메뉴 건너뛰기




Volumn 125, Issue 9, 2015, Pages 3365-3376

Tumor-induced myeloid deviation: When myeloid-derived suppressor cells meet tumor-Associated macrophages

Author keywords

[No Author keywords available]

Indexed keywords

BONE MARROW CELL; CANCER GROWTH; CANCER PATIENT; CANCER PROGNOSIS; CANCER STAGING; CELL ACTIVATION; CELL CONTACT; CELL DIFFERENTIATION; CELL EXPANSION; HUMAN; MACROPHAGE; MONOCYTE; MYELOID DERIVED SUPPRESSOR CELL; MYELOID PROGENITOR CELL; MYELOPOIESIS; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SUPPRESSOR CELL; TUMOR ASSOCIATED LEUKOCYTE; TUMOR GROWTH; TUMOR MICROENVIRONMENT; TUMOR PROMOTION; UPREGULATION; ANIMAL; EPITHELIAL MESENCHYMAL TRANSITION; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; METASTASIS; NEOPLASMS; PATHOLOGY; PROGNOSIS; T LYMPHOCYTE;

EID: 84941622047     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI80006     Document Type: Review
Times cited : (435)

References (161)
  • 3
    • 84888638819 scopus 로고    scopus 로고
    • The microbiome and cancer
    • Schwabe RF, Jobin C. The microbiome and cancer. Nat Rev Cancer. 2013;13(11):800-812
    • (2013) Nat Rev Cancer , vol.13 , Issue.11 , pp. 800-812
    • Schwabe, R.F.1    Jobin, C.2
  • 4
    • 84857141296 scopus 로고    scopus 로고
    • Cancer-related inflammation: Common themes and therapeutic opportunities
    • Balkwill FR, Mantovani A. Cancer-related inflammation: common themes and therapeutic opportunities. Semin Cancer Biol. 2012;22(1):33-40
    • (2012) Semin Cancer Biol , vol.22 , Issue.1 , pp. 33-40
    • Balkwill, F.R.1    Mantovani, A.2
  • 5
    • 84904406680 scopus 로고    scopus 로고
    • Tumor-Associated macrophages: From mechanisms to therapy
    • Noy R, Pollard JW. Tumor-Associated macrophages: from mechanisms to therapy. Immunity. 2014;41(1):49-61
    • (2014) Immunity , vol.41 , Issue.1 , pp. 49-61
    • Noy, R.1    Pollard, J.W.2
  • 6
    • 84871694284 scopus 로고    scopus 로고
    • Prognostic significance of tumor-Associated macrophages in solid tumor: A meta-Analysis of the literature
    • Zhang QW, et al. Prognostic significance of tumor-Associated macrophages in solid tumor: a meta-Analysis of the literature. PLoS One. 2012;7(12):e50946
    • (2012) PLoS One , vol.7 , Issue.12 , pp. e50946
    • Zhang, Q.W.1
  • 8
    • 84875462761 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells suppress antitumor immune responses through IDO expression and correlate with lymph node metastasis in patients with breast cancer
    • Yu J, et al. Myeloid-derived suppressor cells suppress antitumor immune responses through IDO expression and correlate with lymph node metastasis in patients with breast cancer. J Immunol. 2013;190(7):3783-3797
    • (2013) J Immunol , vol.190 , Issue.7 , pp. 3783-3797
    • Yu, J.1
  • 9
    • 0037963473 scopus 로고    scopus 로고
    • Blood monocytes consist of two principal subsets with distinct migratory properties
    • Geissmann F, Jung S, Littman DR. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity. 2003;19(1):71-82
    • (2003) Immunity , vol.19 , Issue.1 , pp. 71-82
    • Geissmann, F.1    Jung, S.2    Littman, D.R.3
  • 10
    • 84857219446 scopus 로고    scopus 로고
    • Monocytic CCR2(+) myeloid-derived suppressor cells promote immune escape by limiting activated CD8 T-cell infiltration into the tumor microenvironment
    • Lesokhin AM, et al. Monocytic CCR2(+) myeloid-derived suppressor cells promote immune escape by limiting activated CD8 T-cell infiltration into the tumor microenvironment. Cancer Res. 2012;72(4):876-886
    • (2012) Cancer Res , vol.72 , Issue.4 , pp. 876-886
    • Lesokhin, A.M.1
  • 11
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: Integrating immunitys roles in cancer suppression and promotion
    • Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunitys roles in cancer suppression and promotion. Science. 2011;331(6024):1565-1570
    • (2011) Science , vol.331 , Issue.6024 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 12
    • 84899640120 scopus 로고    scopus 로고
    • Emergency granulopoiesis
    • Manz MG, Boettcher S. Emergency granulopoiesis. Nat Rev Immunol. 2014;14(5):302-314
    • (2014) Nat Rev Immunol , vol.14 , Issue.5 , pp. 302-314
    • Manz, M.G.1    Boettcher, S.2
  • 13
    • 84925465211 scopus 로고    scopus 로고
    • Tissue-resident macrophages originate from yolk-sacderived erythro-myeloid progenitors
    • Gomez Perdiguero E, et al. Tissue-resident macrophages originate from yolk-sacderived erythro-myeloid progenitors. Nature. 2015;518(7540):547-551
    • (2015) Nature , vol.518 , Issue.7540 , pp. 547-551
    • Gomez Perdiguero, E.1
  • 14
    • 84876775203 scopus 로고    scopus 로고
    • Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes
    • Hashimoto D, et al. Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity. 2013;38(4):792-804
    • (2013) Immunity , vol.38 , Issue.4 , pp. 792-804
    • Hashimoto, D.1
  • 15
    • 84928189502 scopus 로고    scopus 로고
    • C-myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages
    • Hoeffel G, et al. C-myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages. Immunity. 2015;42(4):665-678
    • (2015) Immunity , vol.42 , Issue.4 , pp. 665-678
    • Hoeffel, G.1
  • 16
    • 84900413094 scopus 로고    scopus 로고
    • Tissue-specific signals control reversible program of localization and functional polarization of macrophages
    • Okabe Y, Medzhitov R. Tissue-specific signals control reversible program of localization and functional polarization of macrophages. Cell. 2014;157(4):832-844
    • (2014) Cell , vol.157 , Issue.4 , pp. 832-844
    • Okabe, Y.1    Medzhitov, R.2
  • 17
    • 58249104981 scopus 로고    scopus 로고
    • Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis
    • Kohyama M, et al. Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis. Nature. 2009;457(7227):318-321
    • (2009) Nature , vol.457 , Issue.7227 , pp. 318-321
    • Kohyama, M.1
  • 18
    • 47949090079 scopus 로고    scopus 로고
    • The role of myeloid cells in the promotion of tumour angiogenesis
    • Murdoch C, Muthana M, Coffelt SB, Lewis CE. The role of myeloid cells in the promotion of tumour angiogenesis. Nat Rev Cancer. 2008;8(8):618-631
    • (2008) Nat Rev Cancer , vol.8 , Issue.8 , pp. 618-631
    • Murdoch, C.1    Muthana, M.2    Coffelt, S.B.3    Lewis, C.E.4
  • 19
    • 84920724792 scopus 로고    scopus 로고
    • Environment drives selection and function of enhancers controlling tissue-specific macrophage identities
    • Gosselin D, et al. Environment drives selection and function of enhancers controlling tissue-specific macrophage identities. Cell. 2014;159(6):1327-1340
    • (2014) Cell , vol.159 , Issue.6 , pp. 1327-1340
    • Gosselin, D.1
  • 20
    • 84920724791 scopus 로고    scopus 로고
    • Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment
    • Lavin Y, et al. Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment. Cell. 2014;159(6):1312-1326
    • (2014) Cell , vol.159 , Issue.6 , pp. 1312-1326
    • Lavin, Y.1
  • 21
    • 84921313153 scopus 로고    scopus 로고
    • Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice
    • Bain CC, et al. Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice. Nat Immunol. 2014;15(10):929-937
    • (2014) Nat Immunol , vol.15 , Issue.10 , pp. 929-937
    • Bain, C.C.1
  • 22
    • 84901215262 scopus 로고    scopus 로고
