Challenges in obesity research;Retos de investigación en obesidad

Nutricion Hospitalaria

Volumn 28, Issue SUPPL.5, 2013, Pages 144-153

  Palou, Andreu ^a   Luisa Bonet, M ^a  

^a UNIVERSITAT DE LES ILLES BALEARS   (Spain)

Author keywords

Body weigth; Obesity; Research challenges

Indexed keywords

BODY WEIGHT; DIET; FOOD; GENETICS; HUMAN; LIFESTYLE; MEDICAL RESEARCH; METABOLISM; NUTRIGENOMICS; OBESITY; REVIEW;

BIOMEDICAL RESEARCH; BODY WEIGHT; DIET; FOOD; HUMANS; LIFE STYLE; NUTRIGENOMICS; OBESITY;

EID: 84883191124     PISSN: 02121611     EISSN: 16995198     Source Type: Journal    
DOI: 10.3305/nh.2013.28.sup5.6930     Document Type: Article

References (58)

1. Palou A, Pico C, Bonet ML. The molecular basis of body weight control. Forum Nutr 2003; 56: 164-8.
2. Saito M. Brown adipose tissue as a regulator of energy expenditure and body fat in humans. Diabetes Metab J 2013; 37: 22-9.
3. Bartelt A, Bruns OT, Reimer R, Hohenberg H, Ittrich H, Peldschus K, et al. Brown adipose tissue activity controls triglyceride clearance. Nat Med 2011; 17: 200-5.
4. Stanford KI, Middelbeek RJ, Townsend KL, An D, Nygaard EB, Hitchcox KM, et al. Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J Clin Invest 2013; 123: 215-23.
5. Bonet ML, Oliver P, Palou A. Pharmacological and nutritional agents promoting browning of white adipose tissue. Biochim Biophys Acta 2013; 1831: 969-85.
6. Seale P, Lazar MA. Brown fat in humans: turning up the heat on obesity. Diabetes 2009; 58: 1482-4.
7. Hullar MA, Lampe JW. The gut microbiome and obesity. Nestle Nutr Inst Workshop Ser 2012; 73: 67-79.
8. Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006; 444: 1027-31.
9. Tilg H, Kaser A. Gut microbiome, obesity, and metabolic dysfunction. J Clin Invest 2011; 121: 2126-32.
10. Herrera BM, Keildson S, Lindgren CM. Genetics and epigenetics of obesity. Maturitas 2011; 69: 41-9.
11. Rankinen T, Zuberi A, Chagnon YC, Weisnagel SJ, Argyropoulos G, Walts B, et al. The human obesity gene map: the 2005 update. Obesity (Silver Spring) 2006; 14: 529-644.
12. Sandholt CH, Hansen T, Pedersen O. Beyond the fourth wave of genome-wide obesity association studies. Nutr Diabetes 2012; 2: e37.
13. Bird A. Perceptions of epigenetics. Nature 2007; 447: 396-8.
14. Waterland RA, Jirtle RL. Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition 2004; 20: 63-8.
15. Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 2007; 318: 1469-72.
16. Tateishi K, Okada Y, Kallin EM, Zhang Y. Role of Jhdm2a in regulating metabolic gene expression and obesity resistance. Nature 2009; 458: 757-61.
17. Widiker S, Karst S, Wagener A, Brockmann GA. High-fat diet leads to a decreased methylation of the Mc4r gene in the obese BFMI and the lean B6 mouse lines. J Appl Genet 2010; 51: 193-7.
18. Plagemann A, Harder T, Brunn M, Harder A, Roepke K, Wittrock-Staar M, et al. Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome. J Physiol 2009; 587: 4963-4976.
19. Palou M, Pico C, McKay JA, Sánchez J, Priego T, Mathers JC, Palou A. Protective effects of leptin during the suckling period against later obesity may be associated with changes in promoter methylation of the hypothalamic pro-opiomelanocortin gene. Br J Nutr 2011; 106: 769-78.
20. Milagro FI, Campion J, García-Díaz DF, Goyenechea E, Paternain L, Martínez JA. High fat diet-induced obesity modifies the methylation pattern of leptin promoter in rats. J Physiol Biochem 2009; 65: 1-9.
