-
1
-
-
84858376953
-
Mitochondria: in sickness and in health
-
Nunnari, J., Suomalainen, A., Mitochondria: in sickness and in health. Cell 148 (2012), 1145–1159.
-
(2012)
Cell
, vol.148
, pp. 1145-1159
-
-
Nunnari, J.1
Suomalainen, A.2
-
2
-
-
84901382660
-
Mitochondrial DNA genetics and the heteroplasmy conundrum in evolution and disease
-
Wallace, D.C., Chalkia, D., Mitochondrial DNA genetics and the heteroplasmy conundrum in evolution and disease. Cold Spring Harbor Perspect. Biol., 5, 2013, a021220.
-
(2013)
Cold Spring Harbor Perspect. Biol.
, vol.5
, pp. a021220
-
-
Wallace, D.C.1
Chalkia, D.2
-
3
-
-
79961167180
-
Mitochondrial DNA transcription regulation and nucleoid organization
-
Rebelo, A.P., et al. Mitochondrial DNA transcription regulation and nucleoid organization. J. Inherit. Metab. Dis. 34 (2011), 941–951.
-
(2011)
J. Inherit. Metab. Dis.
, vol.34
, pp. 941-951
-
-
Rebelo, A.P.1
-
4
-
-
84969900519
-
Synchronized mitochondrial and cytosolic translation programs
-
Couvillion, M.T., et al. Synchronized mitochondrial and cytosolic translation programs. Nature 533 (2016), 499–503.
-
(2016)
Nature
, vol.533
, pp. 499-503
-
-
Couvillion, M.T.1
-
5
-
-
84990892316
-
Mitochondrial protein synthesis adapts to influx of nuclear-encoded protein
-
Richter-Dennerlein, R., Mitochondrial protein synthesis adapts to influx of nuclear-encoded protein. Cell 167 (2016), 471–483.
-
(2016)
Cell
, vol.167
, pp. 471-483
-
-
Richter-Dennerlein, R.1
-
6
-
-
84960171872
-
Mitonuclear communication in homeostasis and stress
-
Quiros, P.M., et al. Mitonuclear communication in homeostasis and stress. Nat. Rev. Mol. Cell Biol. 17 (2016), 213–226.
-
(2016)
Nat. Rev. Mol. Cell Biol.
, vol.17
, pp. 213-226
-
-
Quiros, P.M.1
-
7
-
-
77949678340
-
Chromatin structure and the inheritance of epigenetic information
-
Margueron, R., Reinberg, D., Chromatin structure and the inheritance of epigenetic information. Nat. Rev. Genet. 11 (2010), 285–296.
-
(2010)
Nat. Rev. Genet.
, vol.11
, pp. 285-296
-
-
Margueron, R.1
Reinberg, D.2
-
8
-
-
84875149194
-
Regulation of nucleosome dynamics by histone modifications
-
Zentner, G.E., Henikoff, S., Regulation of nucleosome dynamics by histone modifications. Nat. Struct. Mol. Biol. 20 (2013), 259–266.
-
(2013)
Nat. Struct. Mol. Biol.
, vol.20
, pp. 259-266
-
-
Zentner, G.E.1
Henikoff, S.2
-
9
-
-
84976295085
-
The molecular hallmarks of epigenetic control
-
Allis, C.D., Jenuwein, T., The molecular hallmarks of epigenetic control. Nat. Rev. Genet. 17 (2016), 487–500.
-
(2016)
Nat. Rev. Genet.
, vol.17
, pp. 487-500
-
-
Allis, C.D.1
Jenuwein, T.2
-
10
-
-
77957666255
-
Histone methyl transferases and demethylases; can they link metabolism and transcription?
-
Teperino, R., et al. Histone methyl transferases and demethylases; can they link metabolism and transcription?. Cell Metab. 12 (2010), 321–327.
-
(2010)
Cell Metab.
, vol.12
, pp. 321-327
-
-
Teperino, R.1
-
11
-
-
84904042103
-
Transcriptional coregulators: fine-tuning metabolism
-
Mouchiroud, L., et al. Transcriptional coregulators: fine-tuning metabolism. Cell Metab. 20 (2014), 26–40.
