-
1
-
-
84877825884
-
Signaling and damaging functions of free radicals in aging-free radical theory, Hormesis, and TOR
-
Afanas’ev, I. (2010). Signaling and damaging functions of free radicals in aging-free radical theory, Hormesis, and TOR. Aging and Disease 1, 75–88.
-
(2010)
Aging and Disease
, vol.1
, pp. 75-88
-
-
Afanas’Ev, I.1
-
2
-
-
77749233738
-
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
-
Alexander, A., Cai, S. L., Kim, J., Nanez, A., Sahin, M., MacLean, K. H., Inoki, K., Guan, K. L., Shen, J., Person, M. D., Kusewitt, D., Mills, G. B., Kastan, M. B. & Walker, C. L. (2010). ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proceedings of the National Academy of Sciences of the United States of America 107, 4153–4158.
-
(2010)
Proceedings of the National Academy of Sciences of the United States of America
, vol.107
, pp. 4153-4158
-
-
Alexander, A.1
Cai, S.L.2
Kim, J.3
Nanez, A.4
Sahin, M.5
Maclean, K.H.6
Inoki, K.7
Guan, K.L.8
Shen, J.9
Person, M.D.10
Kusewitt, D.11
Mills, G.B.12
Kastan, M.B.13
Walker, C.L.14
-
3
-
-
69449106873
-
Autophagy is required for extension of yeast chronological life span by rapamycin
-
Alvers, A. L., Wood, M. S., Hu, D., Kaywell, A. C., Dunn, W. A. Jr. & Aris, J. P. (2009). Autophagy is required for extension of yeast chronological life span by rapamycin. Autophagy 5, 847–849.
-
(2009)
Autophagy
, vol.5
, pp. 847-849
-
-
Alvers, A.L.1
Wood, M.S.2
Hu, D.3
Kaywell, A.C.4
Dunn, W.A.5
Aris, J.P.6
-
4
-
-
0037038669
-
Mitochondrial stress-induced calcium signaling, phenotypic changes and invasive behavior in human lung carcinoma A549 cells
-
Amuthan, G., Biswas, G., Ananadatheerthavarada, H. K., Vijayasarathy, C., Shephard, H. M. & Avadhani, N. G. (2002). Mitochondrial stress-induced calcium signaling, phenotypic changes and invasive behavior in human lung carcinoma A549 cells. Oncogene 21, 7839–7849.
-
(2002)
Oncogene
, vol.21
, pp. 7839-7849
-
-
Amuthan, G.1
Biswas, G.2
Ananadatheerthavarada, H.K.3
Vijayasarathy, C.4
Shephard, H.M.5
Avadhani, N.G.6
-
5
-
-
69949102009
-
PGC-1alpha in aging and anti-aging interventions
-
Anderson, R. & Prolla, T. (2009). PGC-1alpha in aging and anti-aging interventions. Biochimica et Biophysica Acta 1790, 1059–1066.
-
(2009)
Biochimica Et Biophysica Acta
, vol.1790
, pp. 1059-1066
-
-
Anderson, R.1
Prolla, T.2
-
6
-
-
17144422877
-
Mitochondrial metabolism of reactive oxygen species
-
Andreyev, A. Y., Kushnareva, Y. E. & Starkov, A. A. (2005). Mitochondrial metabolism of reactive oxygen species. Biochemistry 70, 200–214.
-
(2005)
Biochemistry
, vol.70
, pp. 200-214
-
-
Andreyev, A.Y.1
Kushnareva, Y.E.2
Starkov, A.A.3
-
7
-
-
25144510360
-
Antioxidants do not explain the disparate longevity between mice and the longest-living rodent, the naked mole-rat
-
Andziak, B., O’Connor, T. P. & Buffenstein, R. (2005). Antioxidants do not explain the disparate longevity between mice and the longest-living rodent, the naked mole-rat. Mechanisms of Ageing and Development 126, 1206–1212.
-
(2005)
Mechanisms of Ageing and Development
, vol.126
, pp. 1206-1212
-
-
Andziak, B.1
O’Connor, T.P.2
Buffenstein, R.3
-
8
-
-
33751242066
-
High oxidative damage levels in the longest-living rodent, the naked mole-rat
-
Andziak, B., O’Connor, T. P., Qi, W., DeWaal, E. M., Pierce, A., Chaudhuri, A. R., Van Remmen, H. & Buffenstein, R. (2006). High oxidative damage levels in the longest-living rodent, the naked mole-rat. Aging Cell 5, 463–471.
-
(2006)
Aging Cell
, vol.5
, pp. 463-471
-
-
Andziak, B.1
O’Connor, T.P.2
Qi, W.3
Dewaal, E.M.4
Pierce, A.5
Chaudhuri, A.R.6
van Remmen, H.7
Buffenstein, R.8
-
9
-
-
15844375853
-
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
-
Baines, C. P., Kaiser, R. A., Purcell, N. H., Blair, N. S., Osinska, H., Hambleton, M. A., Brunskill, E. W., Sayen, M. R., Gottlieb, R. A., Dorn, G. W., Robbins, J. & Molkentin, J. D. (2005). Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature 434, 658–662.
-
(2005)
Nature
, vol.434
, pp. 658-662
-
-
Baines, C.P.1
Kaiser, R.A.2
Purcell, N.H.3
Blair, N.S.4
Osinska, H.5
Hambleton, M.A.6
Brunskill, E.W.7
Sayen, M.R.8
Gottlieb, R.A.9
Dorn, G.W.10
Robbins, J.11
Molkentin, J.D.12
-
10
-
-
84864065342
-
Protective coupling of mitochondrial function and protein synthesis via the eIF2alpha kinase GCN-2
-
Baker, B. M., Nargund, A. M., Sun, T. & Haynes, C. M. (2012). Protective coupling of mitochondrial function and protein synthesis via the eIF2alpha kinase GCN-2. PLoS Genetics 8, e1002760.
-
(2012)
Plos Genetics
, vol.8
-
-
Baker, B.M.1
Nargund, A.M.2
Sun, T.3
Haynes, C.M.4
-
11
-
-
80855138775
-
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
-
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L. & van Deursen, J. M. (2011). Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479, 232–236.
-
(2011)
Nature
, vol.479
, pp. 232-236
-
-
Baker, D.J.1
Wijshake, T.2
Tchkonia, T.3
Lebrasseur, N.K.4
Childs, B.G.5
van de Sluis, B.6
Kirkland, J.L.7
van Deursen, J.M.8
-
12
-
-
13944278132
-
Mitochondria, oxidants, and aging
-
Balaban, R. S., Nemoto, S. & Finkel, T. (2005). Mitochondria, oxidants, and aging. Cell 120, 483–495.
-
(2005)
Cell
, vol.120
, pp. 483-495
-
-
Balaban, R.S.1
Nemoto, S.2
Finkel, T.3
-
13
-
-
85138280032
-
-
Barja, G. (1998). Mitochondrial free radical production and aging in mammals and birds. Annals of the New York Academy of Sciences 854, 224–238
-
Barja, G. (1998). Mitochondrial free radical production and aging in mammals and birds. Annals of the New York Academy of Sciences 854, 224–238.
-
-
-
-
14
-
-
33748901113
-
Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response
-
Benedetti, C., Haynes, C. M., Yang, Y., Harding, H. P. & Ron, D. (2006). Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response. Genetics 174, 229–239.
-
(2006)
Genetics
, vol.174
, pp. 229-239
-
-
Benedetti, C.1
Haynes, C.M.2
Yang, Y.3
Harding, H.P.4
Ron, D.5
-
15
-
-
54849426651
-
Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy
-
Bentzinger, C. F., Romanino, K., Cloetta, D., Lin, S., Mascarenhas, J. B., Oliveri, F., Xia, J., Casanova, E., Costa, C. F., Brink, M., Zorzato, F., Hall, M. N. & Ruegg, M. A. (2008). Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metabolism 8, 411–424.
-
(2008)
Cell Metabolism
, vol.8
, pp. 411-424
-
-
Bentzinger, C.F.1
Romanino, K.2
Cloetta, D.3
Lin, S.4
Mascarenhas, J.B.5
Oliveri, F.6
Xia, J.7
Casanova, E.8
Costa, C.F.9
Brink, M.10
Zorzato, F.11
Hall, M.N.12
Ruegg, M.A.13
-
16
-
-
20244365941
-
The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation
-
Beuvink, I., Boulay, A., Fumagalli, S., Zilbermann, F., Ruetz, S., O’Reilly, T., Natt, F., Hall, J., Lane, H. A. & Thomas, G. (2005). The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation. Cell 120, 747–759.
-
(2005)
Cell
, vol.120
, pp. 747-759
-
-
Beuvink, I.1
Boulay, A.2
Fumagalli, S.3
Zilbermann, F.4
Ruetz, S.5
O’Reilly, T.6
Natt, F.7
Hall, J.8
Lane, H.A.9
Thomas, G.10
-
17
-
-
34249891333
-
Two neurons mediate diet-restriction-induced longevity in C. elegans
-
Bishop, N. A. & Guarente, L. (2007). Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature 447, 545–549.
-
(2007)
Nature
, vol.447
, pp. 545-549
-
-
Bishop, N.A.1
Guarente, L.2
-
18
-
-
0033081478
-
Retrograde Ca2+ signaling in C2C12 skeletal myocytes in response to mitochondrial genetic and metabolic stress: A novel mode of inter-organelle crosstalk
-
Biswas, G., Adebanjo, O. A., Freedman, B. D., Anandatheerthavarada, H. K., Vijayasarathy, C., Zaidi, M., Kotlikoff, M. & Avadhani, N. G. (1999). Retrograde Ca2+ signaling in C2C12 skeletal myocytes in response to mitochondrial genetic and metabolic stress: a novel mode of inter-organelle crosstalk. EMBO Journal 18, 522–533.
-
(1999)
EMBO Journal
, vol.18
, pp. 522-533
-
-
Biswas, G.1
Adebanjo, O.A.2
Freedman, B.D.3
Anandatheerthavarada, H.K.4
Vijayasarathy, C.5
Zaidi, M.6
Kotlikoff, M.7
Avadhani, N.G.8
-
19
-
-
72649091698
-
Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster
-
Bjedov, I., Toivonen, J. M., Kerr, F., Slack, C., Jacobson, J., Foley, A. & Partridge, L. (2010). Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metabolism 11, 35–46.
-
(2010)
Cell Metabolism
, vol.11
, pp. 35-46
-
-
Bjedov, I.1
Toivonen, J.M.2
Kerr, F.3
Slack, C.4
Jacobson, J.5
Foley, A.6
Partridge, L.7
-
20
-
-
55849152355
-
Aging: ROS or TOR
-
Blagosklonny, M. V. (2008). Aging: ROS or TOR. Cell Cycle 7, 3344–3354.
-
(2008)
Cell Cycle
, vol.7
, pp. 3344-3354
-
-
Blagosklonny, M.V.1
-
21
-
-
77953645579
-
Rapamycin and quasi-programmed aging: Four years later
-
Blagosklonny, M. V. (2010). Rapamycin and quasi-programmed aging: four years later. Cell Cycle 9, 1859–1862.
-
(2010)
Cell Cycle
, vol.9
, pp. 1859-1862
-
-
Blagosklonny, M.V.1
-
22
-
-
33947574775
-
Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression
-
Bonawitz, N. D., Chatenay-Lapointe, M., Pan, Y. & Shadel, G. S. (2007). Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression. Cell Metabolism 5, 265–277.
