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Volumn 74, Issue 20, 2014, Pages 5723-5733

HMGB1 enhances immune suppression by facilitating the differentiation and suppressive activity of myeloid-derived suppressor cells

Author keywords

[No Author keywords available]

Indexed keywords

HIGH MOBILITY GROUP B1 PROTEIN; HMGB1 PROTEIN, MOUSE; IL10 PROTEIN, MOUSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; L SELECTIN; TUMOR ANTIGEN;

EID: 84908054077     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-13-2347     Document Type: Article
Times cited : (190)

References (51)
  • 2
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 2009;9: 162-74
    • (2009) Nat Rev Immunol , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 3
    • 34548805636 scopus 로고    scopus 로고
    • Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response
    • Sinha P, Clements VK, Bunt SK, Albelda SM, Ostrand-Rosenberg S. Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response. J Immunol 2007;179:977-83
    • (2007) J Immunol , vol.179 , pp. 977-983
    • Sinha, P.1    Clements, V.K.2    Bunt, S.K.3    Albelda, S.M.4    Ostrand-Rosenberg, S.5
  • 4
    • 70249140303 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells down-regulate L-selectin expression on CD4+ and CD8+ T cells
    • Hanson EM, Clements VK, Sinha P, Ilkovitch D, Ostrand-Rosenberg S. Myeloid-derived suppressor cells down-regulate L-selectin expression on CD4+ and CD8+ T cells. J Immunol 2009;183:937-44
    • (2009) J Immunol , vol.183 , pp. 937-944
    • Hanson, E.M.1    Clements, V.K.2    Sinha, P.3    Ilkovitch, D.4    Ostrand-Rosenberg, S.5
  • 5
    • 5444225991 scopus 로고    scopus 로고
    • Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis
    • Yang L, DeBusk LM, Fukuda K, Fingleton B, Green-Jarvis B, Shyr Y, et al. Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell 2004;6:409-21
    • (2004) Cancer Cell , vol.6 , pp. 409-421
    • Yang, L.1    Debusk, L.M.2    Fukuda, K.3    Fingleton, B.4    Green-Jarvis, B.5    Shyr, Y.6
  • 6
    • 37349100945 scopus 로고    scopus 로고
    • Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis
    • Yang L, Huang J, Ren X, Gorska AE, Chytil A, Aakre M, et al. Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. Cancer Cell 2008;13:23-35
    • (2008) Cancer Cell , vol.13 , pp. 23-35
    • Yang, L.1    Huang, J.2    Ren, X.3    Gorska, A.E.4    Chytil, A.5    Aakre, M.6
  • 7
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: Back to Virchow?
    • Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet 2001;357:539-45
    • (2001) Lancet , vol.357 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 8
    • 65249138393 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells: Linking inflammation and cancer
    • Ostrand-Rosenberg S, Sinha P. Myeloid-derived suppressor cells: linking inflammation and cancer. J Immunol 2009;182:4499-506
    • (2009) J Immunol , vol.182 , pp. 4499-4506
    • Ostrand-Rosenberg, S.1    Sinha, P.2
  • 10
    • 17144376810 scopus 로고    scopus 로고
    • High-mobility group box 1 protein (HMGB1): Nuclear weapon in the immune arsenal
    • Lotze MT, Tracey KJ. High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol 2005;5: 331-42
    • (2005) Nat Rev Immunol , vol.5 , pp. 331-342
    • Lotze, M.T.1    Tracey, K.J.2
  • 12
    • 0038276946 scopus 로고    scopus 로고
    • Structural basis for the proinflammatory cytokine activity of high mobility group box 1
    • Li J, Kokkola R, Tabibzadeh S, Yang R, Ochani M, Qiang X, et al. Structural basis for the proinflammatory cytokine activity of high mobility group box 1. Mol Med 2003;9:37-45
    • (2003) Mol Med , vol.9 , pp. 37-45
    • Li, J.1    Kokkola, R.2    Tabibzadeh, S.3    Yang, R.4    Ochani, M.5    Qiang, X.6
