Gene expression modulation of lipid and central energetic metabolism related genes by high-fat diet intake in the main homeostatic tissues

Food and Function

Volumn 8, Issue 2, 2017, Pages 629-650

  Reynés, Bàrbara ^a   Palou, Mariona ^b   Palou, Andreu ^a  

^a UNIVERSITAT DE LES ILLES BALEARS   (Spain)

^b Alimentómica SL Spin off no 001 from UIB   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACIDS; GENE EXPRESSION; HEALTH RISKS; HISTOLOGY; INSULIN; METABOLISM; MODULATION; PHYSIOLOGY; RISK PERCEPTION; TISSUE;

ENERGETIC METABOLISM; INSULIN SIGNALLING; INTEGRATIVE ANALYSIS; LIPID METABOLISMS; METABOLIC EFFECTS; METABOLIC SYNDROMES; MINIMALLY INVASIVE; PERIPHERAL BLOOD MONONUCLEAR CELLS;

GENE EXPRESSION REGULATION;

ANIMAL; ENERGY METABOLISM; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMAN; LIPID DIET; LIPID METABOLISM;

ANIMALS; DIET, HIGH-FAT; ENERGY METABOLISM; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMANS; LIPID METABOLISM;

EID: 85013891661     PISSN: 20426496     EISSN: 2042650X     Source Type: Journal    
DOI: 10.1039/c6fo01473a     Document Type: Review

References (215)

1. A. Caimari P. Oliver A. Palou Regulation of adiponutrin expression by feeding conditions in rats is altered in the obese state Obesity 2007 15 591-599
2. P. Oliver A. Caimari R. Díaz-Rúa A. Palou Diet-induced obesity affects expression of adiponutrin/PNPLA3 and adipose triglyceride lipase, two members of the same family Int. J. Obes. 2012 36 225-232
3. B. Reynés E. García-Ruíz R. Díaz-Rúa A. Palou P. Oliver Reversion to a control balanced diet is able to restore body weight and to recover altered metabolic parameters in adult rats long-term fed on a cafeteria diet Food Res. Int. 2014 64 10
4. J. Girard D. Perdereau F. Foufelle C. Prip-Buus P. Ferré Regulation of lipogenic enzyme gene expression by nutrients and hormones FASEB J. 1994 8 36-42
5. D. B. Jump S. D. Clarke Regulation of gene expression by dietary fat Annu. Rev. Nutr. 1999 19 63-90
6. D. B. Jump S. Tripathy C. M. Depner Fatty acid-regulated transcription factors in the liver Annu. Rev. Nutr. 2013 33 249-269
7. B. Grygiel-Górniak Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications-a review Nutr. J. 2014 13 17
8. A. Chaplin A. Palou F. Serra Methylation analysis in fatty-acid-related genes reveals their plasticity associated with conjugated linoleic acid and calcium supplementation in adult mice Eur. J. Nutr. 2015 10.1007/S00394-015-1135-3
9. F. I. Milagro J. Campión D. F. García-Díaz E. Goyenechea L. Paternain J. A. Martínez High fat diet-induced obesity modifies the methylation pattern of leptin promoter in rats J. Physiol. Biochem. 2009 65 1-9
10. L. Geddes High-fat diets raise risk of obesity in offspring Nature News 2016 10.1038/nature.2016.19556
11. T. Priego J. Sánchez C. Picó A. Palou Sex-associated differences in the leptin and ghrelin systems related with the induction of hyperphagia under high-fat diet exposure in rats Horm. Behav. 2009 55 33-40
12. T. Priego J. Sánchez C. Picó A. Palou Sex-differential expression of metabolism-related genes in response to a high-fat diet Obesity 2008 16 819-826
13. L. A. Velloso M. W. Schwartz Altered hypothalamic function in diet-induced obesity Int. J. Obes. 2011 35 1455-1465
14. H. W. Liu C. C. Wei Y. J. Chen Y. A. Chen S. J. Chang Flavanol-rich lychee fruit extract alleviates diet-induced insulin resistance via suppressing mTOR/SREBP-1 mediated lipogenesis in liver and restoring insulin signaling in skeletal muscle Mol. Nutr. Food Res. 2016 60 2288-2296
15. S. Hirako Y. Wakayama H. Kim Y. Iizuka A. Matsumoto N. Wada A. Kimura M. Okabe J. Sakagami M. Suzuki F. Takenoya S. Shioda The relationship between aquaglyceroporin expression and development of fatty liver in diet-induced obesity and ob/ob mice Obes. Res. Clin. Pract. 2016 10 710-718
16. A. C. Könner J. C. Brüning Toll-like receptors: linking inflammation to metabolism Trends Endocrinol. Metab. 2011 22 16-23
17. C. L. Lyons E. B. Kennedy H. M. Roche Metabolic Inflammation-Differential Modulation by Dietary Constituents Nutrients 2016 8
18. pii: E247
19. K. E. Wellen G. S. Hotamisligil Inflammation, stress, and diabetes J. Clin. Invest. 2005 115 1111-1119
20. K. J. Strissel Z. Stancheva H. Miyoshi J. W. Perfield J. DeFuria Z. Jick A. S. Greenberg M. S. Obin Adipocyte death, adipose tissue remodeling, and obesity complications Diabetes 2007 56 2910-2918
21. S. U. Amano J. L. Cohen P. Vangala M. Tencerova S. M. Nicoloro J. C. Yawe Y. Shen M. P. Czech M. Aouadi Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation Cell Metab. 2014 19 162-171
22. C. Zheng Q. Yang J. Cao N. Xie K. Liu P. Shou F. Qian Y. Wang Y. Shi Local proliferation initiates macrophage accumulation in adipose tissue during obesity Cell Death Dis. 2016 7 e2167
23. J. Ye Mechanisms of insulin resistance in obesity Front. Med. 2013 7 14-24
24. R. A. van der Heijden F. Sheedfar M. C. Morrison P. P. Hommelberg D. Kor N. J. Kloosterhuis N. Gruben S. A. Youssef A. de Bruin M. H. Hofker R. Kleemann D. P. Koonen P. Heeringa High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice Aging 2015 7 256-268
25. M. R. Boon L. E. Bakker M. C. Haks E. Quinten G. Schaart L. Van Beek Y. Wang L. Van Schinkel V. Van Harmelen A. E. Meinders T. H. Ottenhoff K. W. Van Dijk B. Guigas I. M. Jazet P. C. Rensen Short-term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signalling in healthy male subjects Clin. Sci. 2015 128 143-151
26. P. S. Dalvi J. A. Chalmers V. Luo D. Y. Han L. Wellhauser Y. Liu D. Q. Tran J. Castel S. Luquet M. B. Wheeler D. D. Belsham High-fat induces acute and chronic inflammation in the hypothalamus: Effect of HFD, palmitate and TNF-α on appetite-regulating NPY neurons Int. J. Obes. 2017 41 1 149-158
