The evolution of cefotaximase activity in the TEM β-lactamase

Journal of Molecular Biology

Volumn 415, Issue 1, 2012, Pages 205-220

  Singh, Manoj Kumar ^a   Dominy, Brian N ^a  

^a CLEMSON UNIVERSITY   (United States)

Author keywords

catalytic activity; enzymatic evolution; MM GBSA; molecular dynamics; TEM lactamase

Indexed keywords

ALANINE; ARGININE; ASPARAGINE; BETA LACTAMASE; BETA LACTAMASE TEM 1; CEFOTAXIME; LYSINE; MUTANT PROTEIN; SERINE;

ANTIBIOTIC RESISTANCE; ARTICLE; BINDING AFFINITY; CATALYSIS; CONTROLLED STUDY; DRUG BINDING SITE; ENERGY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME STRUCTURE; GENE MUTATION; HYDROGEN BOND; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; SIMULATION; WILD TYPE;

EID: 84855254361     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2011.10.041     Document Type: Article

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