    • The cellular and molecular origin of tumor-Associated macrophages
    • Franklin RA, et al. The cellular and molecular origin of tumor-Associated macrophages. Science. 2014;344(6186):921-925
    • (2014) Science , vol.344 , Issue.6186 , pp. 921-925
    • Franklin, R.A.1
  • 23
    • 33749319703 scopus 로고    scopus 로고
    • Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    • Galon J, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science. 2006;313(5795):1960-1964
    • (2006) Science , vol.313 , Issue.5795 , pp. 1960-1964
    • Galon, J.1
  • 24
    • 84863151366 scopus 로고    scopus 로고
    • Origins of tumor-Associated macrophages and neutrophils
    • Cortez-Retamozo V, et al. Origins of tumor-Associated macrophages and neutrophils. Proc Natl Acad Sci U S A. 2012;109(7):2491-2496
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.7 , pp. 2491-2496
    • Cortez-Retamozo, V.1
  • 25
    • 84901675728 scopus 로고    scopus 로고
    • Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes
    • Shand FH, et al. Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes. Proc Natl Acad Sci U S A. 2014;111(21):7771-7776
    • (2014) Proc Natl Acad Sci U S A , vol.111 , Issue.21 , pp. 7771-7776
    • Shand, F.H.1
  • 26
    • 29744454134 scopus 로고    scopus 로고
    • Myeloid dendritic cell precursors generated from bone marrow suppress T cell responses via cell contact and nitric oxide production in vitro
    • Rossner S, Voigtlander C, Wiethe C, Hanig J, Seifarth C, Lutz MB. Myeloid dendritic cell precursors generated from bone marrow suppress T cell responses via cell contact and nitric oxide production in vitro. Eur J Immunol. 2005;35(12):3533-3544
    • (2005) Eur J Immunol , vol.35 , Issue.12 , pp. 3533-3544
    • Rossner, S.1    Voigtlander, C.2    Wiethe, C.3    Hanig, J.4    Seifarth, C.5    Lutz, M.B.6
  • 27
    • 33845534522 scopus 로고    scopus 로고
    • Effect of tumor-derived cytokines and growth factors on differentiation and immune suppressive features of myeloid cells in cancer
    • Kusmartsev S, Gabrilovich DI. Effect of tumor-derived cytokines and growth factors on differentiation and immune suppressive features of myeloid cells in cancer. Cancer Metastasis Rev. 2006;25(3):323-331
    • (2006) Cancer Metastasis Rev , vol.25 , Issue.3 , pp. 323-331
    • Kusmartsev, S.1    Gabrilovich, D.I.2
  • 28
    • 77953914366 scopus 로고    scopus 로고
    • Tumor-induced tolerance and immune suppression depend on the C/EBPβ transcription factor
    • Marigo I, et al. Tumor-induced tolerance and immune suppression depend on the C/EBPβ transcription factor. Immunity. 2010;32(6):790-802
    • (2011) Immunity , vol.32 , Issue.6 , pp. 790-802
    • Marigo, I.1
  • 29
    • 84866920497 scopus 로고    scopus 로고
    • Immune tolerance to tumor antigens occurs in a specialized environment of the spleen
    • Ugel S, et al. Immune tolerance to tumor antigens occurs in a specialized environment of the spleen. Cell Rep. 2012;2(3):628-639
    • (2012) Cell Rep , vol.2 , Issue.3 , pp. 628-639
    • Ugel, S.1
  • 30
    • 84941695057 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells in the tumor microenvironment: Expect the unexpected
    • Marvel D, Gabrilovich DI. Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected. J Clin Invest. 2015;125(9):3356-3364
    • (2015) J Clin Invest , vol.125 , Issue.9 , pp. 3356-3364
    • Marvel, D.1    Gabrilovich, D.I.2
  • 31
    • 74249101123 scopus 로고    scopus 로고
    • Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF
    • Dolcetti L, et al. Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF. Eur J Immunol. 2010;40(1):22-35
    • (2011) Eur J Immunol , vol.40 , Issue.1 , pp. 22-35
    • Dolcetti, L.1
  • 32
    • 43249130187 scopus 로고    scopus 로고
    • Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity
    • Movahedi K, et al. Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity. Blood. 2008;111(8):4233-4244
    • (2008) Blood , vol.111 , Issue.8 , pp. 4233-4244
    • Movahedi, K.1
  • 33
    • 54049134747 scopus 로고    scopus 로고
    • Subsets of myeloid-derived suppressor cells in tumor-bearing mice
    • Youn JI, Nagaraj S, Collazo M, Gabrilovich DI. Subsets of myeloid-derived suppressor cells in tumor-bearing mice. J Immunol. 2008;181(8):5791-5802
    • (2008) J Immunol , vol.181 , Issue.8 , pp. 5791-5802
    • Youn, J.I.1    Nagaraj, S.2    Collazo, M.3    Gabrilovich, D.I.4
  • 34
    • 84876800337 scopus 로고    scopus 로고
    • Macrophage biology in development, homeostasis and disease
    • Wynn TA, Chawla A, Pollard JW. Macrophage biology in development, homeostasis and disease. Nature. 2013;496(7446):445-455
    • (2013) Nature , vol.496 , Issue.7446 , pp. 445-455
    • Wynn, T.A.1    Chawla, A.2    Pollard, J.W.3
  • 35
    • 78149330949 scopus 로고    scopus 로고
    • HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
    • Corzo CA, et al. HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J Exp Med. 2010;207(11):2439-2453
    • (2011) J Exp Med , vol.207 , Issue.11 , pp. 2439-2453
    • Corzo, C.A.1
  • 36
    • 84907223092 scopus 로고    scopus 로고
    • Functional polarization of tumour-Associated macrophages by tumourderived lactic acid
    • Colegio OR, et al. Functional polarization of tumour-Associated macrophages by tumourderived lactic acid. Nature. 2014;513(7519):559-563
    • (2014) Nature , vol.513 , Issue.7519 , pp. 559-563
    • Colegio, O.R.1
  • 37
    • 84863224448 scopus 로고    scopus 로고
    • Immunosuppressive activity enhances central carbon metabolism and bioenergetics in myeloid-derived suppressor cells in vitro models
    • Hammami I, Chen J, Murschel F, Bronte V, De Crescenzo G, Jolicoeur M. Immunosuppressive activity enhances central carbon metabolism and bioenergetics in myeloid-derived suppressor cells in vitro models. BMC Cell Biol. 2012;13:18
    • (2012) BMC Cell Biol , vol.13 , pp. 18
    • Hammami, I.1    Chen, J.2    Murschel, F.3    Bronte, V.4    De Crescenzo, G.5    Jolicoeur, M.6
  • 38
    • 77955038532 scopus 로고    scopus 로고
    • Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes
    • Movahedi K, et al. Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes. Cancer Res. 2010;70(14):5728-5739
    • (2011) Cancer Res , vol.70 , Issue.14 , pp. 5728-5739
    • Movahedi, K.1
  • 39
    • 84904394690 scopus 로고    scopus 로고
    • Macrophage activation and polarization: Nomenclature and experimental guidelines
    • Murray PJ, et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity. 2014;41(1):14-20
    • (2014) Immunity , vol.41 , Issue.1 , pp. 14-20
    • Murray, P.J.1
  • 40
    • 84890849340 scopus 로고    scopus 로고
    • KIT oncogene inhibition drives intratumoral macrophage M2 polarization
    • Cavnar MJ, et al. KIT oncogene inhibition drives intratumoral macrophage M2 polarization. J Exp Med. 2013;210(13):2873-2886
    • (2013) J Exp Med , vol.210 , Issue.13 , pp. 2873-2886
    • Cavnar, M.J.1
  • 41
    • 84912096268 scopus 로고    scopus 로고
    • Molecular profiling reveals a tumor-promoting phenotype of monocytes and macrophages in human cancer progression
    • Chittezhath M, et al. Molecular profiling reveals a tumor-promoting phenotype of monocytes and macrophages in human cancer progression. Immunity. 2014;41(5):815-829
    • (2014) Immunity , vol.41 , Issue.5 , pp. 815-829
    • Chittezhath, M.1
  • 42
    • 84922660501 scopus 로고    scopus 로고
    • Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils
