메뉴 건너뛰기




Volumn 45, Issue 3, 2010, Pages 173-179

Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories

Author keywords

Aging; Caloric restriction; Mitochondria; Neuron; Oxyradical; Redox; ROS

Indexed keywords

AMYLOID BETA PROTEIN; GLUCOSE TRANSPORTER 3; GLUCOSE TRANSPORTER 4; GLUTATHIONE; GLUTATHIONE DISULFIDE; HISTONE H3; INSULIN; LACTATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PROTEIN TYROSINE PHOSPHATASE 1B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SOMATOMEDIN C;

EID: 76749126321     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2009.11.007     Document Type: Note
Times cited : (92)

References (95)
  • 3
    • 0027968491 scopus 로고
    • The DNA-binding efficiency of Sp1 is affected by redox changes
    • Ammendola R., Mesuraca M., Russo T., and Cimino F. The DNA-binding efficiency of Sp1 is affected by redox changes. Eur. J. Biochem. 225 (1994) 483-489
    • (1994) Eur. J. Biochem. , vol.225 , pp. 483-489
    • Ammendola, R.1    Mesuraca, M.2    Russo, T.3    Cimino, F.4
  • 6
    • 9644262490 scopus 로고    scopus 로고
    • Higher respiratory activity decreases mitochondrial reactive oxygen release and increases life span in Saccharomyces cerevisiae
    • Barros M.H., Bandy B., Tahara E.B., and Kowaltowski A.J. Higher respiratory activity decreases mitochondrial reactive oxygen release and increases life span in Saccharomyces cerevisiae. J. Biol. Chem. 279 (2004) 49883-49888
    • (2004) J. Biol. Chem. , vol.279 , pp. 49883-49888
    • Barros, M.H.1    Bandy, B.2    Tahara, E.B.3    Kowaltowski, A.J.4
  • 7
    • 33847378451 scopus 로고    scopus 로고
    • Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis
    • Bjelakovic G., Nikolova D., Gluud L.L., Simonetti R.G., and Gluud C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 297 (2007) 842-857
    • (2007) JAMA , vol.297 , pp. 842-857
    • Bjelakovic, G.1    Nikolova, D.2    Gluud, L.L.3    Simonetti, R.G.4    Gluud, C.5
  • 8
    • 0037942739 scopus 로고    scopus 로고
    • Extended longevity in mice lacking the insulin receptor in adipose tissue
    • Bluher M., Kahn B.B., and Kahn C.R. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299 (2003) 572-574
    • (2003) Science , vol.299 , pp. 572-574
    • Bluher, M.1    Kahn, B.B.2    Kahn, C.R.3
  • 9
    • 0032450937 scopus 로고    scopus 로고
    • Age-related toxicity to lactate, glutamate, and beta-amyloid in cultured adult neurons
    • Brewer G.J. Age-related toxicity to lactate, glutamate, and beta-amyloid in cultured adult neurons. Neurobiol. Aging 19 (1998) 561-568
    • (1998) Neurobiol. Aging , vol.19 , pp. 561-568
    • Brewer, G.J.1
  • 10
    • 0033660406 scopus 로고    scopus 로고
    • Neuronal plasticity and stressor toxicity during aging
    • Brewer G.J. Neuronal plasticity and stressor toxicity during aging. Exp. Gerontol. 35 (2000) 1165-1183
    • (2000) Exp. Gerontol. , vol.35 , pp. 1165-1183
    • Brewer, G.J.1
  • 11
    • 76749170909 scopus 로고    scopus 로고
    • Brewer, G.J., 2009. Why vitamin E therapy fails for treatment of Alzheimer's disease. J. Alzheimers Dis. doi:10.3233/JAD-2009-1238.
    • Brewer, G.J., 2009. Why vitamin E therapy fails for treatment of Alzheimer's disease. J. Alzheimers Dis. doi:10.3233/JAD-2009-1238.
  • 12
    • 77956649516 scopus 로고    scopus 로고
    • Brewer, G.J., Lindsey, A.L., Kunz, E.Z., Torricelli, J.R., Neuman, A., Fisher, D.R., Joseph, J.A., 2010. Age-related toxicity of β-amyloid associated with increased pERK and pCREB in primary hippocampal neurons: reversal by blueberry extract. J. Nutr. Biochem. doi:10.1016/j.jnutbio.2009.08.005.
