S6K1 deficiency protects against apoptosis in hepatocytes

Hepatology

Volumn 50, Issue 1, 2009, Pages 216-229

  González Rodriguez, Águeda ^a,b   Alba, Javier ^a   Zimmerman, Valeri ^c   Kozma, Sara C ^c   Valverde, Ángela M ^a,b  

^a INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c UNIVERSITY OF CINCINNATI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; CASPASE 3; CASPASE 8; CONCANAVALIN A; CYTOCHROME C; DEATH RECEPTOR; DNA; FAS ANTIBODY; INSULIN RECEPTOR SUBSTRATE 1; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL XL; PROTEIN BID; SERINE; TUMOR NECROSIS FACTOR ALPHA; RPS6KA1 PROTEIN, MOUSE; S6 KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; DOWNSTREAM PROCESSING; ENZYME ACTIVATION; IN VIVO STUDY; LIVER CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEFICIENCY; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN TARGETING; WILD TYPE; ANIMAL; CELL CULTURE; CYTOLOGY; MOUSE;

ANIMALS; APOPTOSIS; CELLS, CULTURED; HEPATOCYTES; MICE; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA;

EID: 67651148536     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.22915     Document Type: Article

References (26)

1. Peter ME, Krammer PH. The CD95(APO-1/Fas) DISC and beyond. Cell Death Differ 2003;10:26-35.
2. Guicciardi ME, Gores GJ. Apoptosis: mechanism of acute and chronic liver injury. Gut 2005;54:1024-1033. (Pubitemid 40873921)
3. Schafer ZT, Kornbluth S. The apoptosome: physiological, developmental, and pathological modes of regulation. Dev Cell 2006;10:549-561.
4. Canbay A, Friedman S, Gores GJ. Apoptosis: nexus of liver injury and fibrosis. HEPATOLOGY 2004;39:273-278. (Pubitemid 38222163)
5. Valverde AM, Fabregat I, Burks DJ, White MF, Benito M. IRS-2 mediates the anti-apoptotic effect of insulin in neonatal hepatocytes. HEPATOLOGY 2004;40:1285-1294. (Pubitemid 39657002)
6. Nevado C, Benito M, Valverde AM. Role of insulin receptor and balance in IR isoforms A and B in regulation of apoptosis in SV40-immortalized neonatal hepatocytes. Mol Biol Cell 2008;19:1185-1198.
7. Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002;2:489-501. (Pubitemid 37328931)
8. Bjornsti MA, Houghton PJ. The TOR pathway: target for cancer therapy. Nat Rev Cancer 2004;4:335-348. (Pubitemid 38579480)
9. Kneteman NM, Oberholzer J, Al Saghier M, Meeberg GA, Blitz M, Ma MM, et al. Sirolimus-based immunosuppression for liver transplantation in the presence of extended criteria for hepatocellular carcinoma. Liver Transpl 2004;10:1301-1311. (Pubitemid 39406087)
10. Semela D, Piguet AC, Kolev M, Schmitter K, Hlushchuk R, Djonov V, et al. Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma. J Hepatol 2007;46:840-848. (Pubitemid 46529039)
11. Sahin F, Kannangai R, Adegbola O, Wang J, Su G, Torbenson M. mTOR and P70S6 kinase expression in primary liver neoplasms. Clin Cancer Res 2004;10:8421-8425. (Pubitemid 40053405)
12. Shima H, Pende M, Chen Y, Fumagalli S, Thomas G, Kozma SC. Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J 1998;17:6649-6659.
13. Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, et al. Inhibition of death receptor signals by cellular FLIP. Nature 1997;388:190-195. (Pubitemid 27297457)
14. Gonzalez-Rodriguez A, Escribano O, Benito M, Rondinone CM, Valverde AM. Levels of PTP-1B determine the susceptibility to apoptosis in hepatocytes. J Cell Physiol 2007;212:76-88.
15. Ryo K, Kamogawa Y, Ikeda I, Yamauchi K, Yonehara S, Nagata S, et al. Significance of Fas antigen-mediated apoptosis in human fulminant hepatic failure. Am J Gastroenterol 2000;95:2047-2055. (Pubitemid 30629305)
16. Rosseland CM, Wierød L, Oksvold MP, Werner H, Ostvold AC, Thoresen GH, et al. Cytoplasmic retention of peroxide-activated ERK provides survival in primary cultures of rat hepatocytes.HEPATOLOGY 2005;42:200-207.
17. Fisher TL, White MF. Signaling pathways: the benefits of good communication. Curr Biol 2004;14:R1005-R1007.
18. Dufour J-F, Huber O, Kozma SC, Lu X, Toftgard R. Tumour suppressors in liver carcinogenesis. J Hepatol 2007;47:860-867.
19. Bruix J, Hessheimer AJ, Forner A, Boix L, Vilana R, Llovet JM. New aspects of diagnosis and therapy of hepatocellular carcinoma. Oncogene 2006;25:3848-3856. (Pubitemid 43980480)
20. Um SH, D'Alessio D, Thomas G. Nutrient overload insulin resistance and ribosomal protein S6 kinase 1, S6K1. Cell Metab 2006;3:393-402. (Pubitemid 43811780)
21. Shah OJ, Wang Z, Hunter T. Inappropriate activation of the TSC/Rheb/mTOR/S6K1 cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr Biol 2004;13:1259-1268. (Pubitemid 39239362)
22. Chang L, Kamata H, Solinas G, Luo J-L, Maeda S, Venuprasad K, et al. The E3 ubiquitin ligase Itch couples JNK activation to TNF-α-induced cell death by inducing c-FLIPL turnover. Cell 2006;124:601-613. (Pubitemid 43199444)
23. Das M, Sabio G, Jiang F, Rincón M, Flavell RA, Davis RJ. Induction of hepatitis by JNK-mediated expression of TNF-α. Cell 2009;136:249-260.
24. Moumen A, Ieraci A, Patané S, Solé C, Comella JX, Dono R, et al. Met signals hepatocyte survival by preventing Fas-triggered FLIP degradation in a PI3K-Akt-dependent manner. HEPATOLOGY 2007;45:1210-1217. (Pubitemid 46775784)
25. Dijkers PF, Medema RH, Lammers JW, Koenderman L, Coffer PJ. Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by FKHR-L1. Curr Biol 2000;10:1201-1204.
26. Sun S-Y, Rosenberg LM, Wang X, Zhou Z, Yue P, Fu H, et al. Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res 2005;65:7052-7058. (Pubitemid 41161231)