-
(2014)
Cell Metab.
, vol.20
, pp. 26-40
-
-
Mouchiroud, L.1
-
12
-
-
84949624063
-
Protein acetylation in metabolism–metabolites and cofactors
-
Menzies, K.J., et al. Protein acetylation in metabolism–metabolites and cofactors. Nat. Rev. Endocrinol. 12 (2016), 43–60.
-
(2016)
Nat. Rev. Endocrinol.
, vol.12
, pp. 43-60
-
-
Menzies, K.J.1
-
13
-
-
84908151229
-
Histone core modifications regulating nucleosome structure and dynamics
-
Tessarz, P., Kouzarides, T., Histone core modifications regulating nucleosome structure and dynamics. Nat. Rev. Mol. Cell Biol. 15 (2014), 703–708.
-
(2014)
Nat. Rev. Mol. Cell Biol.
, vol.15
, pp. 703-708
-
-
Tessarz, P.1
Kouzarides, T.2
-
14
-
-
84921425001
-
Erasers of histone acetylation: the histone deacetylase enzymes
-
Seto, E., Yoshida, M., Erasers of histone acetylation: the histone deacetylase enzymes. Cold Spring Harbor Perspect. Biol., 6, 2014, a018713.
-
(2014)
Cold Spring Harbor Perspect. Biol.
, vol.6
, pp. a018713
-
-
Seto, E.1
Yoshida, M.2
-
15
-
-
33947532026
-
Histone acetyltransferase complexes: one size doesn't fit all
-
Lee, K.K., Workman, J.L., Histone acetyltransferase complexes: one size doesn't fit all. Nat. Rev. Mol. Cell Biol. 8 (2007), 284–295.
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 284-295
-
-
Lee, K.K.1
Workman, J.L.2
-
16
-
-
84930589309
-
Acetyl coenzyme A: a central metabolite and second messenger
-
Pietrocola, F., et al. Acetyl coenzyme A: a central metabolite and second messenger. Cell Metab. 21 (2015), 805–821.
-
(2015)
Cell Metab.
, vol.21
, pp. 805-821
-
-
Pietrocola, F.1
-
17
-
-
66249105703
-
ATP-citrate lyase links cellular metabolism to histone acetylation
-
Wellen, K.E., et al. ATP-citrate lyase links cellular metabolism to histone acetylation. Science 324 (2009), 1076–1080.
-
(2009)
Science
, vol.324
, pp. 1076-1080
-
-
Wellen, K.E.1
-
18
-
-
84957439277
-
TCA cycle and mitochondrial membrane potential are necessary for diverse biological functions
-
Martinez-Reyes, I., TCA cycle and mitochondrial membrane potential are necessary for diverse biological functions. Mol. Cell 61 (2016), 199–209.
-
(2016)
Mol. Cell
, vol.61
, pp. 199-209
-
-
Martinez-Reyes, I.1
-
20
-
-
84858797950
-
Sirtuins as regulators of metabolism and healthspan
-
Houtkooper, R.H., et al. Sirtuins as regulators of metabolism and healthspan. Nat. Rev. Mol. Cell Biol. 13 (2012), 225–238.
-
(2012)
Nat. Rev. Mol. Cell Biol.
, vol.13
, pp. 225-238
-
-
Houtkooper, R.H.1
-
21
-
-
84942372058
-
The multifaceted functions of sirtuins in cancer
-
Chalkiadaki, A., Guarente, L., The multifaceted functions of sirtuins in cancer. Nat. Rev. Cancer 15 (2015), 608–624.
-
(2015)
Nat. Rev. Cancer
, vol.15
, pp. 608-624
-
-
Chalkiadaki, A.1
Guarente, L.2
-
22
-
-
84937397484
-
Sirtuins and the metabolic hurdles in cancer
-
German, N.J., Haigis, M.C., Sirtuins and the metabolic hurdles in cancer. Current biology 25 (2015), R569–583.
