메뉴 건너뛰기




Volumn 69, Issue 2, 2013, Pages 165-175

A high-fat diet decreases AMPK activity in multiple tissues in the absence of hyperglycemia or systemic inflammation in rats

Author keywords

Adipose; Blood; Diabetes; Obesity

Indexed keywords

FATTY ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; ISOENZYME;

EID: 84879411833     PISSN: 11387548     EISSN: 18778755     Source Type: Journal    
DOI: 10.1007/s13105-012-0199-2     Document Type: Article
Times cited : (113)

References (61)
  • 3
    • 79955368052 scopus 로고    scopus 로고
    • The PPARbeta/delta activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1alpha-Lipin 1-PPARalpha pathway leading to increased fatty acid oxidation
    • 21363937 10.1210/en.2010-1468
    • Barroso E, Rodriguez-Calvo R, Serrano-Marco L, Astudillo AM, Balsinde J, Palomer X, Vazquez-Carrera M (2011) The PPARbeta/delta activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1alpha-Lipin 1-PPARalpha pathway leading to increased fatty acid oxidation. Endocrinology 152(5):1848-1859
    • (2011) Endocrinology , vol.152 , Issue.5 , pp. 1848-1859
    • Barroso, E.1    Rodriguez-Calvo, R.2    Serrano-Marco, L.3    Astudillo, A.M.4    Balsinde, J.5    Palomer, X.6    Vazquez-Carrera, M.7
  • 4
    • 17844368105 scopus 로고    scopus 로고
    • Unaltered TNF-alpha production by macrophages and monocytes in diet-induced obesity in the rat
    • 10.1186/1476-9255-2-2
    • Bedoui S, Velkoska E, Bozinovski S, Jones JE, Anderson GP, Morris MJ (2005) Unaltered TNF-alpha production by macrophages and monocytes in diet-induced obesity in the rat. J Inflamm (Lond) 2(1):2
    • (2005) J Inflamm (Lond) , vol.2 , Issue.1 , pp. 2
    • Bedoui, S.1    Velkoska, E.2    Bozinovski, S.3    Jones, J.E.4    Anderson, G.P.5    Morris, M.J.6
  • 5
    • 39149116349 scopus 로고    scopus 로고
    • Changes in adiponectin, its receptors and AMPK activity in tissues of diet-induced diabetic mice
    • 18222103 10.1016/j.diabet.2007.09.006
    • Bonnard C, Durand A, Vidal H, Rieusset J (2008) Changes in adiponectin, its receptors and AMPK activity in tissues of diet-induced diabetic mice. Diabetes Metab 34(1):52-61
    • (2008) Diabetes Metab , vol.34 , Issue.1 , pp. 52-61
    • Bonnard, C.1    Durand, A.2    Vidal, H.3    Rieusset, J.4
  • 6
    • 11144337833 scopus 로고    scopus 로고
    • Quantitative real-time PCR protocol for analysis of nuclear receptor signaling pathways
    • 16604184 10.1621/nrs.01012
    • Bookout AL, Mangelsdorf DJ (2003) Quantitative real-time PCR protocol for analysis of nuclear receptor signaling pathways. Nucl Recept Signal 1:e012
    • (2003) Nucl Recept Signal , vol.1 , pp. 012
    • Bookout, A.L.1    Mangelsdorf, D.J.2
  • 8
    • 79960490935 scopus 로고    scopus 로고
    • AMP-activated protein kinase: Nature's energy sensor
    • 21769098 10.1038/nchembio.610
