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Volumn 288, Issue 17, 2013, Pages 11676-11688

Tumor STAT1 transcription factor activity enhances breast tumor growth and immune suppression mediated by myeloid-derived suppressor cells

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER CELLS; CONSTITUTIVELY ACTIVES; DISEASE PROGRESSION; DUCTAL CARCINOMA IN SITU; HUMAN BREAST CANCER; MAMMARY CARCINOMA CELL; MICROARRAY ANALYSIS; TUMOR MICROENVIRONMENT;

EID: 84876921278     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.441402     Document Type: Article
Times cited : (106)

References (64)
  • 1
  • 2
    • 0036852241 scopus 로고    scopus 로고
    • Cancer immunoediting. From immunosurveillance to tumor escape
    • Dunn, G. P., Bruce, A. T., Ikeda, H., Old, L. J., and Schreiber, R. D. (2002) Cancer immunoediting. From immunosurveillance to tumor escape. Nat Immunol. 3, 991-998
    • (2002) Nat Immunol. , vol.3 , pp. 991-998
    • Dunn, G.P.1    Bruce, A.T.2    Ikeda, H.3    Old, L.J.4    Schreiber, R.D.5
  • 3
    • 0036852191 scopus 로고    scopus 로고
    • Natural selection of tumor variants in the generation of "tumor escape" phenotypes
    • Khong, H. T., and Restifo, N. P. (2002) Natural selection of tumor variants in the generation of "tumor escape" phenotypes. Nat. Immunol. 3, 999-1005
    • (2002) Nat. Immunol. , vol.3 , pp. 999-1005
    • Khong, H.T.1    Restifo, N.P.2
  • 4
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens, L. M., and Werb, Z. (2002) Inflammation and cancer. Nature 420, 860-867
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 6
    • 38549167908 scopus 로고    scopus 로고
    • Immunosuppressivemechanisms in human tumors. Why we still cannot cure cancer
    • Gross, S., and Walden, P. (2008) Immunosuppressivemechanisms in human tumors. Why we still cannot cure cancer. Immunol. Lett. 116, 7-14
    • (2008) Immunol. Lett. , vol.116 , pp. 7-14
    • Gross, S.1    Walden, P.2
  • 7
    • 84867031414 scopus 로고    scopus 로고
    • Regulation of COX2 expression in mouse mammary tumor cells controls bone metastasis and PGE2-induction of regulatory T cell migration
    • Karavitis, J., Hix, L. M., Shi, Y. H., Schultz, R. F., Khazaie, K., and Zhang, M. (2012) Regulation of COX2 expression in mouse mammary tumor cells controls bone metastasis and PGE2-induction of regulatory T cell migration. PloS One 7, e46342
    • (2012) PloS One , vol.7
    • Karavitis, J.1    Hix, L.M.2    Shi, Y.H.3    Schultz, R.F.4    Khazaie, K.5    Zhang, M.6
  • 8
    • 0031588358 scopus 로고    scopus 로고
    • Investigation of mammary epithelial cell-bone marrow stroma interactions using primary human cell culture as a model of metastasis
    • Brooks, B., Bundred, N. J., Howell, A., Lang, S. H., and Testa, N. G. (1997) Investigation of mammary epithelial cell-bone marrow stroma interactions using primary human cell culture as a model of metastasis. Int. J. Cancer 73, 690-696
    • (1997) Int. J. Cancer , vol.73 , pp. 690-696
    • Brooks, B.1    Bundred, N.J.2    Howell, A.3    Lang, S.H.4    Testa, N.G.5
  • 9
    • 44349152371 scopus 로고    scopus 로고
    • Increased COX2 expression enhances tumor-induced osteoclastic lesions in breast cancer bone metastasis
    • Li, Z., Schem, C., Shi, Y. H., Medina, D., and Zhang, M. (2008) Increased COX2 expression enhances tumor-induced osteoclastic lesions in breast cancer bone metastasis. Clin. Exp. Metastasis 25, 389-400
    • (2008) Clin. Exp. Metastasis , vol.25 , pp. 389-400
    • Li, Z.1    Schem, C.2    Shi, Y.H.3    Medina, D.4    Zhang, M.5
  • 10
    • 79958759972 scopus 로고    scopus 로고