-
(2007)
Cell Metabolism
, vol.5
, pp. 265-277
-
-
Bonawitz, N.D.1
Chatenay-Lapointe, M.2
Pan, Y.3
Shadel, G.S.4
-
24
-
-
76749126321
-
Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories
-
Brewer, G. J. (2010). Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories. Experimental Gerontology 45, 173–179.
-
(2010)
Experimental Gerontology
, vol.45
, pp. 173-179
-
-
Brewer, G.J.1
-
25
-
-
69249232251
-
Age-related transcriptional changes in gene expression in different organs of mice support the metabolic stability theory of aging
-
Brink, T. C., Demetrius, L., Lehrach, H. & Adjaye, J. (2009). Age-related transcriptional changes in gene expression in different organs of mice support the metabolic stability theory of aging. Biogerontology 10, 549–564.
-
(2009)
Biogerontology
, vol.10
, pp. 549-564
-
-
Brink, T.C.1
Demetrius, L.2
Lehrach, H.3
Adjaye, J.4
-
26
-
-
0029103330
-
Control of p70 s6 kinase by kinase activity of FRAP in vivo
-
Brown, E. J., Beal, P. A., Keith, C. T., Chen, J., Shin, T. B. & Schreiber, S. L. (1995). Control of p70 s6 kinase by kinase activity of FRAP in vivo. Nature 377, 441–446.
-
(1995)
Nature
, vol.377
, pp. 441-446
-
-
Brown, E.J.1
Beal, P.A.2
Keith, C.T.3
Chen, J.4
Shin, T.B.5
Schreiber, S.L.6
-
27
-
-
0347359103
-
Reduced free-radical production and extreme longevity in the little brown bat (Myotis lucifugus) versus two non-flying mammals
-
Brunet-Rossinni, A. K. (2004). Reduced free-radical production and extreme longevity in the little brown bat (Myotis lucifugus) versus two non-flying mammals. Mechanisms of Ageing and Development 125, 11–20.
-
(2004)
Mechanisms of Ageing and Development
, vol.125
, pp. 11-20
-
-
Brunet-Rossinni, A.K.1
-
28
-
-
0030881836
-
Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin
-
Brunn, G. J., Hudson, C. C., Sekulic, A., Williams, J. M., Hosoi, H., Houghton, P. J., Lawrence, J. C. Jr. & Abraham, R. T. (1997). Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science 277, 99–101.
-
(1997)
Science
, vol.277
, pp. 99-101
-
-
Brunn, G.J.1
Hudson, C.C.2
Sekulic, A.3
Williams, J.M.4
Hosoi, H.5
Houghton, P.J.6
Lawrence, J.C.7
Abraham, R.T.8
-
29
-
-
1842665662
-
Mitochondrial signaling: The retrograde response
-
Butow, R. A. & Avadhani, N. G. (2004). Mitochondrial signaling: the retrograde response. Molecular Cell 14, 1–15.
-
(2004)
Molecular Cell
, vol.14
, pp. 1-15
-
-
Butow, R.A.1
Avadhani, N.G.2
-
30
-
-
84860390185
-
Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage
-
Cabreiro, F., Ackerman, D., Doonan, R., Araiz, C., Back, P., Papp, D., Braeckman, B. P. & Gems, D. (2011). Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage. Free Radical Biology and Medicine 51, 1575–1582.
-
(2011)
Free Radical Biology and Medicine
, vol.51
, pp. 1575-1582
-
-
Cabreiro, F.1
Ackerman, D.2
Doonan, R.3
Araiz, C.4
Back, P.5
Papp, D.6
Braeckman, B.P.7
Gems, D.8
-
31
-
-
0033796250
-
Mitochondrial free radical generation, oxidative stress, and aging
-
Cadenas, E. & Davies, K. J. (2000). Mitochondrial free radical generation, oxidative stress, and aging. Free Radical Biology and Medicine 29, 222–230.
-
(2000)
Free Radical Biology and Medicine
, vol.29
, pp. 222-230
-
-
Cadenas, E.1
Davies, K.J.2
-
32
-
-
13944270339
-
Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
-
Campisi, J. (2005). Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120, 513–522.
-
(2005)
Cell
, vol.120
, pp. 513-522
-
-
Campisi, J.1
-
34
-
-
0036160679
-
Mammalian target of rapamycin (mTOR): Pro-and anti-apoptotic
-
Castedo, M., Ferri, K. F. & Kroemer, G. (2002). Mammalian target of rapamycin (mTOR): pro-and anti-apoptotic. Cell Death and Differentiation 9, 99–100.
-
(2002)
Cell Death and Differentiation
, vol.9
, pp. 99-100
-
-
Castedo, M.1
Ferri, K.F.2
Kroemer, G.3
-
35
-
-
33745274726
-
Mitochondria: Dynamic organelles in disease, aging, and development
-
Chan, D. C. (2006). Mitochondria: dynamic organelles in disease, aging, and development. Cell 125, 1241–1252.
-
(2006)
Cell
, vol.125
, pp. 1241-1252
-
-
Chan, D.C.1
-
36
-
-
0037732600
-
LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway
-
Chen, E. J. & Kaiser, C. A. (2003). LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway. Journal of Cell Biology 161, 333–347.
-
(2003)
Journal of Cell Biology
, vol.161
, pp. 333-347
-
-
Chen, E.J.1
Kaiser, C.A.2
-
37
-
-
53349091768
-
TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
-
Chen, C., Liu, Y., Liu, R., Ikenoue, T., Guan, K. L. & Zheng, P. (2008). TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. Journal of Experimental Medicine 205, 2397–2408.
-
(2008)
Journal of Experimental Medicine
, vol.205
, pp. 2397-2408
-
-
Chen, C.1
Liu, Y.2
Liu, R.3
Ikenoue, T.4
Guan, K.L.5
Zheng, P.6
-
38
-
-
84875366769
-
Inhibition of S6K1 enhances glucose deprivation-induced cell death via downregulation of anti-apoptotic proteins in MCF-7 breast cancer cells
-
Choi, H. N., Jin, H. O., Kim, J. H., Hong, S. E., Kim, H. A., Kim, E. K., Lee, J. K., Park, I. C. & Noh, W. C. (2013). Inhibition of S6K1 enhances glucose deprivation-induced cell death via downregulation of anti-apoptotic proteins in MCF-7 breast cancer cells. Biochemical and Biophysical Research Communications 432, 123–128.
-
(2013)
Biochemical and Biophysical Research Communications
, vol.432
, pp. 123-128
-
-
Choi, H.N.1
Jin, H.O.2
Kim, J.H.3
Hong, S.E.4
Kim, H.A.5
Kim, E.K.6
Lee, J.K.7
Park, I.C.8
Noh, W.C.9
-
39
-
-
53149105145
-
Rapamycin-induced cytotoxic signal transduction pathway
-
Choi, S. J., You, H. S. & Chung, S. Y. (2008). Rapamycin-induced cytotoxic signal transduction pathway. Transplantation Proceedings 40, 2737–2739.
-
(2008)
Transplantation Proceedings
, vol.40
, pp. 2737-2739
-
-
Choi, S.J.1
You, H.S.2
Chung, S.Y.3
-
40
-
-
76049083966
-
Reactive oxygen species, cellular redox systems, and apoptosis
-
Circu, M. L. & Aw, T. Y. (2010). Reactive oxygen species, cellular redox systems, and apoptosis. Free Radical Biology and Medicine 48, 749–762.
-
(2010)
Free Radical Biology and Medicine
, vol.48
, pp. 749-762
-
-
Circu, M.L.1
Aw, T.Y.2
-
41
-
-
38349105900
-
Complex I is the major site of mitochondrial superoxide production by paraquat
-
Cocheme, H. M. & Murphy, M. P. (2008). Complex I is the major site of mitochondrial superoxide production by paraquat. Journal of Biological Chemistry 283, 1786–1798.
-
(2008)
Journal of Biological Chemistry
, vol.283
, pp. 1786-1798
-
-
Cocheme, H.M.1
Murphy, M.P.2
-
42
-
-
0035461381
-
Overexpression of Cu2+/Zn2+ superoxide dismutase protects against early diabetic glomerular injury in transgenic mice
-
Craven, P. A., Melhem, M. F., Phillips, S. L. & DeRubertis, F. R. (2001). Overexpression of Cu2+/Zn2+ superoxide dismutase protects against early diabetic glomerular injury in transgenic mice. Diabetes 50, 2114–2125.
-
(2001)
Diabetes
, vol.50
, pp. 2114-2125
-
-
Craven, P.A.1
Melhem, M.F.2
Phillips, S.L.3
Derubertis, F.R.4
-
43
-
-
36749081539
-
mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex
-
Cunningham, J. T., Rodgers, J. T., Arlow, D. H., Vazquez, F., Mootha, V. K. & Puigserver, P. (2007). mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature 450, 736–740.
-
(2007)
Nature
, vol.450
, pp. 736-740
-
-
Cunningham, J.T.1
Rodgers, J.T.2
Arlow, D.H.3
Vazquez, F.4
Mootha, V.K.5
Puigserver, P.6
-
44
-
-
34247569105
-
Lifespan regulation by evolutionarily conserved genes essential for viability
-
Curran, S. P. & Ruvkun, G. (2007). Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genetics 3, e56.
-
(2007)
Plos Genetics
, vol.3
, pp. e56
-
-
Curran, S.P.1
Ruvkun, G.2
-
45
-
-
34648813720
-
ROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis
-
D’Autreaux, B. & Toledano, M. B. (2007). ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Nature Reviews Molecular Cell Biology 8, 813–824.
-
(2007)
Nature Reviews Molecular Cell Biology
, vol.8
, pp. 813-824
-
-
D’Autreaux, B.1
Toledano, M.B.2
-
46
-
-
0027426169
-
Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase
-
Deng, H. X., Hentati, A., Tainer, J. A., Iqbal, Z., Cayabyab, A., Hung, W. Y., Getzoff, E. D., Hu, P., Herzfeldt, B., Roos, R. P., Warner, C., Deng, G., Soriano, E., Smyth, C., Parge, H. E., Ahmed, A., Roses, A. D., Hallewell, R. A., Pericak-Vance, M. A. & Siddique, T. (1993). Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase. Science 261, 1047–1051.
-
(1993)
Science
, vol.261
, pp. 1047-1051
-
-
Deng, H.X.1
Hentati, A.2
Tainer, J.A.3
Iqbal, Z.4
Cayabyab, A.5
Hung, W.Y.6
Getzoff, E.D.7
Hu, P.8
Herzfeldt, B.9
Roos, R.P.10
Warner, C.11
Deng, G.12
Soriano, E.13
Smyth, C.14
Parge, H.E.15
Ahmed, A.16
Roses, A.D.17
Hallewell, R.A.18
Pericak-Vance, M.A.19
Siddique, T.20
more..
-
47
-
-
0037007014
-
FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction
-
Desai, B. N., Myers, B. R. & Schreiber, S. L. (2002). FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction. Proceedings of the National Academy of Sciences of the United States of America 99, 4319–4324.
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, pp. 4319-4324
-
-
Desai, B.N.1
Myers, B.R.2
Schreiber, S.L.3
-
48
-
-
0037022532
-
Mks1 in concert with TOR signaling negatively regulates RTG target gene expression in S. cerevisiae
-
Dilova, I., Chen, C. Y. & Powers, T. (2002). Mks1 in concert with TOR signaling negatively regulates RTG target gene expression in S. cerevisiae. Current Biology 12, 389–395.
-
(2002)
Current Biology
, vol.12
, pp. 389-395
-
-
Dilova, I.1
Chen, C.Y.2
Powers, T.3
-
49
-
-
78650944949
-
The cell-non-autonomous nature of electron transport chain-mediated longevity
-
Durieux, J., Wolff, S. & Dillin, A. (2011). The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell 144, 79–91.