  • 13
    • 74449089862 scopus 로고    scopus 로고
    • Targeting HMGB1 in inflammation
    • Yang H, Tracey KJ. Targeting HMGB1 in inflammation. Biochim Biophys Acta 2010;1799:149-56
    • (2010) Biochim Biophys Acta , vol.1799 , pp. 149-156
    • Yang, H.1    Tracey, K.J.2
  • 14
    • 9144241208 scopus 로고    scopus 로고
    • Reversing established sepsis with antagonists of endogenous high-mobility group box 1
    • Yang H, Ochani M, Li J, Qiang X, Tanovic M, Harris HE, et al. Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc Natl Acad Sci U S A 2004;101:296-301
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 296-301
    • Yang, H.1    Ochani, M.2    Li, J.3    Qiang, X.4    Tanovic, M.5    Harris, H.E.6
  • 15
    • 38449121249 scopus 로고    scopus 로고
    • Altered immune function during long-term host-tumor interactions can be modulated to retard autochthonous neoplastic growth
    • Stewart TJ, Abrams SI. Altered immune function during long-term host-tumor interactions can be modulated to retard autochthonous neoplastic growth. J Immunol 2007;179:2851-9
    • (2007) J Immunol , vol.179 , pp. 2851-2859
    • Stewart, T.J.1    Abrams, S.I.2
  • 16
    • 0033052037 scopus 로고    scopus 로고
    • The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice
    • Calogero S, Grassi F, Aguzzi A, Voigtlander T, Ferrier P, Ferrari S, et al. The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice. Nat Genet 1999;22:276-80
    • (1999) Nat Genet , vol.22 , pp. 276-280
    • Calogero, S.1    Grassi, F.2    Aguzzi, A.3    Voigtlander, T.4    Ferrier, P.5    Ferrari, S.6
  • 17
    • 11844277698 scopus 로고    scopus 로고
    • Reduction of myeloidderived suppressor cells and induction of M1 macrophages facilitate the rejection of established metastatic disease
    • Sinha P, Clements VK, Ostrand-Rosenberg S. Reduction of myeloidderived suppressor cells and induction of M1 macrophages facilitate the rejection of established metastatic disease. J Immunol 2005;174: 636-45
    • (2005) J Immunol , vol.174 , pp. 636-645
    • Sinha, P.1    Clements, V.K.2    Ostrand-Rosenberg, S.3
  • 18
    • 77953914366 scopus 로고    scopus 로고
    • Tumor-induced tolerance and immune suppression depend on the C/ EBPbeta transcription factor
    • Marigo I, Bosio E, Solito S, Mesa C, Fernandez A, Dolcetti L, et al. Tumor-induced tolerance and immune suppression depend on the C/ EBPbeta transcription factor. Immunity 2010;32:790-802
    • (2010) Immunity , vol.32 , pp. 790-802
    • Marigo, I.1    Bosio, E.2    Solito, S.3    Mesa, C.4    Fernandez, A.5    Dolcetti, L.6
  • 19
    • 84888378057 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cell function is reduced by Withaferin A, a potent and abundant component of Withania somnifera root extract
    • Sinha P, Ostrand-Rosenberg S. Myeloid-derived suppressor cell function is reduced by Withaferin A, a potent and abundant component of Withania somnifera root extract. Cancer Immunol Immunother 2013; 62:1663-73
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 1663-1673
    • Sinha, P.1    Ostrand-Rosenberg, S.2
  • 20
    • 53349125963 scopus 로고    scopus 로고
    • Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cells
    • Sinha P, Okoro C, Foell D, Freeze HH, Ostrand-Rosenberg S, Srikrishna G. Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cells. J Immunol 2008;181:4666-75
    • (2008) J Immunol , vol.181 , pp. 4666-4675
    • Sinha, P.1    Okoro, C.2    Foell, D.3    Freeze, H.H.4    Ostrand-Rosenberg, S.5    Srikrishna, G.6
  • 21
    • 0034698830 scopus 로고    scopus 로고
    • High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes
    • Andersson U, Wang H, Palmblad K, Aveberger AC, Bloom O, Erlandsson-Harris H, et al. High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J Exp Med 2000;192:565-70
