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Volumn 36, Issue 2, 2017, Pages 57-73

Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells

Author keywords

inflammation; Pathogen recognition; therapeutics; TLR signaling; Toll like receptor; tumor immunity

Indexed keywords

ANTINEOPLASTIC AGENT; DNA; IMMUNOLOGICAL ADJUVANT; MYELOID DIFFERENTIATION FACTOR 88; PATTERN RECOGNITION RECEPTOR; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3 TICAM 1; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG; PATHOGEN ASSOCIATED MOLECULAR PATTERN;

EID: 85014338689     PISSN: 08830185     EISSN: 15635244     Source Type: Journal    
DOI: 10.1080/08830185.2016.1261318     Document Type: Review
Times cited : (180)

References (152)
  • 1
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • 2010
    • Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell 2010;140(6):805–820.
    • Cell , vol.140 , Issue.6 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 2
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • 2004
    • Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004;4(7):499–511.
    • Nat Rev Immunol , vol.4 , Issue.7 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 3
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    • 1996
    • Lemaitre B, Nicolas E, Michaut L, et al. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 1996;86(6):973–983.
    • Cell , vol.86 , Issue.6 , pp. 973-983
    • Lemaitre, B.1
  • 4
    • 0024299087 scopus 로고    scopus 로고
    • The toll gene of drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein
    • 1988
    • Hashimoto C, Hudson KL, Anderson KV. The toll gene of drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein. Cell 1988;52(2):269–279.
    • Cell , vol.52 , Issue.2 , pp. 269-279
    • Hashimoto, C.1    Hudson, K.L.2    Anderson, K.V.3
  • 5
    • 0032509295 scopus 로고    scopus 로고
    • Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene
    • 1998
    • Poltorak A, He X, Smirnova I, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice:mutations in Tlr4 gene. Science 1998;282(5396):2085–2088.
    • Science , vol.282 , Issue.5396 , pp. 2085-2088
    • Poltorak, A.1
  • 6
    • 0033120081 scopus 로고    scopus 로고
    • Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product
    • 1999
    • Hoshino K, Takeuchi O, Kawai T, et al. Cutting edge:Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide:evidence for TLR4 as the Lps gene product. J Immunol 1999;162(7):3749–3752.
    • J Immunol , vol.162 , Issue.7 , pp. 3749-3752
    • Hoshino, K.1
  • 7
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    • 1997
    • Medzhitov R, Preston-Hurlburt P, Janeway CA, Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997;388(6640):394–397.
    • Nature , vol.388 , Issue.6640 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway, C.A.3
  • 8
    • 3142654210 scopus 로고    scopus 로고
    • Inferences, questions and possibilities in Toll-like receptor signalling
    • 2004
    • Beutler B. Inferences, questions and possibilities in Toll-like receptor signalling. Nature 2004;430(6996):257–263.
    • Nature , vol.430 , Issue.6996 , pp. 257-263
    • Beutler, B.1
  • 9
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
    • 2010
    • Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity:update on Toll-like receptors. Nat Immunol 2010;11(5):373–384.
    • Nat Immunol , vol.11 , Issue.5 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 11
    • 20644450804 scopus 로고    scopus 로고
    • Negative regulation of toll-like receptor-mediated immune responses
    • 2005
    • Liew FY, Xu D, Brint EK, et al. Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol 2005;5(6):446–458.
    • Nat Rev Immunol , vol.5 , Issue.6 , pp. 446-458
    • Liew, F.Y.1
  • 12
    • 0033213590 scopus 로고    scopus 로고
    • Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
    • 1999
    • Takeuchi O, Hoshino K, Kawai T, et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 1999;11(4):443–451.
    • Immunity , vol.11 , Issue.4 , pp. 443-451
    • Takeuchi, O.1
  • 13
    • 67349182481 scopus 로고    scopus 로고
    • The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
    • 2009
    • Park BS, Song DH, Kim HM, et al. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature 2009;458(7242):1191–1195.
    • Nature , vol.458 , Issue.7242 , pp. 1191-1195
    • Park, B.S.1
  • 14
    • 45549099429 scopus 로고    scopus 로고
    • Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5
    • 2008
    • Uematsu S, Fujimoto SK, Jang MH et al. Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat Immunol 2008;9(7):769–776.
    • Nat Immunol , vol.9 , Issue.7 , pp. 769-776
    • Uematsu, S.1
  • 15
    • 33746161021 scopus 로고    scopus 로고
    • Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells
    • 2006
    • Uematsu S, Jang MH, Chevrier N, et al. Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells. Nat Immunol 2006;7(8):868–874.
    • Nat Immunol , vol.7 , Issue.8 , pp. 868-874
    • Uematsu, S.1
  • 16
    • 20644433342 scopus 로고    scopus 로고
    • TLR11 activation of dendritic cells by a protozoan profilin-like protein
    • 2005
    • Yarovinsky F, Zhang D, Andersen JF, et al. TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science 2005;308(5728):1626–1629.
    • Science , vol.308 , Issue.5728 , pp. 1626-1629
    • Yarovinsky, F.1
  • 17
    • 84872761427 scopus 로고    scopus 로고
    • Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii
    • 2013
    • Koblansky AA, Jankovic D, Oh H, et al. Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii. Immunity 2013;38(1):119–130.
    • Immunity , vol.38 , Issue.1 , pp. 119-130
    • Koblansky, A.A.1
  • 18
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • 2006
    • Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell 2006;124(4):783–801.
    • Cell , vol.124 , Issue.4 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 19
    • 67349187318 scopus 로고    scopus 로고
    • Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells
    • 2009
    • Mancuso G, Bambuzza M, Midiri A, et al. Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells. Nat Immunol 2009;10(6):587–594.
    • Nat Immunol , vol.10 , Issue.6 , pp. 587-594
    • Mancuso, G.1
  • 20
    • 0034619794 scopus 로고    scopus 로고
    • A Toll-like receptor recognizes bacterial DNA
    • 2000
    • Hemmi H, Takeuchi O, Kawai T, et al. A Toll-like receptor recognizes bacterial DNA. Nature 2000;408(6813):740–745.
    • Nature , vol.408 , Issue.6813 , pp. 740-745
    • Hemmi, H.1
  • 21
    • 84866159316 scopus 로고    scopus 로고
    • Cutting edge: TLR13 is a receptor for bacterial RNA
    • 2012
    • Hidmark A, von Saint Paul A, Dalpke AH. Cutting edge:TLR13 is a receptor for bacterial RNA. J Immunol 2012;189(6):2717–2721.
    • J Immunol , vol.189 , Issue.6 , pp. 2717-2721
    • Hidmark, A.1    von Saint Paul, A.2    Dalpke, A.H.3
  • 22
    • 84865571191 scopus 로고    scopus 로고
    • TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification
    • 2012
    • Oldenburg M, Kruger A, Ferstl R, et al. TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification. Science 2012;337(6098):1111–1115.