27. T. M. Waise K. Toshinai F. Naznin C. NamKoong A. S. Md Moin H. Sakoda M. Nakazato One-day high-fat diet induces inflammation in the nodose ganglion and hypothalamus of mice Biochem. Biophys. Res. Commun. 2015 464 1157-1162
28. S. Galic J. S. Oakhill G. R. Steinberg Adipose tissue as an endocrine organ Mol. Cell. Endocrinol. 2010 316 129-139
29. G. S. Hotamisligil Inflammation and metabolic disorders Nature 2006 444 860-867
30. N. Tewari S. Awad I. A. Macdonald D. N. Lobo Obesity-related insulin resistance: implications for the surgical patient Int. J. Obes. 2015 39 1575-1588
31. C. de Luca J. M. Olefsky Inflammation and insulin resistance FEBS Lett. 2008 582 97-105
32. S. E. Shoelson J. Lee M. Yuan Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity-and diet-induced insulin resistance Int. J. Obes. Relat. Metab. Disord. 2003 27 Suppl 3 S49-S52
33. Z. Gao X. Zhang A. Zuberi D. Hwang M. J. Quon M. Lefevre J. Ye Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes Mol. Endocrinol. 2004 18 2024-2034
34. G. Boden Obesity, insulin resistance and free fatty acids Curr. Opin. Endocrinol., Diabetes Obes. 2011 18 139-143
35. G. Boden Obesity and free fatty acids Endocrinol. Metab. Clin. North Am. 2008 37 635-646
36. C. Yu Y. Chen G. W. Cline D. Zhang H. Zong Y. Wang R. Bergeron J. K. Kim S. W. Cushman G. J. Cooney B. Atcheson M. F. White E. W. Kraegen G. I. Shulman Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle J. Biol. Chem. 2002 277 50230-50236
37. J. P. Thaler S. J. Guyenet M. D. Dorfman B. E. Wisse M. W. Schwartz Hypothalamic inflammation: marker or mechanism of obesity pathogenesis? Diabetes 2013 62 2629-2634
38. C. Bjørbaek K. El-Haschimi J. D. Frantz J. S. Flier The role of SOCS-3 in leptin signaling and leptin resistance J. Biol. Chem. 1999 274 30059-30065
39. H. Münzberg M. G. Myers Molecular and anatomical determinants of central leptin resistance Nat. Neurosci. 2005 8 566-570
40. C. Picó P. Oliver J. Sánchez O. Miralles A. Caimari T. Priego A. Palou The intake of physiological doses of leptin during lactation in rats prevents obesity in later life Int. J. Obes. 2007 31 1199-1209
41. H. Shi I. Tzameli C. Bjørbaek J. S. Flier Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling J. Biol. Chem. 2004 279 34733-34740
42. J. J. Senn P. J. Klover I. A. Nowak T. A. Zimmers L. G. Koniaris R. W. Furlanetto R. A. Mooney Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes J. Biol. Chem. 2003 278 13740-13746
43. C. R. Lindholm R. L. Ertel J. D. Bauwens E. G. Schmuck J. D. Mulligan K. W. Saupe A high-fat diet decreases AMPK activity in multiple tissues in the absence of hyperglycemia or systemic inflammation in rats J. Physiol. Biochem. 2013 69 165-175
44. H. Castro C. A. Pomar C. Picó J. Sánchez A. Palou Cafeteria diet overfeeding in young male rats impairs the adaptive response to fed/fasted conditions and increases adiposity independent of body weight Int. J. Obes. 2015 39 430-437
45. D. G. Hardie AMP-activated protein kinase: a master switch in glucose and lipid metabolism Rev. Endocr. Metab. Disord. 2004 5 119-125
46. K. F. Leavens R. M. Easton G. I. Shulman S. F. Previs M. J. Birnbaum Akt2 is required for hepatic lipid accumulation in models of insulin resistance Cell Metab. 2009 10 405-418
47. C. R. Hancock D. H. Han M. Chen S. Terada T. Yasuda D. C. Wright J. O. Holloszy High-fat diets cause insulin resistance despite an increase in muscle mitochondria Proc. Natl. Acad. Sci. U. S. A. 2008 105 7815-7820
48. A. M. Lottenberg M. A. S. Afonso M. S. Lavrador R. M. Machado E. R. Nakandakare The role of dietary fatty acids in the pathology of metabolic syndrome J. Nutr. Biochem. 2012 23 1027-1040
49. R. Benítez Y. Núñez A. Fernández B. Isabel A. I. Fernández C. Rodríguez C. Barragán P. Martín-Palomino C. López-Bote L. Silió C. Óvilo Effects of dietary fat saturation on fatty acid composition and gene transcription in different tissues of Iberian pigs Meat Sci. 2015 102 59-68
50. A. Georgiadi S. Kersten Mechanisms of gene regulation by fatty acids Adv. Nutr. 2012 3 127-134
51. X. Yang M. Haghiac P. Glazebrook J. Minium P. M. Catalano S. Hauguel-de Mouzon Saturated fatty acids enhance TLR4 immune pathways in human trophoblasts Hum. Reprod. 2015 30 2152-2159
52. S. J. van Dijk E. J. Feskens M. B. Bos D. W. Hoelen R. Heijligenberg M. G. Bromhaar L. C. de Groot J. H. de Vries M. Müller L. A. Afman A saturated fatty acid-rich diet induces an obesity-linked proinflammatory gene expression profile in adipose tissue of subjects at risk of metabolic syndrome Am. J. Clin. Nutr. 2009 90 1656-1664
53. H. Sampath M. Miyazaki A. Dobrzyn J. M. Ntambi Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat J. Biol. Chem. 2007 282 2483-2493
54. J. Lin R. Yang P. T. Tarr P. H. Wu C. Handschin S. Li W. Yang L. Pei M. Uldry P. Tontonoz C. B. Newgard B. M. Spiegelman Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP Cell 2005 120 261-273
55. L. Ferrucci A. Cherubini S. Bandinelli B. Bartali A. Corsi F. Lauretani A. Martin C. Andres-Lacueva U. Senin J. M. Guralnik Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers J. Clin. Endocrinol. Metab. 2006 91 439-446
56. A. J. Bennett M. A. Billett A. M. Salter E. H. Mangiapane J. S. Bruce K. L. Anderton C. B. Marenah N. Lawson D. A. White Modulation of hepatic apolipoprotein B, 3-hydroxy-3-methylglutaryl-CoA reductase and low-density lipoprotein receptor mRNA and plasma lipoprotein concentrations by defined dietary fats. Comparison of trimyristin, tripalmitin, tristearin and triolein Biochem. J. 1995 311 Pt 1 167-173
57. J. D. Horton J. A. Cuthbert D. K. Spady Dietary fatty acids regulate hepatic low density lipoprotein (LDL) transport by altering LDL receptor protein and mRNA levels J. Clin. Invest. 1993 92 743-749