-
(2011)
Cell
, vol.144
, pp. 79-91
-
-
Durieux, J.1
Wolff, S.2
Dillin, A.3
-
50
-
-
34250308322
-
Apoptosis: A review of programmed cell death
-
Elmore, S. (2007). Apoptosis: a review of programmed cell death. Toxicologic Pathology 35, 495–516.
-
(2007)
Toxicologic Pathology
, vol.35
, pp. 495-516
-
-
Elmore, S.1
-
51
-
-
0035853552
-
Regulation of longevity and stress resistance by Sch9 in yeast
-
Fabrizio, P., Pozza, F., Pletcher, S. D., Gendron, C. M. & Longo, V. D. (2001). Regulation of longevity and stress resistance by Sch9 in yeast. Science 292, 288–290.
-
(2001)
Science
, vol.292
, pp. 288-290
-
-
Fabrizio, P.1
Pozza, F.2
Pletcher, S.D.3
Gendron, C.M.4
Longo, V.D.5
-
52
-
-
79960286223
-
Signal transduction by reactive oxygen species
-
Finkel, T. (2011). Signal transduction by reactive oxygen species. Journal of Cell Biology 194, 7–15.
-
(2011)
Journal of Cell Biology
, vol.194
, pp. 7-15
-
-
Finkel, T.1
-
53
-
-
84867740975
-
Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner
-
Frank, M., Duvezin-Caubet, S., Koob, S., Occhipinti, A., Jagasia, R., Petcherski, A., Ruonala, M. O., Priault, M., Salin, B. & Reichert, A. S. (2012). Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner. Biochimica et Biophysica Acta 1823, 2297–2310.
-
(2012)
Biochimica Et Biophysica Acta
, vol.1823
, pp. 2297-2310
-
-
Frank, M.1
Duvezin-Caubet, S.2
Koob, S.3
Occhipinti, A.4
Jagasia, R.5
Petcherski, A.6
Ruonala, M.O.7
Priault, M.8
Salin, B.9
Reichert, A.S.10
-
54
-
-
0023678537
-
Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene
-
Friedman, D. B. & Johnson, T. E. (1988). Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene. Journal of Gerontology 43, B102–B109.
-
(1988)
Journal of Gerontology
, vol.43
, pp. B102-B109
-
-
Friedman, D.B.1
Johnson, T.E.2
-
55
-
-
84875585306
-
Mammalian target of rapamycin inhibitors induce tumor cell apoptosis in vivo primarily by inhibiting VEGF expression and angiogenesis
-
Frost, P., Berlanger, E., Mysore, V., Hoang, B., Shi, Y., Gera, J. & Lichtenstein, A. (2013). Mammalian target of rapamycin inhibitors induce tumor cell apoptosis in vivo primarily by inhibiting VEGF expression and angiogenesis. Journal of Oncology 2013, 897025.
-
(2013)
Journal of Oncology
, vol.2013
-
-
Frost, P.1
Berlanger, E.2
Mysore, V.3
Hoang, B.4
Shi, Y.5
Gera, J.6
Lichtenstein, A.7
-
56
-
-
10244229652
-
In vivo antitumor effects of the mTOR inhibitor CCI-779 against human multiple myeloma cells in a xenograft model
-
Frost, P., Moatamed, F., Hoang, B., Shi, Y., Gera, J., Yan, H., Gibbons, J. & Lichtenstein, A. (2004). In vivo antitumor effects of the mTOR inhibitor CCI-779 against human multiple myeloma cells in a xenograft model. Blood 104, 4181–4187.
-
(2004)
Blood
, vol.104
, pp. 4181-4187
-
-
Frost, P.1
Moatamed, F.2
Hoang, B.3
Shi, Y.4
Gera, J.5
Yan, H.6
Gibbons, J.7
Lichtenstein, A.8
-
57
-
-
66349109103
-
Superoxide dismutase 3, extracellular (SOD3) variants and lung function
-
Ganguly, K., Depner, M., Fattman, C., Bein, K., Oury, T. D., Wesselkamper, S. C., Borchers, M. T., Schreiber, M., Gao, F., von Mutius, E., Kabesch, M., Leikauf, G. D. & Schulz, H. (2009). Superoxide dismutase 3, extracellular (SOD3) variants and lung function. Physiological Genomics 37, 260–267.
-
(2009)
Physiological Genomics
, vol.37
, pp. 260-267
-
-
Ganguly, K.1
Depner, M.2
Fattman, C.3
Bein, K.4
Oury, T.D.5
Wesselkamper, S.C.6
Borchers, M.T.7
Schreiber, M.8
Gao, F.9
von Mutius, E.10
Kabesch, M.11
Leikauf, G.D.12
Schulz, H.13
-
58
-
-
66449083078
-
ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy
-
Ganley, I. G., Lam du, H., Wang, J., Ding, X., Chen, S. & Jiang, X. (2009). ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. Journal of Biological Chemistry 284, 12297–12305.
-
(2009)
Journal of Biological Chemistry
, vol.284
, pp. 12297-12305
-
-
Ganley, I.G.1
Lam du, H.2
Wang, J.3
Ding, X.4
Chen, S.5
Jiang, X.6
-
59
-
-
84856951239
-
Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition
-
Gilkerson, R. W., De Vries, R. L., Lebot, P., Wikstrom, J. D., Torgyekes, E., Shirihai, O. S., Przedborski, S. & Schon, E. A. (2012). Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition. Human Molecular Genetics 21, 978–990.
-
(2012)
Human Molecular Genetics
, vol.21
, pp. 978-990
-
-
Gilkerson, R.W.1
de Vries, R.L.2
Lebot, P.3
Wikstrom, J.D.4
Torgyekes, E.5
Shirihai, O.S.6
Przedborski, S.7
Schon, E.A.8
-
60
-
-
67651148536
-
S6K1 deficiency protects against apoptosis in hepatocytes
-
Gonzalez-Rodriguez, A., Alba, J., Zimmerman, V., Kozma, S. C. & Valverde, A. M. (2009). S6K1 deficiency protects against apoptosis in hepatocytes. Hepatology 50, 216–229.
-
(2009)
Hepatology
, vol.50
, pp. 216-229
-
-
Gonzalez-Rodriguez, A.1
Alba, J.2
Zimmerman, V.3
Kozma, S.C.4
Valverde, A.M.5
-
61
-
-
0027073347
-
The endosymbiont hypothesis revisited
-
Gray, M. W. (1992). The endosymbiont hypothesis revisited. International Review of Cytology 141, 233–357.
-
(1992)
International Review of Cytology
, vol.141
, pp. 233-357
-
-
Gray, M.W.1
-
62
-
-
0035403165
-
Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart
-
Gredilla, R., Sanz, A., Lopez-Torres, M. & Barja, G. (2001). Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart. FASEB Journal 15, 1589–1591.
-
(2001)
FASEB Journal
, vol.15
, pp. 1589-1591
-
-
Gredilla, R.1
Sanz, A.2
Lopez-Torres, M.3
Barja, G.4
-
63
-
-
0344872685
-
Apoptotic cascade initiated by angiotensin II in neonatal cardiomyocytes: Role of DNA damage
-
Grishko, V., Pastukh, V., Solodushko, V., Gillespie, M., Azuma, J. & Schaffer, S. (2003). Apoptotic cascade initiated by angiotensin II in neonatal cardiomyocytes: role of DNA damage. American Journal of Physiology-Heart and Circulatory Physiology 285, H2364–H2372.
-
(2003)
American Journal of Physiology-Heart and Circulatory Physiology
, vol.285
, pp. H2364-H2372
-
-
Grishko, V.1
Pastukh, V.2
Solodushko, V.3
Gillespie, M.4
Azuma, J.5
Schaffer, S.6
-
64
-
-
38649132337
-
Mitochondria--a nexus for aging, calorie restriction, and sirtuins?
-
Guarente, L. (2008). Mitochondria--a nexus for aging, calorie restriction, and sirtuins? Cell 132, 171–176.
-
(2008)
Cell
, vol.132
, pp. 171-176
-
-
Guarente, L.1
-
65
-
-
22344443522
-
A systematic RNAi screen for longevity genes in C. elegans
-
Hamilton, B., Dong, Y., Shindo, M., Liu, W., Odell, I., Ruvkun, G. & Lee, S. S. (2005). A systematic RNAi screen for longevity genes in C. elegans. Genes and Development 19, 1544–1555.
-
(2005)
Genes and Development
, vol.19
, pp. 1544-1555
-
-
Hamilton, B.1
Dong, Y.2
Shindo, M.3
Liu, W.4
Odell, I.5
Ruvkun, G.6
Lee, S.S.7
-
66
-
-
33645472504
-
New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen
-
Hansen, M., Hsu, A. L., Dillin, A. & Kenyon, C. (2005). New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genetics 1, 119–128.
-
(2005)
Plos Genetics
, vol.1
, pp. 119-128
-
-
Hansen, M.1
Hsu, A.L.2
Dillin, A.3
Kenyon, C.4
-
67
-
-
33846423520
-
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
-
Hansen, M., Taubert, S., Crawford, D., Libina, N., Lee, S. J. & Kenyon, C. (2007). Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 6, 95–110.
-
(2007)
Aging Cell
, vol.6
, pp. 95-110
-
-
Hansen, M.1
Taubert, S.2
Crawford, D.3
Libina, N.4
Lee, S.J.5
Kenyon, C.6
-
68
-
-
77049308856
-
Aging: A theory based on free radical and radiation chemistry
-
Harman, D. (1956). Aging: a theory based on free radical and radiation chemistry. Journal of Gerontology 11, 298–300.
-
(1956)
Journal of Gerontology
, vol.11
, pp. 298-300
-
-
Harman, D.1
-
69
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., Pahor, M., Javors, M. A., Fernandez, E. & Miller, R. A. (2009). Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460, 392–395.
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
Strong, R.2
Sharp, Z.D.3
Nelson, J.F.4
Astle, C.M.5
Flurkey, K.6
Nadon, N.L.7
Wilkinson, J.E.8
Frenkel, K.9
Carter, C.S.10
Pahor, M.11
Javors, M.A.12
Fernandez, E.13
Miller, R.A.14
-
70
-
-
34848861368
-
ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans
-
Haynes, C. M., Petrova, K., Benedetti, C., Yang, Y. & Ron, D. (2007). ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans. Developmental Cell 13, 467–480.
-
(2007)
Developmental Cell
, vol.13
, pp. 467-480
-
-
Haynes, C.M.1
Petrova, K.2
Benedetti, C.3
Yang, Y.4
Ron, D.5
-
71
-
-
78649728763
-
The mitochondrial UPR – protecting organelle protein homeostasis
-
Haynes, C. M. & Ron, D. (2010). The mitochondrial UPR – protecting organelle protein homeostasis. Journal of Cell Science 123, 3849–3855.
-
(2010)
Journal of Cell Science
, vol.123
, pp. 3849-3855
-
-
Haynes, C.M.1
Ron, D.2
-
72
-
-
84859739780
-
The physiological role of mitophagy: New insights into phosphorylation events
-
Hirota, Y., Kang, D. & Kanki, T. (2012). The physiological role of mitophagy: new insights into phosphorylation events. International Journal of Cell Biology 2012, 354914.
-
(2012)
International Journal of Cell Biology
, vol.2012
-
-
Hirota, Y.1
Kang, D.2
Kanki, T.3
-
73
-
-
59649120539
-
Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans
-
Honjoh, S., Yamamoto, T., Uno, M. & Nishida, E. (2009). Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans. Nature 457, 726–730.