    • Carling D, Mayer FV, Sanders MJ, Gamblin SJ (2011) AMP-activated protein kinase: nature's energy sensor. Nat Chem Biol 7(8):512-518
    • (2011) Nat Chem Biol , vol.7 , Issue.8 , pp. 512-518
    • Carling, D.1    Mayer, F.V.2    Sanders, M.J.3    Gamblin, S.J.4
  • 9
    • 33745183847 scopus 로고    scopus 로고
    • Functions of AMP-activated protein kinase in adipose tissue
    • 16709632 10.1113/jphysiol.2006.111484
    • Daval M, Foufelle F, Ferre P (2006) Functions of AMP-activated protein kinase in adipose tissue. J Physiol 574(Pt 1):55-62
    • (2006) J Physiol , vol.574 , Issue.PART 1 , pp. 55-62
    • Daval, M.1    Foufelle, F.2    Ferre, P.3
  • 10
    • 75349099919 scopus 로고    scopus 로고
    • Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer
    • 19778642 10.1016/j.bbapap.2009.09.012
    • Fogarty S, Hardie DG (2010) Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer. Biochim Biophys Acta 1804(3):581-591
    • (2010) Biochim Biophys Acta , vol.1804 , Issue.3 , pp. 581-591
    • Fogarty, S.1    Hardie, D.G.2
  • 11
    • 58149348480 scopus 로고    scopus 로고
    • Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of mice
    • 18728234 10.2337/db07-1187
    • Fujii N, Ho RC, Manabe Y, Jessen N, Toyoda T, Holland WL, Summers SA, Hirshman MF, Goodyear LJ (2008) Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of mice. Diabetes 57(11):2958-2966
    • (2008) Diabetes , vol.57 , Issue.11 , pp. 2958-2966
    • Fujii, N.1    Ho, R.C.2    Manabe, Y.3    Jessen, N.4    Toyoda, T.5    Holland, W.L.6    Summers, S.A.7    Hirshman, M.F.8    Goodyear, L.J.9
  • 12
    • 77950192925 scopus 로고    scopus 로고
    • Dysregulation of lipolysis and lipid metabolism in visceral and subcutaneous adipocytes by high-fat diet: Role of ATGL, HSL, and AMPK
    • 20107043 10.1152/ajpcell.00547.2009
    • Gaidhu MP, Anthony NM, Patel P, Hawke TJ, Ceddia RB (2010) Dysregulation of lipolysis and lipid metabolism in visceral and subcutaneous adipocytes by high-fat diet: role of ATGL, HSL, and AMPK. Am J Physiol Cell Physiol 298(4):C961-971
    • (2010) Am J Physiol Cell Physiol , vol.298 , Issue.4 , pp. 961-971
    • Gaidhu, M.P.1    Anthony, N.M.2    Patel, P.3    Hawke, T.J.4    Ceddia, R.B.5
  • 13
    • 78650964142 scopus 로고    scopus 로고
    • Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans
    • 21130749 10.1016/j.bbrc.2010.11.127
    • Gauthier MS, O'Brien EL, Bigornia S, Mott M, Cacicedo JM, Xu XJ, Gokce N, Apovian C, Ruderman N (2011) Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans. Biochem Biophys Res Commun 404(1):382-387
    • (2011) Biochem Biophys Res Commun , vol.404 , Issue.1 , pp. 382-387
    • Gauthier, M.S.1    O'Brien, E.L.2    Bigornia, S.3    Mott, M.4    Cacicedo, J.M.5    Xu, X.J.6    Gokce, N.7    Apovian, C.8    Ruderman, N.9
  • 14
    • 38149095747 scopus 로고    scopus 로고
    • Are there specific treatments for the metabolic syndrome?
