Inhibition of mitochondrial genome expression triggers the activation of CHOP-10 by a cell signaling dependent on the integrated stress response but not the mitochondrial unfolded protein response

Mitochondrion

Volumn 21, Issue , 2015, Pages 58-68

  Michel, Sebastien ^a   Canonne, Morgane ^a   Arnould, Thierry ^a   Renard, Patricia ^a  

^a University of Namur   (Belgium)

Author keywords

C EBP homologous protein 10 (CHOP 10); Doxycycline; Integrated stress response (ISR); Mitochondria unfolded protein response (mtUPR); Mitochondrial dysfunction; MtDNA depletion

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; CARRIER PROTEIN; CELL PROTEIN; CHAPERONIN 60; CHLORAMPHENICOL; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DOXYCYCLINE; ENDOPEPTIDASE CLP; GENERAL CONTROL NON DEREPRESSIBLE 2 KINASE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HOMOCYSTEINE INDUCIBLE ENDOPLASMIC RETICULUM STRESS INDUCIBLE UBIQUITIN LIKE DOMAIN MEMBER 1; INITIATION FACTOR 2ALPHA; MESSENGER RNA; PHOSPHOTRANSFERASE; SMALL INTERFERING RNA; TRANSLOCASE OF THE OUTER MEMBRANE 40; UNCLASSIFIED DRUG; ATF4 PROTEIN, HUMAN; DDIT3 PROTEIN, HUMAN; INITIATION FACTOR 2;

ARTICLE; BIOLOGICAL MODEL; CELL MODEL; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION AND TRANSLATION; GENOME DEPLETION; HELA CELL LINE; HUMAN; HUMAN CELL; INCUBATION TIME; INTEGRATED STRESS RESPONSE; INTRACELLULAR SIGNALING; LIVER CELL; MCF 7 CELL LINE; MITOCHONDRIAL DNA DEPLETION; MITOCHONDRIAL GENOME; MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE; MOLECULAR DYNAMICS; MOLECULAR GENETICS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; TRANSLATION INHIBITION; UNFOLDED PROTEIN RESPONSE; UPREGULATION; CELL LINE; GENE EXPRESSION; METABOLISM; PHYSIOLOGICAL STRESS; SIGNAL TRANSDUCTION;

ACTIVATING TRANSCRIPTION FACTOR 4; CELL LINE; EUKARYOTIC INITIATION FACTOR-2; GENE EXPRESSION; GENOME, MITOCHONDRIAL; HUMANS; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; TRANSCRIPTION FACTOR CHOP; UNFOLDED PROTEIN RESPONSE;

EID: 84922635413     PISSN: 15677249     EISSN: 18728278     Source Type: Journal    
DOI: 10.1016/j.mito.2015.01.005     Document Type: Article

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