    • (2000) J Exp Med , vol.192 , pp. 565-570
    • Andersson, U.1    Wang, H.2    Palmblad, K.3    Aveberger, A.C.4    Bloom, O.5    Erlandsson-Harris, H.6
  • 22
    • 1542380035 scopus 로고    scopus 로고
    • Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    • Park JS, Svetkauskaite D, He Q, Kim JY, Strassheim D, Ishizaka A, et al. Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem 2004;279:7370-7
    • (2004) J Biol Chem , vol.279 , pp. 7370-7377
    • Park, J.S.1    Svetkauskaite, D.2    He, Q.3    Kim, J.Y.4    Strassheim, D.5    Ishizaka, A.6
  • 24
    • 34249300128 scopus 로고    scopus 로고
    • Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells
    • Sinha P, Clements VK, Fulton AM, Ostrand-Rosenberg S. Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells. Cancer Res 2007;67:4507-13
    • (2007) Cancer Res , vol.67 , pp. 4507-4513
    • Sinha, P.1    Clements, V.K.2    Fulton, A.M.3    Ostrand-Rosenberg, S.4
  • 25
    • 53349099219 scopus 로고    scopus 로고
    • Inhibition of dendritic cell differentiation and accumulation of myeloidderived suppressor cells in cancer is regulated by S100A9 protein
    • Cheng P, Corzo CA, Luetteke N, Yu B, Nagaraj S, Bui MM, et al. Inhibition of dendritic cell differentiation and accumulation of myeloidderived suppressor cells in cancer is regulated by S100A9 protein. J Exp Med 2008;205:2235-49
    • (2008) J Exp Med , vol.205 , pp. 2235-2249
    • Cheng, P.1    Corzo, C.A.2    Luetteke, N.3    Yu, B.4    Nagaraj, S.5    Bui, M.M.6
  • 26
    • 0037125985 scopus 로고    scopus 로고
    • Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation
    • Ulloa L, Ochani M, Yang H, Tanovic M, Halperin D, Yang R, et al. Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc Natl Acad Sci U S A 2002; 99:12351-6
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 12351-12356
    • Ulloa, L.1    Ochani, M.2    Yang, H.3    Tanovic, M.4    Halperin, D.5    Yang, R.6
  • 27
    • 84860862890 scopus 로고    scopus 로고
    • Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1)
    • Yang H, Lundback P, Ottosson L, Erlandsson-Harris H, Venereau E, Bianchi ME, et al. Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1). Mol Med 2012;18:250-9
    • (2012) Mol Med , vol.18 , pp. 250-259
    • Yang, H.1    Lundback, P.2    Ottosson, L.3    Erlandsson-Harris, H.4    Venereau, E.5    Bianchi, M.E.6
  • 28
    • 35748967851 scopus 로고    scopus 로고
    • High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity
    • Bianchi ME, Manfredi AA. High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity. Immunol Rev 2007;220:35-46
    • (2007) Immunol Rev , vol.220 , pp. 35-46
    • Bianchi, M.E.1    Manfredi, A.A.2
  • 29
    • 0034551670 scopus 로고    scopus 로고
    • Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells
    • Bronte V, Apolloni E, Cabrelle A, Ronca R, Serafini P, Zamboni P, et al. Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells. Blood 2000; 96:3838-46
    • (2000) Blood , vol.96 , pp. 3838-3846
    • Bronte, V.1    Apolloni, E.2    Cabrelle, A.3    Ronca, R.4    Serafini, P.5    Zamboni, P.6
  • 30
    • 0035339932 scopus 로고    scopus 로고
    • Mechanism of immune dysfunction in cancer mediated by immature Gr-1+ myeloid cells
    • Gabrilovich DI, Velders MP, Sotomayor EM, Kast WM. Mechanism of immune dysfunction in cancer mediated by immature Gr-1+ myeloid cells. J Immunol 2001;166:5398-406
    • (2001) J Immunol , vol.166 , pp. 5398-5406
    • Gabrilovich, D.I.1    Velders, M.P.2    Sotomayor, E.M.3    Kast, W.M.4
  • 31
    • 0029150389 scopus 로고
    • Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
    • Kontgen F, Grumont RJ, Strasser A, Metcalf D, Li R, Tarlinton D, et al. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev 1995;9:1965-77