-
(2009)
Nature
, vol.457
, pp. 726-730
-
-
Honjoh, S.1
Yamamoto, T.2
Uno, M.3
Nishida, E.4
-
74
-
-
65249119430
-
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy
-
Hosokawa, N., Hara, T., Kaizuka, T., Kishi, C., Takamura, A., Miura, Y., Iemura, S., Natsume, T., Takehana, K., Yamada, N., Guan, J. L., Oshiro, N. & Mizushima, N. (2009). Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Molecular Biology of the Cell 20, 1981–1991.
-
(2009)
Molecular Biology of the Cell
, vol.20
, pp. 1981-1991
-
-
Hosokawa, N.1
Hara, T.2
Kaizuka, T.3
Kishi, C.4
Takamura, A.5
Miura, Y.6
Iemura, S.7
Natsume, T.8
Takehana, K.9
Yamada, N.10
Guan, J.L.11
Oshiro, N.12
Mizushima, N.13
-
75
-
-
84878138385
-
Mitonuclear protein imbalance as a conserved longevity mechanism
-
Houtkooper, R. H., Mouchiroud, L., Ryu, D., Moullan, N., Katsyuba, E., Knott, G., Williams, R. W. & Auwerx, J. (2013). Mitonuclear protein imbalance as a conserved longevity mechanism. Nature 497, 451–457.
-
(2013)
Nature
, vol.497
, pp. 451-457
-
-
Houtkooper, R.H.1
Mouchiroud, L.2
Ryu, D.3
Moullan, N.4
Katsyuba, E.5
Knott, G.6
Williams, R.W.7
Auwerx, J.8
-
76
-
-
85138227874
-
-
Annals of the New York Academy of
-
Huang, T. T., Carlson, E. J., Raineri, I., Gillespie, A. M., Kozy, H. & Epstein, C. J. (1999). The use of transgenic and mutant mice to study oxygen free radical metabolism. Annals of the New York Academy of Sciences 893, 95–112.
-
(1999)
). the Use of Transgenic and Mutant Mice to Study Oxygen Free Radical Metabolism
, vol.Sciences 893
, pp. 95-112
-
-
-
77
-
-
0035870281
-
p53/p21(CIP1) cooperate in enforcing rapamycin-induced G(1) arrest and determine the cellular response to rapamycin
-
Huang, S., Liu, L. N., Hosoi, H., Dilling, M. B., Shikata, T. & Houghton, P. J. (2001). p53/p21(CIP1) cooperate in enforcing rapamycin-induced G(1) arrest and determine the cellular response to rapamycin. Cancer Research 61, 3373–3381.
-
(2001)
Cancer Research
, vol.61
, pp. 3373-3381
-
-
Huang, S.1
Liu, L.N.2
Hosoi, H.3
Dilling, M.B.4
Shikata, T.5
Houghton, P.J.6
-
78
-
-
4344610451
-
Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity
-
Huang, S., Shu, L., Easton, J., Harwood, F. C., Germain, G. S., Ichijo, H. & Houghton, P. J. (2004). Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity. Journal of Biological Chemistry 279, 36490–36496.
-
(2004)
Journal of Biological Chemistry
, vol.279
, pp. 36490-36496
-
-
Huang, S.1
Shu, L.2
Easton, J.3
Harwood, F.C.4
Germain, G.S.5
Ichijo, H.6
Houghton, P.J.7
-
80
-
-
4544311861
-
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
-
Jia, K., Chen, D. & Riddle, D. L. (2004). The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 131, 3897–3906.
-
(2004)
Development
, vol.131
, pp. 3897-3906
-
-
Jia, K.1
Chen, D.2
Riddle, D.L.3
-
81
-
-
84861204926
-
PINK1-and Parkin-mediated mitophagy at a glance
-
Jin, S. M. & Youle, R. J. (2012). PINK1-and Parkin-mediated mitophagy at a glance. Journal of Cell Science 125, 795–799.
-
(2012)
Journal of Cell Science
, vol.125
, pp. 795-799
-
-
Jin, S.M.1
Youle, R.J.2
-
82
-
-
84872527628
-
mTOR is a key modulator of ageing and age-related disease
-
Johnson, S. C., Rabinovitch, P. S. & Kaeberlein, M. (2013). mTOR is a key modulator of ageing and age-related disease. Nature 493, 338–345.
-
(2013)
Nature
, vol.493
, pp. 338-345
-
-
Johnson, S.C.1
Rabinovitch, P.S.2
Kaeberlein, M.3
-
83
-
-
65249176304
-
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery
-
Jung, C. H., Jun, C. B., Ro, S. H., Kim, Y. M., Otto, N. M., Cao, J., Kundu, M. & Kim, D. H. (2009). ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Molecular Biology of the Cell 20, 1992–2003.
-
(2009)
Molecular Biology of the Cell
, vol.20
, pp. 1992-2003
-
-
Jung, C.H.1
Jun, C.B.2
Ro, S.H.3
Kim, Y.M.4
Otto, N.M.5
Cao, J.6
Kundu, M.7
Kim, D.H.8
-
84
-
-
27744511769
-
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients
-
Kaeberlein, M., Powers, R. W. 3rd, Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S. & Kennedy, B. K. (2005). Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310, 1193–1196.
-
(2005)
Science
, vol.310
, pp. 1193-1196
-
-
Kaeberlein, M.1
Powers, R.W.2
Steffen, K.K.3
Westman, E.A.4
Hu, D.5
Dang, N.6
Kerr, E.O.7
Kirkland, K.T.8
Fields, S.9
Kennedy, B.K.10
-
85
-
-
75749090429
-
Tor directly controls the Atg1 kinase complex to regulate autophagy
-
Kamada, Y., Yoshino, K., Kondo, C., Kawamata, T., Oshiro, N., Yonezawa, K. & Ohsumi, Y. (2010). Tor directly controls the Atg1 kinase complex to regulate autophagy. Molecular and Cellular Biology 30, 1049–1058.
-
(2010)
Molecular and Cellular Biology
, vol.30
, pp. 1049-1058
-
-
Kamada, Y.1
Yoshino, K.2
Kondo, C.3
Kawamata, T.4
Oshiro, N.5
Yonezawa, K.6
Ohsumi, Y.7
-
86
-
-
22044443172
-
). Mitochondrial transcription factor A in the maintenance of mitochondrial DNA: Overview of its multiple roles
-
Kang, D. & Hamasaki, N. (2005). Mitochondrial transcription factor A in the maintenance of mitochondrial DNA: overview of its multiple roles. Annals of the New York Academy of Sciences 1042, 101–108.
-
(2005)
. Annals of the New York Academy of Sciences
, vol.1042
, pp. 101-108
-
-
-
87
-
-
57749121573
-
Mitophagy in yeast occurs through a selective mechanism
-
Kanki, T. & Klionsky, D. J. (2008). Mitophagy in yeast occurs through a selective mechanism. Journal of Biological Chemistry 283, 32386–32393.
-
(2008)
Journal of Biological Chemistry
, vol.283
, pp. 32386-32393
-
-
Kanki, T.1
Klionsky, D.J.2
-
88
-
-
73449095225
-
Atg32 is a tag for mitochondria degradation in yeast
-
Kanki, T. & Klionsky, D. J. (2009). Atg32 is a tag for mitochondria degradation in yeast. Autophagy 5, 1201–1202.
-
(2009)
Autophagy
, vol.5
, pp. 1201-1202
-
-
Kanki, T.1
Klionsky, D.J.2
-
89
-
-
73949122199
-
A genomic screen for yeast mutants defective in selective mitochondria autophagy
-
Kanki, T., Wang, K., Baba, M., Bartholomew, C. R., Lynch-Day, M. A., Du, Z., Geng, J., Mao, K., Yang, Z., Yen, W. L. & Klionsky, D. J. (2009). A genomic screen for yeast mutants defective in selective mitochondria autophagy. Molecular Biology of the Cell 20, 4730–4738.
-
(2009)
Molecular Biology of the Cell
, vol.20
, pp. 4730-4738
-
-
Kanki, T.1
Wang, K.2
Baba, M.3
Bartholomew, C.R.4
Lynch-Day, M.A.5
Du, Z.6
Geng, J.7
Mao, K.8
Yang, Z.9
Yen, W.L.10
Klionsky, D.J.11
-
91
-
-
3042648746
-
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
-
Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V. & Benzer, S. (2004). Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Current Biology 14, 885–890.
-
(2004)
Current Biology
, vol.14
, pp. 885-890
-
-
Kapahi, P.1
Zid, B.M.2
Harper, T.3
Koslover, D.4
Sapin, V.5
Benzer, S.6
-
92
-
-
0037438948
-
No increase in lifespan in Caenorhabditis elegans upon treatment with the superoxide dismutase mimetic EUK-8
-
Keaney, M. & Gems, D. (2003). No increase in lifespan in Caenorhabditis elegans upon treatment with the superoxide dismutase mimetic EUK-8. Free Radical Biology and Medicine 34, 277–282.
-
(2003)
Free Radical Biology and Medicine
, vol.34
, pp. 277-282
-
-
Keaney, M.1
Gems, D.2
-
93
-
-
0027771804
-
A C. elegans mutant that lives twice as long as wild type
-
Kenyon, C., Chang, J., Gensch, E., Rudner, A. & Tabtiang, R. (1993). A C. elegans mutant that lives twice as long as wild type. Nature 366, 461–464.
-
(1993)
Nature
, vol.366
, pp. 461-464
-
-
Kenyon, C.1
Chang, J.2
Gensch, E.3
Rudner, A.4
Tabtiang, R.5
-
94
-
-
79954622220
-
Mitophagy selectively degrades individual damaged mitochondria after photoirradiation
-
Kim, I. & Lemasters, J. J. (2011). Mitophagy selectively degrades individual damaged mitochondria after photoirradiation. Antioxidants & Redox Signaling 14, 1919–1928.
-
(2011)
Antioxidants & Redox Signaling
, vol.14
, pp. 1919-1928
-
-
Kim, I.1
Lemasters, J.J.2
-
95
-
-
34249934085
-
Selective degradation of mitochondria by mitophagy
-
Kim, I., Rodriguez-Enriquez, S. & Lemasters, J. J. (2007). Selective degradation of mitochondria by mitophagy. Archives of Biochemistry and Biophysics 462, 245–253.
-
(2007)
Archives of Biochemistry and Biophysics
, vol.462
, pp. 245-253
-
-
Kim, I.1
Rodriguez-Enriquez, S.2
Lemasters, J.J.3
-
96
-
-
84863188554
-
Rapamycin increases oxidative stress response gene expression in adult stem cells
-
Kofman, A. E., McGraw, M. R. & Payne, C. J. (2012). Rapamycin increases oxidative stress response gene expression in adult stem cells. Aging (Albany) 4, 279–289.
-
(2012)
Aging (Albany)
, vol.4
, pp. 279-289
-
-
Kofman, A.E.1
McGraw, M.R.2
Payne, C.J.3
-
97
-
-
0034645038
-
Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors
-
Komeili, A., Wedaman, K. P., O’Shea, E. K. & Powers, T. (2000). Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors. Journal of Cell Biology 151, 863–878.
-
(2000)
Journal of Cell Biology
, vol.151
, pp. 863-878
-
-
Komeili, A.1
Wedaman, K.P.2
O’Shea, E.K.3
Powers, T.4
-
98
-
-
0027365312
-
Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species
-
Ku, H. H., Brunk, U. T. & Sohal, R. S. (1993). Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species. Free Radical Biology and Medicine 15, 621–627.