    • CD1d-expressing breast cancer cells modulate NKT cell-mediated antitumor immunity in a murine model of breast cancer metastasis
    • Hix, L. M., Shi, Y. H., Brutkiewicz, R. R., Stein, P. L., Wang, C. R., and Zhang, M. (2011) CD1d-expressing breast cancer cells modulate NKT cell-mediated antitumor immunity in a murine model of breast cancer metastasis. PloS One 6, e20702
    • (2011) PloS One , vol.6
    • Hix, L.M.1    Shi, Y.H.2    Brutkiewicz, R.R.3    Stein, P.L.4    Wang, C.R.5    Zhang, M.6
  • 12
    • 0030024563 scopus 로고    scopus 로고
    • Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
    • Durbin, J. E., Hackenmiller, R., Simon, M. C., and Levy, D. E. (1996) Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84, 443-450
    • (1996) Cell , vol.84 , pp. 443-450
    • Durbin, J.E.1    Hackenmiller, R.2    Simon, M.C.3    Levy, D.E.4
  • 13
    • 33847073462 scopus 로고    scopus 로고
    • A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-γ in human cancer cells
    • Lynch, R. A., Etchin, J., Battle, T. E., and Frank, D. A. (2007) A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-γ in human cancer cells. Cancer Res. 67, 1254-1261
    • (2007) Cancer Res. , vol.67 , pp. 1254-1261
    • Lynch, R.A.1    Etchin, J.2    Battle, T.E.3    Frank, D.A.4
  • 18
    • 1242319531 scopus 로고    scopus 로고
    • STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells
    • Khodarev, N. N., Beckett, M., Labay, E., Darga, T., Roizman, B., and Weichselbaum, R. R. (2004) STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells. Proc. Natl. Acad. Sci. U. S. A. 101, 1714-1719
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 1714-1719
    • Khodarev, N.N.1    Beckett, M.2    Labay, E.3    Darga, T.4    Roizman, B.5    Weichselbaum, R.R.6
  • 22
    • 31344474166 scopus 로고    scopus 로고
    • Myeloid suppressor cells in cancer. Recruitment, phenotype, properties, and mechanisms of immune suppression. Semin
    • Serafini, P., Borrello, I., and Bronte, V. (2006) Myeloid suppressor cells in cancer. Recruitment, phenotype, properties, and mechanisms of immune suppression. Semin. Cancer Biol. 16, 53-65
    • (2006) Cancer Biol. , vol.16 , pp. 53-65
    • Serafini, P.1    Borrello, I.2    Bronte, V.3
  • 23
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • Gabrilovich, D. I., and Nagaraj, S. (2009) Myeloid-derived suppressor cells as regulators of the immune system. Nat. Rev. Immunol. 9, 162-174
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 24
    • 40349094954 scopus 로고    scopus 로고
    • Inflammation and breast cancer. Balancing immune response. Cross-talk between adaptive and innate immune cells during breast cancer progression
    • DeNardo, D. G., and Coussens, L. M. (2007) Inflammation and breast cancer. Balancing immune response. Cross-talk between adaptive and innate immune cells during breast cancer progression. Breast Cancer Res. 9, 212
    • (2007) Breast Cancer Res. , vol.9 , pp. 212
    • DeNardo, D.G.1    Coussens, L.M.2
  • 26
    • 0035884506 scopus 로고    scopus 로고
    • Blocking tumor growth, invasion, and metastasis by maspin in a syngeneic breast cancer model
    • Shi, H. Y., Zhang, W., Liang, R., Abraham, S., Kittrell, F. S., Medina, D., and Zhang, M. (2001) Blocking tumor growth, invasion, and metastasis by maspin in a syngeneic breast cancer model. Cancer Res. 61, 6945-6951
    • (2001) Cancer Res. , vol.61 , pp. 6945-6951
    • Shi, H.Y.1    Zhang, W.2    Liang, R.3    Abraham, S.4    Kittrell, F.S.5    Medina, D.6    Zhang, M.7
  • 28
    • 0022637224 scopus 로고
    • T cell recruitment from the thymus to the spleen in tumor-bearing mice. I. Analysis of recruited cells by surface markers
