Origins of tumor-associated macrophages and neutrophils

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 7, 2012, Pages 2491-2496

  Cortez Retamozo, Virna ^a   Etzrodt, Martin ^a   Newton, Andita ^a   Rauch, Philipp J ^a   Chudnovskiy, Aleksey ^a   Berger, Cedric ^a   Ryan, Russell J H ^a   Iwamoto, Yoshiko ^a   Marinelli, Brett ^a   Gorbatov, Rostic ^a   Forghani, Reza ^a   Novobrantseva, Tatiana I ^b   Koteliansky, Victor ^b   Figueiredo, Jose Luiz ^a   Chen, John W ^a   Anderson, Daniel G ^c   Nahrendorf, Matthias ^a   Swirski, Filip K ^a   Weissleder, Ralph ^a,d   Pittet, Mikael J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b ALNYLAM PHARMACEUTICALS   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cancer immunity; Tumor microenvironment

Indexed keywords

CD11B ANTIGEN; CHEMOKINE RECEPTOR CCR2; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; GRANULOCYTE; LUNG ADENOCARCINOMA; MOUSE; NEUTROPHIL; NONHUMAN; ONCOGENE K RAS; PRIORITY JOURNAL; SPLEEN; TUMOR ASSOCIATED LEUKOCYTE; TUMOR ASSOCIATED NEUTROPHIL; TUMOR GROWTH;

ANIMALS; HUMANS; MACROPHAGES; MICE; NEOPLASMS; NEUTROPHILS; SPLEEN;

EID: 84863151366     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1113744109     Document Type: Article

References (43)

1. Mantovani A, Allavena P, Sica A, Balkwill F (2008) Cancer-related inflammation. Nature 454:436-444.
2. Weissleder R, Pittet MJ (2008) Imaging in the era of molecular oncology. Nature 452: 580-589. (Pubitemid 351483372)
3. Fridlender ZG, et al. (2009) Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN. Cancer Cell 16:183-194.
4. Grivennikov SI, Greten FR, Karin M (2010) Immunity, inflammation, and cancer. Cell 140:883-899.
5. Qian BZ, Pollard JW (2010) Macrophage diversity enhances tumor progression and metastasis. Cell 141:39-51.
6. Steidl C, et al. (2010) Tumor-associated macrophages and survival in classic Hodgkin's lymphoma. N Engl J Med 362:875-885.
7. Denardo DG, et al. (2011) Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. Cancer Discov 1:54-67.
8. Zhang BC, et al. (2011) Tumor-associated macrophages infiltration is associated with peritumoral lymphangiogenesis and poor prognosis in lung adenocarcinoma. Med Oncol 28:1447-1452.
9. Granot Z, et al. (2011) Tumor entrained neutrophils inhibit seeding in the premetastatic lung. Cancer Cell 20:300-314.
10. Akashi K, Traver D, Miyamoto T, Weissman IL (2000) A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404:193-197. (Pubitemid 30154488)
11. Manz MG, Miyamoto T, Akashi K, Weissman IL (2002) Prospective isolation of human clonogenic common myeloid progenitors. Proc Natl Acad Sci USA 99:11872-11877. (Pubitemid 34994491)
12. Fogg DK, et al. (2006) A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science 311:83-87. (Pubitemid 43063063)
13. Geissmann F, et al. (2010) Development of monocytes, macrophages, and dendritic cells. Science 327:656-661.
14. Sawanobori Y, et al. (2008) Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice. Blood 111:5457-5466.
15. Movahedi K, et al. (2010) Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes. Cancer Res 70: 5728-5739.
16. van Furth R, Cohn ZA (1968) The origin and kinetics of mononuclear phagocytes. J Exp Med 128:415-435.
17. Swirski FK, et al. (2009) Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science 325:612-616.
18. DuPage M, Dooley AL, Jacks T (2009) Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase. Nat Protoc 4:1064-1072.
19. Olive KP, et al. (2009) Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324:1457-1461.
20. Landsman L, Varol C, Jung S (2007) Distinct differentiation potential of blood monocyte subsets in the lung. J Immunol 178:2000-2007. (Pubitemid 46233396)
21. Joyce JA, Pollard JW (2009) Microenvironmental regulation of metastasis. Nat Rev Cancer 9:239-252.
22. Qian BZ, et al. (2011) CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature 475:222-225.
23. Leuschner F, et al. (2011) Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat Biotechnol 29:1005-1010.
24. Auffray C, Sieweke MH, Geissmann F (2009) Blood monocytes: Development, heterogeneity, and relationship with dendritic cells. Annu Rev Immunol 27:669-692.
25. Begg SK, et al. (1993) Delayed hematopoietic development in osteopetrotic (op/op) mice. J Exp Med 177:237-242. (Pubitemid 23008107)
26. Wright DE, Wagers AJ, Gulati AP, Johnson FL, Weissman IL (2001) Physiological migration of hematopoietic stem and progenitor cells. Science 294:1933-1936. (Pubitemid 33101591)
27. Nagai Y, et al. (2006) Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. Immunity 24:801-812. (Pubitemid 43867369)
28. Massberg S, et al. (2007) Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell 131:994-1008. (Pubitemid 350138089)
29. Si Y, Tsou CL, Croft K, Charo IF (2010) CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice. J Clin Invest 120:1192-1203.
30. Mebius RE, Kraal G (2005) Structure and function of the spleen. Nat Rev Immunol 5: 606-616. (Pubitemid 41113192)
31. Snover DC, Frizzera G, Spector BD, Perry GS, 3rd, Kersey JH (1981) Wiskott-Aldrich syndrome: Histopathologic findings in the lymph nodes and spleens of 15 patients. Hum Pathol 12:821-831. (Pubitemid 11015591)
32. O'Keane JC, Wolf BC, Neiman RS (1989) The pathogenesis of splenic extramedullary hematopoiesis in metastatic carcinoma. Cancer 63:1539-1543. (Pubitemid 19093277)
33. Thiele J, Kvasnicka HM, Czieslick C (2002) CD34+ progenitor cells in idiopathic (primary) myelofibrosis: A comparative quantification between spleen and bone marrow tissue. Ann Hematol 81(2):86-89. (Pubitemid 36067581)
34. Liu K, et al. (2007) Origin of dendritic cells in peripheral lymphoid organs of mice. Nat Immunol 8:578-583. (Pubitemid 46785121)
35. Chan IT, et al. (2004) Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease. J Clin Invest 113:528-538. (Pubitemid 38542502)
36. Gabrilovich DI, Nagaraj S (2009) Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 9:162-174.
37. Marigo I, et al. (2010) Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor. Immunity 32:790-802.
38. McAllister SS, et al. (2008) Systemic endocrine instigation of indolent tumor growth requires osteopontin. Cell 133:994-1005. (Pubitemid 351787747)
39. Linet MS, et al. (1996) Risk of cancer following splenectomy. Int J Cancer 66:611-616. (Pubitemid 26197926)
40. Mellemkjoer L, Olsen JH, Linet MS, Gridley G, McLaughlin JK (1995) Cancer risk after splenectomy. Cancer 75:577-583.
41. Robinette CD, Fraumeni JFJ, Jr. (1977) Splenectomy and subsequent mortality in veterans of the 1939-45 war. Lancet 2(8029):127-129. (Pubitemid 8124956)
42. Richman CM, Weiner RS, Yankee RA (1976) Increase in circulating stem cells following chemotherapy in man. Blood 47:1031-1039.
43. Zitvogel L, Apetoh L, Ghiringhelli F, Kroemer G (2008) Immunological aspects of cancer chemotherapy. Nat Rev Immunol 8:59-73.