Loss of mitochondrial peptidase clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors

Human Molecular Genetics

Volumn 22, Issue 24, 2013, Pages 4871-4887

  Gispert, Suzana ^a   Parganlija, Dajana ^a   Klinkenberg, Michael ^a   Dröse, Stefan ^b   Wittig, Ilka ^b   Mittelbronn, Michel ^c   Grzmil, Pawel ^d,e   Koob, Sebastian ^f   Hamann, Andrea ^f   Walter, Michael ^g   Büchel, Finja ^g   Adler, Thure ^h,i   De Angelis, Martin Hrabé ^h   Busch, Dirk H ⁱ   Zell, Andreas ^g   Reichert, Andreas S ^f   Brandt, Ulrich ^b   Osiewacz, Heinz D ^f   Jendrach, Marina ^a   Auburger, Georg ^a  

^a Cluster of Excellence Macromolecular Complexes   (Germany)

^b Cluster of Excellence Macromolecular Complexes   (Germany)

^c GOETHE UNIVERSITY MEDICAL SCHOOL   (Germany)

^d UNIVERSITY OF GÖTTINGEN   (Germany)

^e JAGIELLONIAN UNIVERSITY   (Poland)

^f GOETHE UNIVERSITY   (Germany)

^g UNIVERSITY OF TÜBINGEN   (Germany)

^h INSTITUTE OF EPIDEMIOLOGY   (Germany)

ⁱ TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CASEINOLYTIC PEPTIDASE; CHAPERONE; ENDOPEPTIDASE CLPX; MITOCHONDRIAL DNA; PEPTIDASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; FEMALE; FEMALE INFERTILITY; GENE EXPRESSION; GRANULOSA CELL; GROWTH RETARDATION; HEARING IMPAIRMENT; LOCOMOTION; LYMPHOCYTE SUBPOPULATION; MALE; MALE INFERTILITY; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL RESPIRATION; MOTOR ACTIVITY; MOUSE; NONHUMAN; PERCEPTION DEAFNESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PYODERMA GANGRENOSUM; RESPIRATION CONTROL; RESPIRATORY CHAIN; RESPIRATORY FAILURE; SPERMATID; SPERMATOGENESIS; STARTLE REFLEX; SURVIVAL; T LYMPHOCYTE; UNFOLDED PROTEIN RESPONSE; UPREGULATION;

ANIMALS; CELL RESPIRATION; DISEASE MODELS, ANIMAL; DNA, MITOCHONDRIAL; ENDOPEPTIDASE CLP; FEMALE; GENE ORDER; GONADS; GROWTH DISORDERS; HEARING LOSS; INFERTILITY; INFLAMMATION MEDIATORS; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MOLECULAR CHAPERONES; MOTOR ACTIVITY; MUTATION; PHENOTYPE; SPLEEN; T-LYMPHOCYTE SUBSETS;

EID: 84888196854     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddt338     Document Type: Article

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