    • Tanaka, K., Koga, Y., Taniguchi, K., Kamikaseda, K., and Nomoto, K. (1986) T cell recruitment from the thymus to the spleen in tumor-bearing mice. I. Analysis of recruited cells by surface markers. Cancer Immunol. Immunother. 22, 37-42
    • (1986) Cancer Immunol. Immunother. , vol.22 , pp. 37-42
    • Tanaka, K.1    Koga, Y.2    Taniguchi, K.3    Kamikaseda, K.4    Nomoto, K.5
  • 29
    • 84861790681 scopus 로고    scopus 로고
    • Molecular pathways. Interferon/stat1 pathway. Role in the tumor resistance to geno-toxic stress and aggressive growth
    • Khodarev, N. N., Roizman, B., and Weichselbaum, R. R. (2012) Molecular pathways. Interferon/stat1 pathway. Role in the tumor resistance to geno-toxic stress and aggressive growth. Clin. Cancer Res. 18, 3015-3021
    • (2012) Clin. Cancer Res. , vol.18 , pp. 3015-3021
    • Khodarev, N.N.1    Roizman, B.2    Weichselbaum, R.R.3
  • 30
    • 38849160275 scopus 로고    scopus 로고
    • Characterization of heterotypic interaction effects in vitro to deconvolute global gene expression profiles in cancer
    • Buess, M., Nuyten, D. S., Hastie, T., Nielsen, T., Pesich, R., and Brown, P. O. (2007) Characterization of heterotypic interaction effects in vitro to deconvolute global gene expression profiles in cancer. Genome Biol. 8, R191
    • (2007) Genome Biol. , vol.8
    • Buess, M.1    Nuyten, D.S.2    Hastie, T.3    Nielsen, T.4    Pesich, R.5    Brown, P.O.6
  • 31
    • 33847650413 scopus 로고    scopus 로고
    • Cancer immunosurveillance, immu-noediting and inflammation. Independent or interdependent processes?
    • Bui, J. D., and Schreiber, R. D. (2007) Cancer immunosurveillance, immu-noediting and inflammation. Independent or interdependent processes? Curr. Opin. Immunol. 19, 203-208
    • (2007) Curr. Opin. Immunol. , vol.19 , pp. 203-208
    • Bui, J.D.1    Schreiber, R.D.2
  • 32
    • 35448954376 scopus 로고    scopus 로고
    • Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression
    • Bunt, S. K., Yang, L., Sinha, P., Clements, V. K., Leips, J., and Ostrand Rosenberg, S. (2007) Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression. Cancer Res. 67, 10019-10026
    • (2007) Cancer Res. , vol.67 , pp. 10019-10026
    • Bunt, S.K.1    Yang, L.2    Sinha, P.3    Clements, V.K.4    Leips, J.5    Ostrand Rosenberg, S.6
  • 34
    • 33846891555 scopus 로고    scopus 로고
    • Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma
    • Ochoa, A. C., Zea, A. H., Hernandez, C., and Rodriguez, P. C. (2007) Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma. Clin. Cancer Res. 13, 721s-726s
    • (2007) Clin. Cancer Res. , vol.13
    • Ochoa, A.C.1    Zea, A.H.2    Hernandez, C.3    Rodriguez, P.C.4
  • 36
    • 54849440346 scopus 로고    scopus 로고
    • Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy
    • Diaz-Montero, C. M., Salem, M. L., Nishimura, M. I., Garrett-Mayer, E., Cole, D. J., and Montero, A. J. (2009) Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy. Cancer Immunol. Immunother. 58, 49-59
    • (2009) Cancer Immunol. Immunother. , vol.58 , pp. 49-59
    • Diaz-Montero, C.M.1    Salem, M.L.2    Nishimura, M.I.3    Garrett-Mayer, E.4    Cole, D.J.5    Montero, A.J.6
  • 37
    • 0141456030 scopus 로고    scopus 로고
    • Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity
    • Melani, C., Chiodoni, C., Forni, G., and Colombo, M. P. (2003) Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity. Blood 102, 2138-2145
    • (2003) Blood , vol.102 , pp. 2138-2145
    • Melani, C.1    Chiodoni, C.2    Forni, G.3    Colombo, M.P.4
  • 38
    • 33947258378 scopus 로고    scopus 로고
    • Effects of IFN-7 and Stat1 on gene expression, growth, and survival in non-small cell lung cancer cells