    • Science , vol.337 , Issue.6098 , pp. 1111-1115
    • Oldenburg, M.1
  • 23
    • 79953020324 scopus 로고    scopus 로고
    • A novel Toll-like receptor that recognizes vesicular stomatitis virus
    • 2011
    • Shi Z, Cai Z, Sanchez A, et al. A novel Toll-like receptor that recognizes vesicular stomatitis virus. J Biol Chem 2011;286(6):4517–4524.
    • J Biol Chem , vol.286 , Issue.6 , pp. 4517-4524
    • Shi, Z.1
  • 24
    • 0036829687 scopus 로고    scopus 로고
    • Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2
    • 2002
    • Biragyn A, Ruffini PA, Leifer CA, et al. Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2. Science 2002;298(5595):1025–1029.
    • Science , vol.298 , Issue.5595 , pp. 1025-1029
    • Biragyn, A.1
  • 25
    • 1542380035 scopus 로고    scopus 로고
    • Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    • 2004
    • Park JS, Svetkauskaite D, He Q, et al. Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem 2004;279(9):7370–7377.
    • J Biol Chem , vol.279 , Issue.9 , pp. 7370-7377
    • Park, J.S.1
  • 26
    • 0037097672 scopus 로고    scopus 로고
    • Cutting edge: the immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4
    • 2002
    • Guillot L, Valloy V, McCormack FX, et al. Cutting edge:the immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4. J Immunol 2002;168(12):5989–5992.
    • J Immunol , vol.168 , Issue.12 , pp. 5989-5992
    • Guillot, L.1
  • 27
    • 0035451118 scopus 로고    scopus 로고
    • Fibrinogen stimulates macrophage chemokine secretion through Toll-like receptor 4
    • 2001
    • Smiley ST, King JA, Hancock WW. Fibrinogen stimulates macrophage chemokine secretion through Toll-like receptor 4. J Immunol 2001;167(5):2887–2894.
    • J Immunol , vol.167 , Issue.5 , pp. 2887-2894
    • Smiley, S.T.1    King, J.A.2    Hancock, W.W.3
  • 28
    • 0035971217 scopus 로고    scopus 로고
    • The extra domain A of fibronectin activates Toll-like receptor 4
    • 2001
    • Okamura Y, Wtari M, Jerud ES, et al. The extra domain A of fibronectin activates Toll-like receptor 4. J Biol Chem 2001;276(13):10229–10233.
    • J Biol Chem , vol.276 , Issue.13 , pp. 10229-10233
    • Okamura, Y.1
  • 31
    • 84861999263 scopus 로고    scopus 로고
    • Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain
    • 2012
    • Shichita T, Hasegawa E, Kimura A, et al. Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain. Nat Med 2012;18(6):911–917.
    • Nat Med , vol.18 , Issue.6 , pp. 911-917
    • Shichita, T.1
  • 32
    • 84878141871 scopus 로고    scopus 로고
    • The TLR4 antagonist Eritoran protects mice from lethal influenza infection
    • 2013
    • Shirey KA, Lai W, Scott AJ, et al. The TLR4 antagonist Eritoran protects mice from lethal influenza infection. Nature 2013;497(7450):498–502.
    • Nature , vol.497 , Issue.7450 , pp. 498-502
    • Shirey, K.A.1
  • 33
    • 84886725015 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled, dose-escalating phase I, healthy subjects study of intravenous OPN-305, a humanized anti-TLR2 antibody
    • 2013
    • Reilly M, Miller RM, Thomson, MH, et al. Randomized, double-blind, placebo-controlled, dose-escalating phase I, healthy subjects study of intravenous OPN-305, a humanized anti-TLR2 antibody. Clin Pharmacol Ther 2013;94(5):593–600.
    • Clin Pharmacol Ther , vol.94 , Issue.5 , pp. 593-600
    • Reilly, M.1
  • 34
    • 0025290213 scopus 로고    scopus 로고
    • Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6
    • 1990
    • Lord KA. Hoffman-Liebermann B, Liebermann DA. Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6. Oncogene 1990;5(7):1095–1097.
    • Oncogene , vol.5 , Issue.7 , pp. 1095-1097
    • Lord, K.A.1    Hoffman-Liebermann, B.2    Liebermann, D.A.3
  • 35
    • 0030694108 scopus 로고    scopus 로고
    • IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
    • 1997
    • Muzio M, Ni J, Feng P, et al. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 1997;278(5343):1612–1615.
    • Science , vol.278 , Issue.5343 , pp. 1612-1615
    • Muzio, M.1
  • 37
    • 77953714711 scopus 로고    scopus 로고
    • Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling
    • 2010
    • Lin SC, Lo YC, Wu H. Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature 2010;465(7300):885–890.
    • Nature , vol.465 , Issue.7300 , pp. 885-890
    • Lin, S.C.1    Lo, Y.C.2    Wu, H.3
  • 38
    • 33747615237 scopus 로고    scopus 로고
    • Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling
    • 2006
    • Yamamoto M, Okamoto T, Takeda K, et al. Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. Nat Immunol 2006;7(9):962–970.
    • Nat Immunol , vol.7 , Issue.9 , pp. 962-970
    • Yamamoto, M.1
  • 39
    • 74049136127 scopus 로고    scopus 로고
    • Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines
    • 2010
    • Tseng PH, Matsuzawa A, Zhang W, et al. Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nat Immunol 2010;11(1):70–75.
    • Nat Immunol , vol.11 , Issue.1 , pp. 70-75
    • Tseng, P.H.1
  • 40
    • 84908425487 scopus 로고    scopus 로고
    • Transcriptional control of inflammatory responses
    • 2014
    • Smale ST, Natoli G. Transcriptional control of inflammatory responses. Cold Spring Harb Perspect Biol 2014;6(11):a016261.
    • Cold Spring Harb Perspect Biol , vol.6 , Issue.11 , pp. a016261
    • Smale, S.T.1    Natoli, G.2
  • 41
    • 84896919030 scopus 로고    scopus 로고
    • Chromatin contributions to the regulation of innate immunity
    • 2014
    • Smale ST, Tarakhovsky A, and Natoli G. Chromatin contributions to the regulation of innate immunity. Annu Rev Immunol 2014;32:489–511.
    • Annu Rev Immunol , vol.32 , pp. 489-511
    • Smale, S.T.1    Tarakhovsky, A.2    Natoli, G.3
  • 42
    • 84911473747 scopus 로고    scopus 로고
    • Akirin2 is critical for inducing inflammatory genes by bridging IkappaB-zeta and the SWI/SNF complex
    • 2014
    • Tartey S, Matsushita K, Vandenbon A, et al. Akirin2 is critical for inducing inflammatory genes by bridging IkappaB-zeta and the SWI/SNF complex. EMBO J 2014;33(20):2332–2348.
    • EMBO J , vol.33 , Issue.20 , pp. 2332-2348
    • Tartey, S.1
  • 43
    • 85012048863 scopus 로고    scopus 로고
    • Chromatin remodeling and transcriptional control in innate immunity: emergence of Akirin2 as a novel player
    • 2015
    • Tartey S, Takeuchi O. Chromatin remodeling and transcriptional control in innate immunity:emergence of Akirin2 as a novel player. Biomolecules 2015;5(3):1618–1633.
