Optimization of Conformational Dynamics in an Epistatic Evolutionary Trajectory

Molecular Biology and Evolution

Volumn 33, Issue 7, 2016, Pages 1768-1776

  Gonzalez, Mariano M ^a   Abriata, Luciano A ^a   Tomatis, Pablo E ^a   Vila, Alejandro J ^a,b  

^a UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

^b Ocampo y Esmeralda   (Argentina)

Author keywords

Conformational dynamics; Epistasis; Protein evolution

Indexed keywords

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; ENZYME ACTIVITY; EPISTASIS; MOLECULAR EVOLUTION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ROOM TEMPERATURE; WILD TYPE; CHEMISTRY; DIRECTED MOLECULAR EVOLUTION; ENZYME ACTIVE SITE; GENETICS; GENOTYPE; METABOLISM; MUTATION; NUCLEAR MAGNETIC RESONANCE; PHENOTYPE; PROCEDURES; PROTEIN CONFORMATION; PROTEIN FOLDING; STRUCTURE ACTIVITY RELATION;

BETA LACTAMASE; BETA-LACTAMASE BCII; CARRIER PROTEIN; ZINC-BINDING PROTEIN;

BETA-LACTAMASES; CARRIER PROTEINS; CATALYTIC DOMAIN; DIRECTED MOLECULAR EVOLUTION; EPISTASIS, GENETIC; EVOLUTION, MOLECULAR; GENOTYPE; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHENOTYPE; PROTEIN CONFORMATION; PROTEIN FOLDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84973633349     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/MOLBEV/MSW052     Document Type: Article

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