    • Casbon AJ, et al. Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils. Proc Natl Acad Sci U S A. 2015;112(6):E566-E575
    • (2015) Proc Natl Acad Sci U S A , vol.112 , Issue.6 , pp. E566-E575
    • Casbon, A.J.1
  • 43
    • 78650722060 scopus 로고    scopus 로고
    • Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes
    • Kowanetz M, et al. Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes. Proc Natl Acad Sci U S A. 2010;107(50):21248-21255
    • (2011) Proc Natl Acad Sci U S A , vol.107 , Issue.50 , pp. 21248-21255
    • Kowanetz, M.1
  • 45
    • 84923692138 scopus 로고    scopus 로고
    • Complexity and challenges in defining myeloid-derived suppressor cells
    • Damuzzo V, et al. Complexity and challenges in defining myeloid-derived suppressor cells. Cytometry B Clin Cytom. 2015;88(2):77-91
    • (2015) Cytometry B Clin Cytom , vol.88 , Issue.2 , pp. 77-91
    • Damuzzo, V.1
  • 46
    • 84910025709 scopus 로고    scopus 로고
    • Increased levels of granulocytic myeloid-derived suppressor cells in peripheral blood and tumour tissue of pancreatic cancer patients
    • Khaled YS, Ammori BJ, Elkord E. Increased levels of granulocytic myeloid-derived suppressor cells in peripheral blood and tumour tissue of pancreatic cancer patients. J Immunol Res. 2014;2014:879897
    • (2014) J Immunol Res , vol.2014 , pp. 879897
    • Khaled, Y.S.1    Ammori, B.J.2    Elkord, E.3
  • 47
    • 84862150896 scopus 로고    scopus 로고
    • Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer
    • Bayne LJ, et al. Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer. Cancer Cell. 2012;21(6):822-835
    • (2012) Cancer Cell , vol.21 , Issue.6 , pp. 822-835
    • Bayne, L.J.1
  • 48
    • 84876518040 scopus 로고    scopus 로고
    • Differently immunogenic cancers in mice induce immature myeloid cells that suppress CTL in vitro but not in vivo following transfer
    • Schmidt K, Zilio S, Schmollinger JC, Bronte V, Blankenstein T, Willimsky G. Differently immunogenic cancers in mice induce immature myeloid cells that suppress CTL in vitro but not in vivo following transfer. Blood. 2013;121(10):1740-1748
    • (2013) Blood , vol.121 , Issue.10 , pp. 1740-1748
    • Schmidt, K.1    Zilio, S.2    Schmollinger, J.C.3    Bronte, V.4    Blankenstein, T.5    Willimsky, G.6
  • 49
    • 84900335537 scopus 로고    scopus 로고
    • A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis
    • Su S, et al. A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis. Cancer Cell. 2014;25(5):605-620
    • (2014) Cancer Cell , vol.25 , Issue.5 , pp. 605-620
    • Su, S.1
  • 50
    • 0035911221 scopus 로고    scopus 로고
    • Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy
    • Lin EY, Nguyen AV, Russell RG, Pollard JW. Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J Exp Med. 2001;193(6):727-740
    • (2001) J Exp Med , vol.193 , Issue.6 , pp. 727-740
    • Lin, E.Y.1    Nguyen, A.V.2    Russell, R.G.3    Pollard, J.W.4
  • 51
    • 84887444879 scopus 로고    scopus 로고
    • Microenvironmental regulation of tumor progression and metastasis
    • Quail DF, Joyce JA. Microenvironmental regulation of tumor progression and metastasis. Nat Med. 2013;19(11):1423-1437
    • (2013) Nat Med , vol.19 , Issue.11 , pp. 1423-1437
    • Quail, D.F.1    Joyce, J.A.2
  • 52
    • 77950950894 scopus 로고    scopus 로고
    • Macrophage diversity enhances tumor progression and metastasis
    • Qian BZ, Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell. 2010;141(1):39-51
    • (2011) Cell , vol.141 , Issue.1 , pp. 39-51
    • Qian, B.Z.1    Pollard, J.W.2
  • 53
    • 3042822267 scopus 로고    scopus 로고
    • Cancer and the chemokine network
    • Balkwill F. Cancer and the chemokine network. Nat Rev Cancer. 2004;4(7):540-550
    • (2004) Nat Rev Cancer , vol.4 , Issue.7 , pp. 540-550
    • Balkwill, F.1
  • 54
    • 84855817522 scopus 로고    scopus 로고
    • Immunology in the clinic review series; Focus on cancer: Tumourassociated macrophages: Undisputed stars of the inflammatory tumour microenvironment
    • Allavena P, Mantovani A. Immunology in the clinic review series; focus on cancer: tumourassociated macrophages: undisputed stars of the inflammatory tumour microenvironment. Clin Exp Immunol. 2012;167(2):195-205
    • (2012) Clin Exp Immunol , vol.167 , Issue.2 , pp. 195-205
    • Allavena, P.1    Mantovani, A.2
  • 55
    • 20444424119 scopus 로고    scopus 로고
    • Induction of arginase i transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBPβ
    • Gray MJ, Poljakovic M, Kepka-Lenhart D, Morris SM, Morris SM Jr. Induction of arginase I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBPβ. Gene. 2005;353(1):98-106
    • (2005) Gene , vol.353 , Issue.1 , pp. 98-106
    • Gray, M.J.1    Poljakovic, M.2    Kepka-Lenhart, D.3    Morris, S.M.4    Morris, S.M.5
  • 56
    • 84887149333 scopus 로고    scopus 로고
    • GM-CSF promotes the immunosuppressive activity of glioma-infiltrating myeloid cells through interleukin-4 receptor-α
    • Kohanbash G, et al. GM-CSF promotes the immunosuppressive activity of glioma-infiltrating myeloid cells through interleukin-4 receptor-α. Cancer Res. 2013;73(21):6413-6423
    • (2013) Cancer Res , vol.73 , Issue.21 , pp. 6413-6423
    • Kohanbash, G.1
  • 57
    • 33749425534 scopus 로고    scopus 로고
    • Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells
    • Gallina G, et al. Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. J Clin Invest. 2006;116(10):2777-2790
    • (2006) J Clin Invest , vol.116 , Issue.10 , pp. 2777-2790
    • Gallina, G.1
  • 58
    • 84858202940 scopus 로고    scopus 로고
    • Aptamer-mediated blockade of IL4Rα triggers apoptosis of MDSCs and limits tumor progression
    • Roth F, De La Fuente AC, Vella JL, Zoso A, Inverardi L, Serafini P. Aptamer-mediated blockade of IL4Rα triggers apoptosis of MDSCs and limits tumor progression. Cancer Res. 2012;72(6):1373-1383
    • (2012) Cancer Res , vol.72 , Issue.6 , pp. 1373-1383
    • Roth, F.1    De La Fuente, A.C.2    Vella, J.L.3    Zoso, A.4    Inverardi, L.5    Serafini, P.6
  • 59
    • 76149146398 scopus 로고    scopus 로고
    • IL-4 induces cathepsin protease activity in tumor-Associated macrophages to promote cancer growth and invasion
    • Gocheva V, et al. IL-4 induces cathepsin protease activity in tumor-Associated macrophages to promote cancer growth and invasion. Genes Dev. 2010;24(3):241-255
    • (2011) Genes Dev , vol.24 , Issue.3 , pp. 241-255
    • Gocheva, V.1
  • 60
    • 67651160649 scopus 로고    scopus 로고
    • CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages
    • DeNardo DG, et al. CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell. 2009;16(2):91-102
    • (2009) Cancer Cell , vol.16 , Issue.2 , pp. 91-102
    • Denardo, D.G.1
  • 61
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: Functions of cells recruited to the tumor microenvironment
    • Hanahan D, Coussens LM. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell. 2012;21(3):309-322
    • (2012) Cancer Cell , vol.21 , Issue.3 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 62
    • 48149107380 scopus 로고    scopus 로고
    • Lung cancer patients CD4(+) T cells are activated in vitro by MHC II cell-based vaccines despite the presence of myeloid-derived suppressor cells