58. M. Rincón-Cervera R. Valenzuela M. C. Hernandez-Rodas C. Barrera A. Espinosa M. Marambio A. Valenzuela Vegetable oils rich in alpha linolenic acid increment hepatic n-3 LCPUFA, modulating the fatty acid metabolism and antioxidant response in rats Prostaglandins, Leukotrienes Essent. Fatty Acids 2016 111 25-35
59. C. Z. Larter M. M. Yeh J. Cheng J. Williams S. Brown A. dela Pena K. S. Bell-Anderson G. C. Farrell Activation of peroxisome proliferator-activated receptor alpha by dietary fish oil attenuates steatosis, but does not prevent experimental steatohepatitis because of hepatic lipoperoxide accumulation J. Gastroenterol. Hepatol. 2008 23 267-275
60. N. Assy F. Nassar G. Nasser M. Grosovski Olive oil consumption and non-alcoholic fatty liver disease World J. Gastroenterol. 2009 15 1809-1815
61. S. Hammad S. Pu P. J. Jones Current Evidence Supporting the Link Between Dietary Fatty Acids and Cardiovascular Disease Lipids 2015 5 507-517
62. R. P. Mensink M. B. Katan Effect of dietary trans fatty acids on high-density and low-density lipoprotein cholesterol levels in healthy subjects N. Engl. J. Med. 1990 323 439-445
63. N. R. Matthan F. K. Welty P. H. Barrett C. Harausz G. G. Dolnikowski J. S. Parks R. H. Eckel E. J. Schaefer A. H. Lichtenstein Dietary hydrogenated fat increases high-density lipoprotein apoA-I catabolism and decreases low-density lipoprotein apoB-100 catabolism in hypercholesterolemic women Arterioscler., Thromb., Vasc. Biol. 2004 24 1092-1097
64. F. Shao D. A. Ford Elaidic acid increases hepatic lipogenesis by mediating sterol regulatory element binding protein-1c activity in HuH-7 cells Lipids 2014 49 403-413
65. L. Vendel Nielsen T. P. Krogager C. Young C. Ferreri C. Chatgilialoglu O. Nørregaard Jensen J. J. Enghild Effects of elaidic acid on lipid metabolism in HepG2 cells, investigated by an integrated approach of lipidomics, transcriptomics and proteomics PLoS One 2013 8 e74283
66. N. Obara K. Fukushima Y. Ueno Y. Wakui O. Kimura K. Tamai E. Kakazu J. Inoue Y. Kondo N. Ogawa K. Sato T. Tsuduki K. Ishida T. Shimosegawa Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice J. Hepatol. 2010 53 326-334
67. D. B. Jump Fatty acid regulation of gene transcription Crit. Rev. Clin. Lab. Sci. 2004 41 41-78
68. X. Xu J. S. So J. G. Park A. H. Lee Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP Semin. Liver Dis. 2013 33 301-311
69. H. Al-Hasani H. G. Joost Nutrition-/diet-induced changes in gene expression in white adipose tissue Best Pract. Res., Clin. Endocrinol. Metab. 2005 19 589-603
70. B. P. Kota T. H. Huang B. D. Roufogalis An overview on biological mechanisms of PPARs Pharmacol. Res. 2005 51 85-94
71. C. Wolfrum C. M. Borrmann T. Borchers F. Spener Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha-and gamma-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus Proc. Natl. Acad. Sci. U. S. A. 2001 98 2323-2328
72. M. Rieck W. Meissner S. Ries S. Müller-Brüsselbach R. Müller Ligand-mediated regulation of peroxisome proliferator-activated receptor (PPAR) beta/delta: a comparative analysis of PPAR-selective agonists and all-trans retinoic acid Mol. Pharmacol. 2008 74 1269-1277
73. L. Fang M. Zhang Y. Li Y. Liu Q. Cui N. Wang PPARgene: A Database of Experimentally Verified and Computationally Predicted PPAR Target Genes PPAR Res. 2016 2016 6042162
74. E. Hondares M. Rosell J. Díaz-Delfín Y. Olmos M. Monsalve R. Iglesias F. Villarroya M. Giralt Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16 J. Biol. Chem. 2011 286 43112-43122
75. P. Karagianni I. Talianidis Transcription factor networks regulating hepatic fatty acid metabolism Biochim. Biophys. Acta 2015 1851 2-8
76. D. Patsouris J. K. Reddy M. Müller S. Kersten Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression Endocrinology 2006 147 1508-1516
77. B. Ren A. P. Thelen J. M. Peters F. J. Gonzalez D. B. Jump Polyunsaturated fatty acid suppression of hepatic fatty acid synthase and S14 gene expression does not require peroxisome proliferator-activated receptor alpha J. Biol. Chem. 1997 272 26827-26832
78. J. Zúñiga M. Cancino F. Medina P. Varela R. Vargas G. Tapia L. A. Videla V. Fernández N.-3 PUFA supplementation triggers PPAR-α activation and PPAR-α/NF-κB interaction: anti-inflammatory implications in liver ischemia-reperfusion injury PLoS One 2011 6 e28502
79. R. M. Machado J. T. Stefano C. P. Oliveira E. S. Mello F. D. Ferreira V. S. Nunes V. M. de Lima E. C. Quintão S. Catanozi E. R. Nakandakare A. M. Lottenberg Intake of trans fatty acids causes nonalcoholic steatohepatitis and reduces adipose tissue fat content J. Nutr. 2010 140 1127-1132
80. R. M. Evans G. D. Barish Y. X. Wang PPARs and the complex journey to obesity Nat. Med. 2004 10 355-361
81. S. Kersten Mechanisms of nutritional and hormonal regulation of lipogenesis EMBO Rep. 2001 2 282-286
82. E. Morán-Salvador M. López-Parra V. García-Alonso E. Titos M. Martínez-Clemente A. González-Périz C. López-Vicario Y. Barak V. Arroyo J. Clària Role for PPARγ in obesity-induced hepatic steatosis as determined by hepatocyte-and macrophage-specific conditional knockouts FASEB J. 2011 25 2538-2550
83. R. G. Walton B. Zhu R. Unal M. Spencer M. Sunkara A. J. Morris R. Charnigo W. S. Katz A. Daugherty D. A. Howatt P. A. Kern B. S. Finlin Increasing adipocyte lipoprotein lipase improves glucose metabolism in high fat diet-induced obesity J. Biol. Chem. 2015 290 11547-11556
84. G. den Besten A. Bleeker A. Gerding K. van Eunen R. Havinga T. H. van Dijk M. H. Oosterveer J. W. Jonker A. K. Groen D. J. Reijngoud B. M. Bakker Short-Chain Fatty Acids Protect Against High-Fat Diet-Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation Diabetes 2015 64 2398-2408
