A biophysical protein folding model accounts for most mutational fitness effects in viruses

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 24, 2011, Pages 9916-9921

  Wylie, C Scott ^a   Shakhnovich, Eugene I ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

Epistasis; Fitness landscape; Protein stability

Indexed keywords

BETA LACTAMASE TEM 1;

ARTICLE; BACKGROUND SELECTION; BIOLOGICAL MODEL; EPISTASIS; GENETIC DRIFT; LETHALITY; MUTATION RATE; NONHUMAN; POPULATION GENETICS; POPULATION SIZE; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STABILITY; SIMULATION; THERMODYNAMICS; VIRUS MUTATION;

ALGORITHMS; BIOLOGICAL EVOLUTION; GENETICS, POPULATION; MODELS, CHEMICAL; MODELS, GENETIC; MODELS, MOLECULAR; MUTATION; POPULATION DENSITY; PROTEIN FOLDING; THERMODYNAMICS; VIRAL PROTEINS; VIRUSES;

EID: 79959992592     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1017572108     Document Type: Article

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