    • Srivastava MK, Bosch JJ, Thompson JA, Ksander BR, Edelman MJ, Ostrand-Rosenberg S. Lung cancer patients CD4(+) T cells are activated in vitro by MHC II cell-based vaccines despite the presence of myeloid-derived suppressor cells. Cancer Immunol Immunother. 2008;57(10):1493-1504
    • (2008) Cancer Immunol Immunother , vol.57 , Issue.10 , pp. 1493-1504
    • Srivastava, M.K.1    Bosch, J.J.2    Thompson, J.A.3    Ksander, B.R.4    Edelman, M.J.5    Ostrand-Rosenberg, S.6
  • 63
    • 70350133511 scopus 로고    scopus 로고
    • IL4Rα+ myeloid-derived suppressor cell expansion in cancer patients
    • Mandruzzato S, et al. IL4Rα+ myeloid-derived suppressor cell expansion in cancer patients. J Immunol. 2009;182(10):6562-6568
    • (2009) J Immunol , vol.182 , Issue.10 , pp. 6562-6568
    • Mandruzzato, S.1
  • 64
    • 0018084953 scopus 로고
    • Systemic bacillus Calmette-Guerin (BCG) activates natural suppressor cells
    • Bennett JA, Rao VS, Mitchell MS. Systemic bacillus Calmette-Guerin (BCG) activates natural suppressor cells. Proc Natl Acad Sci U S A. 1978;75(10):5142-5144
    • (1978) Proc Natl Acad Sci U S A , vol.75 , Issue.10 , pp. 5142-5144
    • Bennett, J.A.1    Rao, V.S.2    Mitchell, M.S.3
  • 65
    • 49649093608 scopus 로고    scopus 로고
    • Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFβ-1
    • Savage ND, et al. Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFβ-1. J Immunol. 2008;181(3):2220-2226
    • (2008) J Immunol , vol.181 , Issue.3 , pp. 2220-2226
    • Savage, N.D.1
  • 66
    • 48549085973 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells
    • Serafini P, Mgebroff S, Noonan K, Borrello I. Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells. Cancer Res. 2008;68(13):5439-5449
    • (2008) Cancer Res , vol.68 , Issue.13 , pp. 5439-5449
    • Serafini, P.1    Mgebroff, S.2    Noonan, K.3    Borrello, I.4
  • 67
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel TJ, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med. 2004;10(9):942-949
    • (2004) Nat Med , vol.10 , Issue.9 , pp. 942-949
    • Curiel, T.J.1
  • 68
    • 79955774902 scopus 로고    scopus 로고
    • Tumor-Associated macrophages recruit CCR6+ regulatory T cells and promote the development of colorectal cancer via enhancing CCL20 production in mice
    • Liu J, et al. Tumor-Associated macrophages recruit CCR6+ regulatory T cells and promote the development of colorectal cancer via enhancing CCL20 production in mice. PLoS One. 2011;6(4):e19495
    • (2011) PLoS One , vol.6 , Issue.4 , pp. e19495
    • Liu, J.1
  • 69
    • 84871127292 scopus 로고    scopus 로고
    • Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth
    • Schlecker E, et al. Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth. J Immunol. 2012;189(12):5602-5611
    • (2012) J Immunol , vol.189 , Issue.12 , pp. 5602-5611
    • Schlecker, E.1
  • 70
    • 34548805636 scopus 로고    scopus 로고
    • Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response
    • Sinha P, Clements VK, Bunt SK, Albelda SM, Ostrand-Rosenberg S. Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response. J Immunol. 2007;179(2):977-983
    • (2007) J Immunol , vol.179 , Issue.2 , pp. 977-983
    • Sinha, P.1    Clements, V.K.2    Bunt, S.K.3    Albelda, S.M.4    Ostrand-Rosenberg, S.5
  • 71
    • 34248172324 scopus 로고    scopus 로고
    • Altered macrophage differentiation and immune dysfunction in tumor development
    • Sica A, Bronte V. Altered macrophage differentiation and immune dysfunction in tumor development. J Clin Invest. 2007;117(5):1155-1166
    • (2007) J Clin Invest , vol.117 , Issue.5 , pp. 1155-1166
    • Sica, A.1    Bronte, V.2
  • 72
    • 84862127053 scopus 로고    scopus 로고
    • Cross-talk between myeloid-derived suppressor cells (MDSC), macrophages, and dendritic cells enhances tumor-induced immune suppression
    • Ostrand-Rosenberg S, Sinha P, Beury DW, Clements VK. Cross-talk between myeloid-derived suppressor cells (MDSC), macrophages, and dendritic cells enhances tumor-induced immune suppression. Semin Cancer Biol. 2012;22(4):275-281
    • (2012) Semin Cancer Biol , vol.22 , Issue.4 , pp. 275-281
    • Ostrand-Rosenberg, S.1    Sinha, P.2    Beury, D.W.3    Clements, V.K.4
  • 73
    • 77956976681 scopus 로고    scopus 로고
    • Macrophage plasticity and interaction with lymphocyte subsets: Cancer as a paradigm
    • Biswas SK, Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol. 2010;11(10):889-896
    • (2011) Nat Immunol , vol.11 , Issue.10 , pp. 889-896
    • Biswas, S.K.1    Mantovani, A.2
  • 74
    • 84912089439 scopus 로고    scopus 로고
    • Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells
    • Ruffell B, et al. Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells. Cancer Cell. 2014;26(5):623-637
    • (2014) Cancer Cell , vol.26 , Issue.5 , pp. 623-637
    • Ruffell, B.1
  • 75
    • 23444456772 scopus 로고    scopus 로고
    • Regulation of immune responses by L-Arginine metabolism
    • Bronte V, Zanovello P. Regulation of immune responses by L-Arginine metabolism. Nat Rev Immunol. 2005;5(8):641-654
    • (2005) Nat Rev Immunol , vol.5 , Issue.8 , pp. 641-654
    • Bronte, V.1    Zanovello, P.2
  • 76
    • 19344377474 scopus 로고    scopus 로고
    • GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase
    • Munn DH, et al. GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. Immunity. 2005;22(5):633-642
    • (2005) Immunity , vol.22 , Issue.5 , pp. 633-642
    • Munn, D.H.1
  • 77
    • 75149123468 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine
    • Srivastava MK, Sinha P, Clements VK, Rodriguez P, Ostrand-Rosenberg S. Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine. Cancer Res. 2010;70(1):68-77
    • (2011) Cancer Res , vol.70 , Issue.1 , pp. 68-77
    • Srivastava, M.K.1    Sinha, P.2    Clements, V.K.3    Rodriguez, P.4    Ostrand-Rosenberg, S.5
  • 78
    • 0037080021 scopus 로고    scopus 로고
    • Myeloid suppressor lines inhibit T cell responses by an NO-dependent mechanism
    • Mazzoni A, et al. Myeloid suppressor lines inhibit T cell responses by an NO-dependent mechanism. J Immunol. 2002;168(2):689-695
    • (2002) J Immunol , vol.168 , Issue.2 , pp. 689-695
    • Mazzoni, A.1
  • 79
    • 0142148325 scopus 로고    scopus 로고
    • Nitric oxide regulation of human peripheral blood mononuclear cells: Critical time dependence and selectivity for cytokine versus chemokine expression
    • Macphail SE, Gibney CA, Brooks BM, Booth CG, Flanagan BF, Coleman JW. Nitric oxide regulation of human peripheral blood mononuclear cells: critical time dependence and selectivity for cytokine versus chemokine expression. J Immunol. 2003;171(9):4809-4815
    • (2003) J Immunol , vol.171 , Issue.9 , pp. 4809-4815
    • Macphail, S.E.1    Gibney, C.A.2    Brooks, B.M.3    Booth, C.G.4    Flanagan, B.F.5    Coleman, J.W.6
  • 80
    • 66949145484 scopus 로고    scopus 로고
    • Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells
    • Corzo CA, et al. Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells. J Immunol. 2009;182(9):5693-5701
    • (2009) J Immunol , vol.182 , Issue.9 , pp. 5693-5701
    • Corzo, C.A.1
  • 81
    • 0035294392 scopus 로고    scopus 로고
    • Suppressed T-cell receptor zeta chain expression and cytokine production in pancreatic cancer patients
    • Schmielau J, Nalesnik MA, Finn OJ. Suppressed T-cell receptor zeta chain expression and cytokine production in pancreatic cancer patients. Clin Cancer Res. 2001;7(3):933s-939s.