    • 18175731
    • Giugliano D, Ceriello A, Esposito K (2008) Are there specific treatments for the metabolic syndrome? Am J Clin Nutr 87(1):8-11
    • (2008) Am J Clin Nutr , vol.87 , Issue.1 , pp. 8-11
    • Giugliano, D.1    Ceriello, A.2    Esposito, K.3
  • 15
    • 84860452513 scopus 로고    scopus 로고
    • Long-term high-fat-diet feeding induces skeletal muscle mitochondrial biogenesis in rats in a sex-dependent and muscle-type specific manner
    • 10.1186/1743-7075-9-15
    • Gomez-Perez Y, Capllonch-Amer G, Gianotti M, Llado I, Proenza AM (2012) Long-term high-fat-diet feeding induces skeletal muscle mitochondrial biogenesis in rats in a sex-dependent and muscle-type specific manner. Nutr Metab (Lond) 9:15
    • (2012) Nutr Metab (Lond) , vol.9 , pp. 15
    • Gomez-Perez, Y.1    Capllonch-Amer, G.2    Gianotti, M.3    Llado, I.4    Proenza, A.M.5
  • 16
    • 6044239443 scopus 로고    scopus 로고
    • Metabolic adaptations to fasting and chronic caloric restriction in heart, muscle, and liver do not include changes in AMPK activity
    • 15251868 10.1152/ajpendo.00172.2004
    • Gonzalez AA, Kumar R, Mulligan JD, Davis AJ, Weindruch R, Saupe KW (2004) Metabolic adaptations to fasting and chronic caloric restriction in heart, muscle, and liver do not include changes in AMPK activity. Am J Physiol Endocrinol Metab 287(5):E1032-1037
    • (2004) Am J Physiol Endocrinol Metab , vol.287 , Issue.5 , pp. 1032-1037
    • Gonzalez, A.A.1    Kumar, R.2    Mulligan, J.D.3    Davis, A.J.4    Weindruch, R.5    Saupe, K.W.6
  • 17
    • 38049009575 scopus 로고    scopus 로고
    • Effects of dietary lactose on long-term high-fat-diet-induced obesity in rats
    • 10.1038/oby.2007.312
    • Goseki-Sone M, Maruyama R, Sogabe N, Hosoi T (2007) Effects of dietary lactose on long-term high-fat-diet-induced obesity in rats. Obesity (Silver Spring) 15(11):2605-2613
    • (2007) Obesity (Silver Spring) , vol.15 , Issue.11 , pp. 2605-2613
    • Goseki-Sone, M.1    Maruyama, R.2    Sogabe, N.3    Hosoi, T.4
  • 18
    • 79955993481 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase and adiponectin during development of hepatic steatosis in high-fat diet-induced obesity in rats
    • 21255792 10.1016/j.jcpa.2010.11.011
    • Ha SK, Kim J, Chae C (2011) Role of AMP-activated protein kinase and adiponectin during development of hepatic steatosis in high-fat diet-induced obesity in rats. J Comp Pathol 145(1):88-94
    • (2011) J Comp Pathol , vol.145 , Issue.1 , pp. 88-94
    • Ha, S.K.1    Kim, J.2    Chae, C.3
  • 19
    • 80053035284 scopus 로고    scopus 로고
    • AMP-activated protein kinase: An energy sensor that regulates all aspects of cell function
    • 21937710 10.1101/gad.17420111
    • Hardie DG (2011) AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. Genes Dev 25(18):1895-1908
    • (2011) Genes Dev , vol.25 , Issue.18 , pp. 1895-1908
    • Hardie, D.G.1
  • 20
    • 79953193036 scopus 로고    scopus 로고
    • Sensing of energy and nutrients by AMP-activated protein kinase
    • 21325438 10.3945/ajcn.110.001925
    • Hardie DG (2011) Sensing of energy and nutrients by AMP-activated protein kinase. Am J Clin Nutr 93(4):891S-896S
    • (2011) Am J Clin Nutr , vol.93 , Issue.4
    • Hardie, D.G.1
  • 21
    • 0038199737 scopus 로고    scopus 로고
    • Management of cellular energy by the AMP-activated protein kinase system
    • 12829246 10.1016/S0014-5793(03)00560-X
    • Hardie DG, Scott JW, Pan DA, Hudson ER (2003) Management of cellular energy by the AMP-activated protein kinase system. FEBS Lett 546(1):113-120
    • (2003) FEBS Lett , vol.546 , Issue.1 , pp. 113-120
