Immunol
, vol.37
, pp. 208-220
-
-
Kumar, V.1
Patel, S.2
Tcyganov, E.3
Gabrilovich, D.I.4
-
143
-
-
84866242667
-
IDO is a nodal pathogenic driver of lung cancer and metastasis development
-
Smith, C., Chang, M. Y., Parker, K. H., Beury, D. W., DuHadaway, J. B., Flick, H. E., Boulden, J., Sutanto-Ward, E., Soler, A. P., Laury-Kleintop, L. D., Mandik-Nayak, L., Metz, R., Ostrand-Rosenberg, S., Prendergast, G. C., Muller, A. J. (2012) IDO is a nodal pathogenic driver of lung cancer and metastasis development. Cancer Discov. 2, 722–735.
-
(2012)
Cancer Discov
, vol.2
, pp. 722-735
-
-
Smith, C.1
Chang, M.Y.2
Parker, K.H.3
Beury, D.W.4
Duhadaway, J.B.5
Flick, H.E.6
Boulden, J.7
Sutanto-Ward, E.8
Soler, A.P.9
Laury-Kleintop, L.D.10
Mandik-Nayak, L.11
Metz, R.12
Ostrand-Rosenberg, S.13
Prendergast, G.C.14
Muller, A.J.15
-
144
-
-
84875462761
-
Myeloid-derived suppressor cells suppress antitumor immune responses through IDO expression and correlate with lymph node metastasis in patients with breast cancer
-
Yu, J., Du, W., Yan, F., Wang, Y., Li, H., Cao, S., Yu, W., Shen, C., Liu, J., Ren, X. (2013) Myeloid-derived suppressor cells suppress antitumor immune responses through IDO expression and correlate with lymph node metastasis in patients with breast cancer. J. Immunol. 190, 3783–3797.
-
(2013)
J. Immunol.
, vol.190
, pp. 3783-3797
-
-
Yu, J.1
Du, W.2
Yan, F.3
Wang, Y.4
Li, H.5
Cao, S.6
Yu, W.7
Shen, C.8
Liu, J.9
Ren, X.10
-
145
-
-
19344377474
-
GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase
-
Munn, D. H., Sharma, M. D., Baban, B., Harding, H. P., Zhang, Y., Ron, D., Mellor, A. L. (2005) GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. Immunity 22, 633–642.
-
(2005)
Immunity
, vol.22
, pp. 633-642
-
-
Munn, D.H.1
Sharma, M.D.2
Baban, B.3
Harding, H.P.4
Zhang, Y.5
Ron, D.6
Mellor, A.L.7
-
146
-
-
75149123468
-
Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine
-
Srivastava, M. K., Sinha, P., Clements, V. K., Rodriguez, P., Ostrand-Rosenberg, S. (2010) Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine. Cancer Res. 70, 68–77.
-
(2010)
Cancer Res
, vol.70
, pp. 68-77
-
-
Srivastava, M.K.1
Sinha, P.2
Clements, V.K.3
Rodriguez, P.4
Ostrand-Rosenberg, S.5
-
147
-
-
84863224448
-
Immunosuppressive activity enhances central carbon metabolism and bioenergetics in myeloid-derived suppressor cells in vitro models
-
Hammami, I., Chen, J., Murschel, F., Bronte, V., De Crescenzo, G., Jolicoeur, M. (2012) Immunosuppressive activity enhances central carbon metabolism and bioenergetics in myeloid-derived suppressor cells in vitro models. BMC Cell Biol. 13, 18.
-
(2012)
BMC Cell Biol
, vol.13
, pp. 18
-
-
Hammami, I.1
Chen, J.2
Murschel, F.3
Bronte, V.4
De Crescenzo, G.5
Jolicoeur, M.6
-
148
-
-
84893873953
-
SIRT1 limits the function and fate of myeloid-derived suppressor cells in tumors by orchestrating HIF-1α-dependent glycolysis
-
Liu, G., Bi, Y., Shen, B., Yang, H., Zhang, Y., Wang, X., Liu, H., Lu, Y., Liao, J., Chen, X., Chu, Y. (2014) SIRT1 limits the function and fate of myeloid-derived suppressor cells in tumors by orchestrating HIF-1α-dependent glycolysis. Cancer Res. 74, 727–737.