    • Biomolecules , vol.5 , Issue.3 , pp. 1618-1633
    • Tartey, S.1    Takeuchi, O.2
  • 44
    • 84911479016 scopus 로고    scopus 로고
    • Akirin specifies NF-kappaB selectivity of Drosophila innate immune response via chromatin remodeling
    • 2014
    • Bonnay F, Nguyen XH, Cohen-Berros E, et al. Akirin specifies NF-kappaB selectivity of Drosophila innate immune response via chromatin remodeling. EMBO J 2014;33(20):2349–2362.
    • EMBO J , vol.33 , Issue.20 , pp. 2349-2362
    • Bonnay, F.1
  • 45
    • 84936805550 scopus 로고    scopus 로고
    • Essential function for the nuclear protein Akirin2 in B cell activation and humoral immune responses
    • 2015
    • Tartey S, Matsushita K, Imamura T, et al. Essential function for the nuclear protein Akirin2 in B cell activation and humoral immune responses. J Immunol 2015;195(2):519–527.
    • J Immunol , vol.195 , Issue.2 , pp. 519-527
    • Tartey, S.1
  • 46
    • 30444450839 scopus 로고    scopus 로고
    • Recognition of cytosolic DNA activates an IRF3-dependent innate immune response
    • 2006
    • Stetson DB, Medzhitov R. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 2006;24(1):93–103.
    • Immunity , vol.24 , Issue.1 , pp. 93-103
    • Stetson, D.B.1    Medzhitov, R.2
  • 47
    • 29244471275 scopus 로고    scopus 로고
    • A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
    • 2006
    • Ishii KJ, Coban C, Kato H, et al. A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol 2006;7(1):40–48.
    • Nat Immunol , vol.7 , Issue.1 , pp. 40-48
    • Ishii, K.J.1
  • 48
    • 53349178089 scopus 로고    scopus 로고
    • STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
    • 2008
    • Ishikawa H, Barber GN. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 2008;455(7213):674–678.
    • Nature , vol.455 , Issue.7213 , pp. 674-678
    • Ishikawa, H.1    Barber, G.N.2
  • 49
    • 34547143110 scopus 로고    scopus 로고
    • DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
    • 2007
    • Takaoka A, Wang Z, Choi MK, et al. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 2007;448(7152):501–505.
    • Nature , vol.448 , Issue.7152 , pp. 501-505
    • Takaoka, A.1
  • 50
    • 70349459734 scopus 로고    scopus 로고
    • RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate
    • 2009
    • Ablasser A, Bauernfeind F, Hartmann G, et al. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat Immunol 2009;10(10):1065–1072.
    • Nat Immunol , vol.10 , Issue.10 , pp. 1065-1072
    • Ablasser, A.1
  • 51
    • 77952566304 scopus 로고    scopus 로고
    • The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway
    • 2010
    • Yang P, An H, Liu X, et al. The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. Nat Immunol 2010;11(6):487–494.
    • Nat Immunol , vol.11 , Issue.6 , pp. 487-494
    • Yang, P.1
  • 52
    • 84874278336 scopus 로고    scopus 로고
    • DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking
    • 2013
    • Kondo T, Kobayashi J, Saitoh T, et al. DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking. Proc Natl Acad Sci U S A 2013;110(8):2969–2974.
    • Proc Natl Acad Sci U S A , vol.110 , Issue.8 , pp. 2969-2974
    • Kondo, T.1
  • 53
    • 77957009390 scopus 로고    scopus 로고
    • Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells
    • 2010
    • Kim T, Pazhoor S, Bao M, et al. Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells. Proc Natl Acad Sci U S A 2010;107(34):15181–15186.
    • Proc Natl Acad Sci U S A , vol.107 , Issue.34 , pp. 15181-15186
    • Kim, T.1
  • 54
    • 77951263260 scopus 로고    scopus 로고
    • The AIM2 inflammasome is critical for innate immunity to Francisellatularensis
    • 2010
    • Fernandes-Alnemri T, Yu JW, Juliana C, et al. The AIM2 inflammasome is critical for innate immunity to Francisellatularensis. Nat Immunol 2010;11(5):385–393.
    • Nat Immunol , vol.11 , Issue.5 , pp. 385-393
    • Fernandes-Alnemri, T.1
  • 55
    • 84873711885 scopus 로고    scopus 로고
    • Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
    • 2013
    • Sun L, Wu J, Du F, et al. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 2013;339(6121):786–791.
    • Science , vol.339 , Issue.6121 , pp. 786-791
    • Sun, L.1
  • 57
    • 84884675857 scopus 로고    scopus 로고
    • Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects
    • 2013
    • Li XD, Wu J, Gao D, et al. Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science 2013;341(6152):1390–1394.
    • Science , vol.341 , Issue.6152 , pp. 1390-1394
    • Li, X.D.1
  • 58
    • 33646342149 scopus 로고    scopus 로고
    • Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
    • 2006
    • Kato H, Takeuchi O, Sato S, et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 2006;441(7089):101–105.
    • Nature , vol.441 , Issue.7089 , pp. 101-105
    • Kato, H.1
  • 59
    • 23844508543 scopus 로고    scopus 로고
    • Synergistic enhancement of Toll-like receptor responses by NOD1 activation
    • 2005
    • van Heel DA, Ghosh S, Butler M, et al. Synergistic enhancement of Toll-like receptor responses by NOD1 activation. Eur J Immunol 2005;35(8):2471–2476.
    • Eur J Immunol , vol.35 , Issue.8 , pp. 2471-2476
    • van Heel, D.A.1
  • 60
    • 23844521000 scopus 로고    scopus 로고
    • Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists
    • 2005
    • Fritz JH, Girardin SE, Fitting C, et al. Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists. Eur J Immunol 2005;35(8):2459–2470.
    • Eur J Immunol , vol.35 , Issue.8 , pp. 2459-2470
    • Fritz, J.H.1
  • 61
    • 12444259829 scopus 로고    scopus 로고
    • Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2- and NOD1-dependent manner, respectively, in human monocytic cells in culture
    • 2005
    • Uehara A, Yang S, Fujimoto Y, et al. Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2- and NOD1-dependent manner, respectively, in human monocytic cells in culture. Cell Microbiol 2005;7(1):53–61.
    • Cell Microbiol , vol.7 , Issue.1 , pp. 53-61
    • Uehara, A.1
  • 62
    • 28444471235 scopus 로고    scopus 로고
    • Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells
    • 2005
    • Tada H, Aiba S, Shibata K, et al. Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells. Infect Immun 2005;73(12):7967–7976.
    • Infect Immun , vol.73 , Issue.12 , pp. 7967-7976
    • Tada, H.1
  • 63
    • 79952220311 scopus 로고    scopus 로고
    • Innate immune effectors in mycobacterial infection
    • 2011
    • Saiga H, Shimada Y, Takeda K, Innate immune effectors in mycobacterial infection. Clin Dev Immunol 2011;2011:347594.