-
(1993)
Free Radical Biology and Medicine
, vol.15
, pp. 621-627
-
-
Ku, H.H.1
Brunk, U.T.2
Sohal, R.S.3
-
99
-
-
0036903625
-
Complex I-mediated reactive oxygen species generation: Modulation by cytochrome c and NAD(P) + oxidation-reduction state
-
Kushnareva, Y., Murphy, A. N. & Andreyev, A. (2002). Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P) + oxidation-reduction state. Biochemical Journal 368, 545–553.
-
(2002)
Biochemical Journal
, vol.368
, pp. 545-553
-
-
Kushnareva, Y.1
Murphy, A.N.2
Andreyev, A.3
-
101
-
-
34548617735
-
Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms
-
Lambert, A. J., Boysen, H. M., Buckingham, J. A., Yang, T., Podlutsky, A., Austad, S. N., Kunz, T. H., Buffenstein, R. & Brand, M. D. (2007). Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms. Aging Cell 6, 607–618.
-
(2007)
Aging Cell
, vol.6
, pp. 607-618
-
-
Lambert, A.J.1
Boysen, H.M.2
Buckingham, J.A.3
Yang, T.4
Podlutsky, A.5
Austad, S.N.6
Kunz, T.H.7
Buffenstein, R.8
Brand, M.D.9
-
102
-
-
47049116691
-
Increased respiration in the sch9Delta mutant is required for increasing chronological life span but not replicative life span
-
Lavoie, H. & Whiteway, M. (2008). Increased respiration in the sch9Delta mutant is required for increasing chronological life span but not replicative life span. Eukaryotic Cell 7, 1127–1135.
-
(2008)
Eukaryotic Cell
, vol.7
, pp. 1127-1135
-
-
Lavoie, H.1
Whiteway, M.2
-
103
-
-
77749264562
-
Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies
-
Lee, J. H., Budanov, A. V., Park, E. J., Birse, R., Kim, T. E., Perkins, G. A., Ocorr, K., Ellisman, M. H., Bodmer, R., Bier, E. & Karin, M. (2010a). Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science 327, 1223–1228.
-
(2010)
Science
, vol.327
, pp. 1223-1228
-
-
Lee, J.H.1
Budanov, A.V.2
Park, E.J.3
Birse, R.4
Kim, T.E.5
Perkins, G.A.6
Ocorr, K.7
Ellisman, M.H.8
Bodmer, R.9
Bier, E.10
Karin, M.11
-
104
-
-
78650177082
-
Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity
-
Lee, S. J., Hwang, A. B. & Kenyon, C. (2010b). Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity. Current Biology 20, 2131–2136.
-
(2010)
Current Biology
, vol.20
, pp. 2131-2136
-
-
Lee, S.J.1
Hwang, A.B.2
Kenyon, C.3
-
105
-
-
0037228016
-
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
-
Lee, S. S., Lee, R. Y., Fraser, A. G., Kamath, R. S., Ahringer, J. & Ruvkun, G. (2003). A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nature Genetics 33, 40–48.
-
(2003)
Nature Genetics
, vol.33
, pp. 40-48
-
-
Lee, S.S.1
Lee, R.Y.2
Fraser, A.G.3
Kamath, R.S.4
Ahringer, J.5
Ruvkun, G.6
-
106
-
-
24144463983
-
Metabolic control through the PGC-1 family of transcription coactivators
-
Lin, J., Handschin, C. & Spiegelman, B. M. (2005). Metabolic control through the PGC-1 family of transcription coactivators. Cell Metabolism 1, 361–370.
-
(2005)
Cell Metabolism
, vol.1
, pp. 361-370
-
-
Lin, J.1
Handschin, C.2
Spiegelman, B.M.3
-
107
-
-
0037130175
-
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
-
Lin, S. J., Kaeberlein, M., Andalis, A. A., Sturtz, L. A., Defossez, P. A., Culotta, V. C., Fink, G. R. & Guarente, L. (2002). Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 418, 344–348.
-
(2002)
Nature
, vol.418
, pp. 344-348
-
-
Lin, S.J.1
Kaeberlein, M.2
Andalis, A.A.3
Sturtz, L.A.4
Defossez, P.A.5
Culotta, V.C.6
Fink, G.R.7
Guarente, L.8
-
108
-
-
0032873464
-
A transcriptional switch in the expression of yeast tricarboxylic acid cycle genes in response to a reduction or loss of respiratory function
-
Liu, Z. & Butow, R. A. (1999). A transcriptional switch in the expression of yeast tricarboxylic acid cycle genes in response to a reduction or loss of respiratory function. Molecular and Cellular Biology 19, 6720–6728.
-
(1999)
Molecular and Cellular Biology
, vol.19
, pp. 6720-6728
-
-
Liu, Z.1
Butow, R.A.2
-
109
-
-
33845656956
-
Mitochondrial retrograde signaling
-
Liu, Z. & Butow, R. A. (2006). Mitochondrial retrograde signaling. Annual Review of Genetics 40, 159–185.
-
(2006)
Annual Review of Genetics
, vol.40
, pp. 159-185
-
-
Liu, Z.1
Butow, R.A.2
-
110
-
-
0037126596
-
RTG-dependent mitochondria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p
-
Liu, Z., Sekito, T., Epstein, C. B. & Butow, R. A. (2001). RTG-dependent mitochondria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p. EMBO Journal 20, 7209–7219.
-
(2001)
EMBO Journal
, vol.20
, pp. 7209-7219
-
-
Liu, Z.1
Sekito, T.2
Epstein, C.B.3
Butow, R.A.4
-
111
-
-
0141922982
-
Retrograde signaling is regulated by the dynamic interaction between Rtg2p and Mks1p
-
Liu, Z., Sekito, T., Spirek, M., Thornton, J. & Butow, R. A. (2003). Retrograde signaling is regulated by the dynamic interaction between Rtg2p and Mks1p. Molecular Cell 12, 401–411.
-
(2003)
Molecular Cell
, vol.12
, pp. 401-411
-
-
Liu, Z.1
Sekito, T.2
Spirek, M.3
Thornton, J.4
Butow, R.A.5
-
112
-
-
74949095399
-
Induction of hypertension and peripheral inflammation by reduction of extracellular superoxide dismutase in the central nervous system
-
Lob, H. E., Marvar, P. J., Guzik, T. J., Sharma, S., McCann, L. A., Weyand, C., Gordon, F. J. & Harrison, D. G. (2010). Induction of hypertension and peripheral inflammation by reduction of extracellular superoxide dismutase in the central nervous system. Hypertension 55, 277–283.
-
(2010)
Hypertension
, vol.55
, pp. 277-283
-
-
Lob, H.E.1
Marvar, P.J.2
Guzik, T.J.3
Sharma, S.4
McCann, L.A.5
Weyand, C.6
Gordon, F.J.7
Harrison, D.G.8
-
113
-
-
0036753494
-
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
-
Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J., Bonenfant, D., Oppliger, W., Jenoe, P. & Hall, M. N. (2002). Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Molecular Cell 10, 457–468.
-
(2002)
Molecular Cell
, vol.10
, pp. 457-468
-
-
Loewith, R.1
Jacinto, E.2
Wullschleger, S.3
Lorberg, A.4
Crespo, J.5
Bonenfant, D.6
Oppliger, W.7
Jenoe, P.8
Hall, M.N.9
-
114
-
-
0037015269
-
TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation
-
Long, X., Spycher, C., Han, Z. S., Rose, A. M., Muller, F. & Avruch, J. (2002). TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation. Current Biology 12, 1448–1461.
-
(2002)
Current Biology
, vol.12
, pp. 1448-1461
-
-
Long, X.1
Spycher, C.2
Han, Z.S.3
Rose, A.M.4
Muller, F.5
Avruch, J.6
-
115
-
-
0036569788
-
Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria
-
Lopez-Torres, M., Gredilla, R., Sanz, A. & Barja, G. (2002). Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria. Free Radical Biology and Medicine 32, 882–889.
-
(2002)
Free Radical Biology and Medicine
, vol.32
, pp. 882-889
-
-
Lopez-Torres, M.1
Gredilla, R.2
Sanz, A.3
Barja, G.4
-
116
-
-
0030886976
-
Compromised mitochondrial function leads to increased cytosolic calcium and to activation of MAP kinases
-
Luo, Y., Bond, J. D. & Ingram, V. M. (1997). Compromised mitochondrial function leads to increased cytosolic calcium and to activation of MAP kinases. Proceedings of the National Academy of Sciences of the United States of America 94, 9705–9710.
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, pp. 9705-9710
-
-
Luo, Y.1
Bond, J.D.2
Ingram, V.M.3
-
117
-
-
0035842896
-
VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release
-
Madesh, M. & Hajnoczky, G. (2001). VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release. Journal of Cell Biology 155, 1003–1015.
-
(2001)
Journal of Cell Biology
, vol.155
, pp. 1003-1015
-
-
Madesh, M.1
Hajnoczky, G.2
-
118
-
-
33344479169
-
The effects of exogenous antioxidants on lifespan and oxidative stress resistance in Drosophila melanogaster
-
Magwere, T., West, M., Riyahi, K., Murphy, M. P., Smith, R. A. & Partridge, L. (2006). The effects of exogenous antioxidants on lifespan and oxidative stress resistance in Drosophila melanogaster. Mechanisms of Ageing and Development 127, 356–370.
-
(2006)
Mechanisms of Ageing and Development
, vol.127
, pp. 356-370
-
-
Magwere, T.1
West, M.2
Riyahi, K.3
Murphy, M.P.4
Smith, R.A.5
Partridge, L.6
-
119
-
-
0029825891
-
Selective induction of mitochondrial chaperones in response to loss of the mitochondrial genome
-
Martinus, R. D., Garth, G. P., Webster, T. L., Cartwright, P., Naylor, D. J., Hoj, P. B. & Hoogenraad, N. J. (1996). Selective induction of mitochondrial chaperones in response to loss of the mitochondrial genome. European Journal of Biochemistry 240, 98–103.
-
(1996)
European Journal of Biochemistry
, vol.240
, pp. 98-103
-
-
Martinus, R.D.1
Garth, G.P.2
Webster, T.L.3
Cartwright, P.4
Naylor, D.J.5
Hoj, P.B.6
Hoogenraad, N.J.7
-
120
-
-
69449096141
-
Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer’s disease
-
Massaad, C. A., Washington, T. M., Pautler, R. G. & Klann, E. (2009). Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer’s disease. Proceedings of the National Academy of Sciences of the United States of America 106, 13576–13581.
-
(2009)
Proceedings of the National Academy of Sciences of the United States of America
, vol.106
, pp. 13576-13581
-
-
Massaad, C.A.1
Washington, T.M.2
Pautler, R.G.3
Klann, E.4
-
122
-
-
49349083531
-
Redox control of cell fate by MAP kinase: Physiological roles of ASK1-MAP kinase pathway in stress signaling
-
Matsuzawa, A. & Ichijo, H. (2008). Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling. Biochimica et Biophysica Acta 1780, 1325–1336.
-
(2008)
Biochimica Et Biophysica Acta
, vol.1780
, pp. 1325-1336
-
-
Matsuzawa, A.1
Ichijo, H.2
-
123
-
-
79251487046
-
TOR and ageing: A complex pathway for a complex process
-
McCormick, M. A., Tsai, S. Y. & Kennedy, B. K. (2011). TOR and ageing: a complex pathway for a complex process. Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences 366, 17–27.