-
(2015)
Current biology
, vol.25
, pp. R569-583
-
-
German, N.J.1
Haigis, M.C.2
-
23
-
-
0034677535
-
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
-
Imai, S., et al. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403 (2000), 795–800.
-
(2000)
Nature
, vol.403
, pp. 795-800
-
-
Imai, S.1
-
24
-
-
84859893371
-
Histone methylation: a dynamic mark in health, disease and inheritance
-
Greer, E.L., Shi, Y., Histone methylation: a dynamic mark in health, disease and inheritance. Nat. Rev. Genet. 13 (2012), 343–357.
-
(2012)
Nat. Rev. Genet.
, vol.13
, pp. 343-357
-
-
Greer, E.L.1
Shi, Y.2
-
25
-
-
84879260661
-
A double take on bivalent promoters
-
Voigt, P., et al. A double take on bivalent promoters. Genes Dev. 27 (2013), 1318–1338.
-
(2013)
Genes Dev.
, vol.27
, pp. 1318-1338
-
-
Voigt, P.1
-
26
-
-
0029926820
-
S-adenosylmethionine and methylation
-
Chiang, P.K., et al. S-adenosylmethionine and methylation. FASEB J. 10 (1996), 471–480.
-
(1996)
FASEB J.
, vol.10
, pp. 471-480
-
-
Chiang, P.K.1
-
27
-
-
84994772445
-
One-carbon metabolism in health and disease
-
Ducker, G.S., Rabinowitz, J.D., One-carbon metabolism in health and disease. Cell Metab. 25 (2017), 27–42.
-
(2017)
Cell Metab.
, vol.25
, pp. 27-42
-
-
Ducker, G.S.1
Rabinowitz, J.D.2
-
28
-
-
84943339297
-
Lysine methyltransferase SETD7 (SET7/9) regulates ROS signaling through mitochondria and NFE2L2/ARE pathway
-
He, S., et al. Lysine methyltransferase SETD7 (SET7/9) regulates ROS signaling through mitochondria and NFE2L2/ARE pathway. Sci. Rep., 5, 2015, 14368.
-
(2015)
Sci. Rep.
, vol.5
, pp. 14368
-
-
He, S.1
-
29
-
-
11144332565
-
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
-
Shi, Y., et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 119 (2004), 941–953.
-
(2004)
Cell
, vol.119
, pp. 941-953
-
-
Shi, Y.1
-
30
-
-
24144462170
-
LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
-
Metzger, E., et al. LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature 437 (2005), 436–439.
-
(2005)
Nature
, vol.437
, pp. 436-439
-
-
Metzger, E.1
-
31
-
-
68749108259
-
LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer
-
Wang, Y., et al. LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell 138 (2009), 660–672.
-
(2009)
Cell
, vol.138
, pp. 660-672
-
-
Wang, Y.1
-
32
-
-
25144519737
-
An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation
-
Lee, M.G., et al. An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. Nature 437 (2005), 432–435.
-
(2005)
Nature
, vol.437
, pp. 432-435
-
-
Lee, M.G.1
-
33
-
-
38149045693
-
DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression
-
Perillo, B., et al. DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression. Science 319 (2008), 202–206.
-
(2008)
Science
, vol.319
, pp. 202-206
-
-
Perillo, B.1
-
34
-
-
84902353196
-
LSD1 promotes oxidative metabolism of white adipose tissue
-
Duteil, D., et al. LSD1 promotes oxidative metabolism of white adipose tissue. Nat. Commun., 5, 2014, 4093.
-
(2014)
Nat. Commun.
, vol.5
, pp. 4093
-
-
Duteil, D.1
-
35
-
-
84859176881
-
FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure
-
Hino, S., et al. FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure. Nat. Commun., 3, 2012, 758.
-
(2012)
Nat. Commun.
, vol.3
, pp. 758
-
-
Hino, S.1
-
36
-
-
84986881095
-
Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation
-
Zeng, X., et al. Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation. Genes Dev. 30 (2016), 1822–1836.
-
(2016)
Genes Dev.
