L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

Cell

Volumn 167, Issue 3, 2016, Pages 829-842.e13

  Geiger, Roger ^a,b   Rieckmann, Jan C ^c   Wolf, Tobias ^a,b   Basso, Camilla ^a   Feng, Yuehan ^b   Fuhrer, Tobias ^b   Kogadeeva, Maria ^b   Picotti, Paola ^b   Meissner, Felix ^c   Mann, Matthias ^c   Zamboni, Nicola ^b   Sallusto, Federica ^a   Lanzavecchia, Antonio ^a,b  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

^b ETH ZURICH   (Switzerland)

^c MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

cancer immunotherapy; L arginine; LiP MS; metabolism; metabolite sensing; metabolome; proteome; T cell; T cell survival

Indexed keywords

AGMATINE; AMINO ACID TRANSPORTER; ARGINASE; ARGINASE 2; ARGININE; BAZ1B PROTEIN; CITRULLINE; CREATINE; INTERLEUKIN 2; ORNITHINE OXOACID AMINOTRANSFERASE; OXYGEN; PROLINE; PROTEOME; PSIP1 PROTEIN; PUTRESCINE; RAPAMYCIN; REGULATOR PROTEIN; SPERMIDINE SYNTHASE; TSN PROTEIN; UNCLASSIFIED DRUG; UREA; BAZ1B PROTEIN, HUMAN; DNA BINDING PROTEIN; PSIP1 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TRANSCRIPTION FACTOR; TSN PROTEIN, HUMAN;

ADOPTIVE TRANSFER; AMINO ACID METABOLISM; ANIMAL CELL; ARTICLE; CANCER SURVIVAL; CELL METABOLISM; CELL SURVIVAL; CONTROLLED STUDY; FEMALE; GENE EXPRESSION PROFILING; GLYCOLYSIS; HUMAN; HUMAN CELL; IMMUNOMODULATION; LIQUID CHROMATOGRAPHY; LYMPHOCYTE CLONE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MALE; MASS SPECTROMETRY; MEMORY T LYMPHOCYTE; METABOLOME; METABOLOMICS; MOUSE MODEL; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEOMICS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TUMOR IMMUNITY; UREA CYCLE; ANIMAL; BAGG ALBINO MOUSE; CD4+ T LYMPHOCYTE; EXPERIMENTAL MELANOMA; GENE INACTIVATION; GENETIC TRANSCRIPTION; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; SKIN TUMOR;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ARGININE; CD4-POSITIVE T-LYMPHOCYTES; DNA-BINDING PROTEINS; GENE KNOCKOUT TECHNIQUES; GLYCOLYSIS; HUMANS; IMMUNOLOGIC MEMORY; IMMUNOMODULATION; LYMPHOCYTE ACTIVATION; MELANOMA, EXPERIMENTAL; METABOLOME; MICE; MICE, INBRED BALB C; OXIDATIVE PHOSPHORYLATION; PROTEOME; SKIN NEOPLASMS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 84992478733     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.09.031     Document Type: Article

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