Diet-induced obesity regulates the galanin-mediated signaling cascade in the adipose tissue of mice

Molecular Nutrition and Food Research

Volumn 54, Issue 9, 2010, Pages 1361-1370

  Kim, Ahreum ^a   Park, Taesun ^a  

^a Yonsei University   (South Korea)

Author keywords

Adipogenesis; Adipose tissue; Galanin; High fat diet; Obesity

Indexed keywords

FABP4 PROTEIN, MOUSE; FATTY ACID BINDING PROTEIN; GALANIN; GALANIN RECEPTOR; ISOPROTEIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE C; PROTEIN KINASE C GAMMA;

ADIPOGENESIS; ANIMAL; ARTICLE; C57BL MOUSE; CELL STRAIN 3T3; COMPARATIVE STUDY; FAT INTAKE; GENE EXPRESSION REGULATION; GENETICS; INTRAABDOMINAL FAT; MALE; METABOLISM; MOUSE; OBESITY; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SUBCUTANEOUS FAT;

3T3-L1 CELLS; ADIPOGENESIS; ANIMALS; DIETARY FATS; FATTY ACID-BINDING PROTEINS; GALANIN; GENE EXPRESSION REGULATION; INTRA-ABDOMINAL FAT; MALE; MICE; MICE, INBRED C57BL; MUSCLE, SKELETAL; OBESITY; PPAR GAMMA; PROTEIN ISOFORMS; PROTEIN KINASE C; RECEPTORS, GALANIN; RNA, MESSENGER; SIGNAL TRANSDUCTION; SUBCUTANEOUS FAT;

MUS;

EID: 77957094842     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.200900317     Document Type: Article

References (37)