, vol.30
, pp. 1822-1836
-
-
Zeng, X.1
-
37
-
-
84974712382
-
LSD1 interacts with Zfp516 to promote UCP1 transcription and brown fat program
-
Sambeat, A., et al. LSD1 interacts with Zfp516 to promote UCP1 transcription and brown fat program. Cell Rep. 15 (2016), 2536–2549.
-
(2016)
Cell Rep.
, vol.15
, pp. 2536-2549
-
-
Sambeat, A.1
-
38
-
-
84994824112
-
Lsd1 ablation triggers metabolic reprogramming of brown adipose tissue
-
Duteil, D., et al. Lsd1 ablation triggers metabolic reprogramming of brown adipose tissue. Cell Rep. 17 (2016), 1008–1021.
-
(2016)
Cell Rep.
, vol.17
, pp. 1008-1021
-
-
Duteil, D.1
-
39
-
-
84942926198
-
Lysine demethylase LSD1 coordinates glycolytic and mitochondrial metabolism in hepatocellular carcinoma cells
-
Sakamoto, A., et al. Lysine demethylase LSD1 coordinates glycolytic and mitochondrial metabolism in hepatocellular carcinoma cells. Cancer Res. 75 (2015), 1445–1456.
-
(2015)
Cancer Res.
, vol.75
, pp. 1445-1456
-
-
Sakamoto, A.1
-
40
-
-
84860215207
-
Molecular mechanisms and potential functions of histone demethylases
-
Kooistra, S.M., Helin, K., Molecular mechanisms and potential functions of histone demethylases. Nat. Rev. Mol Cell Biol. 13 (2012), 297–311.
-
(2012)
Nat. Rev. Mol Cell Biol.
, vol.13
, pp. 297-311
-
-
Kooistra, S.M.1
Helin, K.2
-
41
-
-
84862632865
-
Inhibition of alpha-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
-
Xiao, M., et al. Inhibition of alpha-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev. 26 (2012), 1326–1338.
-
(2012)
Genes Dev.
, vol.26
, pp. 1326-1338
-
-
Xiao, M.1
-
42
-
-
84949679994
-
The histone demethylase KDM5 activates gene expression by recognizing chromatin context through its PHD reader motif
-
Liu, X., Secombe, J., The histone demethylase KDM5 activates gene expression by recognizing chromatin context through its PHD reader motif. Cell Rep. 13 (2015), 2219–2231.
-
(2015)
Cell Rep.
, vol.13
, pp. 2219-2231
-
-
Liu, X.1
Secombe, J.2
-
43
-
-
84940839674
-
Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells
-
Varaljai, R., et al. Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells. Genes Dev. 29 (2015), 1817–1834.
-
(2015)
Genes Dev.
, vol.29
, pp. 1817-1834
-
-
Varaljai, R.1
-
44
-
-
49349114931
-
Genome-wide analysis of the H3K4 histone demethylase RBP2 reveals a transcriptional program controlling differentiation
-
Lopez-Bigas, N., et al. Genome-wide analysis of the H3K4 histone demethylase RBP2 reveals a transcriptional program controlling differentiation. Mol. Cell 31 (2008), 520–530.
-
(2008)
Mol. Cell
, vol.31
, pp. 520-530
-
-
Lopez-Bigas, N.1
-
45
-
-
84880514208
-
The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling
-
Sullivan, L.B., et al. The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling. Mol. Cell 51 (2013), 236–248.
-
(2013)
Mol. Cell
, vol.51
, pp. 236-248
-
-
Sullivan, L.B.1
-
46
-
-
84989159124
-
Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
-
Sciacovelli, M., et al. Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition. Nature 537 (2016), 544–547.
-
(2016)
Nature
, vol.537
, pp. 544-547
-
-
Sciacovelli, M.1
-
47
-
-
70450239624
-
Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells
-
Cervera, A.M., et al. Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells. Mol. Cancer, 8, 2009, 89.
