Evolvability as a Function of Purifying Selection in TEM-1 β-Lactamase

Cell

Volumn 160, Issue 5, 2015, Pages 882-892

  Stiffler, Michael A ^a   Hekstra, Doeke R ^a   Ranganathan, Rama ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; BETA LACTAMASE TEM 1; CEFOTAXIME; BETA LACTAMASE; BETA-LACTAMASE TEM-1;

ARTICLE; ENVIRONMENTAL FACTOR; ENZYME ACTIVITY; IN VIVO STUDY; MUTATION; NONHUMAN; PENICILLIN RESISTANCE; PRIORITY JOURNAL; PURIFYING SELECTION; SITE DIRECTED MUTAGENESIS; STRENGTH; WILD TYPE; ANTIBIOTIC RESISTANCE; CHEMISTRY; DIRECTED MOLECULAR EVOLUTION; DRUG EFFECTS; ENZYMOLOGY; ESCHERICHIA COLI; GENETICS; REPRODUCTIVE FITNESS;

AMPICILLIN; AMPICILLIN RESISTANCE; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CEFOTAXIME; DIRECTED MOLECULAR EVOLUTION; ESCHERICHIA COLI; GENETIC FITNESS; MUTATION;

EID: 84923321398     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2015.01.035     Document Type: Article

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