85. Z. H. Yang H. Miyahara Y. Iwasaki J. Takeo M. Katayama Dietary supplementation with long-chain monounsaturated fatty acids attenuates obesity-related metabolic dysfunction and increases expression of PPAR gamma in adipose tissue in type 2 diabetic KK-Ay mice Nutr. Metab. 2013 10 16
86. P. A. Grimaldi Regulatory functions of PPARbeta in metabolism: implications for the treatment of metabolic syndrome Biochim. Biophys. Acta 2007 1771 983-990
87. M. Amemiya-Kudo H. Shimano A. H. Hasty N. Yahagi T. Yoshikawa T. Matsuzaka H. Okazaki Y. Tamura Y. Iizuka K. Ohashi J. Osuga K. Harada T. Gotoda R. Sato S. Kimura S. Ishibashi N. Yamada Transcriptional activities of nuclear SREBP-1a,-1c, and-2 to different target promoters of lipogenic and cholesterogenic genes J. Lipid Res. 2002 43 1220-1235
88. S. M. Soyal C. Nofziger S. Dossena M. Paulmichl W. Patsch Targeting SREBPs for treatment of the metabolic syndrome Trends Pharmacol. Sci. 2015 36 406-416
89. G. Chen G. Liang J. Ou J. L. Goldstein M. S. Brown Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver Proc. Natl. Acad. Sci. U. S. A. 2004 101 11245-11250
90. L. Asnaghi P. Bruno M. Priulla A. Nicolin mTOR: a protein kinase switching between life and death Pharmacol. Res. 2004 50 545-549
91. R. Díaz-Rúa E. García-Ruiz A. Caimari A. Palou P. Oliver Sustained exposure to diets with an unbalanced macronutrient proportion alters key genes involved in energy homeostasis and obesity-related metabolic parameters in rats Food Funct. 2014 5 3117-3131
92. S. Voisin M. S. Almén G. Moschonis G. P. Chrousos Y. Manios H. B. Schiöth Dietary fat quality impacts genome-wide DNA methylation patterns in a cross-sectional study of Greek preadolescents Eur. J. Hum. Genet. 2015 23 654-662
93. L. Parrillo V. Costa G. A. Raciti M. Longo R. Spinelli R. Esposito C. Nigro V. Vastolo A. Desiderio F. Zatterale A. Ciccodicola P. Formisano C. Miele F. Beguinot Hoxa5 undergoes dynamic DNA methylation and transcriptional repression in the adipose tissue of mice exposed to high-fat diet Int. J. Obes. 2016 40 929-937
94. A. Palou M. L. Bonet Challenges in obesity research Nutr. Hosp. 2013 28 Suppl 5 144-153
95. P. D. Taylor L. Poston Developmental programming of obesity in mammals Exp. Physiol. 2007 92 287-298
96. L. V. Mennitti J. L. Oliveira C. A. Morais D. Estadella L. M. Oyama C. M. Oller do Nascimento L. P. Pisani Type of fatty acids in maternal diets during pregnancy and/or lactation and metabolic consequences of the offspring J. Nutr. Biochem. 2015 26 99-111
97. M. Llopis J. Sánchez T. Priego A. Palou C. Picó Maternal fat supplementation during late pregnancy and lactation influences the development of hepatic steatosis in offspring depending on the fat source J. Agric. Food Chem. 2014 62 1590-1601
98. J. Sánchez T. Priego A. P. García M. Llopis M. Palou C. Picó A. Palou Maternal supplementation with an excess of different fat sources during pregnancy and lactation differentially affects feeding behavior in offspring: putative role of the leptin system Mol. Nutr. Food Res. 2012 56 1715-1728
99. A. Khalyfa A. Carreras F. Hakim J. M. Cunningham Y. Wang D. Gozal Effects of late gestational high-fat diet on body weight, metabolic regulation and adipokine expression in offspring Int. J. Obes. 2013 37 1481-1489
100. M. Palou C. Picó J. A. McKay J. Sánchez T. Priego J. C. Mathers A. Palou Protective effects of leptin during the suckling period against later obesity may be associated with changes in promoter methylation of the hypothalamic pro-opiomelanocortin gene Br. J. Nutr. 2011 106 769-778
101. C. Picó A. Pons M. Gianotti A. Palou Sustained changes in blood alpha amino nitrogen compartmentation during recovery from cafeteria feeding in rats Arch. Int. Physiol., Biochim. Biophys. 1991 99 345-348
102. I. Lladó A. M. Proenza F. Serra A. Palou A. Pons Dietary-induced permanent changes in brown and white adipose tissue composition in rats Int. J. Obes. 1991 15 415-419
103. A. M. Proenza I. Lladó F. Serra C. Picó A. Pons A. Palou Tissue composition in persistent dietary obesity after early and adulthood overfeeding in the rat Arch. Int. Physiol., Biochim. Biophys. 1992 100 147-154
104. A. Leikin-Frenkel L. Shomonov-Wagner A. Juknat M. Pasmanik-Chor Maternal Diet Enriched with α-Linolenic or Saturated Fatty Acids Differentially Regulates Gene Expression in the Liver of Mouse Offspring J. Nutrigenet. Nutrigenomics 2015 8 185-194
105. J. Flores-Sierra M. Arredondo-Guerrero B. Cervantes-Paz D. Rodríguez-Ríos Y. Alvarado-Caudillo F. C. Nielsen K. Wrobel S. Zaina G. Lund The trans fatty acid elaidate affects the global DNA methylation profile of cultured cells and in vivo Lipids Health Dis. 2016 15 75
106. S. Widiker S. Karst A. Wagener G. A. Brockmann High-fat diet leads to a decreased methylation of the Mc4r gene in the obese BFMI and the lean B6 mouse lines J. Appl. Genet. 2010 51 193-197
107. R. Buettner J. Schölmerich L. C. Bollheimer High-fat diets: modeling the metabolic disorders of human obesity in rodents Obesity 2007 15 798-808
108. B. P. Sampey A. M. Vanhoose H. M. Winfield A. J. Freemerman M. J. Muehlbauer P. T. Fueger C. B. Newgard L. Makowski Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet Obesity 2011 19 1109-1117
109. M. J. Morris H. Chen R. Watts A. Shulkes D. Cameron-Smith Brain neuropeptide Y and CCK and peripheral adipokine receptors: temporal response in obesity induced by palatable diet Int. J. Obes. 2008 32 249-258
110. E. Ebal H. Cavalié O. Michaux G. Lac Effect of a lipid-enriched diet on body composition and some regulatory hormones of food intake in growing rats Ann. Endocrinol. 2007 68 366-371
111. J. J. Hillebrand D. de Wied R. A. Adan Neuropeptides, food intake and body weight regulation: a hypothalamic focus Peptides 2002 23 2283-2306