21. Gemma C, Sookoian S, Alvarinas J, García SI, Quintana L, Kanevsky D, et al. Maternal pregestational BMI is associated with methylation of the PPARGC1A promoter in newborns. Obesity (Silver Spring) 2009; 17: 1032-9.
22. Brons C, Jacobsen S, Nilsson E, Ronn T, Jensen CB, Storgaard H, et al. Deoxyribonucleic acid methylation and gene expression of PPARGC1A in human muscle is influenced by high-fat overfeeding in a birth-weight-dependent manner. J Clin Endocrinol Metab 2010; 95: 3048-56.
23. Godfrey KM, Sheppard A, Gluckman PD, Lillycrop KA, Burdge GC, McLean C, et al. Epigenetic Gene Promoter Methylation at Birth Is Associated With Child's Later Adiposity. Diabetes 2011; 60: 1528-34.
24. Dehwah MA, Xu A, Huang Q. MicroRNAs and type 2 diabetes/obesity. J Genet Genomics 2012; 39: 11-8.
25. Park T. Nutrigenomics-uncovering dietary signatures in obesity and metabolic diseases. Biotechnol J 2010; 5: 905.
26. Kim KH, and Park Y. Food components with anti-obesity effect. Annu Rev Food Sci Technol 2011; 2: 237-57.
27. Bonet ML, Ribot J, and Palou A. Lipid metabolism in mammalian tissues and its control by retinoic acid. Biochim Biophys Acta 2012; 1821: 177-89.
28. Rudkowska I, Perusse L. Individualized weight management: what can be learned from nutrigenomics and nutrigenetics? Prog Mol Biol Transl Sci 2012; 108: 347-82.
29. Abete I, Navas-Carretero S, Marti A, Martínez JA. Nutrigenetics and nutrigenomics of caloric restriction. Prog Mol Biol Transl Sci 2012; 108: 323-46.
30. de Roos B. Personalised nutrition: ready for practice? Proc Nutr Soc 2012; 72: 48-52.
31. Woods SC, Seeley RJ, Cota D. Regulation of food intake through hypothalamic signaling networks involving mTOR. Annu Rev Nutr 2008; 28: 295-311.
32. Petrovich GD. Forebrain networks and the control of feeding by environmental learned cues. Physiol Behav 2013.
33. Shin AC, Berthoud HR. Food reward functions as affected by obesity and bariatric surgery. Int J Obes (Lond) 2011; 35 (Suppl 3): S40-4.
34. Cohen DA. Obesity and the built environment: changes in environmental cues cause energy imbalances. Int J Obes (Lond) 2008; 32 (Suppl 7): S137-42.
35. Garland T, Jr., Schutz H, Chappell MA, Keeney BK, Meek TH, Copes LE, et al. The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: human and rodent perspectives. J Exp Biol 2011; 214: 206-29.
36. Bray MS, Hagberg JM, Perusse L, Rankinen T, Roth SM, Wolfarth B, et al. The human gene map for performance and health-related fitness phenotypes: the 2006-2007 update. Med Sci Sports Exerc 2009; 41: 35-73.
37. King NA, Horner K, Hills AP, Byrne NM, Wood RE, Bryant E, et al. Exercise, appetite and weight management: understanding the compensatory responses in eating behaviour and how they contribute to variability in exercise-induced weight loss. Br J Sports Med 2012; 46: 315-22.
38. Palou A, Bonet ML, Pico C. On the role and fate of sugars in human nutrition and health. Introduction. Obes Rev 2009; 10 Suppl 1): 1-8.
39. Arola L, Bonet ML, Delzenne N, Duggal MS, Gómez-Candela C, Huyghebaert A, et al. Summary and general conclusions/outcomes on the role and fate of sugars in human nutrition and health. Obes Rev 2009; 10 (Suppl 1): 55-8.
40. Muhlhausler BS, Ailhaud GP. Omega-6 polyunsaturated fatty acids and the early origins of obesity. Curr Opin Endocrinol Diabetes Obes 2013; 20: 56-61.
41. Alvheim AR, Malde MK, Osei-Hyiaman D, Lin YH, Pawlosky RJ, Madsen L, et al. Dietary linoleic acid elevates endogenous 2-AG and anandamide and induces obesity. Obesity (Silver Spring) 2012; 20: 1984-94.