    • Brewer, G.J., Lindsey, A.L., Kunz, E.Z., Torricelli, J.R., Neuman, A., Fisher, D.R., Joseph, J.A., 2010. Age-related toxicity of β-amyloid associated with increased pERK and pCREB in primary hippocampal neurons: reversal by blueberry extract. J. Nutr. Biochem. doi:10.1016/j.jnutbio.2009.08.005.
  • 13
    • 29844450628 scopus 로고    scopus 로고
    • Prevention of age-related dysregulation of calcium dynamics by estrogen in neurons
    • Brewer G.J., Reichensperger J.D., and Brinton R.D. Prevention of age-related dysregulation of calcium dynamics by estrogen in neurons. Neurobiol. Aging 27 (2006) 306-317
    • (2006) Neurobiol. Aging , vol.27 , pp. 306-317
    • Brewer, G.J.1    Reichensperger, J.D.2    Brinton, R.D.3
  • 14
    • 69249202595 scopus 로고    scopus 로고
    • Mutant p53 rescue and modulation of p53 redox state
    • Bykov V.J., Lambert J.M., Hainaut P., and Wiman K.G. Mutant p53 rescue and modulation of p53 redox state. Cell Cycle 8 (2009) 2509-2517
    • (2009) Cell Cycle , vol.8 , pp. 2509-2517
    • Bykov, V.J.1    Lambert, J.M.2    Hainaut, P.3    Wiman, K.G.4
  • 15
    • 0036606952 scopus 로고    scopus 로고
    • A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan
    • Carter C.S., Ramsey M.M., and Sonntag W.E. A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan. Trends Genet. 18 (2002) 295-301
    • (2002) Trends Genet. , vol.18 , pp. 295-301
    • Carter, C.S.1    Ramsey, M.M.2    Sonntag, W.E.3
  • 17
    • 0028650399 scopus 로고
    • Enzymatic/nonenzymatic sources of oxyradicals and regulation of antioxidant defenses
    • Cohen G. Enzymatic/nonenzymatic sources of oxyradicals and regulation of antioxidant defenses. Ann. N. Y. Acad. Sci. 738 (1994) 8-14
    • (1994) Ann. N. Y. Acad. Sci. , vol.738 , pp. 8-14
    • Cohen, G.1
  • 19
    • 33745519729 scopus 로고    scopus 로고
    • The plasma membrane redox system: a candidate source of aging-related oxidative stress
    • DeGrey A. The plasma membrane redox system: a candidate source of aging-related oxidative stress. Age 27 (2005) 129-138
    • (2005) Age , vol.27 , pp. 129-138
    • DeGrey, A.1
  • 20
    • 0030248727 scopus 로고    scopus 로고
    • Influences of age and dietary restriction on gastrocnemius electron transport system activities in mice
    • Desai V.G., Weindruch R., Hart R.W., and Feuers R.J. Influences of age and dietary restriction on gastrocnemius electron transport system activities in mice. Arch. Biochem. Biophys. 333 (1996) 145-151
    • (1996) Arch. Biochem. Biophys. , vol.333 , pp. 145-151
    • Desai, V.G.1    Weindruch, R.2    Hart, R.W.3    Feuers, R.J.4
  • 21
    • 0344980763 scopus 로고    scopus 로고
    • Elevation of mitochondrial glutathione by gamma-glutamylcysteine ethyl ester protects mitochondria against peroxynitrite-induced oxidative stress
    • Drake J., Sultana R., Aksenova M., Calabrese V., and Butterfield D.A. Elevation of mitochondrial glutathione by gamma-glutamylcysteine ethyl ester protects mitochondria against peroxynitrite-induced oxidative stress. J. Neurosci. Res. 74 (2003) 917-927
    • (2003) J. Neurosci. Res. , vol.74 , pp. 917-927
    • Drake, J.1    Sultana, R.2    Aksenova, M.3    Calabrese, V.4    Butterfield, D.A.5
  • 22
    • 0036086130 scopus 로고    scopus 로고
    • Free radicals in the physiological control of cell function
    • Droge W. Free radicals in the physiological control of cell function. Physiol. Rev. 82 (2002) 47-95
    • (2002) Physiol. Rev. , vol.82 , pp. 47-95