    • (1995) Genes Dev , vol.9 , pp. 1965-1977
    • Kontgen, F.1    Grumont, R.J.2    Strasser, A.3    Metcalf, D.4    Li, R.5    Tarlinton, D.6
  • 32
    • 31544446571 scopus 로고    scopus 로고
    • Gr- 1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumorbearing host
    • Huang B, Pan PY, Li Q, Sato AI, Levy DE, Bromberg J, et al. Gr- 1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumorbearing host. Cancer Res 2006;66:1123-31
    • (2006) Cancer Res , vol.66 , pp. 1123-1131
    • Huang, B.1    Pan, P.Y.2    Li, Q.3    Sato, A.I.4    Levy, D.E.5    Bromberg, J.6
  • 33
    • 29644442445 scopus 로고    scopus 로고
    • Inflammation induces myeloid-derived suppressor cells that facilitate tumor progression
    • Bunt SK, Sinha P, Clements VK, Leips J, Ostrand-Rosenberg S. Inflammation induces myeloid-derived suppressor cells that facilitate tumor progression. J Immunol 2006;176:284-90
    • (2006) J Immunol , vol.176 , pp. 284-290
    • Bunt, S.K.1    Sinha, P.2    Clements, V.K.3    Leips, J.4    Ostrand-Rosenberg, S.5
  • 34
    • 35448954376 scopus 로고    scopus 로고
    • Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression
    • Bunt SK, Yang L, Sinha P, Clements VK, Leips J, Ostrand-Rosenberg S. Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression. Cancer Res 2007;67:10019-26
    • (2007) Cancer Res , vol.67 , pp. 10019-10026
    • Bunt, S.K.1    Yang, L.2    Sinha, P.3    Clements, V.K.4    Leips, J.5    Ostrand-Rosenberg, S.6
  • 35
    • 0032053794 scopus 로고    scopus 로고
    • Reduction of established spontaneous mammary carcinoma metastases following immunotherapy with major histocompatibility complex class II and B7.1 cell-based tumor vaccines
    • Pulaski BA, Ostrand-Rosenberg S. Reduction of established spontaneous mammary carcinoma metastases following immunotherapy with major histocompatibility complex class II and B7.1 cell-based tumor vaccines. Cancer Res 1998;58:1486-93
    • (1998) Cancer Res , vol.58 , pp. 1486-1493
    • Pulaski, B.A.1    Ostrand-Rosenberg, S.2
  • 36
    • 79960387864 scopus 로고    scopus 로고
    • Knockdown of HMGB1 in tumor cells attenuates their ability to induce regulatory T cells and uncovers naturally acquired CD8 T cell-dependent antitumor immunity
    • Liu Z, Falo LD Jr, You Z. Knockdown of HMGB1 in tumor cells attenuates their ability to induce regulatory T cells and uncovers naturally acquired CD8 T cell-dependent antitumor immunity. J Immunol 2011;187:118-25
    • (2011) J Immunol , vol.187 , pp. 118-125
    • Liu, Z.1    Falo, L.D.2    You, Z.3
  • 38
    • 29144504335 scopus 로고    scopus 로고
    • CD11b+/Gr-1+immature myeloid cells mediate suppression of T cells in mice bearing tumors of IL-1beta-secreting cells
    • Song X, Krelin Y, Dvorkin T, Bjorkdahl O, Segal S, Dinarello CA, et al. CD11b+/Gr-1+immature myeloid cells mediate suppression of T cells in mice bearing tumors of IL-1beta-secreting cells. J Immunol 2005;175:8200-8
    • (2005) J Immunol , vol.175 , pp. 8200-8208
    • Song, X.1    Krelin, Y.2    Dvorkin, T.3    Bjorkdahl, O.4    Segal, S.5    Dinarello, C.A.6
  • 39
    • 42149192003 scopus 로고    scopus 로고
    • HMGB1 develops enhanced proinflammatory activity by binding to cytokines
    • Sha Y, Zmijewski J, Xu Z, Abraham E. HMGB1 develops enhanced proinflammatory activity by binding to cytokines. J Immunol 2008; 180:2531-7
    • (2008) J Immunol , vol.180 , pp. 2531-2537
    • Sha, Y.1    Zmijewski, J.2    Xu, Z.3    Abraham, E.4
  • 40
    • 33745447910 scopus 로고    scopus 로고
    • High mobility group box-1 protein activates endothelial cells to produce cytokines and has synergistic effect with lipopolysaccharide in inducing interleukin-6 release