    • Hardie, D.G.1    Scott, J.W.2    Pan, D.A.3    Hudson, E.R.4
  • 22
    • 78650535334 scopus 로고    scopus 로고
    • High-fat diet-induced obesity in animal models
    • 20977819 10.1017/S0954422410000168
    • Hariri N, Thibault L (2010) High-fat diet-induced obesity in animal models. Nutr Res Rev 23(2):270-299
    • (2010) Nutr Res Rev , vol.23 , Issue.2 , pp. 270-299
    • Hariri, N.1    Thibault, L.2
  • 23
    • 63849125267 scopus 로고    scopus 로고
    • Insulin resistance and fuel homeostasis: The role of AMP-activated protein kinase
    • 10.1111/j.1748-1716.2009.01968.x
    • Hegarty BD, Turner N, Cooney GJ, Kraegen EW (2009) Insulin resistance and fuel homeostasis: the role of AMP-activated protein kinase. Acta Physiol (Oxf) 196(1):129-145
    • (2009) Acta Physiol (Oxf) , vol.196 , Issue.1 , pp. 129-145
    • Hegarty, B.D.1    Turner, N.2    Cooney, G.J.3    Kraegen, E.W.4
  • 24
    • 0345832116 scopus 로고    scopus 로고
    • Knockout of the alpha2 but not alpha1 5′-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4- ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle
    • 14573616 10.1074/jbc.M306205200
    • Jorgensen SB, Viollet B, Andreelli F, Frosig C, Birk JB, Schjerling P, Vaulont S, Richter EA, Wojtaszewski JF (2004) Knockout of the alpha2 but not alpha1 5′-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle. J Biol Chem 279(2):1070-1079
    • (2004) J Biol Chem , vol.279 , Issue.2 , pp. 1070-1079
    • Jorgensen, S.B.1    Viollet, B.2    Andreelli, F.3    Frosig, C.4    Birk, J.B.5    Schjerling, P.6    Vaulont, S.7    Richter, E.A.8    Wojtaszewski, J.F.9
  • 25
    • 20844451123 scopus 로고    scopus 로고
    • AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
    • 16054041 10.1016/j.cmet.2004.12.003
    • Kahn BB, Alquier T, Carling D, Hardie DG (2005) AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 1(1):15-25
    • (2005) Cell Metab , vol.1 , Issue.1 , pp. 15-25
    • Kahn, B.B.1    Alquier, T.2    Carling, D.3    Hardie, D.G.4
  • 27
    • 46449089402 scopus 로고    scopus 로고
    • Anti-obesity effects of Juniperus chinensis extract are associated with increased AMP-activated protein kinase expression and phosphorylation in the visceral adipose tissue of rats
    • 18591785 10.1248/bpb.31.1415
    • Kim SJ, Jung JY, Kim HW, Park T (2008) Anti-obesity effects of Juniperus chinensis extract are associated with increased AMP-activated protein kinase expression and phosphorylation in the visceral adipose tissue of rats. Biol Pharm Bull 31(7):1415-1421
    • (2008) Biol Pharm Bull , vol.31 , Issue.7 , pp. 1415-1421
    • Kim, S.J.1    Jung, J.Y.2    Kim, H.W.3    Park, T.4
  • 28
    • 70350560556 scopus 로고    scopus 로고
    • Nutrient stress activates inflammation and reduces glucose metabolism by suppressing AMP-activated protein kinase in the heart
    • 19690060 10.2337/db08-1361
    • Ko HJ, Zhang Z, Jung DY, Jun JY, Ma Z, Jones KE, Chan SY, Kim JK (2009) Nutrient stress activates inflammation and reduces glucose metabolism by suppressing AMP-activated protein kinase in the heart. Diabetes 58(11):2536-2546
    • (2009) Diabetes , vol.58 , Issue.11 , pp. 2536-2546
    • Ko, H.J.1    Zhang, Z.2    Jung, D.Y.3    Jun, J.Y.4    Ma, Z.5    Jones, K.E.6    Chan, S.Y.7    Kim, J.K.8
  • 29
    • 33645092172 scopus 로고    scopus 로고
    • Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats
    • 16234268 10.1152/ajpendo.00316.2005
    • Kraegen EW, Saha AK, Preston E, Wilks D, Hoy AJ, Cooney GJ, Ruderman NB (2006) Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats. Am J Physiol Endocrinol Metab 290(3):E471-479
    • (2006) Am J Physiol Endocrinol Metab , vol.290 , Issue.3 , pp. 471-479