    • Clin Dev Immunol , vol.2011 , pp. 347594
    • Saiga, H.1    Shimada, Y.2    Takeda, K.3
  • 64
    • 35648935058 scopus 로고    scopus 로고
    • Nucleotide-binding oligomerization domain protein 2-deficient mice control infection with Mycobacterium tuberculosis
    • 2007
    • Gandotra S, Jang S, Murray PJ, et al. Nucleotide-binding oligomerization domain protein 2-deficient mice control infection with Mycobacterium tuberculosis. Infect Immun 2007;75(11):5127–5134.
    • Infect Immun , vol.75 , Issue.11 , pp. 5127-5134
    • Gandotra, S.1
  • 65
    • 0012722659 scopus 로고    scopus 로고
    • Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection
    • 2003
    • Girardin SE, Boneca IG, Viala J, et al. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 2003;278(11):8869–8872.
    • J Biol Chem , vol.278 , Issue.11 , pp. 8869-8872
    • Girardin, S.E.1
  • 66
    • 67649840704 scopus 로고    scopus 로고
    • Signalling through C-type lectin receptors: shaping immune responses
    • 2009
    • Geijtenbeek TB, Gringhuis SI, Signalling through C-type lectin receptors:shaping immune responses. Nat Rev Immunol 2009;9(7):465–479.
    • Nat Rev Immunol , vol.9 , Issue.7 , pp. 465-479
    • Geijtenbeek, T.B.1    Gringhuis, S.I.2
  • 67
    • 79952206848 scopus 로고    scopus 로고
    • The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections
    • 2010
    • Marakalala MJ, Graham LM, Brown GD. The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections. Clin Dev Immunol 2010;2010:567571.
    • Clin Dev Immunol , vol.2010 , pp. 567571
    • Marakalala, M.J.1    Graham, L.M.2    Brown, G.D.3
  • 68
    • 84907992639 scopus 로고    scopus 로고
    • Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria
    • 2014
    • Yonekawa A, Saijo S, Hoshino Y, et al. Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria. Immunity 2014;41(3):402–413.
    • Immunity , vol.41 , Issue.3 , pp. 402-413
    • Yonekawa, A.1
  • 69
    • 33747036397 scopus 로고    scopus 로고
    • Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity
    • 2006
    • Gross O, Gewies A, Finger K, et al. Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature 2006;442(7103):651–656.
    • Nature , vol.442 , Issue.7103 , pp. 651-656
    • Gross, O.1
  • 70
    • 77952887713 scopus 로고    scopus 로고
    • The SYK tyrosine kinase: a crucial player in diverse biological functions
    • 2010
    • Mocsai A, Ruland J, Tybulewicz VL. The SYK tyrosine kinase:a crucial player in diverse biological functions. Nat Rev Immunol 2010;10(6):387–402.
    • Nat Rev Immunol , vol.10 , Issue.6 , pp. 387-402
    • Mocsai, A.1    Ruland, J.2    Tybulewicz, V.L.3
  • 71
    • 74049126045 scopus 로고    scopus 로고
    • Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production
    • 2010
    • Poeck H, Bscheider M, Gross O, et al. Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production. Nat Immunol 2010;11(1):63–69.
    • Nat Immunol , vol.11 , Issue.1 , pp. 63-69
    • Poeck, H.1
  • 72
    • 77951037591 scopus 로고    scopus 로고
    • The adaptor molecule CARD9 is essential for tuberculosis control
    • 2010
    • Dorhoi A, Desel C, Yeremeev V, et al. The adaptor molecule CARD9 is essential for tuberculosis control. J Exp Med 2010;207(4):777–792.
    • J Exp Med , vol.207 , Issue.4 , pp. 777-792
    • Dorhoi, A.1
  • 73
    • 34548699323 scopus 로고    scopus 로고
    • TLR3 deficiency in patients with herpes simplex encephalitis
    • 2007
    • Zhang SY, Jouanguy E, Ugolini S, et al. TLR3 deficiency in patients with herpes simplex encephalitis. Science 2007;317(5844):1522–1527.
    • Science , vol.317 , Issue.5844 , pp. 1522-1527
    • Zhang, S.Y.1
  • 74
    • 27744534928 scopus 로고    scopus 로고
    • Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses
    • 2005
    • Yang K, Puel A, Zhang S, et al. Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses. Immunity 2005;23(5):465–478.
    • Immunity , vol.23 , Issue.5 , pp. 465-478
    • Yang, K.1
  • 76
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: back to Virchow?
    • 2001
    • Balkwill F, Mantovani A. Inflammation and cancer:back to Virchow? Lancet 2001;357(9255):539–545.
    • Lancet , vol.357 , Issue.9255 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 77
    • 0347123433 scopus 로고    scopus 로고
    • Tumour-educated macrophages promote tumour progression and metastasis
    • 2004
    • Pollard JW. Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 2004;4(1):71–78.
    • Nat Rev Cancer , vol.4 , Issue.1 , pp. 71-78
    • Pollard, J.W.1
  • 78
    • 47949096781 scopus 로고    scopus 로고
    • Cancer-related inflammation
    • 2008
    • Mantovani A, Allavena P, Sica A, et al. Cancer-related inflammation. Nature 2008;454(7203):436–444.
    • Nature , vol.454 , Issue.7203 , pp. 436-444
    • Mantovani, A.1
  • 79
    • 69249222379 scopus 로고    scopus 로고
    • Polarization of tumor-associated neutrophil phenotype by TGF-beta: “N1” versus “N2” TAN
    • 2009
    • Fridlender ZG, Sun J, Kim S, et al. Polarization of tumor-associated neutrophil phenotype by TGF-beta:“N1” versus “N2” TAN. Cancer Cell 2009;16(3):183–194.
    • Cancer Cell , vol.16 , Issue.3 , pp. 183-194
    • Fridlender, Z.G.1
  • 80
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • 2010
    • Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell 2010;140(6):883–899.
    • Cell , vol.140 , Issue.6 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 81
    • 77949345555 scopus 로고    scopus 로고
    • Tumor-associated macrophages and survival in classic Hodgkin's lymphoma
    • 2010
    • Steidl C, Lee T, Shah SP, et al. Tumor-associated macrophages and survival in classic Hodgkin's lymphoma. N Engl J Med 2010;362(10):875–885.
    • N Engl J Med , vol.362 , Issue.10 , pp. 875-885
    • Steidl, C.1
  • 82
    • 77950950894 scopus 로고    scopus 로고
    • Macrophage diversity enhances tumor progression and metastasis
    • 2010
    • Qian BZ, Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell 2010;141(1):39–51.
    • Cell , vol.141 , Issue.1 , pp. 39-51
    • Qian, B.Z.1    Pollard, J.W.2
  • 83
    • 84863151366 scopus 로고    scopus 로고
    • Origins of tumor-associated macrophages and neutrophils
    • 2012
    • Cortez-Retamozo V, Etzrodt M, Newton A, et al. Origins of tumor-associated macrophages and neutrophils. Proc Natl Acad Sci U S A 2012;109(7):2491–2496.
    • Proc Natl Acad Sci U S A , pp. 2491-2496
    • Cortez-Retamozo, V.1
  • 84
    • 84899882509 scopus 로고    scopus 로고
    • Toll-like receptors (TLRs): the role in tumor progression
    • 2010
    • Shcheblyakov DV, Logunov DY, Tukhvatulin AI, et al. Toll-like receptors (TLRs):the role in tumor progression. Actanaturae 2010;2(3):21–29.