-
(2009)
Mol. Cancer
, vol.8
, pp. 89
-
-
Cervera, A.M.1
-
48
-
-
77951976595
-
JmjC enzyme KDM2A is a regulator of rRNA transcription in response to starvation
-
Tanaka, Y., et al. JmjC enzyme KDM2A is a regulator of rRNA transcription in response to starvation. EMBO J. 29 (2010), 1510–1522.
-
(2010)
EMBO J.
, vol.29
, pp. 1510-1522
-
-
Tanaka, Y.1
-
49
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
Yan, H., et al. IDH1 and IDH2 mutations in gliomas. New Eng. J. Med. 360 (2009), 765–773.
-
(2009)
New Eng. J. Med.
, vol.360
, pp. 765-773
-
-
Yan, H.1
-
50
-
-
78650019179
-
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
-
Figueroa, M.E., et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 18 (2010), 553–567.
-
(2010)
Cancer Cell
, vol.18
, pp. 553-567
-
-
Figueroa, M.E.1
-
51
-
-
84945176281
-
Epigenetic regulation by histone demethylases in hypoxia
-
Hancock, R.L., et al. Epigenetic regulation by histone demethylases in hypoxia. Epigenomics 7 (2015), 791–811.
-
(2015)
Epigenomics
, vol.7
, pp. 791-811
-
-
Hancock, R.L.1
-
52
-
-
84937012244
-
DNA methylation on N6-adenine in C elegans
-
Greer, E.L., et al. DNA methylation on N6-adenine in C elegans. Cell 161 (2015), 868–878.
-
(2015)
Cell
, vol.161
, pp. 868-878
-
-
Greer, E.L.1
-
53
-
-
84964471168
-
6-adenine in mammalian embryonic stem cells
-
6-adenine in mammalian embryonic stem cells. Nature 532 (2016), 329–333.
-
(2016)
Nature
, vol.532
, pp. 329-333
-
-
Wu, T.P.1
-
54
-
-
84875129831
-
DNA methylation dynamics in health and disease
-
Bergman, Y., Cedar, H., DNA methylation dynamics in health and disease. Nat. Struct. Mol. Biol. 20 (2013), 274–281.
-
(2013)
Nat. Struct. Mol. Biol.
, vol.20
, pp. 274-281
-
-
Bergman, Y.1
Cedar, H.2
-
55
-
-
84886111619
-
DNA methylation age of human tissues and cell types
-
Horvath, S., DNA methylation age of human tissues and cell types. Genome Biol., 14, 2013, R115.
-
(2013)
Genome Biol.
, vol.14
, pp. R115
-
-
Horvath, S.1
-
56
-
-
84901796479
-
The evidence for functional non-CpG methylation in mammalian cells
-
Patil, V., et al. The evidence for functional non-CpG methylation in mammalian cells. Epigenetics 9 (2014), 823–828.
-
(2014)
Epigenetics
, vol.9
, pp. 823-828
-
-
Patil, V.1
-
57
-
-
84922621952
-
Function and information content of DNA methylation
-
Schubeler, D., Function and information content of DNA methylation. Nature 517 (2015), 321–326.
-
(2015)
Nature
, vol.517
, pp. 321-326
-
-
Schubeler, D.1
-
58
-
-
84906050534
-
Epigenome-wide association study of fasting blood lipids in the genetics of lipid-lowering drugs and diet network study
-
Irvin, M.R., et al. Epigenome-wide association study of fasting blood lipids in the genetics of lipid-lowering drugs and diet network study. Circulation 130 (2014), 565–572.
-
(2014)
Circulation
, vol.130
, pp. 565-572
-
-
Irvin, M.R.1
-
59
-
-
14044261409
-
Alternative usages of multiple promoters of the acetyl-CoA carboxylase beta gene are related to differential transcriptional regulation in human and rodent tissues
-
Oh, S.Y., et al. Alternative usages of multiple promoters of the acetyl-CoA carboxylase beta gene are related to differential transcriptional regulation in human and rodent tissues. J. Biol. Chem. 280 (2005), 5909–5916.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 5909-5916
-
-
Oh, S.Y.1
-
60
-
-
77952060999
-
Role of Ucp1 enhancer methylation and chromatin remodelling in the control of Ucp1 expression in murine adipose tissue
-
Shore, A., et al. Role of Ucp1 enhancer methylation and chromatin remodelling in the control of Ucp1 expression in murine adipose tissue. Diabetologia 53 (2010), 1164–1173.