    • Liu JH, Li ZJ, Tang J, Liu YW, Zhao L, Deng P, et al. [High mobility group box-1 protein activates endothelial cells to produce cytokines and has synergistic effect with lipopolysaccharide in inducing interleukin-6 release]. Zhonghua Yi Xue Za Zhi 2006;86:1191-5
    • (2006) Zhonghua Yi Xue Za Zhi , vol.86 , pp. 1191-1195
    • Liu, J.H.1    Li, Z.J.2    Tang, J.3    Liu, Y.W.4    Zhao, L.5    Deng, P.6
  • 43
    • 84875511757 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha blocks differentiation and enhances suppressive activity of immature myeloid cells during chronic inflammation
    • Sade-Feldman M, Kanterman J, Ish-Shalom E, Elnekave M, Horwitz E, Baniyash M. Tumor necrosis factor-alpha blocks differentiation and enhances suppressive activity of immature myeloid cells during chronic inflammation. Immunity 2013;38:541-54
    • (2013) Immunity , vol.38 , pp. 541-554
    • Sade-Feldman, M.1    Kanterman, J.2    Ish-Shalom, E.3    Elnekave, M.4    Horwitz, E.5    Baniyash, M.6
  • 44
    • 84865084552 scopus 로고    scopus 로고
    • HMGB1 conveys immunosuppressive characteristics on regulatory and conventional T cells
    • Wild CA, Bergmann C, Fritz G, Schuler P, Hoffmann TK, Lotfi R, et al. HMGB1 conveys immunosuppressive characteristics on regulatory and conventional T cells. Int Immunol 2012;24:485-94
    • (2012) Int Immunol , vol.24 , pp. 485-494
    • Wild, C.A.1    Bergmann, C.2    Fritz, G.3    Schuler, P.4    Hoffmann, T.K.5    Lotfi, R.6
  • 46
    • 0034682315 scopus 로고    scopus 로고
    • Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases
    • Taguchi A, Blood DC, del Toro G, Canet A, Lee DC, Qu W, et al. Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Nature 2000;405:354-60
    • (2000) Nature , vol.405 , pp. 354-360
    • Taguchi, A.1    Blood, D.C.2    Del Toro, G.3    Canet, A.4    Lee, D.C.5    Qu, W.6
  • 47
    • 57349100780 scopus 로고    scopus 로고
    • Not just nuclear proteins: 'Novel' autophagy cancer treatment targets - P53 and HMGB1
    • Livesey KM, Tang D, Zeh HJ, Lotze MT. Not just nuclear proteins: 'novel' autophagy cancer treatment targets - p53 and HMGB1. Curr Opin Investig Drugs 2008;9:1259-63
    • (2008) Curr Opin Investig Drugs , vol.9 , pp. 1259-1263
    • Livesey, K.M.1    Tang, D.2    Zeh, H.J.3    Lotze, M.T.4
  • 48
    • 2942700201 scopus 로고    scopus 로고
    • High mobility group box protein 1: An endogenous signal for dendritic cell maturation and Th1 polarization
    • Messmer D, Yang H, Telusma G, Knoll F, Li J, Messmer B, et al. High mobility group box protein 1: an endogenous signal for dendritic cell maturation and Th1 polarization. J Immunol 2004;173:307-13
    • (2004) J Immunol , vol.173 , pp. 307-313
    • Messmer, D.1    Yang, H.2    Telusma, G.3    Knoll, F.4    Li, J.5    Messmer, B.6
  • 49
    • 34948820602 scopus 로고    scopus 로고
    • Toll-like receptor 4-dependent contribution of the immune system to anticancerchemotherapy and radiotherapy
    • Apetoh L, Ghiringhelli F, Tesniere A, Obeid M, Ortiz C, Criollo A, et al. Toll-like receptor 4-dependent contribution of the immune system to anticancerchemotherapy and radiotherapy. NatMed2007;13:1050-9
    • (2007) NatMed , vol.13 , pp. 1050-1059
    • Apetoh, L.1    Ghiringhelli, F.2    Tesniere, A.3    Obeid, M.4    Ortiz, C.5    Criollo, A.6
  • 50
    • 67149115417 scopus 로고    scopus 로고
    • Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4
    • Bunt SK, Clements VK, Hanson EM, Sinha P, Ostrand-Rosenberg S. Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4. J Leukoc Biol 2009;85: 996-1004
    • (2009) J Leukoc Biol , vol.85 , pp. 996-1004
    • Bunt, S.K.1    Clements, V.K.2    Hanson, E.M.3    Sinha, P.4    Ostrand-Rosenberg, S.5
  • 51


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.