Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

Journal of Cell Biology

Volumn 216, Issue 7, 2017, Pages 2027-2045

  Quirós, Pedro M ^a   Prado, Miguel A ^b   Zamboni, Nicola ^c   D'Amico, Davide ^a   Williams, Robert W ^d   Finley, Daniel ^b   Gygi, Steven P ^b   Auwerx, Johan ^a  

^a EPFL   (Switzerland)

^b HARVARD MEDICAL SCHOOL   (United States)

^c ETH ZURICH   (Switzerland)

^d UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ATF4 PROTEIN, HUMAN; ATF4 PROTEIN, MOUSE; ATP DEPENDENT 26S PROTEASE; CLPP PROTEIN, MOUSE; ENDOPEPTIDASE CLP; MITOCHONDRIAL PROTEIN; PROTEASOME; PROTEOME; RIBOSOME PROTEIN; SERINE PROTEINASE; SERINE PROTEINASE OMI; TRANSCRIPTOME;

ANIMAL CELL; ARTICLE; CELL METABOLISM; CELL PROTECTION; CELLULAR STRESS RESPONSE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENE EXPRESSION; HUMAN; HUMAN CELL; MAMMAL; MITOCHONDRION; MULTIOMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN HOMEOSTASIS; PROTEOMICS; QUANTITATIVE TRAIT LOCUS; REGULATORY MECHANISM; UNFOLDED PROTEIN RESPONSE; ANIMAL; BIOLOGY; DISEASE MODEL; ENERGY METABOLISM; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETIC EPIGENESIS; GENETIC PREDISPOSITION; GENETIC TRANSFECTION; GENETICS; GENOMICS; HELA CELL LINE; KNOCKOUT MOUSE; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; PATHOLOGY; PHENOTYPE; PHYSIOLOGICAL STRESS; PROCEDURES; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TIME FACTOR;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; COMPUTATIONAL BIOLOGY; DISEASE MODELS, ANIMAL; ENDOPEPTIDASE CLP; ENERGY METABOLISM; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; GENETIC PREDISPOSITION TO DISEASE; GENOMICS; HELA CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL DISEASES; MITOCHONDRIAL PROTEINS; PHENOTYPE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN INTERACTION MAPS; PROTEOLYSIS; PROTEOME; PROTEOMICS; RIBOSOMAL PROTEINS; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; TIME FACTORS; TRANSCRIPTOME; TRANSFECTION;

EID: 85021857064     PISSN: 00219525     EISSN: 15408140     Source Type: Journal    
DOI: 10.1083/jcb.201702058     Document Type: Article

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