112. L. Varela T. L. Horvath Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis EMBO Rep. 2012 13 1079-1086
113. E. P. Araujo J. C. Moraes D. E. Cintra L. Velloso MECHANISMS IN ENDOCRINOLOGY: Hypothalamic inflammation and nutrition Eur. J. Endocrinol. 2016 175 R97-R105
114. K. C. de Git R. A. Adan Leptin resistance in diet-induced obesity: the role of hypothalamic inflammation Obes. Rev. 2015 16 207-224
115. B. Reynés R. Díaz-Rúa M. Cifre P. Oliver A. Palou Peripheral blood mononuclear cells as a potential source of biomarkers to test the efficacy of weight-loss strategies Obesity 2014 23 28-31
116. I. J. Goldberg R. H. Eckel N. A. Abumrad Regulation of fatty acid uptake into tissues: lipoprotein lipase-and CD36-mediated pathways J. Lipid Res. 2009 50 Suppl S86-S90
117. T. Priego J. Sánchez A. Palou C. Picó Effect of high-fat diet feeding on leptin receptor expression in white adipose tissue in rats: depot-and sex-related differential response Genes Nutr. 2009 4 151-156
118. I. P. López A. Marti F. I. Milagro M. E. L. Zulet Md M. J. Moreno-Aliaga J. A. Martinez C. De Miguel DNA microarray analysis of genes differentially expressed in diet-induced (cafeteria) obese rats Obes. Res. 2003 11 188-194
119. J. Margareto J. Gómez-Ambrosi A. Marti J. A. Martínez Time-dependent effects of a high-energy-yielding diet on the regulation of specific white adipose tissue genes Biochem. Biophys. Res. Commun. 2001 283 6-11
120. E. Lim J. Y. Lim J. H. Shin P. R. Seok S. Jung S. H. Yoo Y. Kim D-Xylose suppresses adipogenesis and regulates lipid metabolism genes in high-fat diet-induced obese mice Nutr. Res. 2015 35 626-636
121. A. Voigt J. Ribot A. G. Sabater A. Palou M. L. Bonet S. Klaus Identification of Mest/Peg1 gene expression as a predictive biomarker of adipose tissue expansion sensitive to dietary anti-obesity interventions Genes Nutr. 2015 10 477
122. A. Voigt K. Agnew E. M. van Schothorst J. Keijer S. Klaus Short-term, high fat feeding-induced changes in white adipose tissue gene expression are highly predictive for long-term changes Mol. Nutr. Food Res. 2013 57 1423-1434
123. X. Liu J. Xu Y. Xue Z. Gao Z. Li K. Leng J. Wang C. Xue Y. Wang Sea cucumber cerebrosides and long-chain bases from Acaudina molpadioides protect against high fat diet-induced metabolic disorders in mice Food Funct. 2015 6 3428-3436
124. A. Sobolewska M. Włodarczyk K. Włodarczyk M. Wiśniewska-Jarosińska J. Fichna Comment on Choi et al.: High-fat diet decreases energy expenditure and expression of genes controlling lipid metabolism, mitochondrial function and skeletal system development in the adipose tissue, along with increased expression of extracellular matrix remodelling-and inflammation-related genes Br. J. Nutr. 2015 114 497-498
125. A. Kim T. Park Diet-induced obesity regulates the galanin-mediated signaling cascade in the adipose tissue of mice Mol. Nutr. Food Res. 2010 54 1361-1370
126. P. Oliver J. Sánchez A. Caimari O. Miralles C. Picó A. Palou The intake of a high-fat diet triggers higher brown adipose tissue UCP1 levels in male rats but not in females Genes Nutr. 2007 2 125-126
127. E. García-Ruiz B. Reynés R. Díaz-Rúa E. Ceresi P. Oliver A. Palou The intake of high-fat diets induces the acquisition of brown adipocyte gene expression features in white adipose tissue Int. J. Obes. 2015 39 1619-1629
128. B. Cannon J. Nedergaard Brown adipose tissue: function and physiological significance Physiol. Rev. 2004 84 277-359
129. S. L. Brooks N. J. Rothwell M. J. Stock A. E. Goodbody P. Trayhurn Increased proton conductance pathway in brown adipose tissue mitochondria of rats exhibiting diet-induced thermogenesis Nature 1980 286 274-276
130. N. J. Rothwell M. J. Stock A role for brown adipose tissue in diet-induced thermogenesis Nature 1979 281 31-35
131. M. L. Bonet P. Oliver A. Palou Pharmacological and nutritional agents promoting browning of white adipose tissue Biochim. Biophys. Acta 2013 1831 969-985
132. S. Crowe S. M. Turpin F. Ke B. E. Kemp M. J. Watt Metabolic remodeling in adipocytes promotes ciliary neurotrophic factor-mediated fat loss in obesity Endocrinology 2008 149 2546-2556
133. T. Fromme M. Klingenspor Uncoupling protein 1 expression and high-fat diets Am. J. Physiol.: Regul., Integr. Comp. Physiol. 2011 300 R1-R8
134. S. H. Chiang M. Bazuine C. N. Lumeng L. M. Geletka J. Mowers N. M. White J. T. Ma J. Zhou N. Qi D. Westcott J. B. Delproposto T. S. Blackwell F. E. Yull A. R. Saltiel The protein kinase IKKepsilon regulates energy balance in obese mice Cell 2009 138 961-975
135. J. Margareto E. Larrarte A. Marti J. A. Martinez Up-regulation of a thermogenesis-related gene (UCP1) and down-regulation of PPARgamma and aP2 genes in adipose tissue: possible features of the antiobesity effects of a beta3-adrenergic agonist Biochem. Pharmacol. 2001 61 1471-1478
136. S. Kim I. Sohn J. I. Ahn K. H. Lee Y. S. Lee Hepatic gene expression profiles in a long-term high-fat diet-induced obesity mouse model Gene 2004 340 99-109
137. B. Reynes E. Garcia-Ruiz R. Diaz-Rua A. Palou P. Oliver Reversion to a control balanced diet is able to restore body weight and to recover altered metabolic parameters in adult rats long-term fed on a cafeteria diet Food Res. Int. 2014 64 839-848
138. E. D. Abel Free fatty acid oxidation in insulin resistance and obesity Heart Metab. 2010 48 5-10
139. P. Oliver B. Reynés A. Caimari A. Palou Peripheral blood mononuclear cells: a potential source of homeostatic imbalance markers associated with obesity development Pflugers Arch 2013 465 459-468
140. Y. Luo C. M. Burrington E. C. Graff J. Zhang R. L. Judd P. Suksaranjit Q. Kaewpoowat S. K. Davenport A. M. O'Neill M. W. Greene Metabolic phenotype and adipose and liver features in a high-fat Western diet-induced mouse model of obesity-linked NAFLD Am. J. Physiol.: Endocrinol. Metab. 2016 310 E418-E439