-
(2011)
Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences
, vol.366
, pp. 17-27
-
-
McCormick, M.A.1
Tsai, S.Y.2
Kennedy, B.K.3
-
124
-
-
0034284973
-
Extension of life-span with superoxide dismutase/catalase mimetics
-
Melov, S., Ravenscroft, J., Malik, S., Gill, M. S., Walker, D. W., Clayton, P. E., Wallace, D. C., Malfroy, B., Doctrow, S. R. & Lithgow, G. J. (2000). Extension of life-span with superoxide dismutase/catalase mimetics. Science 289, 1567–1569.
-
(2000)
Science
, vol.289
, pp. 1567-1569
-
-
Melov, S.1
Ravenscroft, J.2
Malik, S.3
Gill, M.S.4
Walker, D.W.5
Clayton, P.E.6
Wallace, D.C.7
Malfroy, B.8
Doctrow, S.R.9
Lithgow, G.J.10
-
125
-
-
84876018717
-
Loss of mitochondrial membrane potential triggers the retrograde response extending yeast replicative lifespan
-
Miceli, M. V., Jiang, J. C., Tiwari, A., Rodriguez-Quinones, J. F. & Jazwinski, S. M. (2011). Loss of mitochondrial membrane potential triggers the retrograde response extending yeast replicative lifespan. Frontiers in Genetics 2, 102.
-
(2011)
Frontiers in Genetics
, vol.2
, pp. 102
-
-
Miceli, M.V.1
Jiang, J.C.2
Tiwari, A.3
Rodriguez-Quinones, J.F.4
Jazwinski, S.M.5
-
126
-
-
77955292162
-
mTORC1 directly phosphorylates and regulates human MAF1
-
Michels, A. A., Robitaille, A. M., Buczynski-Ruchonnet, D., Hodroj, W., Reina, J. H., Hall, M. N. & Hernandez, N. (2010). mTORC1 directly phosphorylates and regulates human MAF1. Molecular and Cellular Biology 30, 3749–3757.
-
(2010)
Molecular and Cellular Biology
, vol.30
, pp. 3749-3757
-
-
Michels, A.A.1
Robitaille, A.M.2
Buczynski-Ruchonnet, D.3
Hodroj, W.4
Reina, J.H.5
Hall, M.N.6
Hernandez, N.7
-
127
-
-
82255171356
-
SOD1 transcriptional and posttranscriptional regulation and its potential implications in ALS
-
Milani, P., Gagliardi, S., Cova, E. & Cereda, C. (2011). SOD1 transcriptional and posttranscriptional regulation and its potential implications in ALS. Neurology Research International 2011, 458427.
-
(2011)
Neurology Research International
, vol.2011
-
-
Milani, P.1
Gagliardi, S.2
Cova, E.3
Cereda, C.4
-
128
-
-
0019160038
-
Mitochondrial role in cell aging
-
Miquel, J., Economos, A. C., Fleming, J. & Johnson, J. E. Jr. (1980). Mitochondrial role in cell aging. Experimental Gerontology 15, 575–591.
-
(1980)
Experimental Gerontology
, vol.15
, pp. 575-591
-
-
Miquel, J.1
Economos, A.C.2
Fleming, J.3
Johnson, J.E.J.4
-
129
-
-
24344508510
-
The topology of superoxide production by complex III and glycerol 3-phosphate dehydrogenase in Drosophila mitochondria
-
Miwa, S. & Brand, M. D. (2005). The topology of superoxide production by complex III and glycerol 3-phosphate dehydrogenase in Drosophila mitochondria. Biochimica et Biophysica Acta 1709, 214–219.
-
(2005)
Biochimica Et Biophysica Acta
, vol.1709
, pp. 214-219
-
-
Miwa, S.1
Brand, M.D.2
-
130
-
-
58149314211
-
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
-
Narendra, D., Tanaka, A., Suen, D. F. & Youle, R. J. (2008). Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. Journal of Cell Biology 183, 795–803.
-
(2008)
Journal of Cell Biology
, vol.183
, pp. 795-803
-
-
Narendra, D.1
Tanaka, A.2
Suen, D.F.3
Youle, R.J.4
-
131
-
-
84864744900
-
Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation
-
Nargund, A. M., Pellegrino, M. W., Fiorese, C. J., Baker, B. M. & Haynes, C. M. (2012). Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation. Science 337, 587–590.
-
(2012)
Science
, vol.337
, pp. 587-590
-
-
Nargund, A.M.1
Pellegrino, M.W.2
Fiorese, C.J.3
Baker, B.M.4
Haynes, C.M.5
-
132
-
-
67650246357
-
Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy
-
Okamoto, K., Kondo-Okamoto, N. & Ohsumi, Y. (2009). Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy. Developmental Cell 17, 87–97.
-
(2009)
Developmental Cell
, vol.17
, pp. 87-97
-
-
Okamoto, K.1
Kondo-Okamoto, N.2
Ohsumi, Y.3
-
133
-
-
0038712734
-
Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity in Drosophila melanogaster
-
Orr, W. C., Mockett, R. J., Benes, J. J. & Sohal, R. S. (2003). Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity in Drosophila melanogaster. Journal of Biological Chemistry 278, 26418–26422.
-
(2003)
Journal of Biological Chemistry
, vol.278
, pp. 26418-26422
-
-
Orr, W.C.1
Mockett, R.J.2
Benes, J.J.3
Sohal, R.S.4
-
134
-
-
0028220114
-
Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster
-
Orr, W. C. & Sohal, R. S. (1994). Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science 263, 1128–1130.
-
(1994)
Science
, vol.263
, pp. 1128-1130
-
-
Orr, W.C.1
Sohal, R.S.2
-
135
-
-
0037358363
-
Does overexpression of Cu,Zn-SOD extend life span in Drosophila melanogaster?
-
Orr, W. C. & Sohal, R. S. (2003). Does overexpression of Cu,Zn-SOD extend life span in Drosophila melanogaster? Experimental Gerontology 38, 227–230.
-
(2003)
Experimental Gerontology
, vol.38
, pp. 227-230
-
-
Orr, W.C.1
Sohal, R.S.2
-
136
-
-
33846418352
-
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans
-
Pan, K. Z., Palter, J. E., Rogers, A. N., Olsen, A., Chen, D., Lithgow, G. J. & Kapahi, P. (2007). Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell 6, 111–119.
-
(2007)
Aging Cell
, vol.6
, pp. 111-119
-
-
Pan, K.Z.1
Palter, J.E.2
Rogers, A.N.3
Olsen, A.4
Chen, D.5
Lithgow, G.J.6
Kapahi, P.7
-
137
-
-
79958068191
-
Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling
-
Pan, Y., Schroeder, E. A., Ocampo, A., Barrientos, A. & Shadel, G. S. (2011). Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling. Cell Metabolism 13, 668–678.
-
(2011)
Cell Metabolism
, vol.13
, pp. 668-678
-
-
Pan, Y.1
Schroeder, E.A.2
Ocampo, A.3
Barrientos, A.4
Shadel, G.S.5
-
138
-
-
0031864164
-
Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons
-
Parkes, T. L., Elia, A. J., Dickinson, D., Hilliker, A. J., Phillips, J. P. & Boulianne, G. L. (1998). Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons. Nature Genetics 19, 171–174.
-
(1998)
Nature Genetics
, vol.19
, pp. 171-174
-
-
Parkes, T.L.1
Elia, A.J.2
Dickinson, D.3
Hilliker, A.J.4
Phillips, J.P.5
Boulianne, G.L.6
-
139
-
-
84871734834
-
Signaling the mitochondrial unfolded protein response
-
Pellegrino, M. W., Nargund, A. M. & Haynes, C. M. (2013). Signaling the mitochondrial unfolded protein response. Biochimica et Biophysica Acta 1833, 410–416.
-
(2013)
Biochimica Et Biophysica Acta
, vol.1833
, pp. 410-416
-
-
Pellegrino, M.W.1
Nargund, A.M.2
Haynes, C.M.3
-
140
-
-
54849431380
-
Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration
-
Polak, P., Cybulski, N., Feige, J. N., Auwerx, J., Ruegg, M. A. & Hall, M. N. (2008). Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. Cell Metabolism 8, 399–410.
-
(2008)
Cell Metabolism
, vol.8
, pp. 399-410
-
-
Polak, P.1
Cybulski, N.2
Feige, J.N.3
Auwerx, J.4
Ruegg, M.A.5
Hall, M.N.6
-
141
-
-
30944458446
-
Extension of chronological life span in yeast by decreased TOR pathway signaling
-
Powers, R. W. 3rd, Kaeberlein, M., Caldwell, S. D., Kennedy, B. K. & Fields, S. (2006). Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes and Development 20, 174–184.
-
(2006)
Genes and Development
, vol.20
, pp. 174-184
-
-
Powers, R.W.1
Kaeberlein, M.2
Caldwell, S.D.3
Kennedy, B.K.4
Fields, S.5
-
142
-
-
36049018936
-
A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice
-
Quick, K. L., Ali, S. S., Arch, R., Xiong, C., Wozniak, D. & Dugan, L. L. (2008). A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice. Neurobiology of Aging 29, 117–128.
-
(2008)
Neurobiology of Aging
, vol.29
, pp. 117-128
-
-
Quick, K.L.1
Ali, S.S.2
Arch, R.3
Xiong, C.4
Wozniak, D.5
Dugan, L.L.6
-
144
-
-
84878118233
-
Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan
-
Rana, A., Rera, M. & Walker, D. W. (2013). Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan. Proceedings of the National Academy of Sciences of the United States of America 110, 8638–8643.
-
(2013)
Proceedings of the National Academy of Sciences of the United States of America
, vol.110
, pp. 8638-8643
-
-
Rana, A.1
Rera, M.2
Walker, D.W.3
-
145
-
-
66649109663
-
Antioxidants prevent health-promoting effects of physical exercise in humans
-
Ristow, M., Zarse, K., Oberbach, A., Kloting, N., Birringer, M., Kiehntopf, M., Stumvoll, M., Kahn, C. R. & Bluher, M. (2009). Antioxidants prevent health-promoting effects of physical exercise in humans. Proceedings of the National Academy of Sciences of the United States of America 106, 8665–8670.
-
(2009)
Proceedings of the National Academy of Sciences of the United States of America
, vol.106
, pp. 8665-8670
-
-
Ristow, M.1
Zarse, K.2
Oberbach, A.3
Kloting, N.4
Birringer, M.5
Kiehntopf, M.6
Stumvoll, M.7
Kahn, C.R.8
Bluher, M.9
-
146
-
-
84860461929
-
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO
-
Robida-Stubbs, S., Glover-Cutter, K., Lamming, D. W., Mizunuma, M., Narasimhan, S. D., Neumann-Haefelin, E., Sabatini, D. M. & Blackwell, T. K. (2012). TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metabolism 15, 713–724.
-
(2012)
Cell Metabolism
, vol.15
, pp. 713-724
-
-
Robida-Stubbs, S.1
Glover-Cutter, K.2
Lamming, D.W.3
Mizunuma, M.4
Narasimhan, S.D.5
Neumann-Haefelin, E.6
Sabatini, D.M.7
Blackwell, T.K.8
-
147
-
-
84859891123
-
Rapamycin sensitive ROS formation and Na(+)/H(+) exchanger activity in dendritic cells
-
Rotte, A., Pasham, V., Bhandaru, M., Bobbala, D., Zelenak, C. & Lang, F. (2012). Rapamycin sensitive ROS formation and Na(+)/H(+) exchanger activity in dendritic cells. Cellular Physiology and Biochemistry 29, 543–550.
