Multiple Global Suppressors of Protein Stability Defects Facilitate the Evolution of Extended-Spectrum TEM β-Lactamases

Journal of Molecular Biology

Volumn 404, Issue 5, 2010, Pages 832-846

  Brown, Nicholas G ^a   Pennington, Jeanine M ^a   Huang, Wanzhi ^a   Ayvaz, Tulin ^a   Palzkill, Timothy ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Antibiotic resistance; Global suppressor; Protein evolution; Protein stability; lactamase

Indexed keywords

ALANINE; AMPICILLIN; ARGININE; ASPARAGINE; ASPARTIC ACID; BETA LACTAMASE TEM 1; EXTENDED SPECTRUM BETA LACTAMASE; GLUTAMINE; METHIONINE; THREONINE; VALINE;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL MUTATION; BACTERIAL SURVIVAL; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME DEFECT; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STABILITY; ENZYME STRUCTURE; ESCHERICHIA COLI; MOLECULAR EVOLUTION; MOLECULAR MODEL; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SITE DIRECTED MUTAGENESIS; THERMOSTABILITY;

EID: 78649529303     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2010.10.008     Document Type: Article

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