A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. Elegans

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Andreux, Pénélope A ^a,c   Mouchiroud, Laurent ^a   Wang, Xu ^a   Jovaisaite, Virginija ^a   Mottis, Adrienne ^a   Bichet, Sabrina ^a   Moullan, Norman ^a   Houtkooper, Riekelt H ^a,b   Auwerx, Johan ^a  

^a EPFL   (Switzerland)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c Quartier de l'Innovation EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; MEVINOLIN; MONOUNSATURATED FATTY ACID; SIMVASTATIN;

ANIMAL; CAENORHABDITIS ELEGANS; CELL LINE; CLASSIFICATION; CLUSTER ANALYSIS; CYTOLOGY; DRUG APPROVAL; DRUG EFFECTS; DRUG SCREENING; FOOD AND DRUG ADMINISTRATION; GENE EXPRESSION; HUMAN; LIVER CELL CARCINOMA; MCF 7 CELL LINE; METABOLISM; MITOCHONDRION; MOUSE; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PATHOLOGY; PROCEDURES; REPRODUCIBILITY; TUMOR CELL LINE; UNITED STATES;

ANIMALS; CAENORHABDITIS ELEGANS; CARCINOMA, HEPATOCELLULAR; CELL LINE; CELL LINE, TUMOR; CLUSTER ANALYSIS; DRUG APPROVAL; DRUG EVALUATION, PRECLINICAL; FATTY ACIDS, MONOUNSATURATED; GENE EXPRESSION; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMIDAZOLES; INDOLES; LOVASTATIN; MCF-7 CELLS; MICE; MITOCHONDRIA; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PHARMACEUTICAL PREPARATIONS; REPRODUCIBILITY OF RESULTS; SIMVASTATIN; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION;

EID: 84902440656     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep05285     Document Type: Article

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