    • Droge, W.1
  • 23
    • 34249104544 scopus 로고    scopus 로고
    • Oxidative stress and aberrant signaling in aging and cognitive decline
    • Droge W., and Schipper H.M. Oxidative stress and aberrant signaling in aging and cognitive decline. Aging Cell 6 (2007) 361-370
    • (2007) Aging Cell , vol.6 , pp. 361-370
    • Droge, W.1    Schipper, H.M.2
  • 24
    • 67949112817 scopus 로고    scopus 로고
    • Development of DNA methyltransferase inhibitors for the treatment of neoplastic diseases
    • Fandy T.E. Development of DNA methyltransferase inhibitors for the treatment of neoplastic diseases. Curr. Med. Chem. 16 (2009) 2075-2085
    • (2009) Curr. Med. Chem. , vol.16 , pp. 2075-2085
    • Fandy, T.E.1
  • 25
    • 40949093544 scopus 로고    scopus 로고
    • Epigenetics at the epicenter of modern medicine
    • Feinberg A.P. Epigenetics at the epicenter of modern medicine. JAMA 299 (2008) 1345-1350
    • (2008) JAMA , vol.299 , pp. 1345-1350
    • Feinberg, A.P.1
  • 26
    • 47749134502 scopus 로고    scopus 로고
    • Comparison of metabolic rate and oxidative stress between two different strains of mice with varying response to caloric restriction
    • Ferguson M., Rebrin I., Forster M.J., and Sohal R.S. Comparison of metabolic rate and oxidative stress between two different strains of mice with varying response to caloric restriction. Exp. Gerontol. 43 (2008) 757-763
    • (2008) Exp. Gerontol. , vol.43 , pp. 757-763
    • Ferguson, M.1    Rebrin, I.2    Forster, M.J.3    Sohal, R.S.4
  • 28
    • 0037376674 scopus 로고    scopus 로고
    • Oxidant signals and oxidative stress
    • Finkel T. Oxidant signals and oxidative stress. Curr. Opin. Cell Biol. 15 (2003) 247-254
    • (2003) Curr. Opin. Cell Biol. , vol.15 , pp. 247-254
    • Finkel, T.1
  • 29
    • 33847764645 scopus 로고    scopus 로고
    • Aging, adiposity, and calorie restriction
    • Fontana L., and Klein S. Aging, adiposity, and calorie restriction. JAMA 297 (2007) 986-994
    • (2007) JAMA , vol.297 , pp. 986-994
    • Fontana, L.1    Klein, S.2
  • 31
    • 0028906841 scopus 로고
    • Insulin receptor overexpression in 184B5 human mammary epithelial cells induces a ligand-dependent transformed phenotype
    • Frittitta L., Vigneri R., Stampfer M.R., and Goldfine I.D. Insulin receptor overexpression in 184B5 human mammary epithelial cells induces a ligand-dependent transformed phenotype. J. Cell. Biochem. 57 (1995) 666-669
    • (1995) J. Cell. Biochem. , vol.57 , pp. 666-669
    • Frittitta, L.1    Vigneri, R.2    Stampfer, M.R.3    Goldfine, I.D.4
  • 32
    • 0027185251 scopus 로고
    • Cooperative DNA binding of the human HoxB5 (Hox-2.1) protein is under redox regulation in vitro
    • Galang C.K., and Hauser C.A. Cooperative DNA binding of the human HoxB5 (Hox-2.1) protein is under redox regulation in vitro. Mol. Cell. Biol. 13 (1993) 4609-4617
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 4609-4617
    • Galang, C.K.1    Hauser, C.A.2
  • 34
    • 0014340640 scopus 로고
    • Free radical theory of aging: effect of free radical reaction inhibitors on the mortality rate of male LAF mice
    • Harman D. Free radical theory of aging: effect of free radical reaction inhibitors on the mortality rate of male LAF mice. J. Gerontol. 23 (1968) 476-482
    • (1968) J. Gerontol. , vol.23 , pp. 476-482
    • Harman, D.1
  • 35
    • 33644943609 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors sit at crossroads of diet, aging, cancer
