A Mitochondrial RNAi Screen Defines Cellular Bioenergetic Determinants and Identifies an Adenylate Kinase as a Key Regulator of ATP Levels

Cell Reports

Volumn 7, Issue 3, 2014, Pages 907-917

  Lanning, Nathan J ^a   Looyenga, Brendan D ^a,b   Kauffman, Audra L ^a   Niemi, Natalie M ^a   Sudderth, Jessica ^c   DeBerardinis, Ralph J ^c   MacKeigan, Jeffrey P ^a  

^a VAN ANDEL RESEARCH INSTITUTE   (United States)

^b CALVIN COLLEGE   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; RNA; MITOCHONDRIAL RNA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MITOCHONDRIAL PROTEIN; SMALL INTERFERING RNA;

ARTICLE; BIOENERGY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENETIC CODE; GLYCOLYSIS; MITOCHONDRION; PLASTICITY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RESPIRATORY CHAIN; RNA INTERFERENCE; SIGNAL PROCESSING; CONTROLLED STUDY; ELECTRON TRANSPORT; ENZYME ANALYSIS; ENZYME REGULATION; ENZYME SYNTHESIS; GENE LIBRARY; GLIOMA; HOMEOSTASIS; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SURVIVAL RATE; ANTAGONISTS AND INHIBITORS; ENERGY METABOLISM; ENZYMOLOGY; GENETICS; METABOLISM; OXIDATIVE PHOSPHORYLATION; PHOSPHORYLATION;

ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; AMP-ACTIVATED PROTEIN KINASES; ENERGY METABOLISM; GENE LIBRARY; GLYCOLYSIS; HUMANS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OXIDATIVE PHOSPHORYLATION; PHOSPHORYLATION; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84899828061     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.03.065     Document Type: Article

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