-
(2010)
Diabetologia
, vol.53
, pp. 1164-1173
-
-
Shore, A.1
-
61
-
-
36549039059
-
RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes
-
Kiskinis, E., et al. RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes. EMBO J. 26 (2007), 4831–4840.
-
(2007)
EMBO J.
, vol.26
, pp. 4831-4840
-
-
Kiskinis, E.1
-
62
-
-
84876979205
-
Weight loss after gastric bypass surgery in human obesity remodels promoter methylation
-
Barres, R., et al. Weight loss after gastric bypass surgery in human obesity remodels promoter methylation. Cell Rep. 3 (2013), 1020–1027.
-
(2013)
Cell Rep.
, vol.3
, pp. 1020-1027
-
-
Barres, R.1
-
63
-
-
84858055958
-
Acute exercise remodels promoter methylation in human skeletal muscle
-
Barres, R., et al. Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab. 15 (2012), 405–411.
-
(2012)
Cell Metab.
, vol.15
, pp. 405-411
-
-
Barres, R.1
-
64
-
-
69149087790
-
Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density
-
Barres, R., et al. Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density. Cell Metab. 10 (2009), 189–198.
-
(2009)
Cell Metab.
, vol.10
, pp. 189-198
-
-
Barres, R.1
-
65
-
-
84878260646
-
TETonic shift: biological roles of TET proteins in DNA demethylation and transcription
-
Pastor, W.A., et al. TETonic shift: biological roles of TET proteins in DNA demethylation and transcription. Nat. Rev. Mol. Cell Biol. 14 (2013), 341–356.
-
(2013)
Nat. Rev. Mol. Cell Biol.
, vol.14
, pp. 341-356
-
-
Pastor, W.A.1
-
66
-
-
78651463452
-
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
-
Xu, W., et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases. Cancer Cell 19 (2011), 17–30.
-
(2011)
Cancer Cell
, vol.19
, pp. 17-30
-
-
Xu, W.1
-
67
-
-
84878969599
-
SDH mutations establish a hypermethylator phenotype in paraganglioma
-
Letouze, E., et al. SDH mutations establish a hypermethylator phenotype in paraganglioma. Cancer cell 23 (2013), 739–752.
-
(2013)
Cancer cell
, vol.23
, pp. 739-752
-
-
Letouze, E.1
-
68
-
-
84887086564
-
Succinate dehydrogenase deficiency is associated with decreased 5-hydroxymethylcytosine production in gastrointestinal stromal tumors: implications for mechanisms of tumorigenesis
-
Mason, E.F., Hornick, J.L., Succinate dehydrogenase deficiency is associated with decreased 5-hydroxymethylcytosine production in gastrointestinal stromal tumors: implications for mechanisms of tumorigenesis. Modern Pathol. 26 (2013), 1492–1497.
-
(2013)
Modern Pathol.
, vol.26
, pp. 1492-1497
-
-
Mason, E.F.1
Hornick, J.L.2
-
69
-
-
84877141637
-
The mitochondrial nucleoid: integrating mitochondrial DNA into cellular homeostasis
-
Gilkerson, R., et al. The mitochondrial nucleoid: integrating mitochondrial DNA into cellular homeostasis. Cold Spring Harbor Perspect. Biol., 5, 2013, a011080.
-
(2013)
Cold Spring Harbor Perspect. Biol.
, vol.5
, pp. a011080
-
-
Gilkerson, R.1
-
70
-
-
41249098355
-
The layered structure of human mitochondrial DNA nucleoids
-
Bogenhagen, D.F., et al. The layered structure of human mitochondrial DNA nucleoids. J. Biol. Chem. 283 (2008), 3665–3675.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 3665-3675
-
-
Bogenhagen, D.F.1
-
71
-
-
34547117627
-
Roles for the human ATP-dependent Lon protease in mitochondrial DNA maintenance
-
Lu, B., et al. Roles for the human ATP-dependent Lon protease in mitochondrial DNA maintenance. J. Biol. Chem. 282 (2007), 17363–17374.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 17363-17374
-
-
Lu, B.1
-
72
-
-
84941074817
-
Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid
-
Kukat, C., et al. Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid. Proc. Natl. Acad. Sci. U.S.A. 112 (2015), 11288–11293.