141. T. Murase T. Mizuno T. Omachi K. Onizawa Y. Komine H. Kondo T. Hase I. Tokimitsu Dietary diacylglycerol suppresses high fat and high sucrose diet-induced body fat accumulation in C57BL/6J mice J. Lipid Res. 2001 42 372-378
142. F. M. Gregoire Q. Zhang S. J. Smith C. Tong D. Ross H. Lopez D. B. West Diet-induced obesity and hepatic gene expression alterations in C57BL/6J and ICAM-1-deficient mice Am. J. Physiol.: Endocrinol. Metab. 2002 282 E703-E713
143. C. R. Barbosa E. M. Albuquerque E. C. Faria H. C. Oliveira L. N. Castilho Opposite lipemic response of Wistar rats and C57BL/6 mice to dietary glucose or fructose supplementation Braz. J. Med. Biol. Res. 2007 40 323-331
144. M. Y. Um M. K. Moon J. Ahn T. Youl Ha Coumarin attenuates hepatic steatosis by down-regulating lipogenic gene expression in mice fed a high-fat diet Br. J. Nutr. 2013 109 1590-1597
145. L. Zhang B. Yang B. Yu Paeoniflorin Protects against Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet in Mice Biol. Pharm. Bull. 2015 38 1005-1011
146. T. H. Reynolds S. Banerjee V. M. Sharma J. Donohue S. Couldwell A. Sosinsky A. Frulla A. Robinson V. Puri Effects of a High Fat Diet and Voluntary Wheel Running Exercise on Cidea and Cidec Expression in Liver and Adipose Tissue of Mice PLoS One 2015 10 e0130259
147. H. Wu M. Jin D. Han M. Zhou X. Mei Y. Guan C. Liu Protective effects of aerobic swimming training on high-fat diet induced nonalcoholic fatty liver disease: regulation of lipid metabolism via PANDER-AKT pathway Biochem. Biophys. Res. Commun. 2015 458 862-868
148. C. Tang K. Zhang Q. Zhao J. Zhang Effects of Dietary Genistein on Plasma and Liver Lipids, Hepatic Gene Expression, and Plasma Metabolic Profiles of Hamsters with Diet-Induced Hyperlipidemia J. Agric. Food Chem. 2015 63 7929-7936
149. S. Laos A. Caimari A. Crescenti J. Lakkis F. Puiggròs L. Arola J. M. del Bas Long-term intake of soyabean phytosterols lowers serum TAG and NEFA concentrations, increases bile acid synthesis and protects against fatty liver development in dyslipidaemic hamsters Br. J. Nutr. 2014 112 663-673
150. P. de Lange M. Moreno E. Silvestri A. Lombardi F. Goglia A. Lanni Fuel economy in food-deprived skeletal muscle: signaling pathways and regulatory mechanisms FASEB J. 2007 21 3431-3441
151. D. S. Weigle L. E. Selfridge M. W. Schwartz R. J. Seeley D. E. Cummings P. J. Havel J. L. Kuijper H. BeltrandelRio Elevated free fatty acids induce uncoupling protein 3 expression in muscle: a potential explanation for the effect of fasting Diabetes 1998 47 298-302
152. G. Y. Song L. P. Ren S. C. Chen C. Wang N. Liu L. M. Wei F. Li W. Sun L. B. Peng Y. Tang Similar changes in muscle lipid metabolism are induced by chronic high-fructose feeding and high-fat feeding in C57BL/J6 mice Clin. Exp. Pharmacol. Physiol. 2012 39 1011-1018
153. F. Felipe M. L. Bonet J. Ribot A. Palou Up-regulation of muscle uncoupling protein 3 gene expression in mice following high fat diet, dietary vitamin A supplementation and acute retinoic acid-treatment Int. J. Obes. Relat. Metab. Disord. 2003 27 60-69
154. L. M. Sparks H. Xie R. A. Koza R. Mynatt M. W. Hulver G. A. Bray S. R. Smith A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle Diabetes 2005 54 1926-1933
155. M. Palou T. Priego J. Sánchez E. Villegas A. M. Rodríguez A. Palou C. Picó Sequential changes in the expression of genes involved in lipid metabolism in adipose tissue and liver in response to fasting Pflugers Arch. 2008 456 825-836
156. M. Palou J. Sánchez T. Priego A. M. Rodríguez C. Picó A. Palou Regional differences in the expression of genes involved in lipid metabolism in adipose tissue in response to short-and medium-term fasting and refeeding J. Nutr. Biochem. 2010 21 23-33
157. J. C. Matamala M. Gianotti J. Pericás S. Quevedo P. Roca A. Palou F. J. García-Palmer Changes induced by fasting and dietetic obesity in thermogenic parameters of rat brown adipose tissue mitochondrial subpopulations Biochem. J. 1996 319 Pt 2 529-534
158. A. M. Rodríguez P. Roca M. L. Bonet C. Picó P. Oliver A. Palou Positive correlation of skeletal muscle UCP3 mRNA levels with overweight in male, but not in female, rats Am. J. Physiol.: Regul., Integr. Comp. Physiol. 2003 285 R880-R888
159. B. J. Rolls E. A. Rowe R. C. Turner Persistent obesity in rats following a period of consumption of a mixed, high energy diet J. Physiol. 1980 298 415-427
160. T. South F. Westbrook M. J. Morris Neurological and stress related effects of shifting obese rats from a palatable diet to chow and lean rats from chow to a palatable diet Physiol. Behav. 2012 105 1052-1057
161. Z. Y. Ong A. F. Wanasuria M. Z. Lin J. Hiscock B. S. Muhlhausler Chronic intake of a cafeteria diet and subsequent abstinence. Sex-specific effects on gene expression in the mesolimbic reward system Appetite 2013 65 189-199
162. B. E. Levin A. A. Dunn-Meynell Defense of body weight depends on dietary composition and palatability in rats with diet-induced obesity Am. J. Physiol.: Regul., Integr. Comp. Physiol. 2002 282 R46-R54
163. R. Díaz-Rúa E. M. van Schothorst J. Keijer A. Palou P. Oliver Isocaloric high-fat feeding directs hepatic metabolism to handling of nutrient imbalance promoting liver fat deposition Int. J. Obes. 2016 40 1250-1259
164. V. D. de Mello M. Kolehmanien U. Schwab L. Pulkkinen M. Uusitupa Gene expression of peripheral blood mononuclear cells as a tool in dietary intervention studies: What do we know so far? Mol. Nutr. Food Res. 2012 56 1160-1172
165. C. C. Liew J. Ma H. C. Tang R. Zheng A. A. Dempsey The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool J. Lab. Clin. Med. 2006 147 126-132