    • (2001) Clin Cancer Res , vol.7 , Issue.3 , pp. 933s-939s
    • Schmielau, J.1    Nalesnik, M.A.2    Finn, O.J.3
  • 82
    • 44449157285 scopus 로고    scopus 로고
    • Conversion of tyrosine to the inflammation-Associated analog 3-nitrotyrosine at either TCR-or MHC-contact positions can profoundly affect recognition of the MHC class I-restricted epitope of lymphocytic choriomeningitis virus glycoprotein 33 by CD8 T cells
    • Hardy LL, Wick DA, Webb JR. Conversion of tyrosine to the inflammation-Associated analog 3-nitrotyrosine at either TCR-or MHC-contact positions can profoundly affect recognition of the MHC class I-restricted epitope of lymphocytic choriomeningitis virus glycoprotein 33 by CD8 T cells. J Immunol. 2008;180(9):5956-5962
    • (2008) J Immunol , vol.180 , Issue.9 , pp. 5956-5962
    • Hardy, L.L.1    Wick, D.A.2    Webb, J.R.3
  • 83
    • 77950829023 scopus 로고    scopus 로고
    • Mechanism of T cell tolerance induced by myeloid-derived suppressor cells
    • Nagaraj S, Schrum AG, Cho HI, Celis E, Gabrilovich DI. Mechanism of T cell tolerance induced by myeloid-derived suppressor cells. J Immunol. 2010;184(6):3106-3116
    • (2011) J Immunol , vol.184 , Issue.6 , pp. 3106-3116
    • Nagaraj, S.1    Schrum, A.G.2    Cho, H.I.3    Celis, E.4    Gabrilovich, D.I.5
  • 84
    • 84895528474 scopus 로고    scopus 로고
    • The emerging immunological role of post-translational modifications by reactive nitrogen species in cancer microenvironment
    • De Sanctis F, et al. The emerging immunological role of post-translational modifications by reactive nitrogen species in cancer microenvironment. Front Immunol. 2014;5:69
    • (2014) Front Immunol , vol.5 , pp. 69
    • De Sanctis, F.1
  • 85
    • 80054694464 scopus 로고    scopus 로고
    • Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells
    • Molon B, et al. Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells. J Exp Med. 2011;208(10):1949-1962
    • (2011) J Exp Med , vol.208 , Issue.10 , pp. 1949-1962
    • Molon, B.1
  • 86
    • 84890284474 scopus 로고    scopus 로고
    • Therapeutic PD-1 pathway blockade augments with other modalities of immunotherapy T-cell function to prevent immune decline in ovarian cancer
    • Duraiswamy J, Freeman GJ, Coukos G. Therapeutic PD-1 pathway blockade augments with other modalities of immunotherapy T-cell function to prevent immune decline in ovarian cancer. Cancer Res. 2013;73(23):6900-6912
    • (2013) Cancer Res , vol.73 , Issue.23 , pp. 6900-6912
    • Duraiswamy, J.1    Freeman, G.J.2    Coukos, G.3
  • 87
    • 0038302927 scopus 로고    scopus 로고
    • PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
    • Loke P, Allison JP. PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells. Proc Natl Acad Sci U S A. 2003;100(9):5336-5341
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.9 , pp. 5336-5341
    • Loke, P.1    Allison, J.P.2
  • 88
    • 84899753178 scopus 로고    scopus 로고
    • PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
    • Noman MZ, et al. PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation. J Exp Med. 2014;211(5):781-790
    • (2014) J Exp Med , vol.211 , Issue.5 , pp. 781-790
    • Noman, M.Z.1
  • 89
    • 84878712718 scopus 로고    scopus 로고
    • Tumor-Associated macrophages in glioma: Friend or foe?
    • Kennedy BC, et al. Tumor-Associated macrophages in glioma: friend or foe? J Oncol. 2013;2013:486912
    • (2013) J Oncol , vol.2013 , pp. 486912
    • Kennedy, B.C.1
  • 90
    • 84873597334 scopus 로고    scopus 로고
    • Role of macrophage targeting in the antitumor activity of trabectedin
    • Germano G, et al. Role of macrophage targeting in the antitumor activity of trabectedin. Cancer Cell. 2013;23(2):249-262
    • (2013) Cancer Cell , vol.23 , Issue.2 , pp. 249-262
    • Germano, G.1
  • 91
    • 2342559752 scopus 로고    scopus 로고
    • HLA-G1-expressing antigen-presenting cells induce immunosuppressive CD4+ T cells
    • LeMaoult J, Krawice-Radanne I, Dausset J, Carosella ED. HLA-G1-expressing antigen-presenting cells induce immunosuppressive CD4+ T cells. Proc Natl Acad Sci U S A. 2004;101(18):7064-7069
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.18 , pp. 7064-7069
    • Lemaoult, J.1    Krawice-Radanne, I.2    Dausset, J.3    Carosella, E.D.4
  • 92
    • 84912561603 scopus 로고    scopus 로고
    • Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer
    • Di Mitri D, et al. Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer. Nature. 2014;515(7525):134-137
    • (2014) Nature , vol.515 , Issue.7525 , pp. 134-137
    • Di Mitri, D.1
  • 93
    • 84884354300 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2
    • Cui TX, et al. Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2. Immunity. 2013;39(3):611-621
    • (2013) Immunity , vol.39 , Issue.3 , pp. 611-621
    • Cui, T.X.1
  • 94
    • 84899959071 scopus 로고    scopus 로고
    • Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer
    • Panni RZ, et al. Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer. Cancer Immunol Immunother. 2014;63(5):513-528
    • (2014) Cancer Immunol Immunother , vol.63 , Issue.5 , pp. 513-528
    • Panni, R.Z.1
  • 95
    • 84873468174 scopus 로고    scopus 로고
    • Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses
    • Mitchem JB, et al. Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses. Cancer Res. 2013;73(3):1128-1141
    • (2013) Cancer Res , vol.73 , Issue.3 , pp. 1128-1141
    • Mitchem, J.B.1
  • 96
    • 84872600554 scopus 로고    scopus 로고
    • Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties
    • Schwitalla S, et al. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell. 2013;152(1):25-38
    • (2013) Cell , vol.152 , Issue.1 , pp. 25-38
    • Schwitalla, S.1
  • 97
    • 84913580379 scopus 로고    scopus 로고
    • Tumor-Associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells
    • Wan S, et al. Tumor-Associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells. Gastroenterology. 2014;147(6):1393-1404
    • (2014) Gastroenterology , vol.147 , Issue.6 , pp. 1393-1404
    • Wan, S.1
  • 98
    • 84908485098 scopus 로고    scopus 로고
    • A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages
    • Lu H, et al. A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages. Nat Cell Biol. 2014;16(11):1105-1117
    • (2014) Nat Cell Biol , vol.16 , Issue.11 , pp. 1105-1117
    • Lu, H.1
  • 99
    • 79961074770 scopus 로고    scopus 로고
    • Tumor-Associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells
    • Jinushi M, et al. Tumor-Associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells. Proc Natl Acad Sci U S A. 2011;108(30):12425-12430
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.30 , pp. 12425-12430
    • Jinushi, M.1
  • 100
    • 0029068339 scopus 로고
    • Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation
    • Mukhopadhyay D, Tsiokas L, Zhou XM, Foster D, Brugge JS, Sukhatme VP. Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation. Nature. 1995;375(6532):577-581
    • (1995) Nature , vol.375 , Issue.6532 , pp. 577-581
    • Mukhopadhyay, D.1    Tsiokas, L.2    Zhou, X.M.3    Foster, D.4    Brugge, J.S.5    Sukhatme, V.P.6
  • 101
    • 4944244259 scopus 로고    scopus 로고
    • Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues
    • Murdoch C, Giannoudis A, Lewis CE. Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood. 2004;104(8):2224-2234
    • (2004) Blood , vol.104 , Issue.8 , pp. 2224-2234