-
(2015)
Proc. Natl. Acad. Sci. U.S.A.
, vol.112
, pp. 11288-11293
-
-
Kukat, C.1
-
73
-
-
0018802805
-
Mitochondrial DNA from various organisms does not contain internally methylated cytosine in -CCGG- sequences
-
Groot, G.S., Kroon, A.M., Mitochondrial DNA from various organisms does not contain internally methylated cytosine in -CCGG- sequences. Biochim. Biophys. Acta 564 (1979), 355–357.
-
(1979)
Biochim. Biophys. Acta
, vol.564
, pp. 355-357
-
-
Groot, G.S.1
Kroon, A.M.2
-
74
-
-
0015953437
-
5-methylcytidylic acid: absence from mitochondrial DNA of frogs and HeLa cells
-
Dawid, I.B., 5-methylcytidylic acid: absence from mitochondrial DNA of frogs and HeLa cells. Science 184 (1974), 80–81.
-
(1974)
Science
, vol.184
, pp. 80-81
-
-
Dawid, I.B.1
-
75
-
-
0017616953
-
Structure of animal mitochondrial DNA (base composition, pyrimidine clusters, character of methylation)
-
Vanyushin, B.F., Kirnos, M.D., Structure of animal mitochondrial DNA (base composition, pyrimidine clusters, character of methylation). Biochim. Biophys. Acta 475 (1977), 323–336.
-
(1977)
Biochim. Biophys. Acta
, vol.475
, pp. 323-336
-
-
Vanyushin, B.F.1
Kirnos, M.D.2
-
76
-
-
0015812379
-
Differential methylation of mitochondrial and nuclear DNA in cultured mouse, hamster and virus-transformed hamster cells. In vivo and in vitro methylation
-
Nass, M.M., Differential methylation of mitochondrial and nuclear DNA in cultured mouse, hamster and virus-transformed hamster cells. In vivo and in vitro methylation. J. Mol. Biol. 80 (1973), 155–175.
-
(1973)
J. Mol. Biol.
, vol.80
, pp. 155-175
-
-
Nass, M.M.1
-
77
-
-
84937520803
-
Mitochondrial epigenetics: an overlooked layer of regulation?
-
van der Wijst, M.G., Rots, M.G., Mitochondrial epigenetics: an overlooked layer of regulation?. Trends Genet. 31 (2015), 353–356.
-
(2015)
Trends Genet.
, vol.31
, pp. 353-356
-
-
van der Wijst, M.G.1
Rots, M.G.2
-
78
-
-
79952749156
-
DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria
-
Shock, L.S., et al. DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria. Proc. Natl. Acad. Sci. U.S.A. 108 (2011), 3630–3635.
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 3630-3635
-
-
Shock, L.S.1
-
79
-
-
84866755324
-
Effect of aging on 5-hydroxymethylcytosine in brain mitochondria
-
Dzitoyeva, S., et al. Effect of aging on 5-hydroxymethylcytosine in brain mitochondria. Neurobiol. Aging 33 (2012), 2881–2891.
-
(2012)
Neurobiol. Aging
, vol.33
, pp. 2881-2891
-
-
Dzitoyeva, S.1
-
80
-
-
84882847104
-
Mitochondrial DNA methylation as a next-generation biomarker and diagnostic tool
-
Iacobazzi, V., et al. Mitochondrial DNA methylation as a next-generation biomarker and diagnostic tool. Mol. Genet. Metab. 110 (2013), 25–34.
-
(2013)
Mol. Genet. Metab.