    • Kraegen, E.W.1    Saha, A.K.2    Preston, E.3    Wilks, D.4    Hoy, A.J.5    Cooney, G.J.6    Ruderman, N.B.7
  • 31
    • 75749104187 scopus 로고    scopus 로고
    • AMPK as a mediator of hormonal signalling
    • 19625456 10.1677/JME-09-0063
    • Lim CT, Kola B, Korbonits M (2010) AMPK as a mediator of hormonal signalling. J Mol Endocrinol 44(2):87-97
    • (2010) J Mol Endocrinol , vol.44 , Issue.2 , pp. 87-97
    • Lim, C.T.1    Kola, B.2    Korbonits, M.3
  • 32
    • 0034107525 scopus 로고    scopus 로고
    • Development of high fat diet-induced obesity and leptin resistance in C57Bl/6 J mice
    • 10849588 10.1038/sj.ijo.0801209
    • Lin S, Thomas TC, Storlien LH, Huang XF (2000) Development of high fat diet-induced obesity and leptin resistance in C57Bl/6 J mice. Int J Obes Relat Metab Disord 24(5):639-646
    • (2000) Int J Obes Relat Metab Disord , vol.24 , Issue.5 , pp. 639-646
    • Lin, S.1    Thomas, T.C.2    Storlien, L.H.3    Huang, X.F.4
  • 33
    • 28444497837 scopus 로고    scopus 로고
    • High-fat diet feeding impairs both the expression and activity of AMPKa in rats' skeletal muscle
    • 16316631 10.1016/j.bbrc.2005.11.068
    • Liu Y, Wan Q, Guan Q, Gao L, Zhao J (2006) High-fat diet feeding impairs both the expression and activity of AMPKa in rats' skeletal muscle. Biochem Biophys Res Commun 339(2):701-707
    • (2006) Biochem Biophys Res Commun , vol.339 , Issue.2 , pp. 701-707
    • Liu, Y.1    Wan, Q.2    Guan, Q.3    Gao, L.4    Zhao, J.5
  • 34
    • 33745815985 scopus 로고    scopus 로고
    • AMP-activated protein kinase signaling in metabolic regulation
    • 16823475 10.1172/JCI29044
    • Long YC, Zierath JR (2006) AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest 116(7):1776-1783
    • (2006) J Clin Invest , vol.116 , Issue.7 , pp. 1776-1783
    • Long, Y.C.1    Zierath, J.R.2
  • 35
    • 33745224043 scopus 로고    scopus 로고
    • Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle
    • 16687413 10.1074/jbc.M512831200
    • Martin TL, Alquier T, Asakura K, Furukawa N, Preitner F, Kahn BB (2006) Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle. J Biol Chem 281(28):18933-18941
    • (2006) J Biol Chem , vol.281 , Issue.28 , pp. 18933-18941
    • Martin, T.L.1    Alquier, T.2    Asakura, K.3    Furukawa, N.4    Preitner, F.5    Kahn, B.B.6
  • 36
    • 4143070336 scopus 로고    scopus 로고
    • Effect of dietary fat intake and exercise on inflammatory mediators of the immune system in sedentary men and women
    • 15310737
    • Meksawan K, Venkatraman JT, Awad AB, Pendergast DR (2004) Effect of dietary fat intake and exercise on inflammatory mediators of the immune system in sedentary men and women. J Am Coll Nutr 23(4):331-340
    • (2004) J Am Coll Nutr , vol.23 , Issue.4 , pp. 331-340
    • Meksawan, K.1    Venkatraman, J.T.2    Awad, A.B.3    Pendergast, D.R.4
  • 37
    • 0037122766 scopus 로고    scopus 로고
    • Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
    • 11797013 10.1038/415339a
    • Minokoshi Y, Kim YB, Peroni OD, Fryer LG, Muller C, Carling D, Kahn BB (2002) Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415(6869):339-343
    • (2002) Nature , vol.415 , Issue.6869 , pp. 339-343
    • Minokoshi, Y.1    Kim, Y.B.2    Peroni, O.D.3    Fryer, L.G.4    Muller, C.5    Carling, D.6    Kahn, B.B.7
  • 39
    • 79952213256 scopus 로고    scopus 로고
    • L Rodent models for metabolic syndrome research
    • 21253582 10.1155/2011/351982
    • Panchal SK, Brown (2011) L Rodent models for metabolic syndrome research. J Biomed Biotechnol 2011:351982
    • (2011) J Biomed Biotechnol , vol.2011 , pp. 351982