    • Murdoch, C.1    Giannoudis, A.2    Lewis, C.E.3
  • 102
    • 77953428551 scopus 로고    scopus 로고
    • Blood-vessel formation: Bridges that guide and unite
    • Schmidt T, Carmeliet P. Blood-vessel formation: bridges that guide and unite. Nature. 2010;465(7299):697-699
    • (2011) Nature , vol.465 , Issue.7299 , pp. 697-699
    • Schmidt, T.1    Carmeliet, P.2
  • 104
    • 34547820876 scopus 로고    scopus 로고
    • Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells
    • Shojaei F, et al. Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells. Nat Biotechnol. 2007;25(8):911-920
    • (2007) Nat Biotechnol , vol.25 , Issue.8 , pp. 911-920
    • Shojaei, F.1
  • 105
    • 36849013036 scopus 로고    scopus 로고
    • Bv8 regulates myeloidcell-dependent tumour angiogenesis
    • Shojaei F, et al. Bv8 regulates myeloidcell-dependent tumour angiogenesis. Nature. 2007;450(7171):825-831
    • (2007) Nature , vol.450 , Issue.7171 , pp. 825-831
    • Shojaei, F.1
  • 106
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
    • Condeelis J, Pollard JW. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell. 2006;124(2):263-266
    • (2006) Cell , vol.124 , Issue.2 , pp. 263-266
    • Condeelis, J.1    Pollard, J.W.2
  • 107
    • 34047246527 scopus 로고    scopus 로고
    • Direct visualization of macrophage-Assisted tumor cell intravasation in mammary tumors
    • Wyckoff JB, et al. Direct visualization of macrophage-Assisted tumor cell intravasation in mammary tumors. Cancer Res. 2007;67(6):2649-2656
    • (2007) Cancer Res , vol.67 , Issue.6 , pp. 2649-2656
    • Wyckoff, J.B.1
  • 109
    • 53349125963 scopus 로고    scopus 로고
    • Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cells
    • Sinha P, Okoro C, Foell D, Freeze HH, Ostrand-Rosenberg S, Srikrishna G. Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cells. J Immunol. 2008;181(7):4666-4675
    • (2008) J Immunol , vol.181 , Issue.7 , pp. 4666-4675
    • Sinha, P.1    Okoro, C.2    Foell, D.3    Freeze, H.H.4    Ostrand-Rosenberg, S.5    Srikrishna, G.6
  • 110
    • 55549128598 scopus 로고    scopus 로고
    • The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase
    • Hiratsuka S, et al. The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase. Nat Cell Biol. 2008;10(11):1349-1355
    • (2008) Nat Cell Biol , vol.10 , Issue.11 , pp. 1349-1355
    • Hiratsuka, S.1
  • 111
    • 79960411324 scopus 로고    scopus 로고
    • CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
    • Qian BZ, et al. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature. 2011;475(7355):222-225
    • (2011) Nature , vol.475 , Issue.7355 , pp. 222-225
    • Qian, B.Z.1
  • 112
    • 84865130953 scopus 로고    scopus 로고
    • Primary tumor hypoxia recruits CD11b+/Ly6Cmed/Ly6G+ immune suppressor cells and compromises NK cell cytotoxicity in the premetastatic niche
    • Sceneay J, et al. Primary tumor hypoxia recruits CD11b+/Ly6Cmed/Ly6G+ immune suppressor cells and compromises NK cell cytotoxicity in the premetastatic niche. Cancer Res. 2012;72(16):3906-3911
    • (2012) Cancer Res , vol.72 , Issue.16 , pp. 3906-3911
    • Sceneay, J.1
  • 113
    • 84926473508 scopus 로고    scopus 로고
    • IL-17-producing gammadelta T cells and neutrophils conspire to promote breast cancer metastasis
    • Coffelt SB, et al. IL-17-producing gammadelta T cells and neutrophils conspire to promote breast cancer metastasis. Nature. 2015;522(7556):345-348
    • (2015) Nature , vol.522 , Issue.7556 , pp. 345-348
    • Coffelt, S.B.1
  • 114
    • 80053336355 scopus 로고    scopus 로고
    • Mesenchymal transition and dissemination of cancer cells is driven by myeloidderived suppressor cells infiltrating the primary tumor
    • Toh B, et al. Mesenchymal transition and dissemination of cancer cells is driven by myeloidderived suppressor cells infiltrating the primary tumor. PLoS Biol. 2011;9(9):e1001162
    • (2011) PLoS Biol , vol.9 , Issue.9 , pp. e1001162
    • Toh, B.1
  • 115
    • 84862823626 scopus 로고    scopus 로고
    • Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors
    • Bonde AK, Tischler V, Kumar S, Soltermann A, Schwendener RA. Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors. BMC Cancer. 2012;12:35
    • (2012) BMC Cancer , vol.12 , pp. 35
    • Bonde, A.K.1    Tischler, V.2    Kumar, S.3    Soltermann, A.4    Schwendener, R.A.5
  • 116
    • 84918527502 scopus 로고    scopus 로고
    • Macrophage-secreted IL-8 induces epithelial-mesenchymal transition in hepatocellular carcinoma cells by activating the JAK2/STAT3/Snail pathway
    • Fu XT, et al. Macrophage-secreted IL-8 induces epithelial-mesenchymal transition in hepatocellular carcinoma cells by activating the JAK2/STAT3/Snail pathway. Int J Oncol. 2015;46(2):587-596
    • (2015) Int J Oncol , vol.46 , Issue.2 , pp. 587-596
    • Fu, X.T.1
  • 117
    • 84858199187 scopus 로고    scopus 로고
    • Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition
    • Gao D, et al. Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition. Cancer Res. 2012;72(6):1384-1394
    • (2012) Cancer Res , vol.72 , Issue.6 , pp. 1384-1394
    • Gao, D.1
  • 119
    • 84884556145 scopus 로고    scopus 로고
    • History of myeloid-derived suppressor cells
    • Talmadge JE, Gabrilovich DI. History of myeloid-derived suppressor cells. Nat Rev Cancer. 2013;13(10):739-752
    • (2013) Nat Rev Cancer , vol.13 , Issue.10 , pp. 739-752
    • Talmadge, J.E.1    Gabrilovich, D.I.2
  • 120
    • 54849440346 scopus 로고    scopus 로고
    • Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy
    • Diaz-Montero CM, Salem ML, Nishimura MI, Garrett-Mayer E, Cole DJ, Montero AJ. Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy. Cancer Immunol Immunother. 2009;58(1):49-59
    • (2009) Cancer Immunol Immunother , vol.58 , Issue.1 , pp. 49-59
    • Diaz-Montero, C.M.1    Salem, M.L.2    Nishimura, M.I.3    Garrett-Mayer, E.4    Cole, D.J.5    Montero, A.J.6
  • 121
    • 80052194777 scopus 로고    scopus 로고
    • Increased circulating immunosuppressive CD14(+)HLA-DR(-/low) cells correlate with clinical cancer stage and pathological grade in patients with bladder carcinoma
    • Yuan XK, Zhao XK, Xia YC, Zhu X, Xiao P. Increased circulating immunosuppressive CD14(+)HLA-DR(-/low) cells correlate with clinical cancer stage and pathological grade in patients with bladder carcinoma. J Int Med Res. 2011;39(4):1381-1391
    • (2011) J Int Med Res , vol.39 , Issue.4 , pp. 1381-1391
    • Yuan, X.K.1    Zhao, X.K.2    Xia, Y.C.3    Zhu, X.4    Xiao, P.5
  • 122
    • 84866537713 scopus 로고    scopus 로고
    • Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth
    • Porembka MR, et al. Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth. Cancer Immunol Immunother. 2012;61(9):1373-1385
    • (2012) Cancer Immunol Immunother , vol.61 , Issue.9 , pp. 1373-1385
    • Porembka, M.R.1
  • 123
    • 84885956598 scopus 로고    scopus 로고
    • Increased circulating Lin(-/low) CD33(+) HLA-DR(-) myeloid-derived suppressor cells in hepatocellular carcinoma patients
    • Shen P, Wang A, He M, Wang Q, Zheng S. Increased circulating Lin(-/low) CD33(+) HLA-DR(-) myeloid-derived suppressor cells in hepatocellular carcinoma patients. Hepatol Res. 2014;44(6):639-650
    • (2014) Hepatol Res , vol.44 , Issue.6 , pp. 639-650
    • Shen, P.1    Wang, A.2    He, M.3    Wang, Q.4    Zheng, S.5
  • 124
    • 84880924329 scopus 로고    scopus 로고
    • Increase in CD14+HLA-DR-/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis
