Enzyme Efficiency but Not Thermostability Drives Cefotaxime Resistance Evolution in TEM-1 β-Lactamase

Molecular Biology and Evolution

Volumn 34, Issue 5, 2017, Pages 1040-1054

  Knies, Jennifer L ^a,b   Cai, Fei ^a,c   Weinreich, Daniel M ^a  

^a BROWN UNIVERSITY   (United States)

^b CHRISTOPHER NEWPORT UNIVERSITY   (United States)

^c BROWN UNIVERSITY   (United States)

Author keywords

Antagonistic pleiotropy; B lactamase; Drug resistance evolution; Enzyme evolution; Functional synthesis; Sign epistasis

Indexed keywords

BETA LACTAMASE TEM 1; CEFOTAXIME; ANTIINFECTIVE AGENT; BETA LACTAMASE; BETA-LACTAMASE TEM-1; ESCHERICHIA COLI PROTEIN;

ANTIBIOTIC RESISTANCE; ARTICLE; MINIMUM INHIBITORY CONCENTRATION; MISSENSE MUTATION; PHENOTYPE; PLEIOTROPY; THERMOSTABILITY; ADAPTATION; BIOLOGICAL MODEL; EPISTASIS; ESCHERICHIA COLI; EVOLUTION; GENETICS; METABOLISM; MICROBIAL SENSITIVITY TEST; MOLECULAR EVOLUTION; MUTATION;

ADAPTATION, PHYSIOLOGICAL; ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; BIOLOGICAL EVOLUTION; CEFOTAXIME; DRUG RESISTANCE, BACTERIAL; EPISTASIS, GENETIC; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; EVOLUTION, MOLECULAR; MICROBIAL SENSITIVITY TESTS; MODELS, GENETIC; MUTATION;

EID: 85019165716     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/msx053     Document Type: Article

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