    • Hede K. Histone deacetylase inhibitors sit at crossroads of diet, aging, cancer. J. Natl. Cancer Inst. 98 (2006) 377-379
    • (2006) J. Natl. Cancer Inst. , vol.98 , pp. 377-379
    • Hede, K.1
  • 37
    • 1442314701 scopus 로고    scopus 로고
    • Adipose tissue energy metabolism: altered gene expression profile of mice subjected to long-term caloric restriction
    • Higami Y., Pugh T.D., Page G.P., Allison D.B., Prolla T.A., and Weindruch R. Adipose tissue energy metabolism: altered gene expression profile of mice subjected to long-term caloric restriction. FASEB J. 18 (2004) 415-417
    • (2004) FASEB J. , vol.18 , pp. 415-417
    • Higami, Y.1    Pugh, T.D.2    Page, G.P.3    Allison, D.B.4    Prolla, T.A.5    Weindruch, R.6
  • 39
    • 33744494572 scopus 로고    scopus 로고
    • The free radical fantasy: a panoply of paradoxes
    • Howes R.M. The free radical fantasy: a panoply of paradoxes. Ann. N. Y. Acad. Sci. 1067 (2006) 22-26
    • (2006) Ann. N. Y. Acad. Sci. , vol.1067 , pp. 22-26
    • Howes, R.M.1
  • 40
    • 33845938278 scopus 로고    scopus 로고
    • Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging
    • Hyun D.H., Emerson S.S., Jo D.G., Mattson M.P., and De Cabo R. Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging. Proc. Natl. Acad. Sci. USA 103 (2006) 19908-19912
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 19908-19912
    • Hyun, D.H.1    Emerson, S.S.2    Jo, D.G.3    Mattson, M.P.4    De Cabo, R.5
  • 41
    • 62349116477 scopus 로고    scopus 로고
    • The mitochondrial theory of aging: insight from transgenic and knockout mouse models
    • Jang Y.C., and Van Remmen H. The mitochondrial theory of aging: insight from transgenic and knockout mouse models. Exp. Gerontol. 44 (2009) 256-260
    • (2009) Exp. Gerontol. , vol.44 , pp. 256-260
    • Jang, Y.C.1    Van Remmen, H.2
  • 43
    • 0036372619 scopus 로고    scopus 로고
    • Redox potential of GSH/GSSG couple: assay and biological significance
    • Jones D.P. Redox potential of GSH/GSSG couple: assay and biological significance. Methods Enzymol. 348 (2002) 93-112
    • (2002) Methods Enzymol. , vol.348 , pp. 93-112
    • Jones, D.P.1
  • 44
    • 33744962865 scopus 로고    scopus 로고
    • Redefining oxidative stress
    • Jones D.P. Redefining oxidative stress. Antioxid. Redox Signal. 8 (2006) 1865-1879
    • (2006) Antioxid. Redox Signal. , vol.8 , pp. 1865-1879
    • Jones, D.P.1
  • 45
    • 58149522903 scopus 로고    scopus 로고
    • Critical age-related loss of cofactors of neuron cytochrome c oxidase reversed by estrogen
    • Jones T.T., and Brewer G.J. Critical age-related loss of cofactors of neuron cytochrome c oxidase reversed by estrogen. Exp. Neurol. 215 (2009) 212-219
    • (2009) Exp. Neurol. , vol.215 , pp. 212-219
    • Jones, T.T.1    Brewer, G.J.2
  • 47
    • 67651237066 scopus 로고    scopus 로고
    • The many ways to regulate glucose transporter 4
    • Klip A. The many ways to regulate glucose transporter 4. Appl. Physiol. Nutr. Metab. 34 (2009) 481-487
    • (2009) Appl. Physiol. Nutr. Metab. , vol.34 , pp. 481-487
    • Klip, A.1
  • 48
    • 70449701913 scopus 로고    scopus 로고
    • Epigenetic cross-talk between DNA methylation and histone modifications in human cancers
    • Kondo Y. Epigenetic cross-talk between DNA methylation and histone modifications in human cancers. Yonsei Med. J. 50 (2009) 455-463
    • (2009) Yonsei Med. J. , vol.50 , pp. 455-463
    • Kondo, Y.1
  • 51
    • 41149170164 scopus 로고    scopus 로고
