mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

Science

Volumn 351, Issue 6274, 2016, Pages 728-733

  Ben Sahra, Issam ^a   Hoxhaj, Gerta ^a   Ricoult, Stéphane J H ^a   Asara, John M ^b   Manning, Brendan D ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ACTIVATING TRANSCRIPTION FACTOR 4; INITIATION FACTOR 2ALPHA; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; METHYLENETETRAHYDROFOLATE REDUCTASE 2; PURINE; TETRAHYDROFOLIC ACID; UNCLASSIFIED DRUG; INITIATION FACTOR 2; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; MULTIPROTEIN COMPLEX; PURINE DERIVATIVE; TARGET OF RAPAMYCIN KINASE; TETRAHYDROFOLIC ACID DERIVATIVE;

CELLS AND CELL COMPONENTS; ENZYME; ENZYME ACTIVITY; GENE; GENOMICS; MITOCHONDRION; NUCLEIC ACID; ORGANIC COMPOUND; RODENT;

ANIMAL CELL; ARTICLE; CANCER CELL; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PURINE SYNTHESIS; SIGNAL TRANSDUCTION; TETRAHYDROFOLIC ACID CYCLE; ANIMAL; BIOSYNTHESIS; GENETIC TRANSCRIPTION; GENETICS; HEK293 CELL LINE; METABOLISM; MITOCHONDRION; PHOSPHORYLATION; PROTEIN SYNTHESIS;

EUKARYOTA;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; EUKARYOTIC INITIATION FACTOR-2; HEK293 CELLS; HUMANS; METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP); MICE; MITOCHONDRIA; MULTIPROTEIN COMPLEXES; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PURINES; TETRAHYDROFOLATES; TOR SERINE-THREONINE KINASES; TRANSCRIPTION, GENETIC;

EID: 84957899529     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad0489     Document Type: Article

References (21)

1. C. C. Dibble, B. D. Manning, Nat. Cell Biol. 15, 555-564 (2013).
2. I. Ben-Sahra, J. J. Howell, J. M. Asara, B. D. Manning, Science 339, 1323-1328 (2013).
3. A. M. Robitaille et al., Science 339, 1320-1323 (2013).
4. R. Nilsson et al., Nat. Commun. 5, 3128 (2014).
5. S. Menon, B. D. Manning, Oncogene 27 (suppl. 2), S43-S51 (2008).
6. Cancer Genome Atlas Network, Nature 490, 61-70 (2012).
7. J. Fan et al., Nature 510, 298-302 (2014).
8. C. F. Labuschagne, N. J. van den Broek, G. M. Mackay, K. H. Vousden, O. D. Maddocks, Cell Rep. 7, 1248-1258 (2014).
9. M. Mehrmohamadi, X. Liu, A. A. Shestov, J. W. Locasale, Cell Rep. 9, 1507-1519 (2014).
10. C. A. Lewis et al., Mol. Cell 55, 253-263 (2014).
11. J. W. Locasale, Nat. Rev. Cancer 13, 572-583 (2013).
12. K. Düvel et al., Mol. Cell 39, 171-183 (2010).
13. Y. Zhang et al., Nature 513, 440-443 (2014).
14. A. Csibi et al., Curr. Biol. 24, 2274-2280 (2014).
15. C. C. Hudson et al., Mol. Cell. Biol. 22, 7004-7014 (2002).
16. C. M. Adams, J. Biol. Chem. 282, 16744-16753 (2007).
17. J. Ye et al., Proc. Natl. Acad. Sci. U.S.A. 109, 6904-6909 (2012).
18. E. Yuan et al., Hum. Mol. Genet. 21, 4286-4300 (2012).
19. H. P. Harding et al., Mol. Cell 6, 1099-1108 (2000).
20. H. P. Harding et al., Mol. Cell 11, 619-633 (2003).
21. D. Scheuner et al., Mol. Cell 7, 1165-1176 (2001).