    • Actanaturae , vol.2 , Issue.3 , pp. 21-29
    • Shcheblyakov, D.V.1
  • 85
    • 34247331022 scopus 로고    scopus 로고
    • Cancer relapse under chemotherapy: why TLR2/4 receptor agonists can help
    • 2007
    • Garay RP, Viens P, Bauer J, et al. Cancer relapse under chemotherapy:why TLR2/4 receptor agonists can help. Eur J Pharmacol 2007;563(1–3):1–17.
    • Eur J Pharmacol , vol.563 , Issue.1-3 , pp. 1-17
    • Garay, R.P.1
  • 86
    • 0026060863 scopus 로고    scopus 로고
    • The treatment of malignant tumors by repeated inoculations of erysipelas. With a report of ten original cases. 1893
    • Coley WB. The treatment of malignant tumors by repeated inoculations of erysipelas. With a report of ten original cases. 1893. Clin Orthop Relat Res 1991(262):3–11.
    • Clin Orthop Relat Res , vol.1991 , Issue.262 , pp. 3-11
    • Coley, W.B.1
  • 87
    • 79952212690 scopus 로고    scopus 로고
    • TLR3 as a biomarker for the therapeutic efficacy of double-stranded RNA in breast cancer
    • 2011
    • Salaun B, Zitvogel L, Asselin-Paturel C, et al. TLR3 as a biomarker for the therapeutic efficacy of double-stranded RNA in breast cancer. Cancer Res 2011;71(5):1607–1614.
    • Cancer Res , vol.71 , Issue.5 , pp. 1607-1614
    • Salaun, B.1
  • 88
    • 69949154809 scopus 로고    scopus 로고
    • Poly I:C-induced activation of NK cells by CD8 alpha+ dendritic cells via the IPS-1 and TRIF-dependent pathways
    • 2009
    • Miyake T, Kumagai Y, Kato H, et al. Poly I:C-induced activation of NK cells by CD8 alpha+ dendritic cells via the IPS-1 and TRIF-dependent pathways. J Immunol 2009;183(4):2522–2528.
    • J Immunol , vol.183 , Issue.4 , pp. 2522-2528
    • Miyake, T.1
  • 89
    • 33846039130 scopus 로고    scopus 로고
    • Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells
    • 2007
    • Akazawa T, Ebihara T, Okuno M, et al. Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells. Proc Natl Acad Sci U S A 2007;104(1):252–257.
    • Proc Natl Acad Sci U S A , vol.104 , Issue.1 , pp. 252-257
    • Akazawa, T.1
  • 90
    • 79952173864 scopus 로고    scopus 로고
    • Programming the magnitude and persistence of antibody responses with innate immunity
    • 2011
    • Kasturi SP, Skountzou I, Albrecht RA, et al. Programming the magnitude and persistence of antibody responses with innate immunity. Nature 2011;470(7335):543–547.
    • Nature , vol.470 , Issue.7335 , pp. 543-547
    • Kasturi, S.P.1
  • 91
    • 34250854079 scopus 로고    scopus 로고
    • The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4
    • 2007
    • Mata-Haro V, Cekic C, Martin M, et al. The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4. Science 2007;316(5831):1628–1632.
    • Science , vol.316 , Issue.5831 , pp. 1628-1632
    • Mata-Haro, V.1
  • 92
    • 77952540334 scopus 로고    scopus 로고
    • Monophosphoryl lipid A (MPL) as an adjuvant for anti-cancer vaccines: clinical results
    • 2009
    • Cluff CW., Monophosphoryl lipid A (MPL) as an adjuvant for anti-cancer vaccines:clinical results. Adv Exp Med Biol 2009;667:111–123.
    • Adv Exp Med Biol , vol.667 , pp. 111-123
    • Cluff, C.W.1
  • 93
    • 79953320415 scopus 로고    scopus 로고
    • Activation of Toll-like receptor 5 on breast cancer cells by flagellin suppresses cell proliferation and tumor growth
    • 2011
    • Cai Z, Sanchez A, Shi Z, et al. Activation of Toll-like receptor 5 on breast cancer cells by flagellin suppresses cell proliferation and tumor growth. Cancer Res 2011;71(7):2466–2475.
    • Cancer Res , vol.71 , Issue.7 , pp. 2466-2475
    • Cai, Z.1
  • 94
    • 42049095095 scopus 로고    scopus 로고
    • An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models
    • 2008
    • Burdelya LG, Krivokrysenko VI, Tallant TC, et al. An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models. Science 2008;320(5873):226–230.
    • Science , vol.320 , Issue.5873 , pp. 226-230
    • Burdelya, L.G.1
  • 95
    • 33745946911 scopus 로고    scopus 로고
    • Therapeutic potential of Toll-like receptor 9 activation
    • 2006
    • Krieg AM. Therapeutic potential of Toll-like receptor 9 activation. Nat Rev Drug Discov 2006;5(6):471–484.
    • Nat Rev Drug Discov , vol.5 , Issue.6 , pp. 471-484
    • Krieg, A.M.1
  • 96
    • 84865145772 scopus 로고    scopus 로고
    • The human TLR innate immune gene family is differentially influenced by DNA stress and p53 status in cancer cells
    • 2012
    • Shatz M, Menendez D, Resnick MA. The human TLR innate immune gene family is differentially influenced by DNA stress and p53 status in cancer cells. Cancer Res 2012;72(16):3948–3957.
    • Cancer Res , vol.72 , Issue.16 , pp. 3948-3957
    • Shatz, M.1    Menendez, D.2    Resnick, M.A.3
  • 97
    • 84867605321 scopus 로고    scopus 로고
    • STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation
    • 2012
    • Tye H, Kennedy CL, Najdovska M, et al. STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation. Cancer Cell 2012;22(4):466–478.
    • Cancer Cell , vol.22 , Issue.4 , pp. 466-478
    • Tye, H.1
  • 98
    • 0346505340 scopus 로고    scopus 로고
    • The IKK NF-kappa B system: a treasure trove for drug development
    • 2004
    • Karin M, Yamamoto Y, Wang QM. The IKK NF-kappa B system:a treasure trove for drug development. Nat Rev Drug Discov 2004;3(1):17–26.
    • Nat Rev Drug Discov , vol.3 , Issue.1 , pp. 17-26
    • Karin, M.1    Yamamoto, Y.2    Wang, Q.M.3
  • 99
    • 58149269348 scopus 로고    scopus 로고
    • Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis
    • 2009
    • Kim S, Takahashi H, Lin WW, et al. Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis. Nature 2009;457(7225):102–106.
    • Nature , vol.457 , Issue.7225 , pp. 102-106
    • Kim, S.1
  • 100
    • 77952298772 scopus 로고    scopus 로고
    • HMGB1 and RAGE in inflammation and cancer
    • 2010
    • Sims GP, Rowe DC, Rietdijk ST, et al. HMGB1 and RAGE in inflammation and cancer. Ann Rev Immunol 2010;28:367–388.