    • NMDA receptor activity regulates transcription of antioxidant pathways
    • Lipton S.A. NMDA receptor activity regulates transcription of antioxidant pathways. Nat. Neurosci. 11 (2008) 381-382
    • (2008) Nat. Neurosci. , vol.11 , pp. 381-382
    • Lipton, S.A.1
  • 52
    • 24644504840 scopus 로고    scopus 로고
    • Effects of caloric restriction on insulin pathway gene expression in the skeletal muscle and liver of normal and long-lived GHR-KO mice
    • Masternak M.M., Al-Regaiey K.A., Rosario Lim M.M., Jimenez-Ortega V., Panici J.A., Bonkowski M.S., and Bartke A. Effects of caloric restriction on insulin pathway gene expression in the skeletal muscle and liver of normal and long-lived GHR-KO mice. Exp. Gerontol. 40 (2005) 679-684
    • (2005) Exp. Gerontol. , vol.40 , pp. 679-684
    • Masternak, M.M.1    Al-Regaiey, K.A.2    Rosario Lim, M.M.3    Jimenez-Ortega, V.4    Panici, J.A.5    Bonkowski, M.S.6    Bartke, A.7
  • 53
    • 68949096744 scopus 로고    scopus 로고
    • Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease
    • Mastroeni D., McKee A., Grover A., Rogers J., and Coleman P.D. Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease. PLoS ONE 4 (2009) e6617
    • (2009) PLoS ONE , vol.4
    • Mastroeni, D.1    McKee, A.2    Grover, A.3    Rogers, J.4    Coleman, P.D.5
  • 54
    • 3342891368 scopus 로고    scopus 로고
    • Oxidative stress and mitochondrial function with aging-the effects of calorie restriction
    • Merry B.J. Oxidative stress and mitochondrial function with aging-the effects of calorie restriction. Aging Cell 3 (2004) 7-12
    • (2004) Aging Cell , vol.3 , pp. 7-12
    • Merry, B.J.1
  • 57
    • 64949116972 scopus 로고    scopus 로고
    • Cell stress and aging: new emphasis on multiplex resistance mechanisms
    • Miller R.A. Cell stress and aging: new emphasis on multiplex resistance mechanisms. J. Gerontol. A: Biol. Sci. Med. Sci. 64 (2009) 179-182
    • (2009) J. Gerontol. A: Biol. Sci. Med. Sci. , vol.64 , pp. 179-182
    • Miller, R.A.1
  • 60
    • 0034122558 scopus 로고    scopus 로고
    • Surface oxidase and oxidative stress propagation in aging
    • Morre D.M., Lenaz G., and Morre D.J. Surface oxidase and oxidative stress propagation in aging. J. Exp. Biol. 203 Pt. 10 (2000) 1513-1521
    • (2000) J. Exp. Biol. , vol.203 , Issue.PART 10 , pp. 1513-1521
    • Morre, D.M.1    Lenaz, G.2    Morre, D.J.3
  • 61
    • 0029950054 scopus 로고    scopus 로고
    • Effects of habitual physical exercise on physiological age in men aged 20-85 years as estimated using principal component analysis
    • Nakamura E., Moritani T., and Kanetaka A. Effects of habitual physical exercise on physiological age in men aged 20-85 years as estimated using principal component analysis. Eur. J. Appl. Physiol. Occup. Physiol. 73 (1996) 410-418
    • (1996) Eur. J. Appl. Physiol. Occup. Physiol. , vol.73 , pp. 410-418
    • Nakamura, E.1    Moritani, T.2    Kanetaka, A.3
  • 62
    • 1342309919 scopus 로고    scopus 로고
    • Beneficial effects of moderate exercise on mice aging: survival, behavior, oxidative stress, and mitochondrial electron transfer
    • Navarro A., Gomez C., Lopez-Cepero J.M., and Boveris A. Beneficial effects of moderate exercise on mice aging: survival, behavior, oxidative stress, and mitochondrial electron transfer. Am. J. Physiol. Regul. Integr. Comp. Physiol. 286 (2004) R505-R511
    • (2004) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.286