42. Pico C, Oliver P, Sánchez J, Miralles O, Caimari A, Priego T, et al. The intake of physiological doses of leptin during lactation in rats prevents obesity in later life. Int J Obes (Lond) 2007; 31: 1199-209.
43. Pico C, Palou M, Priego T, Sánchez J, Palou A. Metabolic programming of obesity by energy restriction during the perinatal period: different outcomes depending on gender and period, type and severity of restriction. Front Physiol 2012; 3: 436.
44. Delahaye F, Breton C, Risold PY, Enache M, Dutriez-Casteloot I, Laborie C, et al. Maternal perinatal undernutrition drastically reduces postnatal leptin surge and affects the development of arcuate nucleus proopiomelanocortin neurons in neonatal male rat pups. Endocrinology 2008; 149: 470-5.
45. García AP, Palou M, Sánchez J, Priego T, Palou A, Pico C. Moderate caloric restriction during gestation in rats alters adipose tissue sympathetic innervation and later adiposity in offspring. PLoS One 2011; 6: e17313.
46. Rosenberg IH. Metabolic programming of offspring by vitamin B12/folate imbalance during pregnancy. Diabetologia 2008; 51: 6-7.
47. López N, Sánchez J, Pico C, Palou A, Serra F. Dietary l-leucine supplementation of lactating rats results in a tendency to increase lean/fat ratio associated to lower orexigenic neuropeptide expression in hypothalamus. Peptides 2010; 31: 1361-7.
48. Granados N, Amengual J, Ribot J, Musinovic H, Ceresi E, von Lintig J, et al. Vitamin A supplementation in early life affects later response to an obesogenic diet in rats. Int J Obes (Lond) 2012.
49. Priego T, Sánchez J, García AP, Palou A, Pico C. Maternal dietary fat affects milk Fatty Acid profile and impacts on weight gain and thermogenic capacity of suckling rats. Lipids 2013; 48: 481-95.
50. Sánchez J, Priego T, Palou M, Tobaruela A, Palou A, Pico C. Oral supplementation with physiological doses of leptin during lactation in rats improves insulin sensitivity and affects food preferences later in life. Endocrinology 2008; 149: 733-40.
51. Priego T, Sánchez J, Palou A, Pico C. Leptin intake during the suckling period improves the metabolic response of adipose tissue to a high-fat diet. Int J Obes (Lond) 2010; 34: 809-19.
52. Palou A, Sánchez J, and Pico C. Nutrient-gene interactions in early life programming: leptin in breast milk prevents obesity later on in life. Adv Exp Med Biol 2009; 646: 95-104.
53. Miralles O, Sánchez J, Palou A, Pico C. A physiological role of breast milk leptin in body weight control in developing infants. Obesity (Silver Spring) 2006; 14: 1371-7.
54. Doneray H, Orbak Z, Yildiz L. The relationship between breast milk leptin and neonatal weight gain. Acta Paediatr 2009; 98: 643-7.
55. Schuster S, Hechler C, Gebauer C, Kiess W, Kratzsch J. Leptin in maternal serum and breast milk: association with infants' body weight gain in a longitudinal study over 6 months of lactation. Pediatr Res 2011; 70: 633-7.
56. McAllister EJ, Dhurandhar NV, Keith SW, Aronne LJ, Barger J, Baskin M, et al. Ten putative contributors to the obesity epidemic. Crit Rev Food Sci Nutr 2009; 49: 868-913.
57. Joint Programme Initiative A Healthy Diet for a Healthy Life. The vision for 2030. https://www.healthydietforhealthylife.eu/ 2010.
58. Jebb SA, Lang R, Penrose A. Improving communication to tackle obesity in the UK. Proc Nutr Soc 2003; 62: 577-81.