-
(2014)
Cancer Res
, vol.74
, pp. 727-737
-
-
Liu, G.1
Bi, Y.2
Shen, B.3
Yang, H.4
Zhang, Y.5
Wang, X.6
Liu, H.7
Lu, Y.8
Liao, J.9
Chen, X.10
Chu, Y.11
-
149
-
-
78149330949
-
HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
-
Corzo, C. A., Condamine, T., Lu, L., Cotter, M. J., Youn, J. I., Cheng, P., Cho, H. I., Celis, E., Quiceno, D. G., Padhya, T., McCaffrey, T. V., McCaffrey, J. C., Gabrilovich, D. I. (2010) HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J. Exp. Med. 207, 2439–2453.
-
(2010)
J. Exp. Med.
, vol.207
, pp. 2439-2453
-
-
Corzo, C.A.1
Condamine, T.2
Lu, L.3
Cotter, M.J.4
Youn, J.I.5
Cheng, P.6
Cho, H.I.7
Celis, E.8
Quiceno, D.G.9
Padhya, T.10
McCaffrey, T.V.11
McCaffrey, J.C.12
Gabrilovich, D.I.13
-
150
-
-
84899753178
-
PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
-
Noman, M. Z., Desantis, G., Janji, B., Hasmim, M., Karray, S., Dessen, P., Bronte, V., Chouaib, S. (2014) PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation. J. Exp. Med. 211, 781–790.
-
(2014)
J. Exp. Med.
, vol.211
, pp. 781-790
-
-
Noman, M.Z.1
Desantis, G.2
Janji, B.3
Hasmim, M.4
Karray, S.5
Dessen, P.6
Bronte, V.7
Chouaib, S.8
-
151
-
-
84958652204
-
CD45 phosphatase inhibits STAT3 transcription factor activity in myeloid cells and promotes tumor-associated macrophage differentiation
-
Kumar, V., Cheng, P., Condamine, T., Mony, S., Languino, L. R., McCaffrey, J. C., Hockstein, N., Guarino, M., Masters, G., Penman, E., Denstman, F., Xu, X., Altieri, D. C., Du, H., Yan, C., Gabrilovich, D. I. (2016) CD45 phosphatase inhibits STAT3 transcription factor activity in myeloid cells and promotes tumor-associated macrophage differentiation. Immunity 44, 303–315.
-
(2016)
Immunity
, vol.44
, pp. 303-315
-
-
Kumar, V.1
Cheng, P.2
Condamine, T.3
Mony, S.4
Languino, L.R.5
McCaffrey, J.C.6
Hockstein, N.7
Guarino, M.8
Masters, G.9
Penman, E.10
Denstman, F.11
Xu, X.12
Altieri, D.C.13
Du, H.14
Yan, C.15
Gabrilovich, D.I.16
-
152
-
-
84979993733
-
Metabolic reprogramming of myeloid-derived suppressor cells (MDSC) in cancer
-
Al-Khami, A. A., Rodriguez, P. C., Ochoa, A. C. (2016) Metabolic reprogramming of myeloid-derived suppressor cells (MDSC) in cancer. OncoImmunology 5, e1200771.
-
(2016)
Oncoimmunology
, vol.5
-
-
Al-Khami, A.A.1
Rodriguez, P.C.2
Ochoa, A.C.3
-
153
-
-
84941659899
-
Inhibition of fatty acid oxidation modulates immunosuppressive functions of myeloid-derived suppressor cells and enhances cancer therapies
-
Hossain, F., Al-Khami, A. A., Wyczechowska, D., Hernandez, C., Zheng, L., Reiss, K., Valle, L. D., Trillo-Tinoco, J., Maj, T., Zou, W., Rodriguez, P. C., Ochoa, A. C. (2015) Inhibition of fatty acid oxidation modulates immunosuppressive functions of myeloid-derived suppressor cells and enhances cancer therapies. Cancer Immunol. Res. 3, 1236–1247.
-
(2015)
Cancer Immunol. Res.