166. G. Sala G. Stefanoni A. Arosio C. Riva L. Melchionda E. Saracchi S. Fermi L. Brighina C. Ferrarese Reduced expression of the chaperone-mediated autophagy carrier hsc70 protein in lymphomonocytes of patients with Parkinson's disease Brain Res. 2014 1546 46-52
167. Y. Huang S. F. Ma R. Vij J. M. Oldham J. Herazo-Maya S. M. Broderick M. E. Strek S. R. White D. K. Hogarth N. K. Sandbo Y. A. Lussier K. F. Gibson N. Kaminski J. G. Garcia I. Noth A functional genomic model for predicting prognosis in idiopathic pulmonary fibrosis BMC Pulm. Med. 2015 15 147
168. A. Caimari P. Oliver W. Rodenburg J. Keijer A. Palou Slc27a2 expression in peripheral blood mononuclear cells as a molecular marker for overweight development Int. J. Obes. 2010 34 831-839
169. A. Caimari P. Oliver W. Rodenburg J. Keijer A. Palou Feeding conditions control the expression of genes involved in sterol metabolism in peripheral blood mononuclear cells of normoweight and diet-induced (cafeteria) obese rats J. Nutr. Biochem. 2010 21 1127-1133
170. A. Caimari P. Oliver J. Keijer A. Palou Peripheral blood mononuclear cells as a model to study the response of energy homeostasis-related genes to acute changes in feeding conditions OMICS 2010 14 129-141
171. R. Díaz-Rúa J. Keijer A. Caimari E. M. van Schothorst A. Palou P. Oliver Peripheral blood mononuclear cells as a source to detect markers of homeostatic alterations caused by the intake of diets with an unbalanced macronutrient composition J. Nutr. Biochem. 2015 26 398-407
172. B. Reynés E. García-Ruiz A. Palou P. Oliver The intake of high-fat diets induces an obesogenic-like gene expression profile in peripheral blood mononuclear cells, which is reverted by dieting Br. J. Nutr. 2016 1-9
173. B. Reynés E. García-Ruiz P. Oliver A. Palou Gene expression of peripheral blood mononuclear cells is affected by cold exposure Am. J. Physiol.: Regul., Integr. Comp. Physiol. 2015 309 R824-R834
174. J. Konieczna J. Sánchez M. Palou C. Picó A. Palou Blood cell transcriptomic-based early biomarkers of adverse programming effects of gestational calorie restriction and their reversibility by leptin supplementation Sci. Rep. 2015 5 9088
175. J. Konieczna J. Sánchez E. M. van Schothorst J. M. Torrens A. Bunschoten M. Palou C. Picó J. Keijer A. Palou Identification of early transcriptome-based biomarkers related to lipid metabolism in peripheral blood mononuclear cells of rats nutritionally programmed for improved metabolic health Genes Nutr. 2014 9 366
176. M. Kawasaki M. Fujishiro A. Yamaguchi K. Nozawa H. Kaneko Y. Takasaki K. Takamori H. Ogawa I. Sekigawa Fluctuations in the gene expression of peripheral blood mononuclear cells between the active and inactive phases of systemic lupus erythematosus Clin. Exp. Rheumatol. 2010 28 311-317
177. X. Jia H. Yu H. Zhang Y. Si D. Tian X. Zhao J. Luan H. Jia Integrated analysis of different microarray studies to identify candidate genes in type 1 diabetes J. Diabetes 2016 10.1111/1753-0407.12391
178. Y. Y. Wu Y. T. Hwang W. C. Perng C. F. Chian C. L. Ho S. C. Lee H. Chang H. J. Terng T. Y. Chao CPEB4 and IRF4 expression in peripheral mononuclear cells are potential prognostic factors for advanced lung cancer J. Formosan Med. Assoc. 2016
179. pii: S0929-6646(16)00050-4
180. N. Yalçınkaya H. Haytural B. Bilgiç Ö. Özdemir H. Hanağası C. Küçükali Z. Özbek U. Akcan H. A. İdrisoğlu H. Gürvit E. Tüzün Expression changes of genes associated with apoptosis and survival processes in Parkinson's disease Neurosci. Lett. 2016 615 72-77
181. L. M. Browning C. G. Walker A. P. Mander A. L. West J. Gambell J. Madden P. C. Calder S. A. Jebb Compared with Daily, Weekly n-3 PUFA Intake Affects the Incorporation of Eicosapentaenoic Acid and Docosahexaenoic Acid into Platelets and Mononuclear Cells in Humans J. Nutr. 2014 144 667-672
182. J. Sánchez T. Priego C. Picó W. Ahrens S. De Henauw A. Fraterman S. Mårild D. Molnár L. A. Moreno J. Peplies P. Russo A. Siani M. Tornaritis T. Veidebaum A. Palou I. Consortium Blood cells as a source of transcriptional biomarkers of childhood obesity and its related metabolic alterations: results of the IDEFICS study J. Clin. Endocrinol. Metab. 2012 97 E648-E652
183. T. Priego J. Sánchez C. Picó W. Ahrens K. Bammann S. De Henauw A. Fraterman L. Iacoviello L. Lissner D. Molnár L. A. Moreno A. Siani M. Tornaritis T. Veidebaum A. Palou I. Consortium Influence of breastfeeding on blood-cell transcript-based biomarkers of health in children Pediatr. Obes. 2014 9 463-470
184. T. Priego J. Sánchez C. Picó W. Ahrens S. De Henauw Y. Kourides L. Lissner D. Molnár L. A. Moreno P. Russo A. Siani T. Veidebaum A. Palou I. A. T. I. F. Consortia TAS1R3 and UCN2 Transcript Levels in Blood Cells Are Associated With Sugary and Fatty Food Consumption in Children J. Clin. Endocrinol. Metab. 2015 100 3556-3564
185. S. Endres R. Ghorbani V. E. Kelley K. Georgilis G. Lonnemann J. W. van der Meer J. G. Cannon T. S. Rogers M. S. Klempner P. C. Weber The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells N. Engl. J. Med. 1989 320 265-271
186. W. E. Kaminski E. Jendraschak R. Kiefl C. von Schacky Dietary omega-3 fatty acids lower levels of platelet-derived growth factor mRNA in human mononuclear cells Blood 1993 81 1871-1879
187. D. Esser S. J. van Dijk E. Oosterink S. Lopez M. Müller L. A. Afman High fat challenges with different fatty acids affect distinct atherogenic gene expression pathways in immune cells from lean and obese subjects Mol. Nutr. Food Res. 2015 59 1563-1572
188. M. Bouwens M. Grootte Bromhaar J. Jansen M. Müller L. A. Afman Postprandial dietary lipid-specific effects on human peripheral blood mononuclear cell gene expression profiles Am. J. Clin. Nutr. 2010 91 208-217