    • Navarro, A.1    Gomez, C.2    Lopez-Cepero, J.M.3    Boveris, A.4
  • 63
    • 34147219139 scopus 로고    scopus 로고
    • Simultaneous age-related depolarization of mitochondrial membrane potential and increased mitochondrial reactive oxygen species production correlate with age-related glutamate excitotoxicity in rat hippocampal neurons
    • Parihar M.S., and Brewer G.J. Simultaneous age-related depolarization of mitochondrial membrane potential and increased mitochondrial reactive oxygen species production correlate with age-related glutamate excitotoxicity in rat hippocampal neurons. J. Neurosci. Res. 85 (2007) 1018-1032
    • (2007) J. Neurosci. Res. , vol.85 , pp. 1018-1032
    • Parihar, M.S.1    Brewer, G.J.2
  • 64
    • 48249155387 scopus 로고    scopus 로고
    • Age-related decreases in NAD(P)H and glutathione cause redox declines before ATP loss during glutamate treatment of hippocampal neurons
    • Parihar M.S., Kunz E.A., and Brewer G.J. Age-related decreases in NAD(P)H and glutathione cause redox declines before ATP loss during glutamate treatment of hippocampal neurons. J. Neurosci. Res. 86 (2008) 2339-2352
    • (2008) J. Neurosci. Res. , vol.86 , pp. 2339-2352
    • Parihar, M.S.1    Kunz, E.A.2    Brewer, G.J.3
  • 65
    • 0037448097 scopus 로고    scopus 로고
    • Age-related changes in neuronal glucose uptake in response to glutamate and beta-amyloid
    • Patel J.R., and Brewer G.J. Age-related changes in neuronal glucose uptake in response to glutamate and beta-amyloid. J. Neurosci. Res. 72 (2003) 527-536
    • (2003) J. Neurosci. Res. , vol.72 , pp. 527-536
    • Patel, J.R.1    Brewer, G.J.2
  • 66
    • 48249109144 scopus 로고    scopus 로고
    • Age-related changes to tumor necrosis factor receptors affect neuron survival in the presence of beta-amyloid
    • Patel J.R., and Brewer G.J. Age-related changes to tumor necrosis factor receptors affect neuron survival in the presence of beta-amyloid. J. Neurosci. Res. 86 (2008) 2303-2313
    • (2008) J. Neurosci. Res. , vol.86 , pp. 2303-2313
    • Patel, J.R.1    Brewer, G.J.2
  • 67
    • 49349097514 scopus 로고    scopus 로고
    • Age-related differences in NFkappaB translocation and Bcl-2/Bax ratio caused by TNFalpha and Abeta42 promote survival in middle-age neurons and death in old neurons
    • Patel J.R., and Brewer G.J. Age-related differences in NFkappaB translocation and Bcl-2/Bax ratio caused by TNFalpha and Abeta42 promote survival in middle-age neurons and death in old neurons. Exp. Neurol. 213 (2008) 93-100
    • (2008) Exp. Neurol. , vol.213 , pp. 93-100
    • Patel, J.R.1    Brewer, G.J.2
  • 70
    • 59049086591 scopus 로고    scopus 로고
    • The overexpression of major antioxidant enzymes does not extend the lifespan of mice
    • Perez V.I., Van R.H., Bokov A., Epstein C.J., Vijg J., and Richardson A. The overexpression of major antioxidant enzymes does not extend the lifespan of mice. Aging Cell 8 (2009) 73-75
    • (2009) Aging Cell , vol.8 , pp. 73-75
    • Perez, V.I.1    Van, R.H.2    Bokov, A.3    Epstein, C.J.4    Vijg, J.5    Richardson, A.6
  • 71
    • 0037474277 scopus 로고    scopus 로고
    • NAD(P)H, a primary target of 1O2 in mitochondria of intact cells
    • Petrat F., Pindiur S., Kirsch M., and de Groot H. NAD(P)H, a primary target of 1O2 in mitochondria of intact cells. J. Biol. Chem. 278 (2003) 3298-3307
    • (2003) J. Biol. Chem. , vol.278 , pp. 3298-3307
    • Petrat, F.1    Pindiur, S.2    Kirsch, M.3    de Groot, H.4