-
(2012)
Cellular Physiology and Biochemistry
, vol.29
, pp. 543-550
-
-
Rotte, A.1
Pasham, V.2
Bhandaru, M.3
Bobbala, D.4
Zelenak, C.5
Lang, F.6
-
148
-
-
84875968253
-
Surveillance-activated defenses block the ROS-induced mitochondrial unfolded protein response
-
Runkel, E. D., Liu, S., Baumeister, R. & Schulze, E. (2013). Surveillance-activated defenses block the ROS-induced mitochondrial unfolded protein response. PLoS Genetics 9, e1003346.
-
(2013)
Plos Genetics
, vol.9
-
-
Runkel, E.D.1
Liu, S.2
Baumeister, R.3
Schulze, E.4
-
150
-
-
0032080283
-
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
-
Saitoh, M., Nishitoh, H., Fujii, M., Takeda, K., Tobiume, K., Sawada, Y., Kawabata, M., Miyazono, K. & Ichijo, H. (1998). Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO Journal 17, 2596–2606.
-
(1998)
EMBO Journal
, vol.17
, pp. 2596-2606
-
-
Saitoh, M.1
Nishitoh, H.2
Fujii, M.3
Takeda, K.4
Tobiume, K.5
Sawada, Y.6
Kawabata, M.7
Miyazono, K.8
Ichijo, H.9
-
151
-
-
77449156533
-
The mitochondrial free radical theory of aging: A critical view
-
Sanz, A. & Stefanatos, R. K. (2008). The mitochondrial free radical theory of aging: a critical view. Current Aging Science 1, 10–21.
-
(2008)
Current Aging Science
, vol.1
, pp. 10-21
-
-
Sanz, A.1
Stefanatos, R.K.2
-
152
-
-
0033525924
-
Oxidative phosphorylation at the fin de siecle
-
Saraste, M. (1999). Oxidative phosphorylation at the fin de siecle. Science 283, 1488–1493.
-
(1999)
Science
, vol.283
, pp. 1488-1493
-
-
Saraste, M.1
-
153
-
-
27544500981
-
Growing roles for the mTOR pathway
-
Sarbassov, D. D., Ali, S. M. & Sabatini, D. M. (2005). Growing roles for the mTOR pathway. Current Opinion in Cell Biology 17, 596–603.
-
(2005)
Current Opinion in Cell Biology
, vol.17
, pp. 596-603
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sabatini, D.M.3
-
154
-
-
47349098337
-
Age-related increase of superoxide generation in the brains of mammals and birds
-
Sasaki, T., Unno, K., Tahara, S., Shimada, A., Chiba, Y., Hoshino, M. & Kaneko, T. (2008). Age-related increase of superoxide generation in the brains of mammals and birds. Aging Cell 7, 459–469.
-
(2008)
Aging Cell
, vol.7
, pp. 459-469
-
-
Sasaki, T.1
Unno, K.2
Tahara, S.3
Shimada, A.4
Chiba, Y.5
Hoshino, M.6
Kaneko, T.7
-
155
-
-
33750624967
-
Mitochondrial signaling, TOR, and life span
-
Schieke, S. M. & Finkel, T. (2006). Mitochondrial signaling, TOR, and life span. Biological Chemistry 387, 1357–1361.
-
(2006)
Biological Chemistry
, vol.387
, pp. 1357-1361
-
-
Schieke, S.M.1
Finkel, T.2
-
156
-
-
33748752151
-
The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity
-
Schieke, S. M., Phillips, D., McCoy, J. P. Jr., Aponte, A. M., Shen, R. F., Balaban, R. S. & Finkel, T. (2006). The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. Journal of Biological Chemistry 281, 27643–27652.
-
(2006)
Journal of Biological Chemistry
, vol.281
, pp. 27643-27652
-
-
Schieke, S.M.1
Phillips, D.2
McCoy, J.P.3
Aponte, A.M.4
Shen, R.F.5
Balaban, R.S.6
Finkel, T.7
-
157
-
-
77953186247
-
Manipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1
-
Schreiber, M. A., Pierce-Shimomura, J. T., Chan, S., Parry, D. & McIntire, S. L. (2010). Manipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1. PLoS Genetics 6, e1000972.
-
(2010)
Plos Genetics
, vol.6
-
-
Schreiber, M.A.1
Pierce-Shimomura, J.T.2
Chan, S.3
Parry, D.4
McIntire, S.L.5
-
158
-
-
21144434217
-
Extension of murine life span by overexpression of catalase targeted to mitochondria
-
Schriner, S. E., Linford, N. J., Martin, G. M., Treuting, P., Ogburn, C. E., Emond, M., Coskun, P. E., Ladiges, W., Wolf, N., Van Remmen, H., Wallace, D. C. & Rabinovitch, P. S. (2005). Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 308, 1909–1911.
-
(2005)
Science
, vol.308
, pp. 1909-1911
-
-
Schriner, S.E.1
Linford, N.J.2
Martin, G.M.3
Treuting, P.4
Ogburn, C.E.5
Emond, M.6
Coskun, P.E.7
Ladiges, W.8
Wolf, N.9
van Remmen, H.10
Wallace, D.C.11
Rabinovitch, P.S.12
-
159
-
-
10444226462
-
ER stress and the unfolded protein response
-
Schroder, M. & Kaufman, R. J. (2005). ER stress and the unfolded protein response. Mutation Research 569, 29–63.
-
(2005)
Mutation Research
, vol.569
, pp. 29-63
-
-
Schroder, M.1
Kaufman, R.J.2
-
160
-
-
34748850786
-
Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
-
Schulz, T. J., Zarse, K., Voigt, A., Urban, N., Birringer, M. & Ristow, M. (2007). Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metabolism 6, 280–293.
-
(2007)
Cell Metabolism
, vol.6
, pp. 280-293
-
-
Schulz, T.J.1
Zarse, K.2
Voigt, A.3
Urban, N.4
Birringer, M.5
Ristow, M.6
-
161
-
-
0036200999
-
RTG-dependent mitochondria-to-nucleus signaling is regulated by MKS1 and is linked to formation of yeast prion [URE3]
-
Sekito, T., Liu, Z., Thornton, J. & Butow, R. A. (2002). RTG-dependent mitochondria-to-nucleus signaling is regulated by MKS1 and is linked to formation of yeast prion [URE3]. Molecular Biology of the Cell 13, 795–804.
-
(2002)
Molecular Biology of the Cell
, vol.13
, pp. 795-804
-
-
Sekito, T.1
Liu, Z.2
Thornton, J.3
Butow, R.A.4
-
162
-
-
70349669095
-
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
-
Selman, C., Tullet, J. M., Wieser, D., Irvine, E., Lingard, S. J., Choudhury, A. I., Claret, M., Al-Qassab, H., Carmignac, D., Ramadani, F., Woods, A., Robinson, I. C., Schuster, E., Batterham, R. L., Kozma, S. C., Thomas, G., Carling, D., Okkenhaug, K., Thornton, J. M., Partridge, L., Gems, D. & Withers, D. J. (2009). Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 326, 140–144.
-
(2009)
Science
, vol.326
, pp. 140-144
-
-
Selman, C.1
Tullet, J.M.2
Wieser, D.3
Irvine, E.4
Lingard, S.J.5
Choudhury, A.I.6
Claret, M.7
Al-Qassab, H.8
Carmignac, D.9
Ramadani, F.10
Woods, A.11
Robinson, I.C.12
Schuster, E.13
Batterham, R.L.14
Kozma, S.C.15
Thomas, G.16
Carling, D.17
Okkenhaug, K.18
Thornton, J.M.19
Partridge, L.20
Gems, D.21
Withers, D.J.22
more..
-
163
-
-
81255150239
-
Rapamycin reduces reactive oxygen species in cultured human corneal endothelial cells
-
Shin, Y. J., Cho, D. Y., Chung, T. Y., Han, S. B., Hyon, J. Y. & Wee, W. R. (2011). Rapamycin reduces reactive oxygen species in cultured human corneal endothelial cells. Current Eye Research 36, 1116–1122.
-
(2011)
Current Eye Research
, vol.36
, pp. 1116-1122
-
-
Shin, Y.J.1
Cho, D.Y.2
Chung, T.Y.3
Han, S.B.4
Hyon, J.Y.5
Wee, W.R.6
-
164
-
-
0028342438
-
Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse
-
Sohal, R. S., Ku, H. H., Agarwal, S., Forster, M. J. & Lal, H. (1994). Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse. Mechanisms of Ageing and Development 74, 121–133.
-
(1994)
Mechanisms of Ageing and Development
, vol.74
, pp. 121-133
-
-
Sohal, R.S.1
Ku, H.H.2
Agarwal, S.3
Forster, M.J.4
Lal, H.5
-
165
-
-
0025363588
-
Hydrogen peroxide production by liver mitochondria in different species
-
Sohal, R. S., Svensson, I. & Brunk, U. T. (1990). Hydrogen peroxide production by liver mitochondria in different species. Mechanisms of Ageing and Development 53, 209–215.
-
(1990)
Mechanisms of Ageing and Development
, vol.53
, pp. 209-215
-
-
Sohal, R.S.1
Svensson, I.2
Brunk, U.T.3
-
166
-
-
0024323120
-
Superoxide anion radical production in different animal species
-
Sohal, R. S., Svensson, I., Sohal, B. H. & Brunk, U. T. (1989). Superoxide anion radical production in different animal species. Mechanisms of Ageing and Development 49, 129–135.
-
(1989)
Mechanisms of Ageing and Development
, vol.49
, pp. 129-135
-
-
Sohal, R.S.1
Svensson, I.2
Sohal, B.H.3
Brunk, U.T.4
-
167
-
-
0037160091
-
Topology of superoxide production from different sites in the mitochondrial electron transport chain
-
St-Pierre, J., Buckingham, J. A., Roebuck, S. J. & Brand, M. D. (2002). Topology of superoxide production from different sites in the mitochondrial electron transport chain. Journal of Biological Chemistry 277, 44784–44790.
-
(2002)
Journal of Biological Chemistry
, vol.277
, pp. 44784-44790
-
-
St-Pierre, J.1
Buckingham, J.A.2
Roebuck, S.J.3
Brand, M.D.4
-
168
-
-
33749999530
-
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
-
St-Pierre, J., Drori, S., Uldry, M., Silvaggi, J. M., Rhee, J., Jager, S., Handschin, C., Zheng, K., Lin, J., Yang, W., Simon, D. K., Bachoo, R. & Spiegelman, B. M. (2006). Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 127, 397–408.
-
(2006)
Cell
, vol.127
, pp. 397-408
-
-
St-Pierre, J.1
Drori, S.2
Uldry, M.3
Silvaggi, J.M.4
Rhee, J.5
Jager, S.6
Handschin, C.7
Zheng, K.8
Lin, J.9
Yang, W.10
Simon, D.K.11
Bachoo, R.12
Spiegelman, B.M.13
-
169
-
-
43049180323
-
Why have antioxidants failed in clinical trials?
-
Steinhubl, S. R. (2008). Why have antioxidants failed in clinical trials? American Journal of Cardiology 101, 14D–19D.
-
(2008)
American Journal of Cardiology
, vol.101
, pp. 14D-19D
-
-
Steinhubl, S.R.1
-
170
-
-
0032908347
-
FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies
-
Sun, J. & Tower, J. (1999). FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Molecular and Cellular Biology 19, 216–228.
