Epistasis constrains mutational pathways of hemoglobin adaptation in high-altitude pikas

Molecular Biology and Evolution

Volumn 32, Issue 2, 2015, Pages 287-298

  Tufts, Danielle M ^a   Natarajan, Chandrasekhar ^a   Revsbech, Inge G ^b   Projecto Garcia, Joana ^a   Hoffmann, Federico G ^c,d   Weber, Roy E ^b   Fago, Angela ^b   Moriyama, Hideaki ^a   Storz, Jay F ^a  

^a UNIVERSITY OF NEBRASKA   (United States)

^b AARHUS UNIVERSITY   (Denmark)

^c MISSISSIPPI STATE UNIVERSITY   (United States)

^d MISSISSIPPI STATE UNIVERSITY   (United States)

Author keywords

adaptation; epistasis; hemoglobin; high altitude; molecular evolution; protein evolution

Indexed keywords

HEMOGLOBIN; OXYGEN;

ALTITUDE; ARTICLE; EPISTASIS; GENE INTERACTION; GENE MUTATION; LAGOMORPH; MOLECULAR EVOLUTION; NONHUMAN; PLEIOTROPY; PROTEIN ENGINEERING; PROTEIN FUNCTION; ADAPTATION; ANIMAL; GENETIC SELECTION; GENETICS; METABOLISM; MUTATION; PHYSIOLOGY;

LAGOMORPHA; MAMMALIA; OCHOTONIDAE;

ADAPTATION, PHYSIOLOGICAL; ALTITUDE; ANIMALS; EPISTASIS, GENETIC; EVOLUTION, MOLECULAR; HEMOGLOBINS; LAGOMORPHA; MUTATION; OXYGEN; SELECTION, GENETIC;

EID: 84925137444     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/msu311     Document Type: Article

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