, vol.110
, pp. 25-34
-
-
Iacobazzi, V.1
-
81
-
-
84878138385
-
Mitonuclear protein imbalance as a conserved longevity mechanism
-
Houtkooper, R.H., et al. Mitonuclear protein imbalance as a conserved longevity mechanism. Nature 497 (2013), 451–457.
-
(2013)
Nature
, vol.497
, pp. 451-457
-
-
Houtkooper, R.H.1
-
82
-
-
0037147103
-
Rates of behavior and aging specified by mitochondrial function during development
-
Dillin, A., et al. Rates of behavior and aging specified by mitochondrial function during development. Science 298 (2002), 2398–2401.
-
(2002)
Science
, vol.298
, pp. 2398-2401
-
-
Dillin, A.1
-
83
-
-
78650944949
-
The cell-non-autonomous nature of electron transport chain-mediated longevity
-
Durieux, J., et al. The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell 144 (2011), 79–91.
-
(2011)
Cell
, vol.144
, pp. 79-91
-
-
Durieux, J.1
-
84
-
-
76849100919
-
The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans
-
Haynes, C.M., et al. The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Mol. cell 37 (2010), 529–540.
-
(2010)
Mol. cell
, vol.37
, pp. 529-540
-
-
Haynes, C.M.1
-
85
-
-
84864744900
-
Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation
-
Nargund, A.M., et al. Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation. Science 337 (2012), 587–590.
-
(2012)
Science
, vol.337
, pp. 587-590
-
-
Nargund, A.M.1
-
86
-
-
33748901113
-
Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response
-
Benedetti, C., et al. Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response. Genetics 174 (2006), 229–239.
-
(2006)
Genetics
, vol.174
, pp. 229-239
-
-
Benedetti, C.1
-
87
-
-
34848861368
-
ClpP mediates activation of a mitochondrial unfolded protein response in C elegans
-
Haynes, C.M., et al. ClpP mediates activation of a mitochondrial unfolded protein response in C elegans. Dev. cell 13 (2007), 467–480.
-
(2007)
Dev. cell
, vol.13
, pp. 467-480
-
-
Haynes, C.M.1
-
88
-
-
35648947912
-
Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans
-
Rea, S.L., et al. Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans. PLoS Biol., 5, 2007, e259.
-
(2007)
PLoS Biol.
, vol.5
, pp. e259
-
-
Rea, S.L.1
-
89
-
-
84964588008
-
Mitochondrial stress induces chromatin reorganization to promote longevity and UPR(mt)
-
Tian, Y., et al. Mitochondrial stress induces chromatin reorganization to promote longevity and UPR(mt). Cell 165 (2016), 1197–1208.
-
(2016)
Cell
, vol.165
, pp. 1197-1208
-
-
Tian, Y.1
-
90
-
-
84964570084
-
Two conserved histone demethylases regulate mitochondrial stress-induced longevity
-
Merkwirth, C., et al. Two conserved histone demethylases regulate mitochondrial stress-induced longevity. Cell 165 (2016), 1209–1223.
-
(2016)
Cell
, vol.165
, pp. 1209-1223
-
-
Merkwirth, C.1
-
91
-
-
84939493473
-
Repression of the heat shock response is a programmed event at the onset of reproduction
-
Labbadia, J., Morimoto, R.I., Repression of the heat shock response is a programmed event at the onset of reproduction. Mol. cell 59 (2015), 639–650.
-
(2015)
Mol. cell
, vol.59
, pp. 639-650
-
-
Labbadia, J.1
Morimoto, R.I.2
-
92
-
-
84878797603
-
Epigenetic silencing mediates mitochondria stress-induced longevity
-
Schroeder, E.A., et al. Epigenetic silencing mediates mitochondria stress-induced longevity. Cell Metab. 17 (2013), 954–964.
-
(2013)
Cell Metab.
, vol.17
, pp. 954-964
-
-
Schroeder, E.A.1
-
93
-
-
84878864199
-
The hallmarks of aging
-
Lopez-Otin, C., et al. The hallmarks of aging. Cell 153 (2013), 1194–1217.
-
(2013)
Cell
, vol.153
, pp. 1194-1217
-
-
Lopez-Otin, C.1
|