    • Panchal, S.K.1    Brown2
  • 40
    • 74549167737 scopus 로고    scopus 로고
    • Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
    • 20141834 10.1016/j.cell.2009.12.052
    • Park EJ, Lee JH, Yu GY, He G, Ali SR, Holzer RG, Osterreicher CH, Takahashi H, Karin M (2010) Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 140(2):197-208
    • (2010) Cell , vol.140 , Issue.2 , pp. 197-208
    • Park, E.J.1    Lee, J.H.2    Yu, G.Y.3    He, G.4    Ali, S.R.5    Holzer, R.G.6    Osterreicher, C.H.7    Takahashi, H.8    Karin, M.9
  • 41
    • 61449106744 scopus 로고    scopus 로고
    • AMPK and the biochemistry of exercise: Implications for human health and disease
    • 19196246 10.1042/BJ20082055
    • Richter EA, Ruderman NB (2009) AMPK and the biochemistry of exercise: implications for human health and disease. Biochem J 418(2):261-275
    • (2009) Biochem J , vol.418 , Issue.2 , pp. 261-275
    • Richter, E.A.1    Ruderman, N.B.2
  • 42
    • 84856580727 scopus 로고    scopus 로고
    • AMPK as target for intervention in childhood and adolescent obesity
    • 21318055
    • Rojas J, Arraiz N, Aguirre M, Velasco M, Bermudez V (2011) AMPK as target for intervention in childhood and adolescent obesity. J Obes 2011:252817
    • (2011) J Obes , vol.2011 , pp. 252817
    • Rojas, J.1    Arraiz, N.2    Aguirre, M.3    Velasco, M.4    Bermudez, V.5
  • 44
    • 58849115949 scopus 로고    scopus 로고
    • Adenosine 5′-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype
    • 19050283
    • Sag D, Carling D, Stout RD, Suttles J (2008) Adenosine 5′-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype. J Immunol 181(12):8633-8641
    • (2008) J Immunol , vol.181 , Issue.12 , pp. 8633-8641
    • Sag, D.1    Carling, D.2    Stout, R.D.3    Suttles, J.4
  • 45
    • 77957567397 scopus 로고    scopus 로고
    • Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle
    • 20682696 10.2337/db09-1870
    • Saha AK, Xu XJ, Lawson E, Deoliveira R, Brandon AE, Kraegen EW, Ruderman NB (2010) Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle. Diabetes 59(10):2426-2434
    • (2010) Diabetes , vol.59 , Issue.10 , pp. 2426-2434
    • Saha, A.K.1    Xu, X.J.2    Lawson, E.3    Deoliveira, R.4    Brandon, A.E.5    Kraegen, E.W.6    Ruderman, N.B.7
  • 46
    • 64149130937 scopus 로고    scopus 로고
    • Leptin resistance: A prediposing factor for diet-induced obesity
    • 19091915 10.1152/ajpregu.90669.2008
    • Scarpace PJ, Zhang Y (2009) Leptin resistance: a prediposing factor for diet-induced obesity. Am J Physiol Regul Integr Comp Physiol 296(3):R493-500
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.296 , Issue.3 , pp. 493-500
    • Scarpace, P.J.1    Zhang, Y.2
  • 47
    • 64149101055 scopus 로고    scopus 로고
    • Getting away from glucose: Fanning the flames of obesity-induced inflammation
    • 19350009 10.1038/nm0409-373
    • Shoelson SE, Goldfine AB (2009) Getting away from glucose: fanning the flames of obesity-induced inflammation. Nat Med 15(4):373-374
    • (2009) Nat Med , vol.15 , Issue.4 , pp. 373-374
    • Shoelson, S.E.1    Goldfine, A.B.2
  • 48
    • 34247489726 scopus 로고    scopus 로고
    • Inflammation in obesity is the common link between defects in fatty acid metabolism and insulin resistance
    • 17438370 10.4161/cc.6.8.4135
    • Steinberg GR (2007) Inflammation in obesity is the common link between defects in fatty acid metabolism and insulin resistance. Cell Cycle 6(8):888-894
    • (2007) Cell Cycle , vol.6 , Issue.8 , pp. 888-894
    • Steinberg, G.R.1
  • 49
    • 57049084022 scopus 로고    scopus 로고