    • Ann Rev Immunol , vol.28 , pp. 367-388
    • Sims, G.P.1
  • 101
    • 84859812538 scopus 로고    scopus 로고
    • Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4
    • 2012
    • Dapito DH, Mencin A, Gwak GY, et al. Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell 2012;21(4):504–516.
    • Cancer Cell , vol.21 , Issue.4 , pp. 504-516
    • Dapito, D.H.1
  • 102
    • 77957134823 scopus 로고    scopus 로고
    • Significant association between toll-like receptor gene polymorphisms and gallbladder cancer
    • 2010
    • Srivastava K, Srivastava A, Kumar A, et al. Significant association between toll-like receptor gene polymorphisms and gallbladder cancer. Liver Int 2010;30(7):1067–1072.
    • Liver Int , vol.30 , Issue.7 , pp. 1067-1072
    • Srivastava, K.1
  • 103
    • 77950526750 scopus 로고    scopus 로고
    • TLR4 and NOD2/CARD15 genetic polymorphisms and their possible role in gastric carcinogenesis
    • 2010
    • Rigoli L, DiBella C, Fedele F, et al. TLR4 and NOD2/CARD15 genetic polymorphisms and their possible role in gastric carcinogenesis. Anticancer Res 2010;30(2):513–517.
    • Anticancer Res , vol.30 , Issue.2 , pp. 513-517
    • Rigoli, L.1
  • 104
    • 78651254547 scopus 로고    scopus 로고
    • Impact of Toll-like receptor 4 polymorphisms on risk of cancer
    • 2011
    • Kutikhin AG, Impact of Toll-like receptor 4 polymorphisms on risk of cancer. Hum Immunol 2011;72(2):193–206.
    • Hum Immunol , vol.72 , Issue.2 , pp. 193-206
    • Kutikhin, A.G.1
  • 105
    • 79955872080 scopus 로고    scopus 로고
    • Flagellin promotes the proliferation of gastric cancer cells via the Toll-like receptor 5
    • 2011
    • Song EJ, Kang MJ, Kim YS, et al. Flagellin promotes the proliferation of gastric cancer cells via the Toll-like receptor 5. Int J Mol Med 2011;28(1):115–119.
    • Int J Mol Med , vol.28 , Issue.1 , pp. 115-119
    • Song, E.J.1
  • 106
    • 40549144396 scopus 로고    scopus 로고
    • Increased expression of toll-like receptor 5 during progression of cervical neoplasia
    • 2008
    • Kim WY, Lee JW, Choi JJ, et al. Increased expression of toll-like receptor 5 during progression of cervical neoplasia. Int J Gynecol Cancer 2008;18(2):300–305.
    • Int J Gynecol Cancer , vol.18 , Issue.2 , pp. 300-305
    • Kim, W.Y.1
  • 107
    • 25444470242 scopus 로고    scopus 로고
    • Human lung cancer cells express functionally active Toll-like receptor 9
    • 2005
    • Droemann D, Albrecht D, Gerdes J, et al. Human lung cancer cells express functionally active Toll-like receptor 9. Respir Res 2005;6:1.
    • Respir Res , vol.6 , pp. 1
    • Droemann, D.1
  • 109
    • 77951196379 scopus 로고    scopus 로고
    • Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance
    • 2010
    • Cherfils-Vicini J, Platonova S, Gillard, M, et al. Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance. J Clin Invest 2010;120(4):1285–1297.
    • J Clin Invest , pp. 1285-1297
    • Cherfils-Vicini, J.1
  • 110
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: target recognition and regulatory functions
    • 2009
    • Bartel DP. MicroRNAs:target recognition and regulatory functions. Cell 2009;136(2):215–233.
    • Cell , vol.136 , Issue.2 , pp. 215-233
    • Bartel, D.P.1
  • 111
    • 0035966319 scopus 로고    scopus 로고
    • tiny regulators with great potential
    • 2001
    • Ambros V. microRNAs:tiny regulators with great potential. Cell 2001;107(7):823–826.
    • Cell , vol.107 , Issue.7 , pp. 823-826
  • 112
    • 79958776230 scopus 로고    scopus 로고
    • Role of microRNAs in lymphoid biology and disease
    • 2011
    • Fabbri M, Croce CM. Role of microRNAs in lymphoid biology and disease. Curr Opin Hematol 2011;18(4):266–272.
    • Curr Opin Hematol , vol.18 , Issue.4 , pp. 266-272
    • Fabbri, M.1    Croce, C.M.2
  • 113
    • 70349320158 scopus 로고    scopus 로고
    • Causes and consequences of microRNA dysregulation in cancer
    • 2009
    • Croce CM. Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet 2009;10(10):704–714.
    • Nat Rev Genet , vol.10 , Issue.10 , pp. 704-714
    • Croce, C.M.1
  • 114
    • 84864503916 scopus 로고    scopus 로고
    • MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response
    • 2012
    • Fabbri M, Paone A, Calore F, et al. MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. Proc Natl Acad Sci U S A 2012;109(31):E2110–E2116.
    • Proc Natl Acad Sci U S A , vol.109 , Issue.31 , pp. E2110-E2116
    • Fabbri, M.1
  • 115
    • 0036008014 scopus 로고    scopus 로고
    • Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
    • 2002
    • Hemmi H, Kaisho T, Takeuchi O, et al. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 2002;3(2):196–200.
    • Nat Immunol , vol.3 , Issue.2 , pp. 196-200
    • Hemmi, H.1
  • 116
    • 37249041922 scopus 로고    scopus 로고
    • First in human phase I trial of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced cancer
    • 2007
    • Dudek AZ, Yunis C, Harrison LI, et al. First in human phase I trial of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced cancer. Clin Cancer Res 2007;13(23):7119–7125.
    • Clin Cancer Res , vol.13 , Issue.23 , pp. 7119-7125
    • Dudek, A.Z.1
  • 117
    • 38949100471 scopus 로고    scopus 로고
    • An exploratory study of systemic administration of the toll-like receptor-7 agonist 852A in patients with refractory metastatic melanoma
    • 2008
    • Dummer R, et al. An exploratory study of systemic administration of the toll-like receptor-7 agonist 852A in patients with refractory metastatic melanoma. Clin Cancer Res 2008;14(3):856–864.
    • Clin Cancer Res , vol.14 , Issue.3 , pp. 856-864
    • Dummer, R.1
  • 118
    • 84861658289 scopus 로고    scopus 로고
    • Potent immune activation in chronic hepatitis C patients upon administration of an oral inducer of endogenous interferons that acts via Toll-like receptor 7
    • 2012
    • Boonstra A, et al. Potent immune activation in chronic hepatitis C patients upon administration of an oral inducer of endogenous interferons that acts via Toll-like receptor 7. Antivir Ther 2012;17(4):657–667.
    • Antivir Ther , pp. 657-667
    • Boonstra, A.1
  • 119
    • 79958832035 scopus 로고    scopus 로고
    • VTX-1463, a novel TLR8 agonist for the treatment of allergic rhinitis
    • 2011
    • Horak F. VTX-1463, a novel TLR8 agonist for the treatment of allergic rhinitis. Expert Opin Investig Drugs 2011;20(7):981–986.