, vol.3
, pp. 1236-1247
-
-
Hossain, F.1
Al-Khami, A.A.2
Wyczechowska, D.3
Hernandez, C.4
Zheng, L.5
Reiss, K.6
Valle, L.D.7
Trillo-Tinoco, J.8
Maj, T.9
Zou, W.10
Rodriguez, P.C.11
Ochoa, A.C.12
-
154
-
-
85025478245
-
Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients
-
Condamine, T., Dominguez, G. A., Youn, J. I., Kossenkov, A. V., Mony, S., Alicea-Torres, K., Tcyganov, E., Hashimoto, A., Nefedova, Y., Lin, C., Partlova, S., Garfall, A., Vogl, D. T., Xu, X., Knight, S. C., Malietzis, G., Lee, G. H., Eruslanov, E., Albelda, S. M., Wang, X., Mehta, J. L., Bewtra, M., Rustgi, A., Hockstein, N., Witt, R., Masters, G., Nam, B., Smirnov, D., Sepulveda, M. A., Gabrilovich, D. I. (2016) Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients. Sci. Immunol. 1, aaf8943.
-
(2016)
Sci. Immunol.
, vol.1
-
-
Condamine, T.1
Dominguez, G.A.2
Youn, J.I.3
Kossenkov, A.V.4
Mony, S.5
Alicea-Torres, K.6
Tcyganov, E.7
Hashimoto, A.8
Nefedova, Y.9
Lin, C.10
Partlova, S.11
Garfall, A.12
Vogl, D.T.13
Xu, X.14
Knight, S.C.15
Malietzis, G.16
Lee, G.H.17
Eruslanov, E.18
Albelda, S.M.19
Wang, X.20
Mehta, J.L.21
Bewtra, M.22
Rustgi, A.23
Hockstein, N.24
Witt, R.25
Masters, G.26
Nam, B.27
Smirnov, D.28
Sepulveda, M.A.29
Gabrilovich, D.I.30
more..
-
155
-
-
84907223092
-
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
-
Colegio, O. R., Chu, N. Q., Szabo, A. L., Chu, T., Rhebergen, A. M., Jairam, V., Cyrus, N., Brokowski, C. E., Eisenbarth, S. C., Phillips, G. M., Cline, G. W., Phillips, A. J., Medzhitov, R. (2014) Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature 513, 559–563.
-
(2014)
Nature
, vol.513
, pp. 559-563
-
-
Colegio, O.R.1
Chu, N.Q.2
Szabo, A.L.3
Chu, T.4
Rhebergen, A.M.5
Jairam, V.6
Cyrus, N.7
Brokowski, C.E.8
Eisenbarth, S.C.9
Phillips, G.M.10
Cline, G.W.11
Phillips, A.J.12
Medzhitov, R.13
-
156
-
-
84880648196
-
Tumor-derived lactate modifies antitumor immune response: Effect on myeloid-derived suppressor cells and NK cells
-
Husain, Z., Huang, Y., Seth, P., Sukhatme, V. P. (2013) Tumor-derived lactate modifies antitumor immune response: effect on myeloid-derived suppressor cells and NK cells. J. Immunol. 191, 1486–1495.
-
(2013)
J. Immunol.
, vol.191
, pp. 1486-1495
-
-
Husain, Z.1
Huang, Y.2
Seth, P.3
Sukhatme, V.P.4
-
157
-
-
84941344937
-
Metabolic competition in the tumor microenvironment is a driver of cancer progression
-
Chang, C. H., Qiu, J., O’Sullivan, D., Buck, M. D., Noguchi, T., Curtis, J. D., Chen, Q., Gindin, M., Gubin, M. M., van der Windt, G. J., Tonc, E., Schreiber, R. D., Pearce, E. J., Pearce, E. L. (2015) Metabolic competition in the tumor microenvironment is a driver of cancer progression. Cell 162, 1229–1241.
-
(2015)
Cell
, vol.162
, pp. 1229-1241
-
-
Chang, C.H.1
Qiu, J.2
O’Sullivan, D.3
Buck, M.D.4
Noguchi, T.5
Curtis, J.D.6
Chen, Q.7
Gindin, M.8
Gubin, M.M.9
Van Der Windt, G.J.10
Tonc, E.11
Schreiber, R.D.12
Pearce, E.J.13
Pearce, E.L.14
|