Biophysical principles predict fitness landscapes of drug resistance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 11, 2016, Pages E1470-E1478

  Rodrigues, João V ^a   Bershtein, Shimon ^b   Li, Annabel ^c,d   Lozovsky, Elena R ^c   Hartl, Daniel L ^c   Shakhnovich, Eugene I ^a  

^a HARVARD UNIVERSITY   (United States)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^c HARVARD UNIVERSITY   (United States)

^d NONE   (United States)

Author keywords

DHFR; Drug resistance; Fitness landscapes; Molten globule; Protein stability

Indexed keywords

ANTIBIOTIC AGENT; CELL PROTEIN; DIHYDROFOLATE REDUCTASE; TRIMETHOPRIM; ESCHERICHIA COLI PROTEIN;

ANALYTICAL PARAMETERS; ANTIBIOTIC RESISTANCE; ARTICLE; BIOPHYSICS; CATALYTIC EFFICIENCY; CHLAMYDIA MURIDARUM; DENATURATION; DRUG INHIBITION; DRUG RESISTANCE; ENZYME ACTIVITY; ENZYME BINDING; ESCHERICHIA COLI; FITNESS LANDSCAPE; GROWTH CURVE; IC50; LISTERIA GRAYI; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STABILITY; QUALITY CONTROL; SIZE EXCLUSION CHROMATOGRAPHY; STEADY STATE; AMINO ACID SEQUENCE; CHEMISTRY; DIRECTED MOLECULAR EVOLUTION; DRUG EFFECTS; ENZYME STABILITY; EPISTASIS; GENETICS; LISTERIA; METABOLISM; MOLECULAR GENETICS; MUTATION; PROCEDURES;

AMINO ACID SEQUENCE; BIOPHYSICS; CHLAMYDIA MURIDARUM; DIRECTED MOLECULAR EVOLUTION; DRUG RESISTANCE, BACTERIAL; ENZYME STABILITY; EPISTASIS, GENETIC; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; INHIBITORY CONCENTRATION 50; LISTERIA; MOLECULAR SEQUENCE DATA; MUTATION; TETRAHYDROFOLATE DEHYDROGENASE; TRIMETHOPRIM;

EID: 84961838974     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1601441113     Document Type: Article

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