    • Arihara F, et al. Increase in CD14+HLA-DR-/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis. Cancer Immunol Immunother. 2013;62(8):1421-1430
    • (2013) Cancer Immunol Immunother , vol.62 , Issue.8 , pp. 1421-1430
    • Arihara, F.1
  • 125
    • 84872172395 scopus 로고    scopus 로고
    • Increased myeloid-derived suppressor cells in gastric cancer correlate with cancer stage and plasma S100A8/A9 proinflammatory proteins
    • Wang L, Chang EW, Wong SC, Ong SM, Chong DQ, Ling KL. Increased myeloid-derived suppressor cells in gastric cancer correlate with cancer stage and plasma S100A8/A9 proinflammatory proteins. J Immunol. 2013;190(2):794-804
    • (2013) J Immunol , vol.190 , Issue.2 , pp. 794-804
    • Wang, L.1    Chang, E.W.2    Wong, S.C.3    Ong, S.M.4    Chong, D.Q.5    Ling, K.L.6
  • 126
    • 84883447186 scopus 로고    scopus 로고
    • Increased CD14(+)HLA-DR (-/low) myeloid-derived suppressor cells correlate with extrathoracic metastasis and poor response to chemotherapy in non-small cell lung cancer patients
    • Huang A, Zhang B, Wang B, Zhang F, Fan KX, Guo YJ. Increased CD14(+)HLA-DR (-/low) myeloid-derived suppressor cells correlate with extrathoracic metastasis and poor response to chemotherapy in non-small cell lung cancer patients. Cancer Immunol Immunother. 2013;62(9):1439-1451
    • (2013) Cancer Immunol Immunother , vol.62 , Issue.9 , pp. 1439-1451
    • Huang, A.1    Zhang, B.2    Wang, B.3    Zhang, F.4    Fan, K.X.5    Guo, Y.J.6
  • 127
    • 84875866083 scopus 로고    scopus 로고
    • STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients
    • Vasquez-Dunddel D, et al. STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients. J Clin Invest. 2013;123(4):1580-1589
    • (2013) J Clin Invest , vol.123 , Issue.4 , pp. 1580-1589
    • Vasquez-Dunddel, D.1
  • 128
  • 129
    • 63549105681 scopus 로고    scopus 로고
    • Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients
    • Ko JS, et al. Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients. Clin Cancer Res. 2009;15(6):2148-2157
    • (2009) Clin Cancer Res , vol.15 , Issue.6 , pp. 2148-2157
    • Ko, J.S.1
  • 130
    • 71449127523 scopus 로고    scopus 로고
    • Population alterations of L-Arginaseand inducible nitric oxide synthase-expressed CD11b+/CD14-/CD15+/CD33+ myeloidderived suppressor cells and CD8+ T lymphocytes in patients with advanced-stage non-small cell lung cancer
    • Liu CY, et al. Population alterations of L-Arginaseand inducible nitric oxide synthase-expressed CD11b+/CD14-/CD15+/CD33+ myeloidderived suppressor cells and CD8+ T lymphocytes in patients with advanced-stage non-small cell lung cancer. J Cancer Res Clin Oncol. 2010;136(1):35-45
    • (2011) J Cancer Res Clin Oncol , vol.136 , Issue.1 , pp. 35-45
    • Liu, C.Y.1
  • 131
    • 80054102628 scopus 로고    scopus 로고
    • Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13
    • Gabitass RF, Annels NE, Stocken DD, Pandha HA, Middleton GW. Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13. Cancer Immunol Immunother. 2011;60(10):1419-1430
    • (2011) Cancer Immunol Immunother , vol.60 , Issue.10 , pp. 1419-1430
    • Gabitass, R.F.1    Annels, N.E.2    Stocken, D.D.3    Pandha, H.A.4    Middleton, G.W.5
  • 132
    • 84911445469 scopus 로고    scopus 로고
    • Computational algorithm-driven evaluation of monocytic myeloid-derived suppressor cell frequency for prediction of clinical outcomes
    • Kitano S, et al. Computational algorithm-driven evaluation of monocytic myeloid-derived suppressor cell frequency for prediction of clinical outcomes. Cancer Immunol Res. 2014;2(8):812-821
    • (2014) Cancer Immunol Res , vol.2 , Issue.8 , pp. 812-821
    • Kitano, S.1
  • 133
    • 80052178466 scopus 로고    scopus 로고
    • A human promyelocytic-like population is responsible for the immune suppression mediated by myeloid-derived suppressor cells
    • Solito S, et al. A human promyelocytic-like population is responsible for the immune suppression mediated by myeloid-derived suppressor cells. Blood. 2011;118(8):2254-2265
    • (2011) Blood , vol.118 , Issue.8 , pp. 2254-2265
    • Solito, S.1
  • 134
    • 84922446244 scopus 로고    scopus 로고
    • Patients with pancreatic adenocarcinoma exhibit elevated levels of myeloid-derived suppressor cells upon progression of disease
    • Markowitz J, et al. Patients with pancreatic adenocarcinoma exhibit elevated levels of myeloid-derived suppressor cells upon progression of disease. Cancer Immunol Immunother. 2015;64(2):149-159
    • (2015) Cancer Immunol Immunother , vol.64 , Issue.2 , pp. 149-159
    • Markowitz, J.1
  • 135
    • 84864662070 scopus 로고    scopus 로고
    • Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival
    • Walter S, et al. Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival. Nat Med. 2012;18(8):1254-1261
    • (2012) Nat Med , vol.18 , Issue.8 , pp. 1254-1261
    • Walter, S.1
  • 137
    • 84894501478 scopus 로고    scopus 로고
    • Frequencies of circulating MDSC correlate with clinical outcome of melanoma patients treated with ipilimumab
    • Meyer C, et al. Frequencies of circulating MDSC correlate with clinical outcome of melanoma patients treated with ipilimumab. Cancer Immunol Immunother. 2014;63(3):247-257
    • (2014) Cancer Immunol Immunother , vol.63 , Issue.3 , pp. 247-257
    • Meyer, C.1
  • 138
    • 84894639687 scopus 로고    scopus 로고
    • Immune monitoring of the circulation and the tumor microenvironment in patients with regionally advanced melanoma receiving neoadjuvant ipilimumab
    • Tarhini AA, et al. Immune monitoring of the circulation and the tumor microenvironment in patients with regionally advanced melanoma receiving neoadjuvant ipilimumab. PLoS One. 2014;9(2):e87705
    • (2014) PLoS One , vol.9 , Issue.2 , pp. e87705
    • Tarhini, A.A.1
  • 139
    • 0036187615 scopus 로고    scopus 로고
    • The role of tumour-Associated macrophages in tumour progression: Implications for new anticancer therapies
    • Bingle L, Brown NJ, Lewis CE. The role of tumour-Associated macrophages in tumour progression: implications for new anticancer therapies. J Pathol. 2002;196(3):254-265
    • (2002) J Pathol , vol.196 , Issue.3 , pp. 254-265
    • Bingle, L.1    Brown, N.J.2    Lewis, C.E.3
  • 140
    • 84887481716 scopus 로고    scopus 로고
    • CSF-1R inhibition alters macrophage polarization and blocks glioma progression
    • Pyonteck SM, et al. CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat Med. 2013;19(10):1264-1272
    • (2013) Nat Med , vol.19 , Issue.10 , pp. 1264-1272
    • Pyonteck, S.M.1
  • 141
    • 77951086882 scopus 로고    scopus 로고
    • 5-Fluorouracil selectively kills tumor-Associated myeloid-derived suppressor cells resulting in enhanced T celldependent antitumor immunity
    • Vincent J, et al. 5-Fluorouracil selectively kills tumor-Associated myeloid-derived suppressor cells resulting in enhanced T celldependent antitumor immunity. Cancer Res. 2010;70(8):3052-3061
    • (2011) Cancer Res , vol.70 , Issue.8 , pp. 3052-3061
    • Vincent, J.1
  • 142
    • 25144466458 scopus 로고    scopus 로고
    • Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity
    • Suzuki E, Kapoor V, Jassar AS, Kaiser LR, Albelda SM. Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity. Clin Cancer Res. 2005;11(18):6713-6721
    • (2005) Clin Cancer Res , vol.11 , Issue.18 , pp. 6713-6721
    • Suzuki, E.1    Kapoor, V.2    Jassar, A.S.3    Kaiser, L.R.4    Albelda, S.M.5