    • Li, J., Yu, B., Song, L., Eschrich, S., and Haura, E. B. (2007) Effects of IFN-7 and Stat1 on gene expression, growth, and survival in non-small cell lung cancer cells. J. Interferon Cytokine Res. 27, 209-220
    • (2007) J. Interferon Cytokine Res. , vol.27 , pp. 209-220
    • Li, J.1    Yu, B.2    Song, L.3    Eschrich, S.4    Haura, E.B.5
  • 41
    • 77956920766 scopus 로고    scopus 로고
    • Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells
    • Lechner, M. G., Liebertz, D. J., and Epstein, A. L. (2010) Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells. J. Immunol. 185, 2273-2284
    • (2010) J. Immunol. , vol.185 , pp. 2273-2284
    • Lechner, M.G.1    Liebertz, D.J.2    Epstein, A.L.3
  • 43
    • 31544446571 scopus 로고    scopus 로고
    • Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host
    • Huang, B., Pan, P. Y., Li, Q., Sato, A. I., Levy, D. E., Bromberg, J., Divino, C. M., and Chen, S. H. (2006) Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host. Cancer Res. 66, 1123-1131
    • (2006) Cancer Res , vol.66 , pp. 1123-1131
    • Huang, B.1    Pan, P.Y.2    Li, Q.3    Sato, A.I.4    Levy, D.E.5    Bromberg, J.6    Divino, C.M.7    Chen, S.H.8
  • 44
    • 31644440642 scopus 로고    scopus 로고
    • The impact of CD4CD25 Treg on tumor specific CD8 T cell cytotoxicity and cancer
    • Khazaie, K., and von Boehmer, H. (2006) The impact of CD4CD25 Treg on tumor specific CD8 T cell cytotoxicity and cancer. Semin. Cancer Biol. 16, 124-136
    • (2006) Semin. Cancer Biol. , vol.16 , pp. 124-136
    • Khazaie, K.1    Von Boehmer, H.2
  • 45
    • 33847647528 scopus 로고    scopus 로고
    • Regulatory T cells and cancer
    • Wang, H. Y., and Wang, R. F. (2007) Regulatory T cells and cancer. Curr Opin. Immunol. 19, 217-223
    • (2007) Curr Opin. Immunol. , vol.19 , pp. 217-223
    • Wang, H.Y.1    Wang, R.F.2
  • 46
    • 34249709048 scopus 로고    scopus 로고
    • Down-regulation of the interferon signaling pathway in T lymphocytes from patients with metastatic melanoma
    • Critchley-Thorne, R. J., Yan, N., Nacu, S., Weber, J., Holmes, S. P., and Lee, P. P. (2007) Down-regulation of the interferon signaling pathway in T lymphocytes from patients with metastatic melanoma. PLoS Med. 4, e176
    • (2007) PLoS Med. , vol.4
    • Critchley-Thorne, R.J.1    Yan, N.2    Nacu, S.3    Weber, J.4    Holmes, S.P.5    Lee, P.P.6
  • 47
    • 79955561959 scopus 로고    scopus 로고
    • Interferon signaling patterns in peripheral blood lymphocytes may predict clinical outcome after high-dose interferon therapy in melanoma patients
    • Simons, D. L., Lee, G., Kirkwood, J. M., and Lee, P. P. (2011) Interferon signaling patterns in peripheral blood lymphocytes may predict clinical outcome after high-dose interferon therapy in melanoma patients. J. Transl. Med. 9, 52
    • (2011) J. Transl. Med. , vol.9 , pp. 52
    • Simons, D.L.1    Lee, G.2    Kirkwood, J.M.3    Lee, P.P.4
  • 48
    • 0035953308 scopus 로고    scopus 로고
    • IFN7 and lymphocytes prevent primary tumour development and shape tumour immunogenicity
    • Shankaran, V., Ikeda, H., Bruce, A. T., White, J. M., Swanson, P. E., Old, L. J., and Schreiber, R. D. (2001) IFN7 and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 410, 1107-1111
    • (2001) Nature , vol.410 , pp. 1107-1111
    • Shankaran, V.1    Ikeda, H.2    Bruce, A.T.3    White, J.M.4    Swanson, P.E.5    Old, L.J.6    Schreiber, R.D.7
  • 50
    • 77950861762 scopus 로고    scopus 로고
    • Tumor-promoting role of signal transducer and activator of transcription (Stat) 1 in late-stage melanoma growth