  • 72
    • 0026473086 scopus 로고
    • The helix-loop-helix/leucine repeat transcription factor USF can be functionally regulated in a redox-dependent manner
    • Pognonec P., Kato H., and Roeder R.G. The helix-loop-helix/leucine repeat transcription factor USF can be functionally regulated in a redox-dependent manner. J. Biol. Chem. 267 (1992) 24563-24567
    • (1992) J. Biol. Chem. , vol.267 , pp. 24563-24567
    • Pognonec, P.1    Kato, H.2    Roeder, R.G.3
  • 73
    • 55949118714 scopus 로고    scopus 로고
    • Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production
    • Powers S.K., and Jackson M.J. Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol. Rev. 88 (2008) 1243-1276
    • (2008) Physiol. Rev. , vol.88 , pp. 1243-1276
    • Powers, S.K.1    Jackson, M.J.2
  • 74
    • 35648947912 scopus 로고    scopus 로고
    • Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans
    • Rea S.L., Ventura N., and Johnson T.E. Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans. PLoS Biol. 5 (2007) e259
    • (2007) PLoS Biol. , vol.5
    • Rea, S.L.1    Ventura, N.2    Johnson, T.E.3
  • 75
    • 3042821172 scopus 로고    scopus 로고
    • Muscle fat oxidative capacity is not impaired by age but by physical inactivity: association with insulin sensitivity
    • Rimbert V., Boirie Y., Bedu M., Hocquette J.F., Ritz P., and Morio B. Muscle fat oxidative capacity is not impaired by age but by physical inactivity: association with insulin sensitivity. FASEB J. 18 (2004) 737-739
    • (2004) FASEB J. , vol.18 , pp. 737-739
    • Rimbert, V.1    Boirie, Y.2    Bedu, M.3    Hocquette, J.F.4    Ritz, P.5    Morio, B.6
  • 81
    • 43049162647 scopus 로고    scopus 로고
    • Aging by epigenetics - a consequence of chromatin damage?
    • Sedivy J.M., Banumathy G., and Adams P.D. Aging by epigenetics - a consequence of chromatin damage?. Exp. Cell Res. 314 (2008) 1909-1917
    • (2008) Exp. Cell Res. , vol.314 , pp. 1909-1917
    • Sedivy, J.M.1    Banumathy, G.2    Adams, P.D.3
  • 82
    • 70349780606 scopus 로고    scopus 로고
    • The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors
    • Spannhoff A., Hauser A.T., Heinke R., Sippl W., and Jung M. The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors. ChemMedChem. 4 (2009) 1568-1582
    • (2009) ChemMedChem. , vol.4 , pp. 1568-1582
    • Spannhoff, A.1    Hauser, A.T.2    Heinke, R.3    Sippl, W.4    Jung, M.5
  • 83
    • 0025837148 scopus 로고
    • Redox modulatory site of the NMDA receptor-channel complex: regulation by oxidized glutathione
    • Sucher N.J., and Lipton S.A. Redox modulatory site of the NMDA receptor-channel complex: regulation by oxidized glutathione. J. Neurosci. Res. 30 (1991) 582-591
    • (1991) J. Neurosci. Res. , vol.30 , pp. 582-591
    • Sucher, N.J.1    Lipton, S.A.2
  • 84
    • 34547097247 scopus 로고    scopus 로고
    • Brain IRS2 signaling coordinates life span and nutrient homeostasis
    • Taguchi A., Wartschow L.M., and White M.F. Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 317 (2007) 369-372
    • (2007) Science , vol.317 , pp. 369-372
    • Taguchi, A.1    Wartschow, L.M.2    White, M.F.3
  • 86
    • 32644433045 scopus 로고    scopus 로고
    • Insulin regulates neuronal glucose uptake by promoting translocation of glucose transporter GLUT3
    • Uemura E., and Greenlee H.W. Insulin regulates neuronal glucose uptake by promoting translocation of glucose transporter GLUT3. Exp. Neurol. 198 (2006) 48-53
