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Volumn 8, Issue 3, 2001, Pages 238-242
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Predicting the emergence of antibiotic resistance by directed evolution and structural analysis
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Author keywords
[No Author keywords available]
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Indexed keywords
BETA LACTAMASE;
ANTIBIOTIC RESISTANCE;
ARTICLE;
ENZYME STRUCTURE;
EVOLUTION;
GENE MUTATION;
PREDICTION;
PRIORITY JOURNAL;
STRUCTURE ANALYSIS;
AMINO ACID SEQUENCE;
AMINO ACID SUBSTITUTION;
BETA-LACTAMASES;
BINDING SITES;
CEFOTAXIME;
CRYSTALLOGRAPHY, X-RAY;
DATABASES;
DIRECTED MOLECULAR EVOLUTION;
DRUG RESISTANCE, MICROBIAL;
ENZYME STABILITY;
ESCHERICHIA COLI;
EVOLUTION, MOLECULAR;
HYDROGEN BONDING;
MODELS, MOLECULAR;
MOLECULAR SEQUENCE DATA;
MUTAGENESIS;
PROTEIN STRUCTURE, SECONDARY;
PROTEIN STRUCTURE, TERTIARY;
SELECTION (GENETICS);
SEQUENCE ALIGNMENT;
STRUCTURE-ACTIVITY RELATIONSHIP;
SUPPRESSION, GENETIC;
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EID: 0035122917
PISSN: 10728368
EISSN: None
Source Type: Journal
DOI: 10.1038/84981 Document Type: Article |
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Times cited : (202)
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References (26)
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