    • Time course of high-fat diet-induced reductions in adipose tissue mitochondrial proteins: Potential mechanisms and the relationship to glucose intolerance
    • 18780775 10.1152/ajpendo.90408.2008
    • Sutherland LN, Capozzi LC, Turchinsky NJ, Bell RC, Wright DC (2008) Time course of high-fat diet-induced reductions in adipose tissue mitochondrial proteins: potential mechanisms and the relationship to glucose intolerance. Am J Physiol Endocrinol Metab 295(5):E1076-1083
    • (2008) Am J Physiol Endocrinol Metab , vol.295 , Issue.5 , pp. 1076-1083
    • Sutherland, L.N.1    Capozzi, L.C.2    Turchinsky, N.J.3    Bell, R.C.4    Wright, D.C.5
  • 50
    • 41649093318 scopus 로고    scopus 로고
    • Inflammatory mechanisms in the regulation of insulin resistance
    • 18235842
    • Tilg H, Moschen AR (2008) Inflammatory mechanisms in the regulation of insulin resistance. Mol Med 14(3-4):222-231
    • (2008) Mol Med , vol.14 , Issue.3-4 , pp. 222-231
    • Tilg, H.1    Moschen, A.R.2
  • 51
    • 77950348878 scopus 로고    scopus 로고
    • AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol
    • 19934007 10.2337/db09-0482
    • Um JH, Park SJ, Kang H, Yang S, Foretz M, McBurney MW, Kim MK, Viollet B, Chung JH (2010) AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes 59(3):554-563
    • (2010) Diabetes , vol.59 , Issue.3 , pp. 554-563
    • Um, J.H.1    Park, S.J.2    Kang, H.3    Yang, S.4    Foretz, M.5    McBurney, M.W.6    Kim, M.K.7    Viollet, B.8    Chung, J.H.9
  • 55
    • 66949121471 scopus 로고    scopus 로고
    • AMP-activated protein kinase pathway: A potential therapeutic target in cardiometabolic disease
    • 10.1042/CS20080066
    • Wong AK, Howie J, Petrie JR, Lang CC (2009) AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease. Clin Sci (Lond) 116(8):607-620
    • (2009) Clin Sci (Lond) , vol.116 , Issue.8 , pp. 607-620
    • Wong, A.K.1    Howie, J.2    Petrie, J.R.3    Lang, C.C.4
  • 56
    • 0037383261 scopus 로고    scopus 로고
    • A controlled high-fat diet induces an obese syndrome in rats
    • 12672923
    • Woods SC, Seeley RJ, Rushing PA, D'Alessio D, Tso P (2003) A controlled high-fat diet induces an obese syndrome in rats. J Nutr 133(4):1081-1087
    • (2003) J Nutr , vol.133 , Issue.4 , pp. 1081-1087
    • Woods, S.C.1    Seeley, R.J.2    Rushing, P.A.3    D'Alessio, D.4    Tso, P.5
  • 58
    • 33745204479 scopus 로고    scopus 로고
    • AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues
    • 16709629 10.1113/jphysiol.2006.113217
    • Xue B, Kahn BB (2006) AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues. J Physiol 574(Pt 1):73-83
    • (2006) J Physiol , vol.574 , Issue.PART 1 , pp. 73-83
    • Xue, B.1    Kahn, B.B.2
  • 59
    • 77953517927 scopus 로고    scopus 로고
    • Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1
    • 20421294 10.1074/jbc.M110.123620
    • Yang Z, Kahn BB, Shi H, Xue BZ (2010) Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1. J Biol Chem 285(25):19051-19059
    • (2010) J Biol Chem , vol.285 , Issue.25 , pp. 19051-19059
    • Yang, Z.1    Kahn, B.B.2    Shi, H.3    Xue, B.Z.4
  • 60
    • 12144271041 scopus 로고    scopus 로고
    • Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: Prevention of diabetes and ectopic lipid deposition
    • 15578153 10.1007/s00125-004-1570-9
    • Yu X, McCorkle S, Wang M, Lee Y, Li J, Saha AK, Unger RH, Ruderman NB (2004) Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition. Diabetologia 47(11):2012-2021
    • (2004) Diabetologia , vol.47 , Issue.11 , pp. 2012-2021
    • Yu, X.1    McCorkle, S.2    Wang, M.3    Lee, Y.4    Li, J.5    Saha, A.K.6    Unger, R.H.7    Ruderman, N.B.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.