    • (2006) Exp. Neurol. , vol.198 , pp. 48-53
    • Uemura, E.1    Greenlee, H.W.2
  • 87
    • 0022800838 scopus 로고
    • Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity
    • Ullrich A., Gray A., Tam A.W., Yang-Feng T., Tsubokawa M., Collins C., Henzel W., Le B.T., Kathuria S., and Chen E. Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J. 5 (1986) 2503-2512
    • (1986) EMBO J. , vol.5 , pp. 2503-2512
    • Ullrich, A.1    Gray, A.2    Tam, A.W.3    Yang-Feng, T.4    Tsubokawa, M.5    Collins, C.6    Henzel, W.7    Le, B.T.8    Kathuria, S.9    Chen, E.10
  • 89
    • 48249127225 scopus 로고    scopus 로고
    • Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes
    • Villeneuve L.M., Reddy M.A., Lanting L.L., Wang M., Meng L., and Natarajan R. Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes. Proc. Natl. Acad. Sci. USA 105 (2008) 9047-9052
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 9047-9052
    • Villeneuve, L.M.1    Reddy, M.A.2    Lanting, L.L.3    Wang, M.4    Meng, L.5    Natarajan, R.6
  • 90
    • 49949108971 scopus 로고    scopus 로고
    • Age-specific epigenetic drift in late-onset Alzheimer's disease
    • Wang S.C., Oelze B., and Schumacher A. Age-specific epigenetic drift in late-onset Alzheimer's disease. PLoS ONE 3 (2008) e2698
    • (2008) PLoS ONE , vol.3
    • Wang, S.C.1    Oelze, B.2    Schumacher, A.3
  • 91
    • 0035098360 scopus 로고    scopus 로고
    • Microarray profiling of gene expression in aging and its alteration by caloric restriction in mice
    • Weindruch R., Kayo T., Lee C.K., and Prolla T.A. Microarray profiling of gene expression in aging and its alteration by caloric restriction in mice. J. Nutr. 131 (2001) 918S-923S
    • (2001) J. Nutr. , vol.131
    • Weindruch, R.1    Kayo, T.2    Lee, C.K.3    Prolla, T.A.4
  • 92
    • 64849086653 scopus 로고    scopus 로고
    • Alterations in oxygen consumption, respiratory quotient, and heat production in long-lived GHRKO and Ames dwarf mice, and short-lived bGH transgenic mice
    • Westbrook R., Bonkowski M.S., Strader A.D., and Bartke A. Alterations in oxygen consumption, respiratory quotient, and heat production in long-lived GHRKO and Ames dwarf mice, and short-lived bGH transgenic mice. J. Gerontol. A: Biol. Sci. Med. Sci. 64 (2009) 443-451
    • (2009) J. Gerontol. A: Biol. Sci. Med. Sci. , vol.64 , pp. 443-451
    • Westbrook, R.1    Bonkowski, M.S.2    Strader, A.D.3    Bartke, A.4
  • 93
    • 10744228658 scopus 로고    scopus 로고
    • Oxidative inactivation of purified plasma membrane Ca(2+)-ATPase by hydrogen peroxide and protection by calmodulin
    • Zaidi A., Barron L., Sharov V.S., Schoneich C., Michaelis E.K., and Michaelis M.L. Oxidative inactivation of purified plasma membrane Ca(2+)-ATPase by hydrogen peroxide and protection by calmodulin. Biochemistry 42 (2003) 12001-12010
    • (2003) Biochemistry , vol.42 , pp. 12001-12010
    • Zaidi, A.1    Barron, L.2    Sharov, V.S.3    Schoneich, C.4    Michaelis, E.K.5    Michaelis, M.L.6
  • 94
    • 10044228504 scopus 로고    scopus 로고
    • Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
    • Zhang D.D., Lo S.C., Cross J.V., Templeton D.J., and Hannink M. Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol. Cell. Biol. 24 (2004) 10941-10953
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 10941-10953
    • Zhang, D.D.1    Lo, S.C.2    Cross, J.V.3    Templeton, D.J.4    Hannink, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.