1. Seta, Y., Kataoka, S., Toyono, T., Toyoshima, K., Expression of galanin and the galanin receptor in rat taste buds. Arch. Histol. Cytol. 2006, 69, 273-280.
2. Li, R. Y., Song, H. D., Shi, W. J., Hu, S. M. et al., Galanin inhibits leptin expression and secretion in rat adipose tissue and 3T3-L1 adipocytes. J. Mol. Endocrinol. 2004, 33, 11-19.
3. Anselmi, L., Lakhter, A., Hirano, A. A., Tonini, M., Sternini, C., Expression of galanin receptor messenger RNAs in different regions of the rat gastrointestinal tract. Peptides 2005, 26, 815-819.
4. Waters, S. M., Krause, J. E., Distribution of galanin-1, -2 and-3 receptor messenger RNAs in central and peripheral rat tissues. Neuroscience 2000, 95, 265-271.
5. Kyrkouli, S. E., Stanley, B. G., Leibowitz, S. F., Galanin: stimulation of feeding induced by medial hypothalamic injection of this novel peptide. Eur. J. Pharmacol. 1986, 122, 159-160.
6. Adams, A. C., Clapham, J. C., Wynick, D., Speakman, J. R., Feeding behaviour in galanin knockout mice supports a role of galanin in fat intake and preference. J. Neuroendocrinol. 2008, 20, 199-206.
7. Smith, B. K., York, D. A., Bray, G. A., Chronic cerebroventricular galanin does not induce sustained hyperphagia or obesity. Peptides 1994, 15, 1267-1272.
8. Wang, J., Akabayashi, A., Yu, H. J., Dourmashkin, J. et al., Hypothalamic galanin: control by signals of fat metabolism. Brain Res. 1998a, 804, 7-20.
9. Leibowitz, S. F., Akabayashi, A., Wang, J., Obesity on a high-fat diet: role of hypothalamic galanin in neurons of the anterior paraventricular nucleus projecting to the median eminence. J. Neurosci. 1998, 18, 2709-2719.
10. Wang, S., Hashemi, T., Fried, S., Clemmons, A. L., Hawes, B. E., Differential intracellular signaling of the GalR1 and GalR2 galanin receptor subtypes. Biochemistry 1998d, 37, 6711-6717.
11. Smith, K. E., Walker, M. W., Artymyshyn, R., Bard, J. et al., Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K1 channels. J. Biol. Chem. 1998, 273, 23321-23326.
12. Lang, R., Gundlach, A. L., Kofler, B., The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease. Pharmacol. Ther. 2007, 115, 177-207.
13. Badie-Mahdavi, H., Lu, X., Behrens, M. M., Bartfai, T., Role of galanin receptor 1 and galanin receptor 2 activation in synaptic plasticity associated with 30,50-cyclic AMP response element-binding protein phosphorylation in the dentate gyrus: studies with a galanin receptor 2 agonist and galanin receptor 1 knockout mice. Neuroscience 2005, 133, 591-604.
14. Lowell, B. B., Spiegelman, B. M., Towards a molecular understanding of adaptive thermogenesis. Nature 2000, 404, 652-660.
15. Kanazawa, T., Iwashita, T., Kommareddi, P., Nair, T. et al., Galanin and galanin receptor type 1 suppress proliferation in squamous carcinoma cells: activation of the extracellular signal regulated kinase pathway and induction of cyclindependent kinase inhibitors. Oncogene 2007, 26, 5762-5771.
16. Fathi, Z., Cunningham, A. M., Iben, L. G., Battaglino, P. B. et al., Cloning, pharmacological characterization and distribution of a novel galanin receptor. Brain Res. Mol. Brain Res. 1997, 51, 49-59.
17. Smith, K. E., Forray, C., Walker, M. W., Jones, K. A. et al., Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover. J. Biol. Chem. 1997b, 272, 24612-24616.
18. Hawes, J. J., Narasimhaiah, R., Picciotto, M. R., Galanin and galanin-like peptide modulate neurite outgrowth via protein kinase C-mediated activation of extracellular signalrelated kinase. Eur. J. Neurosci. 2006, 23, 2937-2946.
19. Prusty, D., Park, B. H., Davis, K. E., Farmer, S. R., Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator-activated receptor gamma (PPAR gamma) and C/EBPalpha gene expression during the differentiation of 3T3-L1 preadipocytes. J. Biol. Chem. 2002, 277, 46226-46232.
20. Henson, B. S., Neubig, R. R., Jang, I., Ogawa, T. et al., Galanin receptor 1 has anti-proliferative effects in oral squamous cell carcinoma. J. Biol. Chem. 2005, 280, 22564-22571.
21. Folch, J., Lees, M., Sloane Stanley, G. H., A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 1957, 226, 497-509.
22. Lundstrom, L., Elmquist, A., Bartfai, T., Langel, U., Galanin and its receptors in neurological disorders. Neuromolecular Med. 2005, 7, 157-180.
23. Galanin: Basic Research Discoveries and Therapeutic Implications, Proceedings of a conference. Stockholm, Sweden, May 3-5, 1998. Ann. NY Acad. Sci. 1998, 863, 1-469.
24. Bedecs, K., Berthold, M., Bartfai, T., Galanin - 10 years with a neuroendocrine peptide. Int. J. Biochem. Cell Biol. 1995, 27, 337-349.
25. Baranowska, B., Wasilewska-Dziubinska, E., Radzikowska, M., Plonowski, A., Roguski, K., Neuropeptide Y, galanin, and leptin release in obese women and in women with anorexia nervosa. Metabolism 1997, 46, 1384-1389.
26. Perez, S., Basile, M., Mash, D. C., Mufson, E. J., Galanin receptor over-expression within the amygdala in early Alzheimer's disease: an in vitro autoradiographic analysis. J. Chem. Neuroanat. 2002, 24, 109-116.
27. Seufferlein, T., Rozengurt, E., Galanin, neurotensin, and phorbol esters rapidly stimulate activation of mitogen-activated protein kinase in small cell lung cancer cells. Cancer Res. 1996, 56, 5758-5764.
28. Wittau, N., Grosse, R., Kalkbrenner, F., Gohla, A. et al., The galanin receptor type 2 initiates multiple signaling pathways in small cell lung cancer cells by coupling to G(q), G(i) and G(12) proteins. Oncogene 2000, 19, 4199-4209.
29. Berger, A., Lang, R., Moritz, K., Santic, R. et al., Galanin receptor subtype GalR2 mediates apoptosis in SH-SY5Y neuroblastoma cells. Endocrinology 2004, 145, 500-507.
30. Smith, P. J., Wise, L. S., Berkowitz, R., Wan, C., Rubin, C. S., Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytes. J. Biol. Chem. 1988, 263, 9402-9408.
31. Vertino, A. M., Taylor-Jones, J. M., Longo, K. A., Bearden, E. D. et al., Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts. Mol. Biol. Cell 2005, 16, 2039-2048.
32. Massague, J., Seoane, J., Wotton, D., Smad transcription factors. Genes Dev. 2005, 19, 2783-2810.
33. Kawaguchi, N., Toriyama, K., Nicodemou-Lena, E., Inou, K. et al., De novo adipogenesis in mice at the site of injection of basement membrane and basic fibroblast growth factor. Proc. Natl. Acad. Sci. USA 1998, 95, 1062-1066.
34. zur Nieden, N. I., Kempka, G., Rancourt, D. E., Ahr, H. J., Induction of chondro-, osteo- and adipogenesis in embryonic stem cells by bone morphogenetic protein-2: effect of cofactors on differentiating lineages. Biomed Chromatogr. Dev. Biol. 2005, 5, 1.
35. Kanazawa, T., Kommareddi, P. K., Iwashita, T., Kumar, B. et al., Galanin receptor subtype 2 suppresses cell proliferation and induces apoptosis in p53 mutant head and neck cancer cells. Clin. Cancer Res. 2009, 15, 2222-2230.
36. Kovsan, J., Osnis, A., Maissel, A., Mazor, L. et al., Depotspecific adipocyte cell lines reveal differential drug-induced responses of white adipocytes - relevance for partial lipodystrophy. Am. J. Physiol. Endocrinol. Metab. 2009, 296, E315-E322.
37. Karamitri, A., Shore, A. M., Docherty, K., Speakman, J. R., Lomax, M. A., Combinatorial transcription factor regulation of the cyclic AMP response element on the PGC-1alpha promoter in white 3T3-L1 and brown HIB-1B preadipocytes. J. Biol. Chem. 2009, 284, 20738-20752.