  • 143
    • 84887561907 scopus 로고    scopus 로고
    • Low-dose irradiation programs macrophage differentiation to an iNOS(+)/M1 phenotype that orchestrates effective T cell immunotherapy
    • Klug F, et al. Low-dose irradiation programs macrophage differentiation to an iNOS(+)/M1 phenotype that orchestrates effective T cell immunotherapy. Cancer Cell. 2013;24(5):589-602
    • (2013) Cancer Cell , vol.24 , Issue.5 , pp. 589-602
    • Klug, F.1
  • 144
    • 0025804994 scopus 로고
    • Splenic macrophages from tumor-bearing mice co-expressing MAC-1 and MAC-2 antigens exert immunoregulatory functions via two distinct mechanisms
    • Watson GA, Fu YX, Lopez DM. Splenic macrophages from tumor-bearing mice co-expressing MAC-1 and MAC-2 antigens exert immunoregulatory functions via two distinct mechanisms. J Leukoc Biol. 1991;49(2):126-138
    • (1991) J Leukoc Biol , vol.49 , Issue.2 , pp. 126-138
    • Watson, G.A.1    Fu, Y.X.2    Lopez, D.M.3
  • 145
    • 84876424760 scopus 로고    scopus 로고
    • Macrophage regulation of tumor responses to anticancer therapies
    • De Palma M, Lewis CE. Macrophage regulation of tumor responses to anticancer therapies. Cancer Cell. 2013;23(3):277-286
    • (2013) Cancer Cell , vol.23 , Issue.3 , pp. 277-286
    • De Palma, M.1    Lewis, C.E.2
  • 146
    • 84876998346 scopus 로고    scopus 로고
    • Chemotherapy alters monocyte differentiation to favor generation of cancersupporting M2 macrophages in the tumor microenvironment
    • Dijkgraaf EM, et al. Chemotherapy alters monocyte differentiation to favor generation of cancersupporting M2 macrophages in the tumor microenvironment. Cancer Res. 2013;73(8):2480-2492
    • (2013) Cancer Res , vol.73 , Issue.8 , pp. 2480-2492
    • Dijkgraaf, E.M.1
  • 147
    • 34447258415 scopus 로고    scopus 로고
    • Identification of a new subset of myeloid suppressor cells in peripheral blood of melanoma patients with modulation by a granulocyte-macrophage colony-stimulation factor-based antitumor vaccine
    • Filipazzi P, et al. Identification of a new subset of myeloid suppressor cells in peripheral blood of melanoma patients with modulation by a granulocyte-macrophage colony-stimulation factor-based antitumor vaccine. J Clin Oncol. 2007;25(18):2546-2553
    • (2007) J Clin Oncol , vol.25 , Issue.18 , pp. 2546-2553
    • Filipazzi, P.1
  • 148
    • 84899709874 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells in cancer: Therapeutic, predictive, and prognostic implications
    • Diaz-Montero CM, Finke J, Montero AJ. Myeloid-derived suppressor cells in cancer: therapeutic, predictive, and prognostic implications. Semin Oncol. 2014;41(2):174-184
    • (2014) Semin Oncol , vol.41 , Issue.2 , pp. 174-184
    • Diaz-Montero, C.M.1    Finke, J.2    Montero, A.J.3
  • 149
    • 84902546715 scopus 로고    scopus 로고
    • Targeting tumor-Associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy
    • Ries CH, et al. Targeting tumor-Associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy. Cancer Cell. 2014;25(6):846-859
    • (2014) Cancer Cell , vol.25 , Issue.6 , pp. 846-859
    • Ries, C.H.1
  • 150
    • 17144398046 scopus 로고    scopus 로고
    • Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection
    • Guiducci C, Vicari AP, Sangaletti S, Trinchieri G, Colombo MP. Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection. Cancer Res. 2005;65(8):3437-3446
    • (2005) Cancer Res , vol.65 , Issue.8 , pp. 3437-3446
    • Guiducci, C.1    Vicari, A.P.2    Sangaletti, S.3    Trinchieri, G.4    Colombo, M.P.5
  • 151
    • 78149305887 scopus 로고    scopus 로고
    • Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2/anti-CD40 immunotherapy
    • Weiss JM, et al. Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2/anti-CD40 immunotherapy. J Exp Med. 2010;207(11):2455-2467
    • (2011) J Exp Med , vol.207 , Issue.11 , pp. 2455-2467
    • Weiss, J.M.1
  • 152
    • 77949900433 scopus 로고    scopus 로고
    • Targeting distinct tumorinfiltrating myeloid cells by inhibiting CSF-1 receptor: Combating tumor evasion of antiangiogenic therapy
    • Priceman SJ, et al. Targeting distinct tumorinfiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy. Blood. 2010;115(7):1461-1471
    • (2011) Blood , vol.115 , Issue.7 , pp. 1461-1471
    • Priceman, S.J.1
  • 153
    • 84879085632 scopus 로고    scopus 로고
    • Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer
    • Pienta KJ, et al. Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer. Invest New Drugs. 2013;31(3):760-768
    • (2013) Invest New Drugs , vol.31 , Issue.3 , pp. 760-768
    • Pienta, K.J.1
  • 154
    • 84878849941 scopus 로고    scopus 로고
    • A first-in-human, first-in-class, phase i study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors
    • Sandhu SK, et al. A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors. Cancer Chemother Pharmacol. 2013;71(4):1041-1050
    • (2013) Cancer Chemother Pharmacol , vol.71 , Issue.4 , pp. 1041-1050
    • Sandhu, S.K.1
  • 155
    • 84924662639 scopus 로고    scopus 로고
    • Immature myeloid cells directly contribute to skin tumor development by recruiting IL-17-producing CD4+ T cells
    • Ortiz ML, et al. Immature myeloid cells directly contribute to skin tumor development by recruiting IL-17-producing CD4+ T cells. J Exp Med. 2015;212(3):351-367
    • (2015) J Exp Med , vol.212 , Issue.3 , pp. 351-367
    • Ortiz, M.L.1
  • 156
    • 84863393301 scopus 로고    scopus 로고
    • Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis
    • Cassier PA, et al. Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis. Cancer. 2012;118(6):1649-1655
    • (2012) Cancer , vol.118 , Issue.6 , pp. 1649-1655
    • Cassier, P.A.1
  • 157
    • 79953154967 scopus 로고    scopus 로고
    • CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
    • Beatty GL, et al. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science. 2011;331(6024):1612-1616
    • (2011) Science , vol.331 , Issue.6024 , pp. 1612-1616
    • Beatty, G.L.1
  • 158
    • 78651461701 scopus 로고    scopus 로고
    • HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF
    • Rolny C, et al. HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF. Cancer Cell. 2011;19(1):31-44
    • (2011) Cancer Cell , vol.19 , Issue.1 , pp. 31-44
    • Rolny, C.1
  • 159
    • 78650756969 scopus 로고    scopus 로고
    • Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function
    • Condamine T, Gabrilovich DI. Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function. Trends Immunol. 2011;32(1):19-25
    • (2011) Trends Immunol , vol.32 , Issue.1 , pp. 19-25
    • Condamine, T.1    Gabrilovich, D.I.2
  • 160
    • 72849116796 scopus 로고    scopus 로고
    • Anti-tumour effects of bisphosphonates-what have we learned from in vivo models?
    • Brown HK, Holen I. Anti-tumour effects of bisphosphonates-what have we learned from in vivo models? Curr Cancer Drug Targets. 2009;9(7):807-823
    • (2009) Curr Cancer Drug Targets , vol.9 , Issue.7 , pp. 807-823
    • Brown, H.K.1    Holen, I.2
  • 161
    • 77955982989 scopus 로고    scopus 로고
    • Zoledronic acid impairs myeloid differentiation to tumour-Associated macrophages in mesothelioma
    • Veltman JD, et al. Zoledronic acid impairs myeloid differentiation to tumour-Associated macrophages in mesothelioma. Br J Cancer. 2010;103(5):629-641
    • (2011) Br J Cancer , vol.103 , Issue.5 , pp. 629-641
    • Veltman, J.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.