    • Expert Opin Investig Drugs , vol.20 , Issue.7 , pp. 981-986
    • Horak, F.1
  • 120
    • 0034995781 scopus 로고    scopus 로고
    • A well-tolerated grass pollen-specific allergy vaccine containing a novel adjuvant, monophosphoryl lipid A, reduces allergic symptoms after only four preseasonal injections
    • 2001
    • Drachenberg KJ, et al. A well-tolerated grass pollen-specific allergy vaccine containing a novel adjuvant, monophosphoryl lipid A, reduces allergic symptoms after only four preseasonal injections. Allergy 2001;56(6):498–505.
    • Allergy , vol.56 , Issue.6 , pp. 498-505
    • Drachenberg, K.J.1
  • 121
    • 34249650685 scopus 로고    scopus 로고
    • E5564 (Eritoran) inhibits lipopolysaccharide-induced cytokine production in human blood monocytes
    • 2006
    • Czeslick E, et al. E5564 (Eritoran) inhibits lipopolysaccharide-induced cytokine production in human blood monocytes. Inflamm Res 2006;55(11):511–515.
    • Inflamm Res , vol.55 , Issue.11 , pp. 511-515
    • Czeslick, E.1
  • 122
    • 44449120076 scopus 로고    scopus 로고
    • Activation of Toll-like receptor 2 by a novel preparation of cell wall skeleton from Mycobacterium bovis BCG Tokyo (SMP-105) sufficiently enhances immune responses against tumors
    • 2008
    • Murata M. Activation of Toll-like receptor 2 by a novel preparation of cell wall skeleton from Mycobacterium bovis BCG Tokyo (SMP-105) sufficiently enhances immune responses against tumors. Cancer Sci 2008;99(7):1435–1440.
    • Cancer Sci , vol.99 , Issue.7 , pp. 1435-1440
    • Murata, M.1
  • 123
    • 52749085896 scopus 로고    scopus 로고
    • Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis
    • 2008
    • Wurfel MM, et al. Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis. Am J Respir Crit Care Med 2008;178(7):710–720.
    • Am J Respir Crit Care Med , vol.178 , Issue.7 , pp. 710-720
    • Wurfel, M.M.1
  • 124
    • 67650486394 scopus 로고    scopus 로고
    • Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions
    • 2009
    • Schuring RP, et al. Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions. J Infect Dis 2009;199(12):1816–1819.
    • J Infect Dis , vol.199 , Issue.12 , pp. 1816-1819
    • Schuring, R.P.1
  • 125
    • 34250205895 scopus 로고    scopus 로고
    • Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy
    • 2007
    • Johnson CM, et al. Cutting edge:A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy. J Immunol 2007;178(12):7520–7524.
    • J Immunol , vol.178 , Issue.12 , pp. 7520-7524
    • Johnson, C.M.1
  • 126
    • 0036436470 scopus 로고    scopus 로고
    • A polymorphism in the toll-like receptor 2 is associated with IL-12 production from monocyte in lepromatous leprosy
    • 2002
    • Kang TJ, Lee SB, Chae GT. A polymorphism in the toll-like receptor 2 is associated with IL-12 production from monocyte in lepromatous leprosy. Cytokine 2002;20(2):56–62.
    • Cytokine , vol.20 , Issue.2 , pp. 56-62
    • Kang, T.J.1    Lee, S.B.2    Chae, G.T.3
  • 127
    • 1042269515 scopus 로고    scopus 로고
    • The Arg753GLn polymorphism of the human toll-like receptor 2 gene in tuberculosis disease
    • 2004
    • Ogus AC, et al. The Arg753GLn polymorphism of the human toll-like receptor 2 gene in tuberculosis disease. Eur Respir J 2004;23(2):219–223.
    • Eur Respir J , vol.23 , Issue.2 , pp. 219-223
    • Ogus, A.C.1
  • 128
    • 23444453397 scopus 로고    scopus 로고
    • Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borreliaburgdorferi and protects from late stage Lyme disease
    • 2005
    • Schroder NW, et al. Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borreliaburgdorferi and protects from late stage Lyme disease. J Immunol 2005;175(4):2534–2540.
    • J Immunol , vol.175 , Issue.4 , pp. 2534-2540
    • Schroder, N.W.1
  • 129
    • 36248986638 scopus 로고    scopus 로고
    • Association of TLR2 gene Arg753Gln polymorphism with urinary tract infection in children
    • 2007
    • Tabel Y, Berdeli A, Mir S. Association of TLR2 gene Arg753Gln polymorphism with urinary tract infection in children. Int J Immunogenet 2007;34(6):399–405.
    • Int J Immunogenet , vol.34 , Issue.6 , pp. 399-405
    • Tabel, Y.1    Berdeli, A.2    Mir, S.3
  • 130
    • 0033794461 scopus 로고    scopus 로고
    • A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection
    • 2000
    • Lorenz E, et al. A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection. Infect Immun 2000;68(11):6398–6401.
    • Infect Immun , vol.68 , Issue.11 , pp. 6398-6401
    • Lorenz, E.1
  • 132
    • 80053919303 scopus 로고    scopus 로고
    • Toll-like receptor 3 C1234T may protect against geographic atrophy through decreased dsRNA binding capacity
    • 2011
    • Zhou P, et al. Toll-like receptor 3 C1234T may protect against geographic atrophy through decreased dsRNA binding capacity. FASEB J 2011;25(10):3489–3495.
    • FASEB J , vol.25 , Issue.10 , pp. 3489-3495
    • Zhou, P.1
  • 133
    • 84856013847 scopus 로고    scopus 로고
    • A common polymorphism in TLR3 confers natural resistance to HIV-1 infection
    • 2012
    • Sironi M, et al. A common polymorphism in TLR3 confers natural resistance to HIV-1 infection. J Immunol 2012;188(2):818–823.
    • J Immunol , vol.188 , Issue.2 , pp. 818-823
    • Sironi, M.1
  • 134
    • 0037130195 scopus 로고    scopus 로고
    • Toll-like receptor 4 polymorphisms and atherogenesis
    • 2002
    • Kiechl S, et al. Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med 2002;347(3):185–192.
    • N Engl J Med , vol.347 , Issue.3 , pp. 185-192
    • Kiechl, S.1
  • 135
    • 0037111078 scopus 로고    scopus 로고
    • Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections
    • 2002
    • Agnese DM, et al. Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections. J Infect Dis 2002;186(10):1522–1525.
    • J Infect Dis , vol.186 , Issue.10 , pp. 1522-1525
    • Agnese, D.M.1
  • 136
    • 19944432321 scopus 로고    scopus 로고
    • Epithelioid granulomas, pattern recognition receptors, and phenotypes of Crohn's disease
    • 2005
    • Pierik M, et al. Epithelioid granulomas, pattern recognition receptors, and phenotypes of Crohn's disease. Gut 2005;54(2):223–227.