    • Schultz, J., Koczan, D., Schmitz, U., Ibrahim, S. M., Pilch, D., Landsberg, J., and Kunz, M. (2010) Tumor-promoting role of signal transducer and activator of transcription (Stat) 1 in late-stage melanoma growth. Clin. Exp. Metastasis 27, 133-140
    • (2010) Clin. Exp. Metastasis , vol.27 , pp. 133-140
    • Schultz, J.1    Koczan, D.2    Schmitz, U.3    Ibrahim, S.M.4    Pilch, D.5    Landsberg, J.6    Kunz, M.7
  • 51
    • 0035067108 scopus 로고    scopus 로고
    • Requirement for STAT1 in LPS-induced gene expression in macrophages
    • Ohmori, Y., and Hamilton, T. A. (2001) Requirement for STAT1 in LPS-induced gene expression in macrophages. J. Leukoc. Biol. 69, 598-604
    • (2001) J. Leukoc. Biol. , vol.69 , pp. 598-604
    • Ohmori, Y.1    Hamilton, T.A.2
  • 53
    • 80051492646 scopus 로고    scopus 로고
    • Short interfering RNA against STAT1 attenuates cisplatin-induced ototoxicity in the rat by suppressing inflammation
    • Kaur, T., Mukherjea, D., Sheehan, K., Jajoo, S., Rybak, L. P., and Ramku-mar, V. (2011) Short interfering RNA against STAT1 attenuates cisplatin-induced ototoxicity in the rat by suppressing inflammation. Cell Death Dis. 2, e180
    • (2011) Cell Death Dis. , vol.2
    • Kaur, T.1    Mukherjea, D.2    Sheehan, K.3    Jajoo, S.4    Rybak, L.P.5    Ramku-mar, V.6
  • 55
    • 0034292328 scopus 로고    scopus 로고
    • Distinct requirements for IFNs and STAT1 in NK cell function
    • Lee, C. K., Rao, D. T., Gertner, R., Gimeno, R., Frey, A. B., and Levy, D. E. (2000) Distinct requirements for IFNs and STAT1 in NK cell function. J. Immunol. 165, 3571-3577
    • (2000) J. Immunol. , vol.165 , pp. 3571-3577
    • Lee, C.K.1    Rao, D.T.2    Gertner, R.3    Gimeno, R.4    Frey, A.B.5    Levy, D.E.6
  • 56
    • 29144504335 scopus 로고    scopus 로고
    • CD11b+/Gr-1+ immature myeloid cells mediate suppression of T cells in mice bearing tumors of IL-1β-secreting cells
    • Song, X., Krelin, Y., Dvorkin, T., Bjorkdahl, O., Segal, S., Dinarello, C. A., Voronov, E., and Apte, R. N. (2005) CD11b+/Gr-1+ immature myeloid cells mediate suppression of T cells in mice bearing tumors of IL-1β-secreting cells. J. Immunol. 175, 8200-8208
    • (2005) J. Immunol. , vol.175 , pp. 8200-8208
    • Song, X.1    Krelin, Y.2    Dvorkin, T.3    Bjorkdahl, O.4    Segal, S.5    Dinarello, C.A.6    Voronov, E.7    Apte, R.N.8
  • 57
    • 54049134747 scopus 로고    scopus 로고
    • Subsets of myeloid-derived suppressor cells in tumor-bearingmice
    • Youn, J. I., Nagaraj, S., Collazo, M., and Gabrilovich, D. I. (2008) Subsets of myeloid-derived suppressor cells in tumor-bearingmice. J. Immunol. 181, 5791-5802
    • (2008) J. Immunol. , vol.181 , pp. 5791-5802
    • Youn, J.I.1    Nagaraj, S.2    Collazo, M.3    Gabrilovich, D.I.4
  • 58
    • 24644495576 scopus 로고    scopus 로고
    • Implication of Toll-like receptor and tumor necrosis factor a signaling in septic shock
    • Lin, W. J., and Yeh, W. C. (2005) Implication of Toll-like receptor and tumor necrosis factor a signaling in septic shock. Shock 24, 206-209
    • (2005) Shock , vol.24 , pp. 206-209
    • Lin, W.J.1    Yeh, W.C.2
  • 63
    • 84861783871 scopus 로고    scopus 로고
    • The prognostic value of FoxP3+ tumor-infiltrating lymphocytes in cancer. A critical review of the literature
    • deLeeuw, R. J., Kost, S. E., Kakal, J. A., and Nelson, B. H. (2012) The prognostic value of FoxP3+ tumor-infiltrating lymphocytes in cancer. A critical review of the literature. Clin. Cancer Res. 18, 3022-3029
    • (2012) Clin. Cancer Res. , vol.18 , pp. 3022-3029
    • DeLeeuw, R.J.1    Kost, S.E.2    Kakal, J.A.3    Nelson, B.H.4


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