189. P. C. Tsiotra V. Pappa S. A. Raptis C. Tsigos Expression of the long and short leptin receptor isoforms in peripheral blood mononuclear cells: implications for leptin's actions Metabolism 2000 49 1537-1541
190. S. Goldstein M. Blecher R. Binder P. V. Perrino L. Recant Hormone receptors, 5. Binding of glucagon and insulin to human circulating mononuclear cells in diabetes mellitus Endocr. Res. Commun. 1975 2 367-376
191. A. C. Powers S. S. Solomon W. C. Duckworth Insulin degradation by mononuclear cells Diabetes 1980 29 27-32
192. A. Samara B. Marie M. Pfister S. Visvikis-Siest Leptin expression in Peripheral Blood Mononuclear Cells (PBMCs) is related with blood pressure variability Clin. Chim. Acta 2008 395 47-50
193. P. C. Tsiotra C. Tsigos E. Yfanti E. Anastasiou M. Vikentiou K. Psarra C. Papasteriades S. A. Raptis Visfatin, TNF-alpha and IL-6 mRNA expression is increased in mononuclear cells from type 2 diabetic women Horm. Metab. Res. 2007 39 758-763
194. U. Mager M. Kolehmainen V. D. de Mello U. Schwab D. E. Laaksonen R. Rauramaa H. Gylling M. Atalay L. Pulkkinen M. Uusitupa Expression of ghrelin gene in peripheral blood mononuclear cells and plasma ghrelin concentrations in patients with metabolic syndrome Eur. J. Endocrinol. 2008 158 499-510
195. K. Sato H. Arai A. Mizuno M. Fukaya T. Sato M. Koganei H. Sasaki H. Yamamoto Y. Taketani T. Doi E. Takeda Dietary palatinose and oleic acid ameliorate disorders of glucose and lipid metabolism in Zucker fatty rats J. Nutr. 2007 137 1908-1915
196. V. M. Rodríguez M. P. Portillo C. Picó M. T. Macarulla A. Palou Olive oil feeding up-regulates uncoupling protein genes in rat brown adipose tissue and skeletal muscle Am. J. Clin. Nutr. 2002 75 213-220
197. T. A. Burns S. K. Duckett S. L. Pratt T. C. Jenkins Supplemental palmitoleic (C16:1 cis-9) acid reduces lipogenesis and desaturation in bovine adipocyte cultures J. Anim. Sci. 2012 90 3433-3441
198. A. E. Huerta P. L. Prieto-Hontoria N. Sáinz J. A. Martínez M. J. Moreno-Aliaga Supplementation with α-Lipoic Acid Alone or in Combination with Eicosapentaenoic Acid Modulates the Inflammatory Status of Healthy Overweight or Obese Women Consuming an Energy-Restricted Diet J. Nutr. 2016 46 889S-896S
199. Y. J. Chen C. C. Chen T. K. Li P. H. Wang L. R. Liu F. Y. Chang Y. C. Wang Y. H. Yu S. P. Lin H. J. Mersmann S. T. Ding Docosahexaenoic acid suppresses the expression of FoxO and its target genes J. Nutr. Biochem. 2012 23 1609-1616
200. D. B. Jump N-3 polyunsaturated fatty acid regulation of hepatic gene transcription Curr. Opin. Lipidol. 2008 19 242-247
201. Y. J. Kim J. Y. Choi R. Ryu J. Lee S. J. Cho E. Y. Kwon M. K. Lee K. H. Liu Y. Rina M. K. Sung M. S. Choi Platycodon grandiflorus Root Extract Attenuates Body Fat Mass, Hepatic Steatosis and Insulin Resistance through the Interplay between the Liver and Adipose Tissue Nutrients 2016 8
202. pii: E532
203. F. Xu B. Lin X. Zheng Z. Chen H. Cao H. Xu H. Liang J. Weng GLP-1 receptor agonist promotes brown remodelling in mouse white adipose tissue through SIRT1 Diabetologia 2016 59 1059-1069
204. K. Misawa K. Hashizume M. Yamamoto Y. Minegishi T. Hase A. Shimotoyodome Ginger extract prevents high-fat diet-induced obesity in mice via activation of the peroxisome proliferator-activated receptor δ pathway J. Nutr. Biochem. 2015 26 1058-1067
205. K. D. Shearer N. Morrice C. Henderson J. Reekie G. D. Mcilroy P. J. McCaffery M. Delibegovic N. Mody Fenretinide prevents obesity in aged female mice in association with increased retinoid and estrogen signaling Obesity 2015 23 1655-1662
206. I. R. Hansen K. M. Jansson B. Cannon J. Nedergaard Contrasting effects of cold acclimation versus obesogenic diets on chemerin gene expression in brown and brite adipose tissues Biochim. Biophys. Acta 2014 1841 1691-1699
207. B. Xue J. Nie X. Wang D. C. DuBois W. J. Jusko R. R. Almon Effects of High Fat Feeding on Adipose Tissue Gene Expression in Diabetic Goto-Kakizaki Rats Gene Regul. Syst. Biol. 2015 9 15-26
208. M. Gao Y. Ma M. Alsaggar D. Liu Dual Outcomes of Rosiglitazone Treatment on Fatty Liver AAPS J. 2016 18 1023-1031
209. A. M. Hall N. Soufi K. T. Chambers Z. Chen G. G. Schweitzer K. S. McCommis D. M. Erion M. J. Graham X. Su B. N. Finck Abrogating monoacylglycerol acyltransferase activity in liver improves glucose tolerance and hepatic insulin signaling in obese mice Diabetes 2014 63 2284-2296
210. Y. J. Choi H. R. Suh Y. Yoon K. J. Lee D. G. Kim S. Kim B. H. Lee Protective effect of resveratrol derivatives on high-fat diet induced fatty liver by activating AMP-activated protein kinase Arch. Pharmacal Res. 2014 37 1169-1176
211. M. Dahlhoff S. Pfister A. Blutke J. Rozman M. Klingenspor M. J. Deutsch B. Rathkolb B. Fink M. Gimpfl M. Hrabě de Angelis A. A. Roscher E. Wolf R. Ensenauer Peri-conceptional obesogenic exposure induces sex-specific programming of disease susceptibilities in adult mouse offspring Biochim. Biophys. Acta 2014 1842 304-317
212. A. Ferramosca A. Conte F. Damiano L. Siculella V. Zara Differential effects of high-carbohydrate and high-fat diets on hepatic lipogenesis in rats Eur. J. Nutr. 2014 53 1103-1114
213. M. Suk Y. Shin Effect of high-intensity exercise and high-fat diet on lipid metabolism in the liver of rats J. Exerc. Nutr. Biochem. 2015 19 289-295
214. X. Li J. Li X. Lu H. Ma H. Shi H. Li D. Xie L. Dong C. Liang Treatment with PPARδ agonist alleviates non-alcoholic fatty liver disease by modulating glucose and fatty acid metabolic enzymes in a rat model Int. J. Mol. Med. 2015 36 767-775
215. A. Caimari A. Crescenti F. Puiggròs N. Boqué L. Arola J. M. Del Bas The intake of a high-fat diet and grape seed procyanidins induces gene expression changes in peripheral blood mononuclear cells of hamsters: capturing alterations in lipid and cholesterol metabolisms Genes Nutr. 2015 10 438