Joint mouse-human phenome-wide association to test gene function and disease risk

Nature Communications

Volumn 7, Issue , 2016, Pages

  Wang, Xusheng ^a,b   Pandey, Ashutosh K ^a   Mulligan, Megan K ^a   Williams, Evan G ^c   Mozhui, Khyobeni ^a   Li, Zhengsheng ^a   Jovaisaite, Virginija ^c   Quarles, L Darryl ^a   Xiao, Zhousheng ^a   Huang, Jinsong ^a   Capra, John A ^d   Chen, Zugen ^e   Taylor, William L ^a   Bastarache, Lisa ^d   Niu, Xinnan ^d   Pollard, Katherine S ^f,g   Ciobanu, Daniel C ^a,h   Reznik, Alexander O ⁱ   Tishkov, Artem V ⁱ   Zhulin, Igor B ⁱ   Peng, Junmin ^b   Nelson, Stanley F ^e   Denny, Joshua C ^d   Auwerx, Johan ^c   Lu, Lu ^a   Williams, Robert W ^a   more..

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c EPFL   (Switzerland)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f GLADSTONE INSTITUTES   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h UNIVERSITY OF NEBRASKA LINCOLN   (United States)

ⁱ Oak Ridge National Laboratory   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUMARATE HYDRATASE; PROTEOME; TRANSCRIPTOME;

BONE; COHORT ANALYSIS; DISEASE INCIDENCE; ENZYME ACTIVITY; GENE; GENOME; HEALTH RISK; HISTOPATHOLOGY; MITOCHONDRION; PHENOTYPE; PROTEIN; RODENT;

ARTICLE; BONE DENSITY; CAENORHABDITIS ELEGANS; DNA SEQUENCE; FRAMESHIFT MUTATION; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENE LOSS; GENE MAPPING; GENE STRUCTURE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC RISK; GENETIC VARIABILITY; GENOME; HUMAN; INDEL MUTATION; MAJOR CLINICAL STUDY; METABOLOME; METAGENOME; MISSENSE MUTATION; MOUSE; NONHUMAN; PHENOME; PHENOME WIDE ASSOCIATION STUDY; PHENOTYPE; PHENOTYPIC VARIATION; PROTEIN FUNCTION; PROTEOMICS; QUANTITATIVE TRAIT LOCUS; SEQUENCE ALIGNMENT; SINGLE NUCLEOTIDE POLYMORPHISM; STOP CODON; UNFOLDED PROTEIN RESPONSE; UPREGULATION; ANIMAL; DBA MOUSE; GENE EXPRESSION REGULATION; GENE LIBRARY; GENETIC VARIATION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GENOMICS; METABOLISM; PHYSIOLOGY;

CAENORHABDITIS ELEGANS; MURINAE;

ANIMALS; BONE DENSITY; CAENORHABDITIS ELEGANS; FUMARATE HYDRATASE; GENE EXPRESSION REGULATION; GENE LIBRARY; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOMICS; HUMANS; MICE; MICE, INBRED DBA; QUANTITATIVE TRAIT LOCI;

EID: 84957555626     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10464     Document Type: Article

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