-
(1999)
Molecular and Cellular Biology
, vol.19
, pp. 216-228
-
-
Sun, J.1
Tower, J.2
-
171
-
-
0141480258
-
Tor1/2 regulation of retrograde gene expression in Saccharomyces cerevisiae derives indirectly as a consequence of alterations in ammonia metabolism
-
Tate, J. J. & Cooper, T. G. (2003). Tor1/2 regulation of retrograde gene expression in Saccharomyces cerevisiae derives indirectly as a consequence of alterations in ammonia metabolism. Journal of Biological Chemistry 278, 36924–36933.
-
(2003)
Journal of Biological Chemistry
, vol.278
, pp. 36924-36933
-
-
Tate, J.J.1
Cooper, T.G.2
-
172
-
-
39749182234
-
Apoptosis: Controlled demolition at the cellular level
-
Taylor, R. C., Cullen, S. P. & Martin, S. J. (2008). Apoptosis: controlled demolition at the cellular level. Nature Reviews Molecular Cell Biology 9, 231–241.
-
(2008)
Nature Reviews Molecular Cell Biology
, vol.9
, pp. 231-241
-
-
Taylor, R.C.1
Cullen, S.P.2
Martin, S.J.3
-
173
-
-
43249124698
-
PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis
-
Thedieck, K., Polak, P., Kim, M. L., Molle, K. D., Cohen, A., Jeno, P., Arrieumerlou, C. & Hall, M. N. (2007). PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis. PLoS ONE 2, e1217.
-
(2007)
Plos ONE
, vol.2
-
-
Thedieck, K.1
Polak, P.2
Kim, M.L.3
Molle, K.D.4
Cohen, A.5
Jeno, P.6
Arrieumerlou, C.7
Hall, M.N.8
-
174
-
-
0041695625
-
Effects of FK506 and rapamycin on generation of reactive oxygen species, nitric oxide production and nuclear factor kappa B activation in rat hepatocytes
-
Tunon, M. J., Sanchez-Campos, S., Gutierrez, B., Culebras, J. M. &Gonzalez-Gallego, J. (2003). Effects of FK506 and rapamycin on generation of reactive oxygen species, nitric oxide production and nuclear factor kappa B activation in rat hepatocytes. Biochemical Pharmacology 66, 439–445.
-
(2003)
Biochemical Pharmacology
, vol.66
, pp. 439-445
-
-
Tunon, M.J.1
Sanchez-Campos, S.2
Gutierrez, B.3
Culebras, J.M.4
Gonzalez-Gallego, J.5
-
175
-
-
34249813098
-
Sch9 is a major target of TORC1 in Saccharomyces cerevisiae
-
Urban, J., Soulard, A., Huber, A., Lippman, S., Mukhopadhyay, D., Deloche, O., Wanke, V., Anrather, D., Ammerer, G., Riezman, H., Broach, J. R., De Virgilio, C., Hall, M. N. & Loewith, R. (2007). Sch9 is a major target of TORC1 in Saccharomyces cerevisiae. Molecular Cell 26, 663–674.
-
(2007)
Molecular Cell
, vol.26
, pp. 663-674
-
-
Urban, J.1
Soulard, A.2
Huber, A.3
Lippman, S.4
Mukhopadhyay, D.5
Deloche, O.6
Wanke, V.7
Anrather, D.8
Ammerer, G.9
Riezman, H.10
Broach, J.R.11
de Virgilio, C.12
Hall, M.N.13
Loewith, R.14
-
176
-
-
30344432706
-
Role of mitochondrial DNA in toxic responses to oxidative stress
-
Van Houten, B., Woshner, V. & Santos, J. H. (2006). Role of mitochondrial DNA in toxic responses to oxidative stress. DNA Repair (Amsterdam) 5, 145–152.
-
(2006)
DNA Repair (Amsterdam)
, vol.5
, pp. 145-152
-
-
van Houten, B.1
Woshner, V.2
Santos, J.H.3
-
177
-
-
61449184625
-
Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans
-
Van Raamsdonk, J. M. &Hekimi, S. (2009). Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genetics 5, e1000361.
-
(2009)
Plos Genetics
, vol.5
-
-
van Raamsdonk, J.M.1
Hekimi, S.2
-
179
-
-
0642367846
-
Genetics: Influence of TOR kinase on lifespan in C. elegans
-
Vellai, T., Takacs-Vellai, K., Zhang, Y., Kovacs, A. L., Orosz, L. & Muller, F. (2003). Genetics: influence of TOR kinase on lifespan in C. elegans. Nature 426, 620.
-
(2003)
Nature
, vol.426
, pp. 620
-
-
Vellai, T.1
Takacs-Vellai, K.2
Zhang, Y.3
Kovacs, A.L.4
Orosz, L.5
Muller, F.6
-
180
-
-
84866864351
-
mTOR kinase inhibitor potentiates apoptosis of PI3K and MEK inhibitors in diagnostically defined subpopulations
-
Vijapurkar, U., Robillard, L., Zhou, S., Degtyarev, M., Lin, K., Truong, T., Tremayne, J., Ross, L. B., Pei, Z., Friedman, L. S., Blackwood, E. M. & Belvin, M. (2012). mTOR kinase inhibitor potentiates apoptosis of PI3K and MEK inhibitors in diagnostically defined subpopulations. Cancer Letters 326, 168–175.
-
(2012)
Cancer Letters
, vol.326
, pp. 168-175
-
-
Vijapurkar, U.1
Robillard, L.2
Zhou, S.3
Degtyarev, M.4
Lin, K.5
Truong, T.6
Tremayne, J.7
Ross, L.B.8
Pei, Z.9
Friedman, L.S.10
Blackwood, E.M.11
Belvin, M.12
-
181
-
-
77952062668
-
PINK1/Parkin direct mitochondria to autophagy
-
Vives-Bauza, C., de Vries, R. L., Tocilescu, M. & Przedborski, S. (2010). PINK1/Parkin direct mitochondria to autophagy. Autophagy 6, 315–316.
-
(2010)
Autophagy
, vol.6
, pp. 315-316
-
-
Vives-Bauza, C.1
de Vries, R.L.2
Tocilescu, M.3
Przedborski, S.4
-
182
-
-
0035890085
-
The expanding role of mitochondria in apoptosis
-
Wang, X. (2001). The expanding role of mitochondria in apoptosis. Genes and Development 15, 2922–2933.
-
(2001)
Genes and Development
, vol.15
, pp. 2922-2933
-
-
Wang, X.1
-
183
-
-
84867273800
-
ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy
-
Wang, Y., Nartiss, Y., Steipe, B., McQuibban, G. A. & Kim, P. K. (2012). ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy. Autophagy 8, 1462–1476.
-
(2012)
Autophagy
, vol.8
, pp. 1462-1476
-
-
Wang, Y.1
Nartiss, Y.2
Steipe, B.3
McQuibban, G.A.4
Kim, P.K.5
-
184
-
-
45149108690
-
Caffeine extends yeast lifespan by targeting TORC1
-
Wanke, V., Cameroni, E., Uotila, A., Piccolis, M., Urban, J., Loewith, R. & De Virgilio, C. (2008). Caffeine extends yeast lifespan by targeting TORC1. Molecular Microbiology 69, 277–285.
-
(2008)
Molecular Microbiology
, vol.69
, pp. 277-285
-
-
Wanke, V.1
Cameroni, E.2
Uotila, A.3
Piccolis, M.4
Urban, J.5
Loewith, R.6
de Virgilio, C.7
-
186
-
-
68249159982
-
Mechanisms of regulation of RNA polymerase III-dependent transcription by TORC1
-
Wei, Y., Tsang, C. K. & Zheng, X. F. (2009). Mechanisms of regulation of RNA polymerase III-dependent transcription by TORC1. EMBO Journal 28, 2220–2230.
-
(2009)
EMBO Journal
, vol.28
, pp. 2220-2230
-
-
Wei, Y.1
Tsang, C.K.2
Zheng, X.F.3
-
187
-
-
84882245462
-
Growth or longevity: The TOR’s decision on lifespan regulation
-
Wei, Y., Zhang, Y. J. & Cai, Y. (2013). Growth or longevity: the TOR’s decision on lifespan regulation. Biogerontology 14(4), 353–363.
-
(2013)
Biogerontology
, vol.14
, Issue.4
, pp. 353-363
-
-
Wei, Y.1
Zhang, Y.J.2
Cai, Y.3
-
188
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger, S., Loewith, R. & Hall, M. N. (2006). TOR signaling in growth and metabolism. Cell 124, 471–484.
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
189
-
-
78650455712
-
A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans
-
Yang, W. & Hekimi, S. (2010). A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans. PLoS Biology 8, e1000556.
-
(2010)
Plos Biology
, vol.8
-
-
Yang, W.1
Hekimi, S.2
-
190
-
-
84862303982
-
Reactive oxygen species-mediated control of mitochondrial biogenesis
-
Yoboue, E. D. & Devin, A. (2012). Reactive oxygen species-mediated control of mitochondrial biogenesis. International Journal of Cell Biology 2012, 403870.
-
(2012)
International Journal of Cell Biology
, vol.2012
-
-
Yoboue, E.D.1
Devin, A.2
-
191
-
-
4944234936
-
Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones
-
Yoneda, T., Benedetti, C., Urano, F., Clark, S. G., Harding, H. P. & Ron, D. (2004). Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. Journal of Cell Science 117, 4055–4066.
-
(2004)
Journal of Cell Science
, vol.117
, pp. 4055-4066
-
-
Yoneda, T.1
Benedetti, C.2
Urano, F.3
Clark, S.G.4
Harding, H.P.5
Ron, D.6
-
192
-
-
84859475161
-
Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal
-
Zarse, K., Schmeisser, S., Groth, M., Priebe, S., Beuster, G., Kuhlow, D., Guthke, R., Platzer, M., Kahn, C. R. & Ristow, M. (2012). Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. Cell Metabolism 15, 451–465.
-
(2012)
Cell Metabolism
, vol.15
, pp. 451-465
-
-
Zarse, K.1
Schmeisser, S.2
Groth, M.3
Priebe, S.4
Beuster, G.5
Kuhlow, D.6
Guthke, R.7
Platzer, M.8
Kahn, C.R.9
Ristow, M.10
-
193
-
-
0037009521
-
A mitochondrial specific stress response in mammalian cells
-
Zhao, Q., Wang, J., Levichkin, I. V., Stasinopoulos, S., Ryan, M. T. & Hoogenraad, N. J. (2002). A mitochondrial specific stress response in mammalian cells. EMBO Journal 21, 4411–4419.
-
(2002)
EMBO Journal
, vol.21
, pp. 4411-4419
-
-
Zhao, Q.1
Wang, J.2
Levichkin, I.V.3
Stasinopoulos, S.4
Ryan, M.T.5
Hoogenraad, N.J.6
-
194
-
-
78651393239
-
A role for mitochondria in NLRP3 inflammasome activation
-
Zhou, R., Yazdi, A. S., Menu, P. & Tschopp, J. (2011). A role for mitochondria in NLRP3 inflammasome activation. Nature 469, 221–225.
-
(2011)
Nature
, vol.469
, pp. 221-225
-
-
Zhou, R.1
Yazdi, A.S.2
Menu, P.3
Tschopp, J.4
-
195
-
-
70349438679
-
4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila
-
Zid, B. M., Rogers, A. N., Katewa, S. D., Vargas, M. A., Kolipinski, M. C., Lu, T. A., Benzer, S. & Kapahi, P. (2009). 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Cell 139, 149–160.
-
(2009)
Cell
, vol.139
, pp. 149-160
-
-
Zid, B.M.1
Rogers, A.N.2
Katewa, S.D.3
Vargas, M.A.4
Kolipinski, M.C.5
Lu, T.A.6
Benzer, S.7
Kapahi, P.8
|