    • Gut , vol.54 , Issue.2 , pp. 223-227
    • Pierik, M.1
  • 137
    • 10744226016 scopus 로고    scopus 로고
    • A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease
    • 2003
    • Hawn TR, et al. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J Exp Med 2003;198(10):1563–1572.
    • J Exp Med , vol.198 , Issue.10 , pp. 1563-1572
    • Hawn, T.R.1
  • 138
    • 23044475966 scopus 로고    scopus 로고
    • A stop codon polymorphism of toll-like receptor 5 is associated with resistance to systemic lupus erythematosus
    • 2005
    • Hawn TR, et al. A stop codon polymorphism of toll-like receptor 5 is associated with resistance to systemic lupus erythematosus. Proc Natl Acad Sci U S A 2005;102(30):10593–10597.
    • Proc Natl Acad Sci U S A , vol.102 , Issue.30 , pp. 10593-10597
    • Hawn, T.R.1
  • 139
    • 26444608592 scopus 로고    scopus 로고
    • Evaluation of the toll-like receptor 6 Ser249Pro polymorphism in patients with asthma, atopic dermatitis and chronic obstructive pulmonary disease
    • 2005
    • Hoffjan S, et al. Evaluation of the toll-like receptor 6 Ser249Pro polymorphism in patients with asthma, atopic dermatitis and chronic obstructive pulmonary disease. BMC Med Genet 2005;6:34.
    • BMC Med Genet , vol.6 , pp. 34
    • Hoffjan, S.1
  • 140
    • 33745492610 scopus 로고    scopus 로고
    • TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation
    • 2005
    • Kesh S, et al. TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation. Ann N Y Acad Sci 2005;1062:95–103.
    • Ann N Y Acad Sci , vol.1062 , pp. 95-103
    • Kesh, S.1
  • 141
    • 77952548759 scopus 로고    scopus 로고
    • Toll-like receptor 6 Ser249Pro polymorphism is associated with lower left ventricular wall thickness and inflammatory response in hypertensive women
    • 2010
    • Sales ML, et al. Toll-like receptor 6 Ser249Pro polymorphism is associated with lower left ventricular wall thickness and inflammatory response in hypertensive women. Am J Hypertens 2010;23(6):649–654.
    • Am J Hypertens , vol.23 , Issue.6 , pp. 649-654
    • Sales, M.L.1
  • 142
    • 79952116889 scopus 로고    scopus 로고
    • Toll-like receptor 7 rs179008/Gln11Leu gene variants in chronic hepatitis C virus infection
    • 2010
    • Askar E, Ramadori G, Mihm S. Toll-like receptor 7 rs179008/Gln11Leu gene variants in chronic hepatitis C virus infection. J Med Virol 2010;82(11):1859–1868.
    • J Med Virol , vol.82 , Issue.11 , pp. 1859-1868
    • Askar, E.1    Ramadori, G.2    Mihm, S.3
  • 143
    • 59849086382 scopus 로고    scopus 로고
    • A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression
    • 2009
    • Oh DY, et al. A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression. AIDS 2009;23(3):297–307.
    • AIDS , vol.23 , Issue.3 , pp. 297-307
    • Oh, D.Y.1
  • 144
    • 77957673544 scopus 로고    scopus 로고
    • Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus
    • 2010
    • Shen N, et al. Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus. Proc Natl Acad Sci U S A 2010;107(36):15838–15843.
    • Proc Natl Acad Sci U S A , vol.107 , Issue.36 , pp. 15838-15843
    • Shen, N.1
  • 145
    • 34347381278 scopus 로고    scopus 로고
    • A Toll-like receptor 7 single nucleotide polymorphism protects from advanced inflammation and fibrosis in male patients with chronic HCV-infection
    • 2007
    • Schott E, et al. A Toll-like receptor 7 single nucleotide polymorphism protects from advanced inflammation and fibrosis in male patients with chronic HCV-infection. J Hepatol 2007;47(2):203–211.
    • J Hepatol , vol.47 , Issue.2 , pp. 203-211
    • Schott, E.1
  • 146
    • 77958110833 scopus 로고    scopus 로고
    • Toll-like receptor 8 and 9 polymorphisms in Crimean-Congo hemorrhagic fever
    • 2010
    • Engin A, et al. Toll-like receptor 8 and 9 polymorphisms in Crimean-Congo hemorrhagic fever. Microbes Infect 2010;12(12–13):1071–1078.
    • Microbes Infect , vol.12 , Issue.12-13 , pp. 1071-1078
    • Engin, A.1
  • 147
    • 55449113946 scopus 로고    scopus 로고
    • Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis
    • 2008
    • Davila S, et al. Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis. PLoS Genet 2008;4(10):e1000218.
    • PLoS Genet , vol.4 , Issue.10 , pp. e1000218
    • Davila, S.1
  • 148
    • 81755184094 scopus 로고    scopus 로고
    • The C allele of rs5743836 polymorphism in the human TLR9 promoter links IL-6 and TLR9 up-regulation and confers increased B-cell proliferation
    • 2011
    • Carvalho A, et al. The C allele of rs5743836 polymorphism in the human TLR9 promoter links IL-6 and TLR9 up-regulation and confers increased B-cell proliferation. PLoS One 2011;6(11):e28256.
    • PLoS One , vol.6 , Issue.11 , pp. e28256
    • Carvalho, A.1
  • 149
    • 77950938002 scopus 로고    scopus 로고
    • TLR9 polymorphisms are associated with altered IFN-gamma levels in children with cerebral malaria
    • 2010
    • Sam-Agudu NA, et al. TLR9 polymorphisms are associated with altered IFN-gamma levels in children with cerebral malaria. Am J Trop Med Hyg 2010;82(4):548–555.
    • Am J Trop Med Hyg , vol.82 , Issue.4 , pp. 548-555
    • Sam-Agudu, N.A.1
  • 150
    • 77957008935 scopus 로고    scopus 로고
    • Association of TLR9 gene polymorphisms with lupus nephritis in a Chinese Han population
    • 2010
    • Zhou XJ, et al. Association of TLR9 gene polymorphisms with lupus nephritis in a Chinese Han population. Clin Exp Rheumatol 2010;28(3):397–400.
    • Clin Exp Rheumatol , vol.28 , Issue.3 , pp. 397-400
    • Zhou, X.J.1
  • 151
    • 80052453174 scopus 로고    scopus 로고
    • Evaluation of Toll-like receptors 3 (c.1377C/T) and 9 (G2848A) gene polymorphisms in cervical cancer susceptibility
    • 2011
    • Pandey S, et al. Evaluation of Toll-like receptors 3 (c.1377C/T) and 9 (G2848A) gene polymorphisms in cervical cancer susceptibility. Mol Biol Rep 2011;38(7):4715–4721.
    • Mol Biol Rep , vol.38 , Issue.7 , pp. 4715-4721
    • Pandey, S.1
  • 152
    • 4444279410 scopus 로고    scopus 로고
    • TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples
    • 2004
    • Lazarus R, et al. TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples. Am J Respir Crit Care Med 2004;170(6):594–600.
    • Am J Respir Crit Care Med , vol.170 , Issue.6 , pp. 594-600
    • Lazarus, R.1


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